{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T05:31:41Z","timestamp":1782192701497,"version":"3.54.5"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"vor","delay-in-days":731,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","resmedjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Medicine"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.rmed.2019.04.017","type":"journal-article","created":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T20:07:43Z","timestamp":1556222863000},"page":"20-24","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Association between exhaled nitric oxide and nasal polyposis in severe asthma"],"prefix":"10.1016","volume":"152","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6751-9921","authenticated-orcid":false,"given":"Mauro","family":"Maniscalco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Calabrese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"D'Amato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Guida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Molino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Aliani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato","family":"De Tullio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariapia","family":"Foschino Barbaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1826-5018","authenticated-orcid":false,"given":"Fabio Luigi Massimo","family":"Ricciardolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7931-4704","authenticated-orcid":false,"given":"Giovanna Elisiana","family":"Carpagnano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rmed.2019.04.017_bib1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1365-2796.2012.02558.x","article-title":"European severe asthma cohorts: what can they teach us about severe asthma?","volume":"272","author":"Kupczyk","year":"2012","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.rmed.2019.04.017_bib2","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1016\/j.jaci.2013.11.042","article-title":"Unsupervised phenotyping of Severe Asthma Research Program participants using expanded lung data","volume":"133","author":"Wu","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.rmed.2019.04.017_bib3","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1111\/all.13342","article-title":"RItA: the Italian severe\/uncontrolled asthma registry","volume":"73","author":"Maio","year":"2018","journal-title":"Allergy"},{"key":"10.1016\/j.rmed.2019.04.017_bib4","first-page":"1","article-title":"Last station in the eosinophilic asthma with chronic rhinosinusitis and\/or nasal polyposis march: eosinophilic asthma with radiological findings associated with blood eosinophilia","author":"Yilmaz","year":"2018","journal-title":"J. Asthma"},{"key":"10.1016\/j.rmed.2019.04.017_bib5","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1164\/rccm.201412-2278OC","article-title":"Cytokines in chronic rhinosinusitis. Role in eosinophilia and aspirin-exacerbated respiratory disease","volume":"192","author":"Stevens","year":"2015","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.rmed.2019.04.017_bib6","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1146\/annurev-pathol-052016-100401","article-title":"Immunopathogenesis of chronic rhinosinusitis and nasal polyposis","volume":"12","author":"Schleimer","year":"2017","journal-title":"Annu. Rev. Pathol."},{"issue":"1","key":"10.1016\/j.rmed.2019.04.017_bib7","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00938-2018","article-title":"T2-high\" in severe asthma related to blood eosinophil, exhaled nitric oxide and serum periostin","volume":"53","author":"Pavlidis","year":"2019","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.rmed.2019.04.017_bib8","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1016\/j.jaci.2017.10.005","article-title":"Biomarkers for severe eosinophilic asthma","volume":"140","author":"Yancey","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.rmed.2019.04.017_bib9","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.rmed.2016.04.001","article-title":"Assessing biomarkers in a real-world severe asthma study (ARIETTA)","volume":"115","author":"Buhl","year":"2016","journal-title":"Respir. Med."},{"key":"10.1016\/j.rmed.2019.04.017_bib10","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1016\/j.jaci.2011.12.979","article-title":"Asthma outcomes: biomarkers","volume":"129","author":"Szefler","year":"2012","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.rmed.2019.04.017_bib11","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1177\/039463200802100419","article-title":"Breath markers of oxidative stress and airway inflammation in Seasonal Allergic Rhinitis","volume":"21","author":"Gratziou","year":"2008","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"10.1016\/j.rmed.2019.04.017_bib12","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.niox.2018.12.005","article-title":"Exhaled and Nasal Nitric Oxide Measurement in the Evaluation of Chronic Cough","volume":"83","author":"Maniscalco","year":"2019","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.rmed.2019.04.017_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00005-016-0407-9","article-title":"Biomarkers guided treatment strategies in adult patients with asthma: ready for the clinical field?","volume":"65","author":"Tsilogianni","year":"2017","journal-title":"Arch. Immunol. Ther. Exp."},{"key":"10.1016\/j.rmed.2019.04.017_bib14","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S2213-2600(18)30184-X","article-title":"Tralokinumab for severe, uncontrolled asthma (STRATOS 1 and STRATOS 2): two randomised, double-blind, placebo-controlled, phase 3 clinical trials","volume":"6","author":"Panettieri","year":"2018","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.rmed.2019.04.017_bib15","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1056\/NEJMoa1704064","article-title":"Tezepelumab in adults with uncontrolled asthma","volume":"377","author":"Corren","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.rmed.2019.04.017_bib16","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0140-6736(16)30307-5","article-title":"Dupilumab efficacy and safety in adults with uncontrolled persistent asthma despite use of medium-to-high-dose inhaled corticosteroids plus a long-acting beta2 agonist: a randomised double-blind placebo-controlled pivotal phase 2b dose-ranging trial","volume":"388","author":"Wenzel","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.rmed.2019.04.017_bib17","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.pupt.2017.08.010","article-title":"Model-based clinical pharmacology profiling and exposure-response relationships of the efficacy and biomarker of lebrikizumab in patients with moderate-to-severe asthma","volume":"46","author":"Zhu","year":"2017","journal-title":"Pulm. Pharmacol. Therapeut."