{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T02:06:08Z","timestamp":1771034768781,"version":"3.50.1"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"vor","delay-in-days":730,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100005620","name":"North Carolina GlaxoSmithKline Foundation","doi-asserted-by":"publisher","award":["113782"],"award-info":[{"award-number":["113782"]}],"id":[{"id":"10.13039\/100005620","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005620","name":"North Carolina GlaxoSmithKline Foundation","doi-asserted-by":"publisher","award":["NCT01313676"],"award-info":[{"award-number":["NCT01313676"]}],"id":[{"id":"10.13039\/100005620","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","resmedjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Medicine"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.rmed.2017.07.060","type":"journal-article","created":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T05:00:13Z","timestamp":1501563613000},"page":"27-34","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Pneumonia risk with inhaled fluticasone furoate and vilanterol in COPD patients with moderate airflow limitation: The SUMMIT trial"],"prefix":"10.1016","volume":"131","author":[{"given":"Courtney","family":"Crim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter M.A.","family":"Calverley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie A.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew P.","family":"Holmes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally","family":"Kilbride","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando J.","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert D.","family":"Brook","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David E.","family":"Newby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie C.","family":"Yates","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bartolom\u00e9 R.","family":"Celli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f8rgen","family":"Vestbo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.rmed.2017.07.060_bib1","unstructured":"World Health Organization. The top 10 causes of death. The 10 leading causes of death in the world, 2000 and 2012;[accessed 2016 March 24]. Available from: http:\/\/www.who.int\/mediacentre\/factsheets\/fs310\/en."},{"key":"10.1016\/j.rmed.2017.07.060_bib2","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1086\/425615","article-title":"The burden of community-acquired pneumonia in seniors: results of a population-based study","volume":"39","author":"Jackson","year":"2004","journal-title":"Clin. Inf. Dis."},{"key":"10.1016\/j.rmed.2017.07.060_bib3","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1183\/09031936.95.08101694","article-title":"Risk factors for death and hospitalisation from pneumonia. A prospective study of a general population","volume":"8","author":"Lange","year":"1995","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.rmed.2017.07.060_bib4","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1183\/09031936.00193908","article-title":"Pneumonia risk in COPD patients receiving inhaled corticosteroids alone or in combination: TORCH study results","volume":"34","author":"Crim","year":"2009","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.rmed.2017.07.060_bib5","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.rmed.2011.07.020","article-title":"Effect of budesonide\/formoterol pMDI on COPD exacerbations: a double-blind randomized study","volume":"106","author":"Sharafkhaneh","year":"2012","journal-title":"Respir. Med."},{"key":"10.1016\/j.rmed.2017.07.060_bib6","first-page":"CD010115","article-title":"Inhaled steroids and risk of pneumonia for chronic obstructive pulmonary disease","volume":"3","author":"Kew","year":"2014","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.rmed.2017.07.060_bib7","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1513\/AnnalsATS.201409-413OC","article-title":"Pneumonia risk with inhaled fluticasone furoate and vilanterol compared with vilanterol alone in patients with COPD","volume":"12","author":"Crim","year":"2015","journal-title":"Ann. Am. Thorac. Soc."},{"key":"10.1016\/j.rmed.2017.07.060_bib8","series-title":"ADVAIR\u00ae DISKUS\u00ae [package Insert]","year":"2016"},{"key":"10.1016\/j.rmed.2017.07.060_bib9","series-title":"BREO\u00ae ELLIPTA\u00ae [package Insert]","year":"2015"},{"key":"10.1016\/j.rmed.2017.07.060_bib10","unstructured":"EMA Completes Review of Inhaled Corticosteroids for Chronic Obstructive Pulmonary Disease; [accessed 2016 May 6]. Available from: http:\/\/www.ema.europa.eu\/ema\/index.jsp?curl=pages\/news_and_events\/news\/2016\/04\/news_detail_002521.jsp&mid=WC0b01ac058004d5c1."},{"key":"10.1016\/j.rmed.2017.07.060_bib11","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/1465-9921-6-68","article-title":"Toll-like receptor 2 expression is decreased on alveolar macrophages in cigarette smokers and COPD patients","volume":"6","author":"Droemann","year":"2005","journal-title":"Respir. Res."},{"key":"10.1016\/j.rmed.2017.07.060_bib12","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/1465-9921-8-84","article-title":"Epithelial expression of TLR4 is modulated in COPD and by steroids, salmeterol and cigarette smoke","volume":"8","author":"MacRedmond","year":"2007","journal-title":"Respir. Res."