{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:20:31Z","timestamp":1777368031183,"version":"3.51.4"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"vor","delay-in-days":730,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","resmedjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Medicine"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.rmed.2020.106041","type":"journal-article","created":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T20:31:18Z","timestamp":1590525078000},"page":"106041","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Hypersensitivity to dipyrone in aspirin-exacerbated respiratory disease patients is associated with urticaria"],"prefix":"10.1016","volume":"170","author":[{"given":"Rosana C\u00e2mara","family":"Agondi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella Melo Fontes Silva","family":"Dias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u0101o Paulo de","family":"Assis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosilane","family":"Pacheco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Kalil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Giavina-Bianchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.rmed.2020.106041_bib1","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1067\/mai.2003.1487","article-title":"Aspirin-induced asthma: advances in pathogenesis, diagnosis, and management","volume":"111","author":"Szczeklik","year":"2003","journal-title":"J. Allergy Clin. Immunol."},{"issue":"1","key":"10.1016\/j.rmed.2020.106041_bib2","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/all.13599","article-title":"Diagnosis and management of NSAID-exacerbated respiratory disease (NERD) \u2013 a EAACI position paper","volume":"74","author":"Kowalski","year":"2019","journal-title":"Allergy"},{"issue":"1","key":"10.1016\/j.rmed.2020.106041_bib3","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1097\/MCP.0000000000000530","article-title":"Heterogeneity of NSAID-exacerbated respiratory disease: has the time come for subphenotyping?","volume":"25","author":"Kowalski","year":"2019","journal-title":"Curr. Opin. Pulm. Med."},{"issue":"3","key":"10.1016\/j.rmed.2020.106041_bib4","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.jaci.2014.08.020","article-title":"Prevalence of aspirin-exacerbated respiratory disease among asthmatic patients: a meta-analysis of the literature","volume":"135","author":"Rajan","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"issue":"4","key":"10.1016\/j.rmed.2020.106041_bib5","first-page":"643","article-title":"Clinical characteristics of aspirin-exacerbated respiratory disease","volume":"36","author":"Stevenson","year":"2016","journal-title":"Immunol. Allergy Clin."},{"key":"10.1016\/j.rmed.2020.106041_bib6","doi-asserted-by":"crossref","first-page":"217","DOI":"10.2147\/JAA.S164806","article-title":"NSAID-induced reactions: classification, prevalence, impact, and management strategies","volume":"12","author":"Blanca-Lopez","year":"2019","journal-title":"J. Asthma Allergy"},{"issue":"5","key":"10.1016\/j.rmed.2020.106041_bib7","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.anai.2019.02.007","article-title":"Drug hypersensitivity reactions in the Americas: similarities and differences","volume":"122","author":"Giavina-Bianchi","year":"2019","journal-title":"Ann. Allergy Asthma Immunol."},{"issue":"10","key":"10.1016\/j.rmed.2020.106041_bib8","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1111\/all.12260","article-title":"Classification and practical approach to the diagnosis and management of hypersensitivity to nonsteroidal anti-inflammatory drugs","volume":"68","author":"Kowalski","year":"2013","journal-title":"Allergy"},{"issue":"4","key":"10.1016\/j.rmed.2020.106041_bib9","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1111\/all.13075","article-title":"Identification of phenotypic clusters of nonsteroidal anti-inflammatory drugs exacerbated respiratory disease","volume":"72","author":"Lee","year":"2017","journal-title":"Allergy"},{"issue":"1","key":"10.1016\/j.rmed.2020.106041_bib10","doi-asserted-by":"crossref","first-page":"16710","DOI":"10.1038\/s41598-018-34668-1","article-title":"NSAIDs-hypersensitivity often induces a blended reaction pattern involving multiple organs","volume":"8","author":"Do\u00f1a","year":"2018","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.rmed.2020.106041_bib11","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1365-2222.2010.03651.x","article-title":"Characteristics of subjects experiencing hypersensitivity to nonsteroidal anti-inflammatory drugs: patterns of response","volume":"41","author":"Do\u00f1a","year":"2011","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.rmed.2020.106041_bib12","series-title":"Global Strategy for Asthma Management and Prevention","author":"Global Initiative for Asthma (GINA)","year":"2019"},{"issue":"5","key":"10.1016\/j.rmed.2020.106041_bib13","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1183\/09031936.05.00035205","article-title":"Interpretative strategies for lung function tests","volume":"26","author":"Pellegrino","year":"2005","journal-title":"Eur. Respir. J."},{"issue":"Suppl 86","key":"10.1016\/j.rmed.2020.106041_bib14","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1398-9995.2007.01620.x","article-title":"Allergic rhinitis and its impact on asthma (ARIA) 2008 update","volume":"63","author":"Bousquet","year":"2008","journal-title":"Allergy"},{"issue":"11","key":"10.1016\/j.rmed.2020.106041_bib15","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1111\/all.13200","article-title":"Non-allergic rhinitis: position paper of the European Academy of allergy and clinical immunology","volume":"72","author":"Hellings","year":"2017","journal-title":"Allergy"},{"issue":"10","key":"10.1016\/j.rmed.2020.106041_bib16","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1111\/j.1398-9995.2005.00895.x","article-title":"Standard skin prick test and sensitization to inhalant allergens across Europe - a survey from the GA2LEN