{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:12:50Z","timestamp":1790813570729,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"vor","delay-in-days":730,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51576214"],"award-info":[{"award-number":["51576214"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","resmedjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Medicine"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.rmed.2016.10.016","type":"journal-article","created":{"date-parts":[[2016,10,26]],"date-time":"2016-10-26T14:30:19Z","timestamp":1477492219000},"page":"67-73","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":121,"special_numbering":"C","title":["Early life exposure to traffic-related air pollution and allergic rhinitis in preschool children"],"prefix":"10.1016","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9824-3534","authenticated-orcid":false,"given":"Qihong","family":"Deng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichen","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuguo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Sundell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Norb\u00e4ck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rmed.2016.10.016_bib1","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1111\/all.12782","article-title":"Latest developments in allergic rhinitis in allergy for clinicians and researchers","volume":"70","author":"Ng","year":"2015","journal-title":"Allergy"},{"key":"10.1016\/j.rmed.2016.10.016_bib2","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S0140-6736(06)69283-0","article-title":"Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC phases one and three repeat multicountry cross-sectional surveys","volume":"368","author":"Asher","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.rmed.2016.10.016_bib3","doi-asserted-by":"crossref","first-page":"S147","DOI":"10.1067\/mai.2001.118891","article-title":"Allergic rhinitis and its impact on asthma","volume":"108","author":"Bousquet","year":"2001","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.rmed.2016.10.016_bib4","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1183\/09031936.00083406","article-title":"Air pollution and development of asthma, allergy and infections in a birth cohort","volume":"29","author":"Brauer","year":"2007","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.rmed.2016.10.016_bib5","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1164\/rccm.200906-0858OC","article-title":"Traffic-related air pollution and the development of asthma and allergies during the first 8 years of life","volume":"181","author":"Gehring","year":"2010","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.rmed.2016.10.016_bib6","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1111\/j.1398-9995.2006.01070.x","article-title":"Is outdoor air pollution associated with physician visits for allergic rhinitis among the elderly in Toronto, Canada?","volume":"61","author":"Villeneuve","year":"2006","journal-title":"Allergy"},{"key":"10.1016\/j.rmed.2016.10.016_bib7","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1016\/j.scitotenv.2011.04.007","article-title":"Time-series studies on air pollution and daily outpatient visits for allergic rhinitis in Beijing, China","volume":"409","author":"Zhang","year":"2011","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.rmed.2016.10.016_bib8","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1080\/15287394.2016.1182002","article-title":"Air pollution exposure and daily clinical visits for allergic rhinitis in a subtropical city: Taipei, Taiwan","volume":"79","author":"Chen","year":"2016","journal-title":"J.\u00a0Toxicol. Environ. Health A"},{"key":"10.1016\/j.rmed.2016.10.016_bib9","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1097\/00130832-200410000-00003","article-title":"Traffic related pollutants in Europe and their effect on allergic disease","volume":"4","author":"Heinrich","year":"2004","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"10.1016\/j.rmed.2016.10.016_bib10","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/all.12561","article-title":"The influence of childhood traffic related air pollution exposure on asthma, allergy and sensitization: a systematic review and a meta-analysis of birth cohort studies","volume":"70","author":"Bowatte","year":"2015","journal-title":"Allergy"},{"key":"10.1016\/j.rmed.2016.10.016_bib11","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.envint.2016.04.019","article-title":"Associations of gestational and early life exposures to ambient air pollution with childhood respiratory diseases in Shanghai, China: a retrospective cohort study","volume":"92\u201393","author":"Liu","year":"2016","journal-title":"Environ. Int."