},{"key":"10.1016\/j.rmed.2017.07.060_bib13","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1093\/infdis\/jit400","article-title":"Phagocytic dysfunction of human alveolar macrophages and severity of chronic obstructive pulmonary disease","volume":"208","author":"Berenson","year":"2013","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.rmed.2017.07.060_bib14","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1084\/jem.20082058","article-title":"Efferocytosis impairs pulmonary macrophage and lung antibacterial function via PGE2\/EP2 signaling","volume":"206","author":"Medeiros","year":"2009","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.rmed.2017.07.060_bib15","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1164\/rccm.200711-1661OC","article-title":"Surfactant proteins A and D suppress alveolar macrophage phagocytosis via interaction with SIRP\u03b1","volume":"178","author":"Janssen","year":"2008","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.rmed.2017.07.060_bib16","doi-asserted-by":"crossref","first-page":"112","DOI":"10.4049\/jimmunol.1200984","article-title":"Glucocorticoids relieve collectin-driven suppression of apoptotic cell uptake in murine alveolar macrophages through downregulation of SIRP\u03b1","volume":"189","author":"McCubbrey","year":"2012","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.rmed.2017.07.060_bib17","doi-asserted-by":"crossref","first-page":"174","DOI":"10.4049\/jimmunol.1402217","article-title":"Glucocorticoid-augmented efferocytosis inhibits pulmonary pneumococcal clearance in mice by reducing alveolar macrophage bactericidal function","volume":"195","author":"Stolberg","year":"2015","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.rmed.2017.07.060_bib18","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1056\/NEJMra0800353","article-title":"Infection in the pathogenesis and course of chronic obstructive pulmonary disease","volume":"359","author":"Sethi","year":"2008","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.rmed.2017.07.060_bib19","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1183\/09031936.00087312","article-title":"The study to understand mortality and morbidity in COPD (SUMMIT) study protocol","volume":"41","author":"Vestbo","year":"2013","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.rmed.2017.07.060_bib20","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1016\/S0140-6736(16)30069-1","article-title":"Fluticasone furoate and vilanterol and survival in chronic obstructive pulmonary disease with heightened cardiovascular risk (SUMMIT): a double-blind randomised controlled trial","volume":"387","author":"Vestbo","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.rmed.2017.07.060_bib21","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1136\/thx.2006.072348","article-title":"Ascertainment of cause-specific mortality in COPD: operations of the TORCH clinical endpoints committee","volume":"62","author":"McGarvey","year":"2007","journal-title":"Thorax"},{"key":"10.1016\/j.rmed.2017.07.060_bib22","series-title":"From the Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD)","year":"2016"},{"key":"10.1016\/j.rmed.2017.07.060_bib23","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1164\/rccm.201409-1654PP","article-title":"Incident pneumonia and mortality in patients with chronic obstructive pulmonary disease","volume":"191","author":"Festic","year":"2015","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.rmed.2017.07.060_bib24","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.rmed.2008.04.019","article-title":"Effect of fluticasone propionate\/salmeterol (250\/50 \u03bcg) or salmeterol (50 \u03bcg) on COPD exacerbations","volume":"102","author":"Ferguson","year":"2008","journal-title":"Respir. Med."},{"key":"10.1016\/j.rmed.2017.07.060_bib25","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1080\/15412550903140881","article-title":"Effect of fluticasone propionate\/salmeterol (250\/50) on COPD exacerbations and impact on patient outcomes","volume":"6","author":"Anzueto","year":"2009","journal-title":"COPD"},{"key":"10.1016\/j.rmed.2017.07.060_bib26","series-title":"Choice of Control Group and Related Issues in Clinical Trials","author":"ICH Harmonised Tripartite Guideline","year":"2000"},{"key":"10.1016\/j.rmed.2017.07.060_bib27","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S1286-4579(00)01363-0","article-title":"Pulmonary collectins and innate host defense of the lung","volume":"3","author":"LeVine","year":"2001","journal-title":"Microbes Infect."},{"key":"10.1016\/j.rmed.2017.07.060_bib28","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1165\/ajrcmb.18.2.2824","article-title":"KGF increases SP-A and SP-D mRNA levels and secretion in cultured rat alveolar type II cells","volume":"18","author":"Xu","year":"1998","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.rmed.2017.07.060_bib29","doi-asserted-by":"crossref","first-page":"L331","DOI":"10.1152\/ajplung.00334.2003","article-title":"Pulmonary surfactant secretion in briefly cultured mouse type II cells","volume":"286","author":"Gobran","year":"2004","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.rmed.2017.07.060_bib30","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1164\/rccm.200711-1661OC","article-title":"Surfactant proteins A and D suppress alveolar macrophage phagocytosis via interaction with SIRP\u03b1","volume":"178","author":"Janssen","year":"2008","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.rmed.2017.07.060_bib31","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1378\/chest.09-2992","article-title":"Reported pneumonia in patients with COPD. Findings from the INSPIRE study","volume":"139","author":"Calverley","year":"2011","journal-title":"Chest"}],"container-title":["Respiratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611117302597?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611117302597?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T11:36:50Z","timestamp":1760614610000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0954611117302597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":31,"alternative-id":["S0954611117302597"],"URL":"https:\/\/doi.org\/10.1016\/j.rmed.2017.07.060","relation":{},"ISSN":["0954-6111"],"issn-type":[{"value":"0954-6111","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pneumonia risk with inhaled fluticasone furoate and vilanterol in COPD patients with moderate airflow limitation: The SUMMIT trial","name":"articletitle","label":"Article Title"},{"value":"Respiratory Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rmed.2017.07.060","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}