{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T19:06:31Z","timestamp":1780081591723,"version":"3.54.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"vor","delay-in-days":731,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100008349","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","award":["1237-0054"],"award-info":[{"award-number":["1237-0054"]}],"id":[{"id":"10.13039\/100008349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","resmedjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Medicine"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.rmed.2019.09.006","type":"journal-article","created":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T11:53:58Z","timestamp":1568116438000},"page":"59-68","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Effects of lung deflation induced by tiotropium\/olodaterol on the cardiocirculatory responses to exertion in COPD"],"prefix":"10.1016","volume":"157","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8393-3126","authenticated-orcid":false,"given":"Danilo C.","family":"Berton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata D.","family":"Marques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon","family":"Palmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis E.","family":"O'Donnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.Alberto","family":"Neder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rmed.2019.09.006_bib1","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1378\/chest.12-0938","article-title":"Cardiovascular disease in COPD: mechanisms","volume":"143","author":"Maclay","year":"2013","journal-title":"Chest"},{"key":"10.1016\/j.rmed.2019.09.006_bib2","doi-asserted-by":"crossref","DOI":"10.1164\/rccm.201901-0061ED","article-title":"On trapped air and trapped blood in COPD","author":"Watz","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.rmed.2019.09.006_bib3","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1080\/14779072.2018.1510319","article-title":"Current challenges in managing comorbid heart failure and COPD","volume":"16","author":"Neder","year":"2018","journal-title":"Expert Rev. Cardiovasc. Ther."},{"key":"10.1016\/j.rmed.2019.09.006_bib4","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ccm.2013.09.008","article-title":"Chronic obstructive pulmonary disease: clinical integrative physiology","volume":"35","author":"O'Donnell","year":"2014","journal-title":"Clin. Chest Med."},{"issue":"2008","key":"10.1016\/j.rmed.2019.09.006_bib5","first-page":"753","article-title":"The major limitation to exercise performance in COPD is dynamic hyperinflation","volume":"105","author":"O'Donnell","year":"1985","journal-title":"J. Appl. Physiol. Bethesda Md"},{"key":"10.1016\/j.rmed.2019.09.006_bib6","first-page":"1341","article-title":"Kinetics of muscle deoxygenation are accelerated at the onset of heavy-intensity exercise in patients with COPD: relationship to central cardiovascular dynamics","volume":"104","author":"Chiappa","year":"1985","journal-title":"J. Appl. Physiol. Bethesda Md"},{"key":"10.1016\/j.rmed.2019.09.006_bib7","first-page":"1013","article-title":"Limitation of lower limb VO(2) during cycling exercise in COPD patients","volume":"90","author":"Simon","year":"1985","journal-title":"J. Appl. Physiol. Bethesda Md"},{"key":"10.1016\/j.rmed.2019.09.006_bib8","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1097\/00005768-200106000-00010","article-title":"Effects of oxygen on lower limb blood flow and O2 uptake during exercise in COPD","volume":"33","author":"Maltais","year":"2001","journal-title":"Med. Sci. Sport. Exerc."},{"key":"10.1016\/j.rmed.2019.09.006_bib9","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1164\/rccm.201203-0404OC","article-title":"Influences of spinal anesthesia on exercise tolerance in patients with chronic obstructive pulmonary disease","volume":"186","author":"Gagnon","year":"2012","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.rmed.2019.09.006_bib10","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.rmed.2017.06.020","article-title":"Impact of LABA\/LAMA combination on exercise endurance and lung hyperinflation in COPD: a pair-wise and network meta-analysis","volume":"129","author":"Calzetta","year":"2017","journal-title":"Respir. Med."},{"key":"10.1016\/j.rmed.2019.09.006_bib11","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/S2213-2600(18)30054-7","article-title":"Effect of lung deflation with indacaterol plus glycopyrronium on ventricular filling in patients with hyperinflation and COPD (CLAIM): a double-blind, randomised, crossover, placebo-controlled, single-centre trial","volume":"6","author":"Hohlfeld","year":"2018","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.rmed.2019.09.006_bib12","doi-asserted-by":"crossref","DOI":"10.1164\/rccm.201805-0995OC","article-title":"Effect of indacaterol\/glycopyrronium on pulmonary perfusion and ventilation in hyperinflated COPD patients (CLAIM): a double-blind, randomised, crossover trial","author":"Vogel-Claussen","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.rmed.2019.09.006_bib13","doi-asserted-by":"crossref","first-page":"H2465","DOI":"10.1152\/ajpheart.91520.2007","article-title":"Effects of respiratory muscle unloading on leg muscle oxygenation and blood volume during high-intensity exercise in chronic heart