{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T09:08:02Z","timestamp":1769159282653,"version":"3.49.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":731,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Foreest Medical School, Alkmaar"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","resmedjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Medicine"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.rmed.2015.10.009","type":"journal-article","created":{"date-parts":[[2015,11,3]],"date-time":"2015-11-03T16:04:45Z","timestamp":1446566685000},"page":"46-52","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Effects of doxycycline on local and systemic inflammation in stable COPD patients, a randomized clinical trial"],"prefix":"10.1016","volume":"110","author":[{"given":"Hendrik J.","family":"Prins","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes M.A.","family":"Daniels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan H.","family":"Lindeman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9","family":"Lutter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wim G.","family":"Boersma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.rmed.2015.10.009_bib1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1080\/15412550701597720","article-title":"Repeatability of inflammatory parameters in induced sputum of COPD patients","volume":"4","author":"Boorsma","year":"2007","journal-title":"COPD"},{"issue":"4","key":"10.1016\/j.rmed.2015.10.009_bib2","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1034\/j.1399-3003.1999.13d24.x","article-title":"The cellular composition of induced sputum in chronic obstructive pulmonary disease","volume":"13","author":"Peleman","year":"1999","journal-title":"Eur. Respir. J."},{"issue":"5","key":"10.1016\/j.rmed.2015.10.009_bib3","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1165\/rcmb.2012-0492TR","article-title":"The neutrophil in chronic obstructive pulmonary disease","volume":"48","author":"Hoenderdos","year":"2013","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"6","key":"10.1016\/j.rmed.2015.10.009_bib4","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1378\/chest.126.6.1802","article-title":"Increased activity of matrix metalloproteinase-8 and matrix metalloproteinase-9 in induced sputum from patients with COPD","volume":"126","author":"Vernooy","year":"2004","journal-title":"Chest"},{"issue":"9435","key":"10.1016\/j.rmed.2015.10.009_bib5","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0140-6736(04)16900-6","article-title":"Pathophysiology of airflow limitation in chronic obstructive pulmonary disease","volume":"364","author":"Hogg","year":"2004","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.rmed.2015.10.009_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-2999(02)02182-9","article-title":"The role of neutrophil elastase in acute lung injury","volume":"451","author":"Kawabata","year":"2002","journal-title":"Eur. J. Pharmacol."},{"issue":"3 Pt 1","key":"10.1016\/j.rmed.2015.10.009_bib7","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1164\/ajrccm.161.3.9907080","article-title":"Goblet cell hyperplasia and epithelial inflammation in peripheral airways of smokers with both symptoms of chronic bronchitis and chronic airflow limitation","volume":"161","author":"Saetta","year":"2000","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"5","key":"10.1016\/j.rmed.2015.10.009_bib8","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1378\/chest.06-2194","article-title":"The association between small airway obstruction and emphysema phenotypes in COPD","volume":"131","author":"Kim","year":"2007","journal-title":"Chest"},{"issue":"5","key":"10.1016\/j.rmed.2015.10.009_bib9","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1111\/j.1600-0765.1983.tb00388.x","article-title":"Minocycline reduces gingival collagenolytic activity during diabetes. Preliminary observations and a proposed new mechanism of action","volume":"18","author":"Golub","year":"1983","journal-title":"J.\u00a0Periodontal Res."},{"issue":"2","key":"10.1016\/j.rmed.2015.10.009_bib10","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s10787-011-0077-5","article-title":"Anti-inflammatory properties of doxycycline and minocycline in experimental models: an in\u00a0vivo and in\u00a0vitro comparative study","volume":"19","author":"Leite","year":"2011","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.rmed.2015.10.009_bib11","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1477-5956-8-3","article-title":"Effects of MMP-9 inhibition by doxycycline on proteome of lungs in high tidal volume mechanical ventilation-induced acute lung injury","volume":"8","author":"Doroszko","year":"2010","journal-title":"Proteome Sci."},{"issue":"2","key":"10.1016\/j.rmed.2015.10.009_bib12","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1159\/000212080","article-title":"Inhibition of matrix metalloproteinase-9 with doxycycline reduces pancreatitis-associated lung injury","volume":"80","author":"Sochor","year":"2009","journal-title":"Digestion"},{"issue":"4","key":"10.1016\/j.rmed.2015.10.009_bib13","doi-asserted-by":"crossref","first-page":"221","DOI":"10.4103\/1817-1737.84777","article-title":"Effect of doxycycline in patients of moderate to severe chronic obstructive pulmonary disease with stable symptoms","volume":"6","author":"Dalvi","year":"2011","journal-title":"Ann. Thorac. Med."