{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T01:11:20Z","timestamp":1789002680238,"version":"build-2803163510"},"reference-count":91,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"vor","delay-in-days":731,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100010414","name":"Health Research Board","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010414","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","resmedjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Medicine"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.rmed.2018.06.031","type":"journal-article","created":{"date-parts":[[2018,6,30]],"date-time":"2018-06-30T13:32:14Z","timestamp":1530365534000},"page":"132-143","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"special_numbering":"C","title":["A qualitative synthesis of gastro-oesophageal reflux in bronchiectasis: Current understanding and future risk"],"prefix":"10.1016","volume":"141","author":[{"given":"M.J.","family":"McDonnell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"O'Toole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6954-9611","authenticated-orcid":false,"given":"C.","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.P.","family":"Pearson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.L.","family":"Lordan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"De Soyza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Loebinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.D.","family":"Chalmers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1246-9573","authenticated-orcid":false,"given":"J.G.","family":"Laffey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.M.","family":"Rutherford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.rmed.2018.06.031_bib1","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1183\/09031936.00119114","article-title":"Management of bronchiectasis in adults","volume":"45","author":"Chalmers","year":"2015","journal-title":"Eur. Respir. J."},{"issue":"2","key":"10.1016\/j.rmed.2018.06.031_bib2","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1378\/chest.11-2209","article-title":"Trends in bronchiectasis among medicare beneficiaries in the United States, 2000 to 2007","volume":"142","author":"Seitz","year":"2012","journal-title":"Chest"},{"issue":"7","key":"10.1016\/j.rmed.2018.06.031_bib3","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.rmed.2010.02.022","article-title":"Trends in bronchiectasis mortality in England and wales","volume":"104","author":"Roberts","year":"2010","journal-title":"Respir. Med."},{"issue":"6","key":"10.1016\/j.rmed.2018.06.031_bib4","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1183\/13993003.00954-2015","article-title":"Bronchiectasis in Germany: a population-based estimation of disease prevalence","volume":"46","author":"Ringshausen","year":"2015","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.rmed.2018.06.031_bib5","first-page":"6","article-title":"Inflammation: a two-edged sword\u2013the model of bronchiectasis","volume":"147","author":"Cole","year":"1986","journal-title":"Eur. J. Respir. Dis. Suppl."},{"issue":"2","key":"10.1016\/j.rmed.2018.06.031_bib6","doi-asserted-by":"crossref","first-page":"43","DOI":"10.4103\/2225-6482.184910","article-title":"Exacerbations of bronchiectasis in adults","volume":"3","author":"Redondo","year":"2016","journal-title":"Community Acquir. Infect."},{"issue":"12","key":"10.1016\/j.rmed.2018.06.031_bib7","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/S2213-2600(16)30320-4","article-title":"Comorbidities and the risk of mortality in patients with bronchiectasis: an international multicentre cohort study","volume":"4","author":"McDonnell","year":"2016","journal-title":"The lancet Respiratory medicine"},{"issue":"8","key":"10.1016\/j.rmed.2018.06.031_bib8","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1111\/j.1572-0241.2006.00630.x","article-title":"The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus","volume":"101","author":"Vakil","year":"2006","journal-title":"Am. J. Gastroenterol."},{"issue":"6","key":"10.1016\/j.rmed.2018.06.031_bib9","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1136\/gutjnl-2012-304269","article-title":"Update on the epidemiology of gastro-oesophageal reflux disease: a systematic review","volume":"63","author":"El-Serag","year":"2014","journal-title":"Gut"},{"issue":"8A","key":"10.1016\/j.rmed.2018.06.031_bib10","article-title":"Combined multichannel intraluminal impedance and pH-metry: an evolving technique to measure type and proximal extent of gastroesophageal reflux","volume":"111","author":"Castell","year":"2001","journal-title":"Am. J. Med."