},{"key":"10.1016\/j.rmed.2019.04.017_bib18","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.jaci.2010.07.019","article-title":"Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma","volume":"126","author":"Bousquet","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.rmed.2019.04.017_bib19","first-page":"1107","article-title":"Update. American thoracic society","volume":"152","author":"Standardization of Spirometry","year":"1994","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.rmed.2019.04.017_bib20","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1164\/rccm.200406-710ST","article-title":"American Thoracic S., European Respiratory S. ATS\/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide","volume":"171","year":"2005","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.rmed.2019.04.017_bib21","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1001\/jama.293.5.572","article-title":"Adhere Scientific Advisory Committee S. G. et al Risk stratification for in-hospital mortality in acutely decompensated heart failure: classification and regression tree analysis","volume":"293","author":"Fonarow","year":"2005","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.rmed.2019.04.017_bib22","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.jaci.2013.04.052","article-title":"Severe adult-onset asthma: a distinct phenotype","volume":"132","author":"Amelink","year":"2013","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.rmed.2019.04.017_bib23","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1183\/09031936.00201813","article-title":"Importance of concomitant local and systemic eosinophilia in uncontrolled asthma","volume":"44","author":"Schleich","year":"2014","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.rmed.2019.04.017_bib24","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1183\/13993003.00779-2015","article-title":"Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort","volume":"46","author":"Shaw","year":"2015","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.rmed.2019.04.017_bib25","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.3109\/02770903.2015.1054404","article-title":"Residual exhaled nitric oxide elevation in asthmatics is associated with eosinophilic chronic rhinosinusitis","volume":"52","author":"Kobayashi","year":"2015","journal-title":"J. Asthma"},{"key":"10.1016\/j.rmed.2019.04.017_bib26","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01785-2017","article-title":"Predictors of accelerated decline in lung function in adult-onset asthma","volume":"51","author":"Coumou","year":"2018","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.rmed.2019.04.017_bib27","first-page":"120","article-title":"The prevalence of nasal polyps and the corresponding urinary LTE4 levels in severe compared to mild and moderate asthma","volume":"42","author":"Micheletto","year":"2010","journal-title":"Eur. Ann. Allergy Clin. Immunol."},{"key":"10.1016\/j.rmed.2019.04.017_bib28","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.anai.2016.12.018","article-title":"Two inflammatory phenotypes of nasal polyps and comorbid asthma","volume":"118","author":"Wu","year":"2017","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"10.1016\/j.rmed.2019.04.017_bib29","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1016\/j.rmed.2014.10.007","article-title":"Heterogeneity of phenotypes in severe asthmatics. The Belgian severe asthma registry (BSAR)","volume":"108","author":"Schleich","year":"2014","journal-title":"Respir. Med."},{"key":"10.1016\/j.rmed.2019.04.017_bib30","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1378\/chest.09-0667","article-title":"Determinants of exhaled nitric oxide in chronic rhinosinusitis","volume":"137","author":"Guida","year":"2010","journal-title":"Chest"},{"key":"10.1016\/j.rmed.2019.04.017_bib31","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1164\/rccm.201602-0419OC","article-title":"Inflammatory and comorbid features of patients with severe asthma and frequent exacerbations","volume":"195","author":"Denlinger","year":"2017","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.rmed.2019.04.017_bib32","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1177\/0003489417731782","article-title":"Anti-IgE and anti-IL5 biologic therapy in the treatment of nasal polyposis: a systematic review and meta-analysis","volume":"126","author":"Rivero","year":"2017","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"10.1016\/j.rmed.2019.04.017_bib33","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1001\/jama.2015.19330","article-title":"Effect of subcutaneous dupilumab on nasal polyp burden in patients with chronic sinusitis and nasal polyposis: a randomized clinical trial","volume":"315","author":"Bachert","year":"2016","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.rmed.2019.04.017_bib34","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1164\/rccm.201406-1099OC","article-title":"Gene expression in relation to exhaled nitric oxide identifies novel asthma phenotypes with unique biomolecular pathways","volume":"190","author":"Modena","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med."}],"container-title":["Respiratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611119301386?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611119301386?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T11:48:55Z","timestamp":1760615335000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0954611119301386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":34,"alternative-id":["S0954611119301386"],"URL":"https:\/\/doi.org\/10.1016\/j.rmed.2019.04.017","relation":{},"ISSN":["0954-6111"],"issn-type":[{"value":"0954-6111","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between exhaled nitric oxide and nasal polyposis in severe asthma","name":"articletitle","label":"Article Title"},{"value":"Respiratory Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rmed.2019.04.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}