},{"key":"10.1016\/j.rmed.2016.10.016_bib12","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.chemosphere.2016.03.032","article-title":"Preconceptional, prenatal and postnatal exposure to outdoor and indoor environmental factors on allergic diseases\/symptoms in preschool children","volume":"152","author":"Deng","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.rmed.2016.10.016_bib13","doi-asserted-by":"crossref","first-page":"e193","DOI":"10.7717\/peerj.193","article-title":"A\u00a0longitudinal analysis of associations between traffic-related air pollution with asthma, allergies and sensitization in the GINIplus and LISAplus birth cohorts","volume":"1","author":"Fuertes","year":"2013","journal-title":"PeerJ"},{"key":"10.1016\/j.rmed.2016.10.016_bib14","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1056\/NEJMra0708473","article-title":"Effect of in utero and early-life conditions on adult health and disease","volume":"359","author":"Gluckman","year":"2008","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.rmed.2016.10.016_bib15","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1289\/ehp.1205281","article-title":"Early-life exposure to outdoor air pollution and respiratory health, ear infections, and eczema in infants from the INMA study","volume":"121","author":"Aguilera","year":"2013","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.rmed.2016.10.016_bib16","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.envres.2015.09.032","article-title":"Early life exposure to ambient air pollution and childhood asthma in China","volume":"143","author":"Deng","year":"2015","journal-title":"Environ. Res."},{"key":"10.1016\/j.rmed.2016.10.016_bib17","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.envres.2016.05.050","article-title":"Exposure to outdoor air pollution during trimesters of pregnancy and childhood asthma, allergic rhinitis, and eczema","volume":"150","author":"Deng","year":"2016","journal-title":"Environ. Res."},{"key":"10.1016\/j.rmed.2016.10.016_bib18","article-title":"Early exposure to traffic-related air pollution, respiratory symptoms at 4 years of age, and potential effect modification by parental allergy, stressful family events, and gender: a prospective follow-up study of the PARIS Birth Cohort","author":"Ranci\u00e8re","year":"2016","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.rmed.2016.10.016_bib19","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1289\/ehp.7187","article-title":"The association between asthma and allergic symptoms in children and phthalates in house dust: a nested case-control study","volume":"112","author":"Bornehag","year":"2004","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.rmed.2016.10.016_bib20","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.envint.2011.03.003","article-title":"Ambient air pollution, climate change, and population health in China","volume":"42","author":"Kan","year":"2012","journal-title":"Environ. Int."},{"key":"10.1016\/j.rmed.2016.10.016_bib21","doi-asserted-by":"crossref","first-page":"e0114022","DOI":"10.1371\/journal.pone.0114022","article-title":"Pre- and postnatal risk factors in relation to allergic rhinitis in school-aged children in China","volume":"10","author":"Li","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.rmed.2016.10.016_bib22","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1111\/j.1365-2222.2009.03206.x","article-title":"Prevalence of allergic rhinitis in 3-6-year-old children in Wuhan of China","volume":"39","author":"Kong","year":"2009","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.rmed.2016.10.016_bib23","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/lary.23573","article-title":"Prevalence and associated risk factors of allergic rhinitis in preschool children in Beijing","volume":"123","author":"Zhang","year":"2013","journal-title":"Laryngoscope"},{"key":"10.1016\/j.rmed.2016.10.016_bib24","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1046\/j.1365-2222.2003.01766.x","article-title":"Rhinitis in pre-school children: prevalence, association with allergic diseases and risk factors","volume":"33","author":"Peroni","year":"2003","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.rmed.2016.10.016_bib25","doi-asserted-by":"crossref","first-page":"268","DOI":"10.3390\/ijerph13030268","article-title":"Association between the first occurrence of allergic rhinitis in preschool children and air pollution in Taiwan","volume":"13","author":"Chung","year":"2016","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.rmed.2016.10.016_bib26","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.buildenv.2014.01.019","article-title":"Associations between building characteristics and children's allergic symptoms \u2013 a cross-sectional study on child's health and home in Seoul, South Korea","volume":"75","author":"Choi","year":"2014","journal-title":"Build. Environ."