},{"key":"10.1016\/j.rmed.2015.10.009_bib14","unstructured":"Global Initiative for chronic obstructive lung disease Global Strategy for the Diagnosis, Management and Prevention of Chronic Obstructive Pulmonary Disease 2013"},{"issue":"2","key":"10.1016\/j.rmed.2015.10.009_bib15","doi-asserted-by":"crossref","first-page":"196","DOI":"10.7326\/0003-4819-106-2-196","article-title":"Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease","volume":"106","author":"Anthonisen","year":"1987","journal-title":"Ann. Intern Med."},{"issue":"4","key":"10.1016\/j.rmed.2015.10.009_bib16","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/BF00914095","article-title":"Myeloperoxidase in human lung lavage. I. A marker of local neutrophil activity","volume":"14","author":"Schmekel","year":"1990","journal-title":"Inflammation"},{"issue":"3","key":"10.1016\/j.rmed.2015.10.009_bib17","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.jvs.2008.09.055","article-title":"Doxycycline therapy for abdominal aneurysm: improved proteolytic balance through reduced neutrophil content","volume":"49","author":"Abdul-Hussien","year":"2009","journal-title":"J.\u00a0Vasc. Surg."},{"issue":"16","key":"10.1016\/j.rmed.2015.10.009_bib18","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1161\/CIRCULATIONAHA.108.806505","article-title":"Clinical trial of doxycycline for matrix metalloproteinase-9 inhibition in patients with an abdominal aneurysm: doxycycline selectively depletes aortic wall neutrophils and cytotoxic T cells","volume":"119","author":"Lindeman","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.rmed.2015.10.009_bib19","first-page":"19s","article-title":"Methods of sputum processing for cell counts, immunocytochemistry and in situ hybridisation","volume":"37","author":"Efthimiadis","year":"2002","journal-title":"Eur. Respir. J. Suppl."},{"issue":"3 Pt. 1","key":"10.1016\/j.rmed.2015.10.009_bib20","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1164\/ajrccm.162.3.9908103","article-title":"Airway inflammation in nonobstructive and obstructive chronic bronchitis with chronic haemophilus influenzae airway infection. Comparison with noninfected patients with chronic obstructive pulmonary disease","volume":"162","author":"Bresser","year":"2000","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.rmed.2015.10.009_bib21","doi-asserted-by":"crossref","unstructured":"S.A. Julious. Sample size of 12 per group rule of thumb for a pilot study. 4(4), 287\u2013291. 25-12-0005. Wiley online library.","DOI":"10.1002\/pst.185"},{"issue":"4","key":"10.1016\/j.rmed.2015.10.009_bib22","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1183\/09031936.03.00040703","article-title":"Chronic obstructive pulmonary disease: molecular and cellular mechanisms","volume":"22","author":"Barnes","year":"2003","journal-title":"Eur. Respir. J."},{"issue":"5","key":"10.1016\/j.rmed.2015.10.009_bib23","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1189\/jlb.1204697","article-title":"Myeloperoxidase: friend and foe","volume":"77","author":"Klebanoff","year":"2005","journal-title":"J.\u00a0Leukoc. Biol."},{"issue":"2","key":"10.1016\/j.rmed.2015.10.009_bib24","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1189\/jlb.0712349","article-title":"Myeloperoxidase: a front-line defender against phagocytosed microorganisms","volume":"93","author":"Klebanoff","year":"2013","journal-title":"J.\u00a0Leukoc. Biol."},{"issue":"1","key":"10.1016\/j.rmed.2015.10.009_bib25","first-page":"1","article-title":"Neutrophil activation and acute lung injury","volume":"7","author":"Lee","year":"2001","journal-title":"Curr. Opin. Crit. Care"},{"issue":"3","key":"10.1016\/j.rmed.2015.10.009_bib26","doi-asserted-by":"crossref","first-page":"262","DOI":"10.14219\/jada.archive.2011.0165","article-title":"The effect of subantimicrobial-dose-doxycycline periodontal therapy on serum biomarkers of systemic inflammation: a randomized, double-masked, placebo-controlled clinical trial","volume":"142","author":"Payne","year":"2011","journal-title":"J.\u00a0Am. Dent. Assoc."},{"issue":"4","key":"10.1016\/j.rmed.2015.10.009_bib27","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1517\/14728222.10.4.547","article-title":"Pharmacological targets in the treatment of abdominal aortic aneurysms","volume":"10","author":"Bergoeing","year":"2006","journal-title":"Expert Opin. Ther. Targets"},{"issue":"2","key":"10.1016\/j.rmed.2015.10.009_bib28","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1034\/j.1600-051x.2001.028002146.x","article-title":"Adjunctive treatment with subantimicrobial doses of doxycycline: effects on gingival fluid collagenase activity and attachment loss in adult periodontitis","volume":"28","author":"Golub","year":"2001","journal-title":"J.\u00a0Clin. Periodontol."