failure","volume":"294","author":"Borghi-Silva","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.rmed.2019.09.006_bib14","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1164\/rccm.201508-1647OC","article-title":"Lung deflation and cardiovascular structure and function in chronic obstructive pulmonary disease. A randomized controlled trial","volume":"193","author":"Stone","year":"2016","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.rmed.2019.09.006_bib15","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/j.1475-097X.2012.01135.x","article-title":"Signal-morphology impedance cardiography during incremental cardiopulmonary exercise testing in pulmonary arterial hypertension","volume":"32","author":"Ferreira","year":"2012","journal-title":"Clin. Physiol. Funct. Imaging"},{"key":"10.1016\/j.rmed.2019.09.006_bib16","first-page":"947","article-title":"Near-infrared spectroscopy using indocyanine green dye for minimally invasive measurement of respiratory and leg muscle blood flow in patients with COPD","volume":"125","author":"Louvaris","year":"1985","journal-title":"J. Appl. Physiol. Bethesda Md"},{"key":"10.1016\/j.rmed.2019.09.006_bib17","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.02049-2018","article-title":"Dual bronchodilation with tiotropium\/olodaterol further reduces activity-related breathlessness versus tiotropium alone in COPD","author":"Maltais","year":"2019","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.rmed.2019.09.006_bib18","first-page":"252","article-title":"Canadian Respiratory Research Network (CRRN), Acute bronchodilator therapy does not reduce wasted ventilation during exercise in COPD","author":"Elbehairy","year":"2018","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.rmed.2019.09.006_bib19","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1164\/rccm.200811-1793OC","article-title":"Heliox improves oxygen delivery and utilization during dynamic exercise in patients with chronic obstructive pulmonary disease","volume":"179","author":"Chiappa","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.rmed.2019.09.006_bib20","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1136\/thx.2009.120857","article-title":"Bronchodilators accelerate the dynamics of muscle O2 delivery and utilisation during exercise in COPD","volume":"65","author":"Berton","year":"2010","journal-title":"Thorax"},{"key":"10.1016\/j.rmed.2019.09.006_bib21","author":"GOLD Executive Committee"},{"key":"10.1016\/j.rmed.2019.09.006_bib22","doi-asserted-by":"crossref","first-page":"956081","DOI":"10.1155\/2013\/956081","article-title":"Inspiratory capacity during exercise: measurement, analysis, and interpretation","volume":"2013","author":"Guenette","year":"2013","journal-title":"Pulm. Med."},{"key":"10.1016\/j.rmed.2019.09.006_bib23","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1183\/09031936.05.00035205","article-title":"Interpretative strategies for lung function tests","volume":"26","author":"Pellegrino","year":"2005","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.rmed.2019.09.006_bib24","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1378\/chest.93.3.580","article-title":"Evaluation of clinical methods for rating dyspnea","volume":"93","author":"Mahler","year":"1988","journal-title":"Chest"},{"key":"10.1016\/j.rmed.2019.09.006_bib25","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1378\/chest.11-0787","article-title":"Decline of resting inspiratory capacity in COPD: the impact on breathing pattern, dyspnea, and ventilatory capacity during exercise","volume":"141","author":"O'Donnell","year":"2012","journal-title":"Chest"},{"key":"10.1016\/j.rmed.2019.09.006_bib26","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1183\/13993003.00745-2015","article-title":"Use of exercise testing in the evaluation of interventional efficacy: an official ERS statement","volume":"47","author":"Puente-Maestu","year":"2016","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.rmed.2019.09.006_bib27","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s004210000226","article-title":"A new impedance cardiograph device for the non-invasive evaluation of cardiac output at rest and during exercise: comparison with the \u201cdirect\u201d Fick method","volume":"82","author":"Charloux","year":"2000","journal-title":"Eur. J. Appl. Physiol."},{"key":"10.1016\/j.rmed.2019.09.006_bib28","first-page":"962","article-title":"Near-infrared spectroscopy and indocyanine green derived blood flow index for noninvasive measurement of muscle perfusion during exercise","volume":"108","author":"Habazettl","year":"1985","journal-title":"J. Appl. Physiol. Bethesda Md"},{"key":"10.1016\/j.rmed.2019.09.006_bib29","first-page":"1012","article-title":"Heliox increases quadriceps muscle oxygen delivery during exercise in COPD patients with and without dynamic hyperinflation","volume":"113","author":"Louvaris","year":"1985","journal-title":"J. Appl. Physiol. Bethesda Md"},{"key":"10.1016\/j.rmed.2019.09.006_bib30","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1081\/COPD-200050576","article-title":"Factors determining constant work rate exercise tolerance in COPD and their role in dictating the minimal clinically important difference in response to interventions","volume":"2","author":"Casaburi","year":"2005","journal-title":"COPD"},{"key":"10.1016\/j.rmed.2019.09.006_bib31","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.1513\/AnnalsATS.201708-667KV","article-title":"Rethinking chronic obstructive pulmonary disease. Chronic pulmonary insufficiency and combined cardiopulmonary insufficiency","volume":"15","author":"Barr","year":"2018","journal-title":"Ann. Am. Thorac. Soc."