{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T01:27:53Z","timestamp":1771550873262,"version":"3.50.1"},"reference-count":28,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,18]],"date-time":"2013-07-18T00:00:00Z","timestamp":1374105600000},"content-version":"vor","delay-in-days":778,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","resmedjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Medicine"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1016\/j.rmed.2011.02.007","type":"journal-article","created":{"date-parts":[[2011,3,16]],"date-time":"2011-03-16T16:29:57Z","timestamp":1300292997000},"page":"900-906","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Effects of formoterol and tiotropium bromide on mucus clearance in patients with COPD"],"prefix":"10.1016","volume":"105","author":[{"given":"Thomas","family":"Meyer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Reitmeir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Brand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiane","family":"Herpich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Knut","family":"Sommerer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja","family":"Schulze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard","family":"Scheuch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Newman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.rmed.2011.02.007_bib1","series-title":"Global initiative for chronic obstructive lung disease","author":"GOLD Guidelines","year":"2007"},{"key":"10.1016\/j.rmed.2011.02.007_bib2","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1136\/bmj.330.7492.640","article-title":"Recent developments in inhaled therapy in stable chronic obstructive pulmonary disease","volume":"330","author":"Cooper","year":"2005","journal-title":"Br Med J"},{"key":"10.1016\/j.rmed.2011.02.007_bib3","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1172\/JCI0215217","article-title":"Mucus clearance as a primary innate defense mechanism for mammalian airways","volume":"109","author":"Knowles","year":"2002","journal-title":"J Clin Invest"},{"issue":"Suppl. 127","key":"10.1016\/j.rmed.2011.02.007_bib4","first-page":"41","article-title":"Measurement of bronchial mucociliary clearance","volume":"64","author":"Pavia","year":"1983","journal-title":"Eur J Respir Dis"},{"key":"10.1016\/j.rmed.2011.02.007_bib5","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1378\/chest.103.5.1390","article-title":"Regional impairment of mucociliary clearance in chronic obstructive pulmonary disease","volume":"103","author":"Smaldone","year":"1993","journal-title":"Chest"},{"key":"10.1016\/j.rmed.2011.02.007_bib6","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.pupt.2005.04.001","article-title":"Effect of salmeterol on mucociliary clearance and cough clearance in chronic bronchitis","volume":"19","author":"Bennett","year":"2005","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1016\/j.rmed.2011.02.007_bib7","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1378\/chest.103.2.488","article-title":"The acute effect of ipratropium bromide bronchodilator therapy on cough clearance in COPD","volume":"103","author":"Bennett","year":"1993","journal-title":"Chest"},{"key":"10.1016\/j.rmed.2011.02.007_bib8","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1034\/j.1399-3003.1999.14b35.x","article-title":"Effects of drugs on mucus clearance","volume":"14","author":"Houtmeyers","year":"1999","journal-title":"Eur Respir J"},{"key":"10.1016\/j.rmed.2011.02.007_bib9","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/0002-9343(86)90459-6","article-title":"Airway mucus membrane: effects of beta-adrenergic and anticholinergic stimulation","volume":"81","author":"Foster","year":"1986","journal-title":"Am J Med"},{"key":"10.1016\/j.rmed.2011.02.007_bib10","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0002-9343(86)90458-4","article-title":"Effect of ipratropium bromide on airway mucociliary function","volume":"14","author":"Wanner","year":"1986","journal-title":"Am J Med"},{"key":"10.1016\/j.rmed.2011.02.007_bib11","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1136\/thx.41.4.295","article-title":"Effect of four weeks\u2019 high dose ipratropium bromide treatment on lung mucociliary clearance","volume":"41","author":"Taylor","year":"1986","journal-title":"Thorax"},{"key":"10.1016\/j.rmed.2011.02.007_bib12","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1378\/chest.125.5.1726","article-title":"The effect of inhaled tiotropium bromide on lung mucociliary clearance in patients with COPD","volume":"125","author":"Hasani","year":"2004","journal-title":"Chest"},{"key":"10.1016\/j.rmed.2011.02.007_bib13","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/BF00286771","article-title":"Investigation into the effect of fenoterol on mucociliary clearance in patients with chronic bronchitis","volume":"14","author":"Weich","year":"1988","journal-title":"Eur J Nucl Med"},{"issue":"Suppl.","key":"10.1016\/j.rmed.2011.02.007_bib14","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1378\/chest.80.6.827","article-title":"Effect