{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T19:28:21Z","timestamp":1789932501541,"version":"4.0.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,8,28]],"date-time":"2017-08-28T00:00:00Z","timestamp":1503878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","resmedjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Medicine"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.rmed.2017.08.016","type":"journal-article","created":{"date-parts":[[2017,8,25]],"date-time":"2017-08-25T14:21:15Z","timestamp":1503670875000},"page":"192-198","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":80,"special_numbering":"C","title":["Sputum microbiota in severe asthma patients: Relationship to eosinophilic inflammation"],"prefix":"10.1016","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8492-9524","authenticated-orcid":false,"given":"Naijian","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rihuang","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaowei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kian Fan","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanshan","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.rmed.2017.08.016_bib1","first-page":"1071","article-title":"Airway microbial dysbiosis in asthmatic patients: a target for prevention and treatment?","volume":"139","author":"Chung","year":"2017","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"issue":"8","key":"10.1016\/j.rmed.2017.08.016_bib2","first-page":"701","article-title":"GABRIELA Transregio 22 Study Group. Exposure to environmental microorganisms and childhood asthma","volume":"364","author":"Ege","year":"2011","journal-title":"N.\u00a0Engl. J. Med."},{"issue":"3","key":"10.1016\/j.rmed.2017.08.016_bib3","first-page":"646","article-title":"Reduced diversity of the intestinal microbiota during infancy is associated with increased risk of allergic disease at school age","volume":"128","author":"Bisgaard","year":"2011","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.rmed.2017.08.016_bib4","first-page":"19","article-title":"Early intestinal Bacteroides fragilis colonisation and development of asthma","volume":"8","author":"Vael","year":"2008","journal-title":"BMC Pulm. Med."},{"issue":"2","key":"10.1016\/j.rmed.2017.08.016_bib5","first-page":"9","article-title":"Chlamydophila pneumoniae, Mycoplasma pneumoniae infections, and asthma control","volume":"32","author":"Specjalski","year":"2011","journal-title":"Allergy Asthma Proc."},{"issue":"1","key":"10.1016\/j.rmed.2017.08.016_bib6","first-page":"e8578","article-title":"Disordered microbial communities in asthmatic airways","volume":"5","author":"Hilty","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.rmed.2017.08.016_bib7","first-page":"372","article-title":"Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma","volume":"127","author":"Huang","year":"2011","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.rmed.2017.08.016_bib8","first-page":"346","article-title":"Asthma-associated differences in microbial composition of induced sputum","volume":"131","author":"Marri","year":"2013","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"issue":"4","key":"10.1016\/j.rmed.2017.08.016_bib9","first-page":"874","article-title":"The airway microbiome in patients with severe asthma: associations with disease features and severity","volume":"136","author":"Huang","year":"2015","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.rmed.2017.08.016_bib10","first-page":"25","article-title":"The microbiome in asthma","volume":"135","author":"Huang","year":"2015","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"issue":"4","key":"10.1016\/j.rmed.2017.08.016_bib11","first-page":"e0152724","article-title":"Airway microbiota in severe asthma and relationship to asthma severity and phenotypes","volume":"11","author":"Zhang","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.rmed.2017.08.016_bib12","first-page":"276","article-title":"Complex sputum microbial composition in patients with pulmonary tuberculosis","volume":"12","author":"Cui","year":"2012","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.rmed.2017.08.016_bib13","first-page":"e54574","article-title":"Sputum microbiota in tuberculosis as revealed by 16S rRNA pyrosequencing","volume":"8","author":"Cheung","year":"2013","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.rmed.2017.08.016_bib14","first-page":"355","article-title":"The respiratory microbiome: an underappreciated player in the human response to inhaled pollutants?","volume":"26","author":"Adar","year":"2016","journal-title":"Ann. Epidemiol."},{"key":"10.1016\/j.rmed.2017.08.016_bib15","first-page":"163","article-title":"Characterizing human lung tissue microbiota and its relationship to epidemiological and clinical features","volume":"17","author":"Yu","year":"2016","journal-title":"Genome Biol."