},{"issue":"9881","key":"10.1016\/j.rmed.2018.06.031_bib11","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1016\/S0140-6736(12)62171-0","article-title":"Gastro-oesophageal reflux disease","volume":"381","author":"Bredenoord","year":"2013","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.rmed.2018.06.031_bib12","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.3949\/ccjm.70.Suppl_5.S4","article-title":"GERD pathogenesis, pathophysiology, and clinical manifestations","volume":"70","author":"Kahrilas","year":"2003","journal-title":"Cleve. Clin. J. Med."},{"issue":"4","key":"10.1016\/j.rmed.2018.06.031_bib13","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.arbres.2011.02.001","article-title":"Relationship between gastro-oesophageal reflux and airway diseases: the airway reflux paradigm","volume":"47","author":"Pacheco-Galv\u00e1n","year":"2011","journal-title":"Arch. Bronconeumol."},{"issue":"7","key":"10.1016\/j.rmed.2018.06.031_bib14","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1038\/ajg.2013.132","article-title":"The acid pocket: a target for treatment in reflux disease?","volume":"108","author":"Kahrilas","year":"2013","journal-title":"Am. J. Gastroenterol."},{"issue":"3","key":"10.1016\/j.rmed.2018.06.031_bib15","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/ajg.2012.444","article-title":"Guidelines for the diagnosis and management of gastroesophageal reflux disease","volume":"108","author":"Katz","year":"2013","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.rmed.2018.06.031_bib16","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.2147\/COPD.S77562","article-title":"Gastroesophageal reflux disease in COPD: links and risks","volume":"10","author":"Lee","year":"2015","journal-title":"Int. J. Chronic Obstr. Pulm. Dis."},{"key":"10.1016\/j.rmed.2018.06.031_bib17","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3389\/fphar.2011.00040","article-title":"Diagnosing GORD in respiratory medicine","volume":"2","author":"Timms","year":"2011","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.rmed.2018.06.031_bib18","first-page":"395020","article-title":"Gastro-oesophageal reflux in noncystic fibrosis bronchiectasis","author":"Lee","year":"2011","journal-title":"Pulmonary medicine"},{"issue":"4","key":"10.1016\/j.rmed.2018.06.031_bib19","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.giec.2014.07.002","article-title":"Diagnostic work-up of GERD","volume":"24","author":"Vela","year":"2014","journal-title":"Gastrointestinal endoscopy clinics of North America"},{"issue":"2","key":"10.1016\/j.rmed.2018.06.031_bib20","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1365-2036.2006.03039.x","article-title":"Review article: complete gastro-oesophageal reflux monitoring - combined pH and impedance","volume":"24","author":"Tutuian","year":"2006","journal-title":"Aliment. Pharmacol. Ther."},{"issue":"9","key":"10.1016\/j.rmed.2018.06.031_bib21","first-page":"1102","article-title":"Ambulatory 24-h esophageal pH monitoring: normal values, optimal thresholds, specificity, sensitivity, and reproducibility","volume":"87","author":"Jamieson","year":"1992","journal-title":"Am. J. Gastroenterol."},{"issue":"Suppl 1","key":"10.1016\/j.rmed.2018.06.031_bib22","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1097\/00004836-198606001-00008","article-title":"Development of the 24-hour intraesophageal pH monitoring composite scoring system","volume":"8","author":"Johnson","year":"1986","journal-title":"J. Clin. Gastroenterol."},{"issue":"4","key":"10.1016\/j.rmed.2018.06.031_bib23","first-page":"325","article-title":"Twenty-four-hour pH monitoring of the distal esophagus. A quantitative measure of gastroesophageal reflux","volume":"62","author":"Johnson","year":"1974","journal-title":"Am. J. Gastroenterol."