of inhaled salbutamol on mucociliary clearance in patients with chronic bronchitis","volume":"80","author":"Fazio","year":"1981","journal-title":"Chest"},{"key":"10.1016\/j.rmed.2011.02.007_bib15","first-page":"503","article-title":"The influence of a new beta agonist: formoterol on mucociliary function","volume":"9","author":"Melloni","year":"1992","journal-title":"Rev Mal Respir"},{"key":"10.1016\/j.rmed.2011.02.007_bib16","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0014-2999(95)00416-I","article-title":"The effects of formoterol, a long-acting beta 2-adrenoceptor agonist, on mucociliary activity","volume":"285","author":"Lindberg","year":"1995","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.rmed.2011.02.007_bib17","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S0304-8853(00)01221-X","article-title":"Preparation of spherical monodisperse ferrimagnetic iron-oxide microparticles between 1 and 5 \u03bcm","volume":"225","author":"M\u00f6ller","year":"2001","journal-title":"J Magnet Magn Mat"},{"key":"10.1016\/j.rmed.2011.02.007_bib18","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1089\/jam.1996.9.35","article-title":"An approach to deposition and clearance measurements in the human airways","volume":"9","author":"Scheuch","year":"1996","journal-title":"J Aerosol Med"},{"key":"10.1016\/j.rmed.2011.02.007_bib19","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1080\/019021402753355526","article-title":"Alveolar deposition of monodisperse aerosol particles in the lung of patients with COPD","volume":"28","author":"Brand","year":"2002","journal-title":"Exp Lung Res"},{"key":"10.1016\/j.rmed.2011.02.007_bib20","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1183\/09031936.96.09040725","article-title":"Inhalation of hypertonic saline aerosol enhances mucociliary clearance in asthmatic and healthy subjects","volume":"9","author":"Daviskas","year":"1996","journal-title":"Eur Respir J"},{"key":"10.1016\/j.rmed.2011.02.007_bib21","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1164\/ajrccm.153.2.8564129","article-title":"Effect of rhDNase on airflow obstruction and mucociliary clearance in cystic fibrosis","volume":"153","author":"Laube","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"issue":"Suppl.","key":"10.1016\/j.rmed.2011.02.007_bib22","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1378\/chest.80.6.885","article-title":"Effect of terbutaline on mucociliary transport and sputum properties in chronic bronchitis","volume":"80","author":"Sadoul","year":"1981","journal-title":"Chest"},{"key":"10.1016\/j.rmed.2011.02.007_bib23","first-page":"245","article-title":"Clearance of lung secretions in patients with chronic bronchitis: effect of terbutaline and ipratropium bromide aerosols","volume":"61","author":"Pavia","year":"1980","journal-title":"Eur J Respir Dis"},{"key":"10.1016\/j.rmed.2011.02.007_bib24","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.rmed.2004.07.004","article-title":"Mucociliary clearance in COPD can be increased by both a D2\/beta2 and a standard beta2 agonist","volume":"99","author":"Hasani","year":"2005","journal-title":"Respir Med"},{"issue":"Suppl. 110","key":"10.1016\/j.rmed.2011.02.007_bib25","first-page":"157","article-title":"Techniques for measuring lung mucociliary clearance","volume":"61","author":"Pavia","year":"1980","journal-title":"Eur J Respir Dis"},{"key":"10.1016\/j.rmed.2011.02.007_bib26","doi-asserted-by":"crossref","first-page":"343","DOI":"10.3109\/01902149209031689","article-title":"Deposition and dispersion of aerosols in the airways of the human respiratory tract: the effect of particle size","volume":"18","author":"Scheuch","year":"1992","journal-title":"Exp Lung Res"},{"key":"10.1016\/j.rmed.2011.02.007_bib27","doi-asserted-by":"crossref","first-page":"S291","DOI":"10.1067\/mai.2002.129704","article-title":"Effect of beta-adrenergic agonists on mucociliary clearance","volume":"110","author":"Bennett","year":"2002","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.rmed.2011.02.007_bib28","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1378\/chest.120.1.258","article-title":"Alternative mechanisms for long-acting beta-2 adrenergic agonists in COPD","volume":"120","author":"Johnson","year":"2001","journal-title":"Chest"}],"container-title":["Respiratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611111000564?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611111000564?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T11:13:36Z","timestamp":1760613216000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0954611111000564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["S0954611111000564"],"URL":"https:\/\/doi.org\/10.1016\/j.rmed.2011.02.007","relation":{},"ISSN":["0954-6111"],"issn-type":[{"value":"0954-6111","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of formoterol and tiotropium bromide on mucus clearance in patients with COPD","name":"articletitle","label":"Article Title"},{"value":"Respiratory Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rmed.2011.02.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}