},{"key":"10.1016\/j.rmed.2019.09.006_bib32","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1378\/chest.09-2810","article-title":"Decreasing cardiac chamber sizes and associated heart dysfunction in COPD: role of hyperinflation","volume":"138","author":"Watz","year":"2010","journal-title":"Chest"},{"key":"10.1016\/j.rmed.2019.09.006_bib33","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1378\/chest.12-1779","article-title":"Percent emphysema and right ventricular structure and function: the multi-ethnic study of atherosclerosis-lung and multi-ethnic study of atherosclerosis-right ventricle studies","volume":"144","author":"Grau","year":"2013","journal-title":"Chest"},{"key":"10.1016\/j.rmed.2019.09.006_bib34","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1097\/RTI.0000000000000076","article-title":"Cardiopulmonary coupling in chronic obstructive pulmonary disease: the role of imaging","volume":"29","author":"Rahaghi","year":"2014","journal-title":"J. Thorac. Imaging"},{"key":"10.1016\/j.rmed.2019.09.006_bib35","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1242\/jeb.100.1.175","article-title":"Cardiopulmonary coupling during exercise","volume":"100","author":"Whipp","year":"1982","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.rmed.2019.09.006_bib36","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1378\/chest.14-0800","article-title":"Recent advances in dyspnea","volume":"147","author":"Mahler","year":"2015","journal-title":"Chest"},{"key":"10.1016\/j.rmed.2019.09.006_bib37","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.resp.2015.06.006","article-title":"Hemodynamic effects of high intensity interval training in COPD patients exhibiting exercise-induced dynamic hyperinflation","volume":"217","author":"Nasis","year":"2015","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.rmed.2019.09.006_bib38","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/s00421-009-1169-4","article-title":"Bronchodilator effect on ventilatory, pulmonary gas exchange, and heart rate kinetics during high-intensity exercise in COPD","volume":"107","author":"Laveneziana","year":"2009","journal-title":"Eur. J. Appl. Physiol."},{"key":"10.1016\/j.rmed.2019.09.006_bib39","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1378\/chest.15-0404","article-title":"Effective bronchoscopic lung volume reduction accelerates exercise oxygen uptake kinetics in emphysema","volume":"149","author":"Faisal","year":"2016","journal-title":"Chest"},{"key":"10.1016\/j.rmed.2019.09.006_bib40","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1183\/09031936.00165410","article-title":"Subclinical atherosclerosis, airflow obstruction and emphysema: the MESA lung study","volume":"39","author":"Barr","year":"2012","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.rmed.2019.09.006_bib41","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1056\/NEJMoa0808836","article-title":"Percent emphysema, airflow obstruction, and impaired left ventricular filling","volume":"362","author":"Barr","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.rmed.2019.09.006_bib42","doi-asserted-by":"crossref","DOI":"10.1164\/rccm.201801-0095PP","article-title":"Pulmonary vascular involvement in COPD - is there a pulmonary vascular phenotype?","author":"Kovacs","year":"2018","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.rmed.2019.09.006_bib43","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1378\/chest.11-2798","article-title":"Ventilatory and cardiocirculatory exercise profiles in COPD: the role of pulmonary hypertension","volume":"142","author":"Boerrigter","year":"2012","journal-title":"Chest"},{"key":"10.1016\/j.rmed.2019.09.006_bib44","doi-asserted-by":"crossref","DOI":"10.1164\/rccm.201704-0675OC","article-title":"Excess ventilation in COPD-heart failure overlap: implications for dyspnea and exercise intolerance","author":"Rocha","year":"2017","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.rmed.2019.09.006_bib45","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.ccm.2019.02.006","article-title":"Clinical and physiologic implications of negative cardiopulmonary interactions in coexisting chronic obstructive pulmonary disease-heart failure","volume":"40","author":"Neder","year":"2019","journal-title":"Clin. Chest Med."}],"container-title":["Respiratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611119302860?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611119302860?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T11:55:58Z","timestamp":1760615758000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0954611119302860"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":45,"alternative-id":["S0954611119302860"],"URL":"https:\/\/doi.org\/10.1016\/j.rmed.2019.09.006","relation":{},"ISSN":["0954-6111"],"issn-type":[{"value":"0954-6111","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of lung deflation induced by tiotropium\/olodaterol on the cardiocirculatory responses to exertion in COPD","name":"articletitle","label":"Article Title"},{"value":"Respiratory Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rmed.2019.09.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}