},{"key":"10.1016\/j.rmed.2015.10.009_bib29","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1186\/1741-7015-11-241","article-title":"The link between chronic periodontitis and COPD: a common role for the neutrophil?","volume":"11","author":"Usher","year":"2013","journal-title":"BMC Med."},{"issue":"2","key":"10.1016\/j.rmed.2015.10.009_bib30","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.ejvs.2012.05.016","article-title":"An association between chronic obstructive pulmonary disease and abdominal aortic aneurysm beyond smoking: results from a case-control study","volume":"44","author":"Meijer","year":"2012","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"issue":"5","key":"10.1016\/j.rmed.2015.10.009_bib31","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s00011-013-0704-2","article-title":"The effect of prolonged systemic doxycycline therapy on serum tissue degrading proteinases in coronary bypass patients: a randomized, double-masked, placebo-controlled clinical trial","volume":"63","author":"Kormi","year":"2014","journal-title":"Inflamm. Res."},{"issue":"1","key":"10.1016\/j.rmed.2015.10.009_bib32","first-page":"35","article-title":"Proof of concept: matrix metalloproteinase inhibitor decreases inflammation and improves muscle insulin sensitivity in people with type 2 diabetes","volume":"9","author":"Frankwich","year":"2012","journal-title":"J.\u00a0Inflamm. Lond."},{"issue":"5","key":"10.1016\/j.rmed.2015.10.009_bib33","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/j.jaci.2010.02.020","article-title":"Oral steroids and doxycycline: two different approaches to treat nasal polyps","volume":"125","author":"Van Zele","year":"2010","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"issue":"5 Suppl.","key":"10.1016\/j.rmed.2015.10.009_bib34","first-page":"e30","article-title":"Airway and systemic inflammation and decline in lung function in patients with COPD","volume":"136","author":"Donaldson","year":"2005","journal-title":"Chest 2009"},{"issue":"3 Suppl.","key":"10.1016\/j.rmed.2015.10.009_bib35","first-page":"67","article-title":"Low-dose doxycycline plus additional therapies may lower systemic inflammation in postmenopausal women with periodontitis","volume":"12","author":"Bretz","year":"2012","journal-title":"J.\u00a0Evid. Based Dent. Pract."},{"issue":"1","key":"10.1016\/j.rmed.2015.10.009_bib36","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1159\/000330667","article-title":"Profiling of sputum inflammatory mediators in asthma and chronic obstructive pulmonary disease","volume":"83","author":"Bafadhel","year":"2012","journal-title":"Respiration"},{"issue":"2","key":"10.1016\/j.rmed.2015.10.009_bib37","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3109\/15412555.2011.636407","article-title":"Effect of bronchial colonisation on airway and systemic inflammation in stable COPD","volume":"9","author":"Marin","year":"2012","journal-title":"COPD"},{"issue":"2 Suppl.","key":"10.1016\/j.rmed.2015.10.009_bib38","doi-asserted-by":"crossref","first-page":"70S","DOI":"10.1378\/chest.125.2_suppl.70S","article-title":"Immunomodulatory activity and effectiveness of macrolides in chronic airway disease","volume":"125","author":"Rubin","year":"2004","journal-title":"Chest"},{"issue":"5","key":"10.1016\/j.rmed.2015.10.009_bib39","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S2213-2600(14)70019-0","article-title":"Azithromycin maintenance treatment in patients with frequent exacerbations of chronic obstructive pulmonary disease (COLUMBUS): a randomised, double-blind, placebo-controlled trial","volume":"2","author":"Uzun","year":"2014","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.rmed.2015.10.009_bib40","first-page":"CD009764","article-title":"Prophylactic antibiotic therapy for chronic obstructive pulmonary disease (COPD)","volume":"11","author":"Herath","year":"2013","journal-title":"Cochrane Database Syst. Rev."},{"issue":"5","key":"10.1016\/j.rmed.2015.10.009_bib41","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1183\/09031936.04.00056804","article-title":"Impact of sputum bacteria on airway inflammation and health status in clinical stable COPD","volume":"23","author":"Banerjee","year":"2004","journal-title":"Eur. Respir. J."}],"container-title":["Respiratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611115300731?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611115300731?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T11:33:35Z","timestamp":1760614415000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0954611115300731"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":41,"alternative-id":["S0954611115300731"],"URL":"https:\/\/doi.org\/10.1016\/j.rmed.2015.10.009","relation":{},"ISSN":["0954-6111"],"issn-type":[{"value":"0954-6111","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of doxycycline on local and systemic inflammation in stable COPD patients, a randomized clinical trial","name":"articletitle","label":"Article Title"},{"value":"Respiratory Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rmed.2015.10.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}