{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:21:37Z","timestamp":1791897697184,"version":"4.3.4"},"reference-count":18,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T00:00:00Z","timestamp":1517875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","resmedjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Medicine"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.rmed.2018.02.001","type":"journal-article","created":{"date-parts":[[2018,2,3]],"date-time":"2018-02-03T18:16:10Z","timestamp":1517681770000},"page":"77-82","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":85,"special_numbering":"C","title":["Interstitial lung abnormalities are associated with increased mortality in smokers"],"prefix":"10.1016","volume":"136","author":[{"given":"Nils","family":"Hoyer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde M.W.","family":"Wille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura H.","family":"Thomsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torgny","family":"Wilcke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asger","family":"Dirksen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper H.","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaigham","family":"Saghir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haseem","family":"Ashraf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saher B.","family":"Shaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rmed.2018.02.001_bib1","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1164\/rccm.2009-040GL","article-title":"An official ATS\/ERS\/JRS\/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management","volume":"183","author":"Raghu","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.rmed.2018.02.001_bib2","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1164\/rccm.200702-254OC","article-title":"Early interstitial lung disease in familial pulmonary fibrosis","volume":"176","author":"Rosas","year":"2007","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.rmed.2018.02.001_bib3","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1183\/09031936.00201809","article-title":"Interstitial lung diseases in a lung cancer screening trial","volume":"38","author":"Sverzellati","year":"2011","journal-title":"Eur. Respir. J. [Internet]"},{"key":"10.1016\/j.rmed.2018.02.001_bib4","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1148\/radiol.13120816","article-title":"Interstitial lung abnormalities in a CT lung cancer screening population: prevalence and progression rate","volume":"268","author":"Jin","year":"2013","journal-title":"Radiology [Internet]"},{"key":"10.1016\/j.rmed.2018.02.001_bib5","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1016\/j.rmed.2010.05.014","article-title":"The radiological patterns of interstitial change at an early phase: over a 4-year follow-up","volume":"104","author":"Tsushima","year":"2010","journal-title":"Respir. Med. [Internet]"},{"key":"10.1016\/j.rmed.2018.02.001_bib6","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1164\/rccm.200812-1966OC","article-title":"Cigarette smoking is associated with subclinical parenchymal lung disease: the Multi-Ethnic Study of Atherosclerosis (MESA)-lung study","volume":"180","author":"Lederer","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.rmed.2018.02.001_bib7","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1056\/NEJMoa1007285","article-title":"COPDGene Investigators. Lung volumes and emphysema in smokers with interstitial lung abnormalities","volume":"364","author":"Washko","year":"2011","journal-title":"N. Engl. J. Med. [Internet]"},{"key":"10.1016\/j.rmed.2018.02.001_bib8","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1164\/rccm.201109-1618OC","article-title":"COPDGene Investigators. Interstitial lung abnormalities and reduced exercise capacity","volume":"185","author":"Doyle","year":"2012","journal-title":"Am. J. Respir. Crit. Care Med. [Internet]"},{"key":"10.1016\/j.rmed.2018.02.001_bib9","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1001\/jama.2016.0518","article-title":"Evaluation of COPD longitudinally to identify predictive surrogate endpoints (ECLIPSE) investigators, COPDGene investigators. Association between interstitial lung abnormalities and all-cause mortality","volume":"315","author":"Putman","year":"2016","journal-title":"JAMA [Internet]"},{"key":"10.1016\/j.rmed.2018.02.001_bib10","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1183\/13993003.00129-2016","article-title":"High attenuation areas on chest computed tomography in community-dwelling adults: the MESA study","volume":"48","author":"Podolanczuk","year":"2016","journal-title":"Eur. Respir. J. [Internet]"},{"key":"10.1016\/j.rmed.2018.02.001_bib11","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1097\/JTO.0b013e3181a0d98f","article-title":"The Danish randomized lung cancer CT screening trial\u2013overall design and results of the prevalence round","volume":"4","author":"Pedersen","year":"2009","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.rmed.2018.02.001_bib12","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1164\/rccm.201505-1040OC","article-title":"Results of the randomized Danish lung cancer screening trial with focus on high-risk profiling","volume":"193","author":"Wille","year":"2016","journal-title":"Am. J. Respir. Crit. Care Med. [Internet]"},{"key":"10.1016\/j.rmed.2018.02.001_bib13","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.1007\/s00330-014-3294-7","article-title":"Emphysema progression is visually detectable in low-dose CT in continuous but not in former smokers","volume":"24","author":"Wille","year":"2014","journal-title":"Eur. Radiol. [Internet]"},{"key":"10.1016\/j.rmed.2018.02.001_bib14","doi-asserted-by":"crossref","first-page":"3803","DOI":"10.1002\/sim.2098","article-title":"Choice of time-scale in Cox's model analysis of epidemiologic cohort data: a simulation study","volume":"23","author":"Thi\u00e9baut","year":"2004","journal-title":"Stat. Med. [Internet]"},{"key":"10.1016\/j.rmed.2018.02.001_bib15","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s00330-015-3826-9","article-title":"Visual assessment of early emphysema and interstitial abnormalities on CT is useful in lung cancer risk analysis","volume":"26","author":"Wille","year":"2016","journal-title":"Eur. Radiol. [Internet]"},{"key":"10.1016\/j.rmed.2018.02.001_bib16","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.humpath.2009.09.003","article-title":"Clinically occult interstitial fibrosis in smokers: classification and significance of a surprisingly common finding in lobectomy specimens","volume":"41","author":"Katzenstein","year":"2010","journal-title":"Hum. Pathol. [Internet]"},{"key":"10.1016\/j.rmed.2018.02.001_bib17","article-title":"Incidence of non-pulmonary cancer and lung cancer by amount of emphysema and airway wall thickness: a community-based cohort","volume":"49","author":"Aamli Gagnat","year":"2017","journal-title":"Eur. Respir. J. [Internet]"},{"key":"10.1016\/j.rmed.2018.02.001_bib18","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1164\/rccm.201006-0894CI","article-title":"Clinical course and prediction of survival in idiopathic pulmonary fibrosis","volume":"183","author":"Ley","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."}],"container-title":["Respiratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611118300301?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611118300301?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T11:39:32Z","timestamp":1760614772000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0954611118300301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":18,"alternative-id":["S0954611118300301"],"URL":"https:\/\/doi.org\/10.1016\/j.rmed.2018.02.001","relation":{},"ISSN":["0954-6111"],"issn-type":[{"value":"0954-6111","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interstitial lung abnormalities are associated with increased mortality in smokers","name":"articletitle","label":"Article Title"},{"value":"Respiratory Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rmed.2018.02.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}