},{"issue":"11 Pt 1","key":"10.1016\/j.rmed.2018.06.031_bib24","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1097\/00005537-200111000-00019","article-title":"Ambulatory 24-hour double-probe pH monitoring: the importance of manometry","volume":"111","author":"Johnson","year":"2001","journal-title":"Laryngoscope"},{"issue":"3","key":"10.1016\/j.rmed.2018.06.031_bib25","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1055\/s-0031-1291541","article-title":"Wireless pH capsule\u2013yield in clinical practice","volume":"44","author":"Roman","year":"2012","journal-title":"Endoscopy"},{"issue":"7","key":"10.1016\/j.rmed.2018.06.031_bib26","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1053\/gast.2001.24841","article-title":"Acid, nonacid, and gas reflux in patients with gastroesophageal reflux disease during ambulatory 24-hour pH-impedance recordings","volume":"120","author":"Sifrim","year":"2001","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.rmed.2018.06.031_bib27","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1053\/j.gastro.2008.05.048","article-title":"High-resolution manometry and impedance-pH\/manometry: valuable tools in clinical and investigational esophagology","volume":"135","author":"Kahrilas","year":"2008","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.rmed.2018.06.031_bib28","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S1579-2129(11)70046-5","article-title":"Relationship between gastro-oesophageal reflux and airway diseases: the airway reflux paradigm","volume":"47","author":"Pacheco-Galvan","year":"2011","journal-title":"Arch. Bronconeumol."},{"issue":"2","key":"10.1016\/j.rmed.2018.06.031_bib29","first-page":"54","article-title":"From gastric aspiration to airway inflammation. Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace\/Fondazione clinica del lavoro, IRCCS [and] Istituto di clinica tisiologica e malattie apparato respiratorio","volume":"73","author":"Brownlee","year":"2010","journal-title":"Universita di Napoli, Secondo ateneo"},{"issue":"2","key":"10.1016\/j.rmed.2018.06.031_bib30","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/resp.12182","article-title":"Proximal and distal gastro-oesophageal reflux in chronic obstructive pulmonary disease and bronchiectasis","volume":"19","author":"Lee","year":"2014","journal-title":"Respirology"},{"issue":"2","key":"10.1016\/j.rmed.2018.06.031_bib31","doi-asserted-by":"crossref","first-page":"244","DOI":"10.4187\/respcare.03570","article-title":"Exhaled breath condensate pepsin: potential noninvasive test for gastroesophageal reflux in COPD and bronchiectasis","volume":"60","author":"Lee","year":"2015","journal-title":"Respir. Care"},{"issue":"6","key":"10.1016\/j.rmed.2018.06.031_bib32","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1111\/j.1440-1746.2011.06968.x","article-title":"Effect of bed head elevation during sleep in symptomatic patients of nocturnal gastroesophageal reflux","volume":"27","author":"Khan","year":"2012","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"4","key":"10.1016\/j.rmed.2018.06.031_bib33","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1097\/MOG.0b013e328360433c","article-title":"Management of gastro-oesophageal reflux disease symptoms that do not respond to proton pump inhibitors","volume":"29","author":"Woodland","year":"2013","journal-title":"Curr. Opin. Gastroenterol."},{"issue":"30","key":"10.1016\/j.rmed.2018.06.031_bib34","doi-asserted-by":"crossref","first-page":"3745","DOI":"10.3748\/wjg.v16.i30.3745","article-title":"Gastroesophageal reflux disease: from pathophysiology to treatment","volume":"16","author":"Herbella","year":"2010","journal-title":"World J. Gastroenterol."},{"issue":"1","key":"10.1016\/j.rmed.2018.06.031_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11938-017-0115-5","article-title":"Clinical implications of emerging data on the safety of proton pump inhibitors","volume":"15","author":"Schnoll-Sussman","year":"2017","journal-title":"Curr. Treat. Options Gastroenterol."},{"issue":"3","key":"10.1016\/j.rmed.2018.06.031_bib36","doi-asserted-by":"crossref","first-page":"258","DOI":"10.5056\/jnm.2010.16.3.258","article-title":"The role of weakly acidic reflux in proton pump inhibitor failure, has dust settled?","volume":"16","author":"Tsoukali","year":"2010","journal-title":"Journal of neurogastroenterology and motility"},{"issue":"8","key":"10.1016\/j.rmed.2018.06.031_bib37","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1111\/bph.12077","article-title":"The antibiotic azithromycin is a motilin receptor agonist in human stomach: comparison with erythromycin","volume":"168","author":"Broad","year":"2013","journal-title":"Br. J. Pharmacol."