},{"key":"10.1016\/j.rmed.2016.10.016_bib27","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.1600-0668.2008.00577.x","article-title":"Dampness at dorm and its associations with allergy and airways infection among college students in China: a cross-sectional study","volume":"19","author":"Sun","year":"2009","journal-title":"Indoor Air"},{"key":"10.1016\/j.rmed.2016.10.016_bib28","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1183\/09031936.03.00094602","article-title":"Climate, traffic-related air pollutants and allergic rhinitis prevalence in middle-school children in Taiwan","volume":"21","author":"Lee","year":"2003","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.rmed.2016.10.016_bib29","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1164\/rccm.200710-1511PP","article-title":"Environmental epigenetics and asthma: current concepts and call for studies","volume":"177","author":"Miller","year":"2008","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.rmed.2016.10.016_bib30","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1034\/j.1398-9995.2000.00118.x","article-title":"The development of the immune system during pregnancy and earl life","volume":"55","author":"Holt","year":"2000","journal-title":"Allergy"},{"key":"10.1016\/j.rmed.2016.10.016_bib31","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.ijheh.2009.03.002","article-title":"The influence of air pollution during intrauterine development and early childhood on respiratory functions at later age","volume":"212","author":"Turnovska","year":"2009","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"10.1016\/j.rmed.2016.10.016_bib32","doi-asserted-by":"crossref","first-page":"280","DOI":"10.2188\/jea.JE20120175","article-title":"Effects of outdoor and indoor air pollution on respiratory health of Chinese children from 50 kindergartens","volume":"23","author":"Liu","year":"2013","journal-title":"J.\u00a0Epidemiol."},{"key":"10.1016\/j.rmed.2016.10.016_bib33","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1164\/rccm.200701-036OC","article-title":"Atopic diseases, allergic sensitization, and exposure to traffic-related air pollution in children","volume":"177","author":"Morgenstern","year":"2008","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.rmed.2016.10.016_bib34","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1289\/ehp.1205281","article-title":"Early-life exposure to outdoor air pollution and respiratory health, ear infections, and eczema in infants from the inma study","volume":"121","author":"Aguilera","year":"2013","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.rmed.2016.10.016_bib35","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1164\/rccm.201504-0658OC","article-title":"Prenatal particulate air pollution and asthma onset in urban children. Identifying sensitive windows and sex differences","volume":"192","author":"Hsu","year":"2015","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.rmed.2016.10.016_bib36","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1111\/bjd.14039","article-title":"Prenatal air pollutant exposure and occurrence of atopic dermatitis","volume":"173","author":"Huang","year":"2015","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.rmed.2016.10.016_bib37","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1136\/thoraxjnl-2014-205413","article-title":"Intrauterine and early postnatal exposure to outdoor air pollution and lung function at preschool age","volume":"70","author":"Morales","year":"2015","journal-title":"Thorax"},{"key":"10.1016\/j.rmed.2016.10.016_bib38","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1097\/MOP.0b013e32835e78cc","article-title":"Programming of respiratory health in childhood: influence of outdoor air pollution","volume":"25","author":"Wright","year":"2013","journal-title":"Curr. Opin. Pediatr."},{"key":"10.1016\/j.rmed.2016.10.016_bib39","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1398-9995.1997.tb04869.x","article-title":"Mechanisms of pollution-induced airway disease: in\u00a0vivo studies","volume":"52","author":"Peden","year":"1997","journal-title":"Allergy"},{"key":"10.1016\/j.rmed.2016.10.016_bib40","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1097\/MOP.0b013e3283267726","article-title":"Air pollution and childhood asthma: recent advances and future directions","volume":"21","author":"Patel","year":"2009","journal-title":"Curr. Opin. Pediatr."}],"container-title":["Respiratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611116302797?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611116302797?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T11:35:16Z","timestamp":1760614516000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0954611116302797"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":40,"alternative-id":["S0954611116302797"],"URL":"https:\/\/doi.org\/10.1016\/j.rmed.2016.10.016","relation":{},"ISSN":["0954-6111"],"issn-type":[{"value":"0954-6111","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early life exposure to traffic-related air pollution and allergic rhinitis in preschool children","name":"articletitle","label":"Article Title"},{"value":"Respiratory Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rmed.2016.10.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}