{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:25:34Z","timestamp":1773296734917,"version":"3.50.1"},"reference-count":16,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,9,29]],"date-time":"2016-09-29T00:00:00Z","timestamp":1475107200000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","resmedjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Medicine"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.rmed.2016.07.001","type":"journal-article","created":{"date-parts":[[2016,7,3]],"date-time":"2016-07-03T09:59:08Z","timestamp":1467539948000},"page":"102-111","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Safety and tolerability of once-daily tiotropium Respimat\u00ae as add-on to at least inhaled corticosteroids in adult patients with symptomatic asthma: A pooled safety analysis"],"prefix":"10.1016","volume":"118","author":[{"given":"Ronald","family":"Dahl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Engel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5820-3789","authenticated-orcid":false,"given":"Daniel","family":"Dusser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Halpin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huib A.M.","family":"Kerstjens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliana","family":"Zaremba-Pechmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra","family":"Moroni-Zentgraf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2591-4696","authenticated-orcid":false,"given":"William W.","family":"Busse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric D.","family":"Bateman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.rmed.2016.07.001_bib1","series-title":"Global Strategy for Asthma Management and Prevention","author":"Global Initiative for Asthma","year":"2015"},{"issue":"8","key":"10.1016\/j.rmed.2016.07.001_bib2","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1164\/rccm.200401-033OC","article-title":"Can guideline-defined asthma control be achieved? The Gaining Optimal Asthma ControL study","volume":"170","author":"Bateman","year":"2004","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"3","key":"10.1016\/j.rmed.2016.07.001_bib3","doi-asserted-by":"crossref","first-page":"315","DOI":"10.4104\/pcrj.2011.00056","article-title":"Understanding patients with asthma and COPD: insights from a European study","volume":"20","author":"Partridge","year":"2011","journal-title":"Prim. Care Respir. J."},{"issue":"112","key":"10.1016\/j.rmed.2016.07.001_bib4","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1183\/09059180.00001209","article-title":"Prevalence of asthma control among adults in France, Germany, Italy, Spain and the UK","volume":"18","author":"Demoly","year":"2009","journal-title":"Eur. Respir. Rev."},{"issue":"2","key":"10.1016\/j.rmed.2016.07.001_bib5","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.jaci.2011.04.039","article-title":"Tiotropium improves lung function in patients with severe uncontrolled asthma: a randomized controlled trial","volume":"128","author":"Kerstjens","year":"2011","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"issue":"2","key":"10.1016\/j.rmed.2016.07.001_bib6","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.jaci.2011.06.004","article-title":"Tiotropium is noninferior to salmeterol in maintaining improved lung function in B16-Arg\/Arg patients with asthma","volume":"128","author":"Bateman","year":"2011","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.rmed.2016.07.001_bib7","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/1465-9921-15-61","article-title":"Tiotropium Respimat\u00ae in asthma: a double-blind, randomised, dose-ranging study in adult patients with moderate asthma","volume":"15","author":"Beeh","year":"2014","journal-title":"Respir. Res."},{"issue":"3","key":"10.1016\/j.rmed.2016.07.001_bib8","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.rmed.2014.12.005","article-title":"Once-daily tiotropium Respimat\u00ae 5 \u03bcg is an efficacious 24-hour bronchodilator in adults with symptomatic asthma","volume":"109","author":"Timmer","year":"2015","journal-title":"Respir. Med."},{"issue":"13","key":"10.1016\/j.rmed.2016.07.001_bib9","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1056\/NEJMoa1208606","article-title":"Tiotropium in asthma poorly controlled with standard combination therapy","volume":"367","author":"Kerstjens","year":"2012","journal-title":"N.\u00a0Engl. J. Med."},{"issue":"5","key":"10.1016\/j.rmed.2016.07.001_bib10","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S2213-2600(15)00031-4","article-title":"Tiotropium or salmeterol as add-on therapy to inhaled corticosteroids for patients with moderate symptomatic asthma: two replicate, double-blind, placebo-controlled, parallel-group, active-comparator, randomised trials","volume":"3","author":"Kerstjens","year":"2015","journal-title":"Lancet Respir. Med."},{"issue":"4","key":"10.1016\/j.rmed.2016.07.001_bib11","doi-asserted-by":"crossref","first-page":"e0124109","DOI":"10.1371\/journal.pone.0124109","article-title":"Long-term once-daily tiotropium Respimat\u00ae is well tolerated and maintains efficacy over 52 weeks in patients with symptomatic asthma in Japan: a randomised, placebo-controlled study","volume":"10","author":"Ohta","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.rmed.2016.07.001_bib12","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jaip.2015.08.017","article-title":"The effect of tiotropium in symptomatic asthma despite low- to medium-dose inhaled corticosteroids: a randomized controlled trial","volume":"4","author":"Paggiaro","year":"2016","journal-title":"J.\u00a0Allergy Clin. Immunol. Pract."},{"key":"10.1016\/j.rmed.2016.07.001_bib13","doi-asserted-by":"crossref","DOI":"10.1089\/jamp.2015.1260","article-title":"Pharmacodynamics and pharmacokinetics following once-daily and twice-daily dosing of tiotropium Respimat\u00ae in asthma using standardized sample-contamination avoidance","author":"Beeh","year":"2016","journal-title":"J.\u00a0Aerosol Med. Pulm. Drug Deliv."},{"issue":"1","key":"10.1016\/j.rmed.2016.07.001_bib14","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1476-5381.2010.01190.x","article-title":"Muscarinic receptor antagonists, from folklore to pharmacology; finding drugs that actually work in asthma and COPD","volume":"163","author":"Moulton","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.rmed.2016.07.001_bib15","series-title":"SPIRIVA\u00ae RESPIMAT\u00ae (tiotropium bromide) inhalation spray, for oral inhalation","author":"Boehringer Ingelheim Pharmaceuticals, Inc.","year":"2015"},{"issue":"5","key":"10.1016\/j.rmed.2016.07.001_bib16","first-page":"482","article-title":"Tiotropium and the risk of death in COPD","volume":"370","author":"Wise","year":"2014","journal-title":"N.\u00a0Engl. J. Med."}],"container-title":["Respiratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611116301482?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611116301482?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T11:35:50Z","timestamp":1760614550000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0954611116301482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":16,"alternative-id":["S0954611116301482"],"URL":"https:\/\/doi.org\/10.1016\/j.rmed.2016.07.001","relation":{},"ISSN":["0954-6111"],"issn-type":[{"value":"0954-6111","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Safety and tolerability of once-daily tiotropium Respimat\u00ae as add-on to at least inhaled corticosteroids in adult patients with symptomatic asthma: A pooled safety analysis","name":"articletitle","label":"Article Title"},{"value":"Respiratory Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rmed.2016.07.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}