},{"issue":"18","key":"10.1016\/j.rmed.2018.06.031_bib38","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.2165\/11597300-000000000-00000","article-title":"Gastro-oesophageal reflux disease: beyond proton pump inhibitor therapy","volume":"71","author":"Hershcovici","year":"2011","journal-title":"Drugs"},{"key":"10.1016\/j.rmed.2018.06.031_bib39","first-page":"A23","article-title":"Simultaneous oesophageal and tracheal pH monitoring in bronchiectasis","volume":"50","author":"Ahmed","year":"1995","journal-title":"Thorax"},{"issue":"4","key":"10.1016\/j.rmed.2018.06.031_bib40","first-page":"409","article-title":"Chest physiotherapy does not exacerbate gastroesophageal reflux in patients with chronic bronchitis and bronchiectasis","volume":"21","author":"Chen","year":"1998","journal-title":"Changgeng yi xue za zhi\/Changgeng ji nian yi yuan = Chang Gung medical journal \/ Chang Gung Memorial Hospital"},{"issue":"4","key":"10.1016\/j.rmed.2018.06.031_bib41","first-page":"491","article-title":"The prevalence of distal and proximal gastroesophageal reflux in patients awaiting lung transplantation","volume":"244","author":"Sweet","year":"2006","journal-title":"Ann. Surg."},{"issue":"6","key":"10.1016\/j.rmed.2018.06.031_bib42","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1378\/chest.06-2280","article-title":"Prevalence of gastroesophageal reflux disease in patients with nontuberculous mycobacterial lung disease","volume":"131","author":"Koh","year":"2007","journal-title":"Chest"},{"issue":"1","key":"10.1016\/j.rmed.2018.06.031_bib43","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4103\/1817-1737.30354","article-title":"A review of 151 cases of pediatric noncystic fibrosis bronchiectasis in a tertiary care center","volume":"2","author":"Banjar","year":"2007","journal-title":"Ann. Thorac. Med."},{"issue":"10","key":"10.1016\/j.rmed.2018.06.031_bib44","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1590\/S1806-37132008001000004","article-title":"Prevalence of gastroesophageal reflux in lung transplant candidates with advanced lung disease","volume":"34","author":"Fortunato","year":"2008","journal-title":"J. Bras. Pneumol.: publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia"},{"issue":"3","key":"10.1016\/j.rmed.2018.06.031_bib45","first-page":"77","article-title":"A decade of non-cystic fibrosis bronchiectasis 1996-2006","volume":"103","author":"Zaid","year":"2010","journal-title":"Ir. Med. J."},{"issue":"9","key":"10.1016\/j.rmed.2018.06.031_bib46","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.4187\/respcare.01498","article-title":"Upright positive expiratory pressure therapy and exercise: effects on gastroesophageal reflux in COPD and bronchiectasis","volume":"57","author":"Lee","year":"2012","journal-title":"Respir. Care"},{"issue":"7","key":"10.1016\/j.rmed.2018.06.031_bib47","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.rmed.2013.04.006","article-title":"Symptoms of airway reflux predict exacerbations and quality of life in bronchiectasis","volume":"107","author":"Mandal","year":"2013","journal-title":"Respir. Med."},{"issue":"suppl 59","key":"10.1016\/j.rmed.2018.06.031_bib48","article-title":"Increased disease severity and mortality associated with the Bronchiectasis-GORD phenotype","volume":"46","author":"McDonnell","year":"2015","journal-title":"Eur. Respir. J."},{"issue":"5","key":"10.1016\/j.rmed.2018.06.031_bib49","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1111\/resp.12522","article-title":"Hiatal hernias are correlated with increased severity of non-cystic fibrosis bronchiectasis","volume":"20","author":"McDonnell","year":"2015","journal-title":"Respirology"},{"issue":"5","key":"10.1016\/j.rmed.2018.06.031_bib50","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.chest.2016.10.055","article-title":"Adult bronchiectasis patients: a first look at the United States bronchiectasis research registry","volume":"151","author":"Aksamit","year":"2017","journal-title":"Chest"},{"issue":"12","key":"10.1016\/j.rmed.2018.06.031_bib51","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1164\/rccm.200610-1485OC","article-title":"Pepsin, a biomarker of gastric aspiration in lung allografts: a putative association with rejection","volume":"175","author":"Stovold","year":"2007","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"2","key":"10.1016\/j.rmed.2018.06.031_bib52","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1136\/thx.2009.130914","article-title":"High concentrations of pepsin in bronchoalveolar lavage fluid from children with cystic fibrosis are associated with high interleukin-8 concentrations","volume":"66","author":"McNally","year":"2011","journal-title":"Thorax"},{"issue":"2","key":"10.1016\/j.rmed.2018.06.031_bib53","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1183\/09031936.00050911","article-title":"Bronchoalveolar lavage pepsin in acute exacerbation of idiopathic pulmonary fibrosis","volume":"39","author":"Lee","year":"2012","journal-title":"Eur. Respir. J."