network","volume":"60","author":"Heinzerling","year":"2005","journal-title":"Allergy"},{"issue":"7","key":"10.1016\/j.rmed.2020.106041_bib17","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1111\/all.13397","article-title":"The EAACI\/GA(2)LEN\/EDF\/WAO guidelines for the definition, classification, diagnosis, and management of urticarial","volume":"73","author":"Zuberbier","year":"2018","journal-title":"Allergy"},{"issue":"1","key":"10.1016\/j.rmed.2020.106041_bib18","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jaci.2013.07.004","article-title":"Certain subphenotypes of aspirin-exacerbated respiratory disease distinguished by latent class analysis","volume":"133","author":"Bochenek","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"issue":"5","key":"10.1016\/j.rmed.2020.106041_bib19","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.rmed.2015.02.015","article-title":"Factors associated with asthma control in patients with aspirin-exacerbated respiratory disease","volume":"109","author":"Bochenek","year":"2015","journal-title":"Respir. Med."},{"issue":"1","key":"10.1016\/j.rmed.2020.106041_bib20","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s12931-018-0909-6","article-title":"The utility of biomarkers in diagnosis of aspirin exacerbated respiratory disease","volume":"19","author":"Comhair","year":"2018","journal-title":"Respir. Res."},{"issue":"4","key":"10.1016\/j.rmed.2020.106041_bib21","first-page":"259","article-title":"Hypersensitivity to nonsteroidal anti-inflammatory drugs in children and adolescents: cross-intolerance reactions","volume":"25","author":"Blanca-L\u00f3pez","year":"2015","journal-title":"J Investig. Allergol. Clin. Immunol."},{"issue":"1","key":"10.1016\/j.rmed.2020.106041_bib22","doi-asserted-by":"crossref","first-page":"4","DOI":"10.2500\/aap.2019.40.4188","article-title":"Clinical updates in aspirin-exacerbated respiratory disease","volume":"40","author":"Laidlaw","year":"2019","journal-title":"Allergy Asthma Proc."},{"issue":"4","key":"10.1016\/j.rmed.2020.106041_bib23","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.jaip.2014.03.014","article-title":"Nonsteroidal anti-inflammatory drugs are major causes of drug-induced anaphylaxis","volume":"2","author":"Aun","year":"2014","journal-title":"J. Allergy Clin. Immunol. Pract."},{"issue":"10","key":"10.1016\/j.rmed.2020.106041_bib24","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1096\/fj.06-8061com","article-title":"Dipyrone elicits substantial inhibition of peripheral cyclooxygenases in humans: new insights into the pharmacology of an old analgesic","volume":"21","author":"Hinz","year":"2007","journal-title":"Faseb. J."},{"issue":"4","key":"10.1016\/j.rmed.2020.106041_bib25","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/sj.bjp.0707239","article-title":"Inhibition of cyclooxygenases by dipyrone","volume":"151","author":"Pierre","year":"2007","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.rmed.2020.106041_bib26","doi-asserted-by":"crossref","first-page":"207","DOI":"10.2478\/pjvs-2014-0030","article-title":"Pharmacological characteristics of metamizole","volume":"17","author":"Jasiecka","year":"2014","journal-title":"Pol. J. Vet. Sci."},{"issue":"4","key":"10.1016\/j.rmed.2020.106041_bib27","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1159\/000444798","article-title":"Allergic reactions to metamizole: immediate and delayed responses","volume":"169","author":"Blanca-L\u00f3pez","year":"2016","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.rmed.2020.106041_bib28","article-title":"Progress in understanding hypersensitivity reactions to nonsteroidal anti-inflammatory drugs","author":"Do\u00f1a","year":"2019","journal-title":"Allergy"},{"issue":"1","key":"10.1016\/j.rmed.2020.106041_bib29","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1056\/NEJMcp1800215","article-title":"Chronic rhinosinusitis with nasal polyps","volume":"381","author":"Hopkins","year":"2019","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.rmed.2020.106041_bib30","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/alr.21258","article-title":"The association between allergy and chronic rhinosinusitis with and without nasal polyps: an evidence-based review with recommendations","volume":"4","author":"Wilson","year":"2014","journal-title":"Int. Forum Allergy Rhinol."},{"issue":"9","key":"10.1016\/j.rmed.2020.106041_bib31","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1002\/alr.22367","article-title":"Central compartment involvement in aspirin-exacerbated respiratory disease: the role of allergy and previous sinus surgery","volume":"9","author":"DelGaudio","year":"2019","journal-title":"Int. Forum Allergy Rhinol."},{"issue":"11","key":"10.1016\/j.rmed.2020.106041_bib32","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S2213-2600(15)00367-7","article-title":"Blood eosinophil count and prospective annual asthma disease burden: a UK cohort study","volume":"3","author":"Price","year":"2015","journal-title":"Lancet Respir. Med."},{"issue":"1","key":"10.1016\/j.rmed.2020.106041_bib33","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s12890-016-0271-8","article-title":"Value of peripheral blood eosinophil markers to predict severity of asthma","volume":"16","author":"Casciano","year":"2016","journal-title":"BMC Pulm. Med."}],"container-title":["Respiratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611120301815?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611120301815?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T12:06:11Z","timestamp":1760616371000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0954611120301815"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":33,"alternative-id":["S0954611120301815"],"URL":"https:\/\/doi.org\/10.1016\/j.rmed.2020.106041","relation":{},"ISSN":["0954-6111"],"issn-type":[{"value":"0954-6111","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hypersensitivity to dipyrone in aspirin-exacerbated respiratory disease patients is associated with urticaria","name":"articletitle","label":"Article Title"},{"value":"Respiratory Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rmed.2020.106041","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"106041"}}