},{"issue":"2","key":"10.1016\/j.rmed.2017.08.016_bib16","first-page":"343","article-title":"International ERS\/ATS guidelines on definition, evaluation and treatment of severe asthma","volume":"43","author":"Chung","year":"2014","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.rmed.2017.08.016_bib17","series-title":"Global Strategy for Asthma Management and Prevention","year":"2014"},{"key":"10.1016\/j.rmed.2017.08.016_bib18","first-page":"2","article-title":"Plaque bacterial microbiome diversity in children younger than 30 months with or without caries prior to eruption of second primary molars","volume":"9","author":"Xu","year":"2014","journal-title":"PLoS One"},{"issue":"23","key":"10.1016\/j.rmed.2017.08.016_bib19","first-page":"7537","article-title":"Introducing mothur: open-source, platform-independent, community-supported software for describing and comparing microbial communities","volume":"75","author":"Schloss","year":"2009","journal-title":"Appl. Environ. Microbiol."},{"issue":"27","key":"10.1016\/j.rmed.2017.08.016_bib20","first-page":"11276","article-title":"Regulation of myocardial ketone body metabolism by the gut microbiota during nutrient deprivation","volume":"106","author":"Crawford","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.rmed.2017.08.016_bib21","first-page":"1","article-title":"VennDiagram: a package for the generation of highly-customizable Venn and Euler diagrams in R","volume":"12","author":"Hanbo","year":"2011","journal-title":"BMC Bioinforma."},{"key":"10.1016\/j.rmed.2017.08.016_bib22","first-page":"218","article-title":"Cluster analysis and clinical asthma phenotypes","volume":"178","author":"Haldar","year":"2008","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.rmed.2017.08.016_bib23","first-page":"559","article-title":"Differential proteolytic enzyme activity in eosinophilic and neutrophilic asthma","volume":"172","author":"Simpson","year":"2005","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.rmed.2017.08.016_bib24","first-page":"54","article-title":"Inflammatory subtypes in asthma: assessment and identification using induced sputum","volume":"11","author":"Simpson","year":"2006","journal-title":"Respirology"},{"key":"10.1016\/j.rmed.2017.08.016_bib25","first-page":"1286","article-title":"Airway eosinophilia in children with severe asthma: predictive values of noninvasive tests","volume":"174","author":"Lex","year":"2006","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"10","key":"10.1016\/j.rmed.2017.08.016_bib26","first-page":"1193","article-title":"The effects of airway microbiome on corticosteroid responsiveness in asthma","volume":"188","author":"Goleva","year":"2013","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"7","key":"10.1016\/j.rmed.2017.08.016_bib27","first-page":"588","article-title":"Combined Haemophilus influenzae respiratory infection and allergic airways disease drives chronic infection and features of neutrophilic asthma","volume":"67","author":"Essilfie","year":"2012","journal-title":"Thorax"},{"issue":"4","key":"10.1016\/j.rmed.2017.08.016_bib28","first-page":"322","article-title":"Azithromycin for prevention of exacerbations in severe asthma (AZISAST): a multicentre randomised double-blind placebo-controlled trial","volume":"68","author":"Brusselle","year":"2013","journal-title":"Thorax"},{"key":"10.1016\/j.rmed.2017.08.016_bib29","first-page":"594","article-title":"Clarithromycin suppresses bronchial hyperresponsiveness associated with eosinophilic inflammation in patients with asthma","volume":"84","author":"Amayasu","year":"2000","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"10.1016\/j.rmed.2017.08.016_bib30","first-page":"480","article-title":"A\u00a0core gut microbiome in obese and lean twins","volume":"457","author":"Turnbaugh","year":"2009","journal-title":"Nature"}],"container-title":["Respiratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095461111730286X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095461111730286X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T11:39:19Z","timestamp":1760614759000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S095461111730286X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":30,"alternative-id":["S095461111730286X"],"URL":"https:\/\/doi.org\/10.1016\/j.rmed.2017.08.016","relation":{},"ISSN":["0954-6111"],"issn-type":[{"value":"0954-6111","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sputum microbiota in severe asthma patients: Relationship to eosinophilic inflammation","name":"articletitle","label":"Article Title"},{"value":"Respiratory Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rmed.2017.08.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}