},{"issue":"1","key":"10.1016\/j.rmed.2018.06.031_bib54","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/hel.12340","article-title":"Helicobacter pylori and extragastric diseases","volume":"21","author":"Goni","year":"2016","journal-title":"Helicobacter"},{"issue":"4","key":"10.1016\/j.rmed.2018.06.031_bib55","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1164\/ajrccm.158.4.9712104","article-title":"High seroprevalence of Helicobacter pylori in active bronchiectasis","volume":"158","author":"Tsang","year":"1998","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"6","key":"10.1016\/j.rmed.2018.06.031_bib56","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1183\/09031936.99.14613459","article-title":"Helicobacter pylori and upper gastrointestinal symptoms in bronchiectasis","volume":"14","author":"Tsang","year":"1999","journal-title":"Eur. Respir. J."},{"issue":"12","key":"10.1016\/j.rmed.2018.06.031_bib57","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1111\/j.1651-2227.2002.tb02843.x","article-title":"Does Helicobacter pylori cause bronchiectasis?","volume":"91","author":"Yalcin","year":"2002","journal-title":"Acta Paediatr."},{"issue":"3","key":"10.1016\/j.rmed.2018.06.031_bib58","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.1198-743X.2004.00868.x","article-title":"Investigation of Helicobacter pylori in bronchoscopic lung specimens of young male patients with bronchiectasis but without gastrointestinal symptoms","volume":"10","author":"Ilvan","year":"2004","journal-title":"Clin. Microbiol. Infect.: Off. Publ. Eur. Soc. Clin. Microbiol. Infect. Dis."},{"issue":"7","key":"10.1016\/j.rmed.2018.06.031_bib59","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.rmed.2005.10.021","article-title":"Does Helicobacter pylori have a pathogenic role in bronchiectasis?","volume":"100","author":"Angrill","year":"2006","journal-title":"Respir. Med."},{"issue":"3","key":"10.1016\/j.rmed.2018.06.031_bib60","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.arcmed.2006.11.010","article-title":"Helicobacter pylori in bronchiectasis: a polymerase chain reaction assay in bronchoalveolar lavage fluid and bronchiectatic lung tissue","volume":"38","author":"Gulhan","year":"2007","journal-title":"Arch. Med. Res."},{"issue":"9","key":"10.1016\/j.rmed.2018.06.031_bib61","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1111\/ped.12918","article-title":"Does Helicobacter pylori play a role in the pathogenesis of non-cystic fibrosis bronchiectasis","volume":"58","author":"Aydin Teke","year":"2016","journal-title":"Pediatr. Int.: Off. J. Jap. Pediatr. Soc."},{"issue":"10","key":"10.1016\/j.rmed.2018.06.031_bib62","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1136\/thoraxjnl-2015-207059","article-title":"The relationship between Helicobacter pylori seropositivity and COPD","volume":"70","author":"Sze","year":"2015","journal-title":"Thorax"},{"issue":"11","key":"10.1016\/j.rmed.2018.06.031_bib63","doi-asserted-by":"crossref","DOI":"10.5812\/jjm.32144","article-title":"Detection of Helicobacter pylori in the bronchoalveolar lavage of patients with lung cancer using real-time PCR","volume":"9","author":"Samareh-Fekri","year":"2016","journal-title":"Jundishapur J. Microbiol."},{"issue":"4","key":"10.1016\/j.rmed.2018.06.031_bib64","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.tim.2016.12.004","article-title":"Helicobacter pylori: a paradigm pathogen for subverting host cell signal transmission","volume":"25","author":"Naumann","year":"2017","journal-title":"Trends Microbiol."},{"issue":"1","key":"10.1016\/j.rmed.2018.06.031_bib65","doi-asserted-by":"crossref","first-page":"10","DOI":"10.4166\/kjg.2016.68.1.10","article-title":"Effect of proton pump inhibitors in bronchiectatic patients with gastroesophageal reflux disease","volume":"68","author":"Ahn","year":"2016","journal-title":"The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi"},{"key":"10.1016\/j.rmed.2018.06.031_bib66","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1471-2466-13-34","article-title":"Gastroesophageal reflux in bronchiectasis and the effect of anti-reflux treatment","volume":"13","author":"Hu","year":"2013","journal-title":"BMC Pulmonary Medicine"},{"issue":"3","key":"10.1016\/j.rmed.2018.06.031_bib67","doi-asserted-by":"crossref","DOI":"10.1183\/09031936.00061811","article-title":"Anti-reflux surgery in lung transplant recipients: outcomes and effects on quality of life","volume":"39","author":"Robertson","year":"2012","journal-title":"Eur. Respir. J."},{"issue":"2","key":"10.1016\/j.rmed.2018.06.031_bib68","first-page":"431","article-title":"Effects of cruroraphy and laparoscopic Nissen fundoplication procedures on pulmonary function tests in gastroesophageal reflux patients","volume":"7","author":"Ozaydin","year":"2014","journal-title":"Int. J. Clin. Exp. Med."},{"issue":"3","key":"10.1016\/j.rmed.2018.06.031_bib69","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1378\/chest.106.3.731","article-title":"Gastroesophageal reflux-induced bronchoconstriction. An intraesophageal acid infusion study using state-of-the-art technology","volume":"106","author":"Schan","year":"1994","journal-title":"Chest"},{"issue":"6","key":"10.1016\/j.rmed.2018.06.031_bib70","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1007\/s00464-013-3388-3","article-title":"The diagnostic value of gastroesophageal reflux disease (GERD) symptoms and detection of pepsin and bile acids in bronchoalveolar lavage fluid and exhaled breath condensate for identifying lung transplantation patients with GERD-induced aspiration","volume":"28","author":"Reder","year":"2014","journal-title":"Surg. Endosc."},{"issue":"4","key":"10.1016\/j.rmed.2018.06.031_bib71","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1164\/ajrccm.185.4.463","article-title":"Bile acids are present in the lower airways of people with cystic fibrosis","volume":"185","author":"Aseeri","year":"2012","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"1","key":"10.1016\/j.rmed.2018.06.031_bib72","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.molimm.2012.09.011","article-title":"Mechanisms of immune dysfunction and bacterial persistence in non-cystic fibrosis bronchiectasis","volume":"55","author":"Chalmers","year":"2013","journal-title":"Mol. Immunol."},{"issue":"10","key":"10.1016\/j.rmed.2018.06.031_bib73","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1111\/j.1365-2982.2009.01327.x","article-title":"Does acute psychological stress increase perception of oesophageal acid","volume":"21","author":"Hemmink","year":"2009","journal-title":"Neuro Gastroenterol. Motil.: Off. J. Eur. Gastrointest. Motil. Soc."},{"issue":"3","key":"10.1016\/j.rmed.2018.06.031_bib74","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s11136-012-0188-5","article-title":"Depression and anxiety symptoms in bronchiectasis: associations with health-related quality of life","volume":"22","author":"Olveira","year":"2013","journal-title":"Qual. life Res.: Int. J. Qual. Life Aspects Treatment, Care Rehabilit."},{"issue":"2","key":"10.1016\/j.rmed.2018.06.031_bib75","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.bpg.2010.02.005","article-title":"Adverse effects of drugs on the esophagus","volume":"24","author":"Tutuian","year":"2010","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"issue":"3","key":"10.1016\/j.rmed.2018.06.031_bib76","doi-asserted-by":"crossref","first-page":"267","DOI":"10.5009\/gnl.2011.5.3.267","article-title":"Clinical significance of hiatal hernia","volume":"5","author":"Hyun","year":"2011","journal-title":"Gut Liver"},{"issue":"6","key":"10.1016\/j.rmed.2018.06.031_bib77","doi-asserted-by":"crossref","first-page":"G1052","DOI":"10.1152\/ajpgi.00279.2001","article-title":"Esophagogastric junction distensibility: a factor contributing to sphincter incompetence","volume":"282","author":"Pandolfino","year":"2002","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"4","key":"10.1016\/j.rmed.2018.06.031_bib78","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1136\/gut.2009.178061","article-title":"The position of the acid pocket as a major risk factor for acidic reflux in healthy subjects and patients with GORD","volume":"59","author":"Beaumont","year":"2010","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.rmed.2018.06.031_bib79","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1365-2036.2011.04678.x","article-title":"An alginate-antacid formulation (Gaviscon Double Action Liquid) can eliminate or displace the postprandial 'acid pocket' in symptomatic GERD patients","volume":"34","author":"Kwiatek","year":"2011","journal-title":"Aliment Pharmacol. Therapeut."},{"issue":"12","key":"10.1016\/j.rmed.2018.06.031_bib80","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1136\/gutjnl-2011-300926","article-title":"Effect of azithromycin on acid reflux, hiatus hernia and proximal acid pocket in the postprandial period","volume":"61","author":"Rohof","year":"2012","journal-title":"Gut"},{"issue":"8","key":"10.1016\/j.rmed.2018.06.031_bib81","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1177\/000348941011900808","article-title":"Rationale for targeting pepsin in the treatment of reflux disease","volume":"119","author":"Johnston","year":"2010","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"issue":"12","key":"10.1016\/j.rmed.2018.06.031_bib82","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1177\/000348940711601211","article-title":"Receptor-mediated uptake of pepsin by laryngeal epithelial cells","volume":"116","author":"Johnston","year":"2007","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"issue":"4","key":"10.1016\/j.rmed.2018.06.031_bib83","first-page":"203","article-title":"Pathogenic flora in the gastric juice and bronchial secretion of long-term ventilated intensive-care patients","volume":"34","author":"Mauritz","year":"1985","journal-title":"Anaesthesist"},{"issue":"4","key":"10.1016\/j.rmed.2018.06.031_bib84","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1183\/09031936.00003709","article-title":"Mortality in bronchiectasis: a long-term study assessing the factors influencing survival","volume":"34","author":"Loebinger","year":"2009","journal-title":"Eur. Respir. J."},{"issue":"5","key":"10.1016\/j.rmed.2018.06.031_bib85","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1378\/chest.07-0490","article-title":"Factors associated with lung function decline in adult patients with stable non-cystic fibrosis bronchiectasis","volume":"132","author":"Martinez-Garcia","year":"2007","journal-title":"Chest"},{"issue":"5","key":"10.1016\/j.rmed.2018.06.031_bib86","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1164\/rccm.201309-1575OC","article-title":"The bronchiectasis severity index. An international derivation and validation study","volume":"189","author":"Chalmers","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"6","key":"10.1016\/j.rmed.2018.06.031_bib87","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/ppul.21598","article-title":"The impact of reflux burden on Pseudomonas positivity in children with cystic fibrosis","volume":"47","author":"Palm","year":"2012","journal-title":"Pediatr. Pulmonol."},{"key":"10.1016\/j.rmed.2018.06.031_bib88","doi-asserted-by":"crossref","first-page":"26985","DOI":"10.1038\/srep26985","article-title":"Microbiological profiles of sputum and gastric juice aspirates in Cystic Fibrosis patients","volume":"6","author":"Al-Momani","year":"2016","journal-title":"Sci. Rep."},{"issue":"10","key":"10.1016\/j.rmed.2018.06.031_bib89","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1164\/rccm.201210-1937OC","article-title":"Lung microbiota and bacterial abundance in patients with bronchiectasis when clinically stable and during exacerbation","volume":"187","author":"Tunney","year":"2013","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"9","key":"10.1016\/j.rmed.2018.06.031_bib90","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0045978","article-title":"Respiratory pathogens adopt a chronic lifestyle in response to bile","volume":"7","author":"Reen","year":"2012","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.rmed.2018.06.031_bib91","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1007\/s10620-008-0413-9","article-title":"The association between obesity and GERD: a review of the epidemiological evidence","volume":"53","author":"El-Serag","year":"2008","journal-title":"Dig. Dis. Sci."}],"container-title":["Respiratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611118302294?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611118302294?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T11:47:56Z","timestamp":1760615276000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0954611118302294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":91,"alternative-id":["S0954611118302294"],"URL":"https:\/\/doi.org\/10.1016\/j.rmed.2018.06.031","relation":{},"ISSN":["0954-6111"],"issn-type":[{"value":"0954-6111","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A qualitative synthesis of gastro-oesophageal reflux in bronchiectasis: Current understanding and future risk","name":"articletitle","label":"Article Title"},{"value":"Respiratory Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rmed.2018.06.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}