{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T13:38:01Z","timestamp":1783690681158,"version":"3.55.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"vor","delay-in-days":730,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Boehringer Ingelheim"},{"name":"Boehringer Ingelheim"},{"name":"GSK"},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006259","name":"Teva","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006259","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","resmedjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Medicine"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.rmed.2020.106067","type":"journal-article","created":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T02:52:20Z","timestamp":1592362340000},"page":"106067","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Sputum quantitative cytometry in patients with interstitial lung disease and chronic cough"],"prefix":"10.1016","volume":"170","author":[{"given":"Terence","family":"Ho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciaran","family":"Scallan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahid","family":"Rezaee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Hambly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Gerard","family":"Cox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Kolb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parameswaran","family":"Nair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rmed.2020.106067_bib1","doi-asserted-by":"crossref","first-page":"180S","DOI":"10.1378\/chest.129.1_suppl.180S","article-title":"Chronic cough due to chronic interstitial pulmonary diseases ACCP evidence-based clinical practice guidelines","volume":"129","author":"Brown","year":"2006","journal-title":"Chest"},{"key":"10.1016\/j.rmed.2020.106067_bib2","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1136\/thx.2004.035220","article-title":"Health-related quality of life in patients with idiopathic pulmonary fibrosis: a systematic review","volume":"60","author":"Swigris","year":"2005","journal-title":"Thorax"},{"key":"10.1016\/j.rmed.2020.106067_bib3","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.pupt.2015.10.009","article-title":"Cough in interstitial lung disease","volume":"35","author":"Garner","year":"2015","journal-title":"Pulm. Pharmacol. Therapeut."},{"key":"10.1016\/j.rmed.2020.106067_bib4","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1183\/09031936.06.00137704","article-title":"Determining asthma treatment by monitoring sputum cell counts: effect on exacerbations","volume":"27","author":"Jayaram","year":"2006","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.rmed.2020.106067_bib5","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1183\/09031936.06.00072105","article-title":"Stable COPD: predicting benefit from high-dose inhaled corticosteroid treatment","volume":"27","author":"Leigh","year":"2006","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.rmed.2020.106067_bib6","first-page":"117","article-title":"Update on clinical inflammometry for the management of airway diseases","volume":"20","author":"Nair","year":"2013","journal-title":"Canc. Res. J."},{"key":"10.1016\/j.rmed.2020.106067_bib7","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1034\/j.1399-3003.2000.16f17.x","article-title":"Lipid-laden macrophages in induced sputum are a marker of oropharyngeal reflux and possible gastric aspiration","volume":"16","author":"Parameswaran","year":"2000","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.rmed.2020.106067_bib8","first-page":"138","article-title":"Neutrophilic inflammation in induced sputum of patients with idiopathic pulmonary fibrosis. Sarcoidosis","volume":"20","author":"Beeh","year":"2003","journal-title":"Vasc Diffus lung Dis Off J WASOG"},{"key":"10.1016\/j.rmed.2020.106067_bib9","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1159\/000187725","article-title":"Induced sputum in interstitial lung diseases: novel insights in the diagnosis, evaluation and research","volume":"77","author":"Economidou","year":"2009","journal-title":"Respiration"},{"key":"10.1016\/j.rmed.2020.106067_bib10","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1164\/ajrccm.161.2.9903097","article-title":"Induced sputum cell counts in healthy adults","volume":"161","author":"Belda","year":"2000","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.rmed.2020.106067_bib11","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1016\/S0140-6736(99)01813-9","article-title":"Non-eosinophilic corticosteroid unresponsive asthma","volume":"353","author":"Pavord","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.rmed.2020.106067_bib12","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1164\/ajrccm.158.5.9804028","article-title":"Sputum eosinophilia predicts benefit from prednisone in smokers with chronic obstructive bronchitis","volume":"158","author":"Pizzichini","year":"1998","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.rmed.2020.106067_bib13","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1111\/resp.13084","article-title":"Cough is less common and less severe in systemic sclerosis-associated interstitial lung disease compared to other fibrotic interstitial lung diseases","volume":"22","author":"Cheng","year":"2017","journal-title":"Respirology"},{"key":"10.1016\/j.rmed.2020.106067_bib14","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1111\/j.1440-1843.2011.01996.x","article-title":"Cough predicts prognosis in idiopathic pulmonary fibrosis","volume":"16","author":"Ryerson","year":"2011","journal-title":"Respirology"},{"key":"10.1016\/j.rmed.2020.106067_bib15","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1378\/chest.115.6.1611","article-title":"Induced sputum in patients with newly diagnosed sarcoidosis","volume":"115","author":"D'Ippolito","year":"1999","journal-title":"Chest"},{"key":"10.1016\/j.rmed.2020.106067_bib16","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s00011-004-1321-x","article-title":"Sputum eosinophilia in idiopathic pulmonary fibrosis","volume":"54","author":"Birring","year":"2005","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.rmed.2020.106067_bib17","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.4187\/respcare.04706","article-title":"Induced sputum analysis in subjects with systemic sclerosis","volume":"61","author":"Litinsky","year":"2016","journal-title":"Respir. Care"},{"key":"10.1016\/j.rmed.2020.106067_bib18","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1159\/000083398","article-title":"Induced sputum versus bronchoalveolar lavage fluid in the evaluation of patients with idiopathic pulmonary fibrosis","volume":"72","author":"Antoniou","year":"2005","journal-title":"Respiration"},{"key":"10.1016\/j.rmed.2020.106067_bib19","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/j.rmed.2007.02.003","article-title":"Induced sputum as a tool for early detection of airway inflammation in connective diseases-related lung involvement","volume":"101","author":"Vatrella","year":"2007","journal-title":"Respir. Med."},{"key":"10.1016\/j.rmed.2020.106067_bib20","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1159\/000164720","article-title":"Induced sputum in systemic sclerosis interstitial lung disease: comparison to healthy controls and bronchoalveolar lavage","volume":"78","author":"Damjanov","year":"2009","journal-title":"Respiration"},{"key":"10.1016\/j.rmed.2020.106067_bib21","first-page":"8","article-title":"Latent pulmonary inflammation in patients with systemic sclerosis","volume":"48","author":"S\u00e1nchez-Vidaurre","year":"2012","journal-title":"Arch Bronconeumol (English Ed"},{"key":"10.1016\/j.rmed.2020.106067_bib22","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/2047-783X-14-S4-165","article-title":"Increased levels of Treg cells in bronchoalveolar lavage fluid and induced sputum of patients with active pulmonary sarcoidosis","volume":"14","author":"Mroz","year":"2009","journal-title":"Eur. J. Med. Res."},{"key":"10.1016\/j.rmed.2020.106067_bib23","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S0954-6111(99)90269-X","article-title":"Induced sputum compared to bronchoalveolar lavage for evaluating patients with sarcoidosis and non-granulomatous interstitial lung disease","volume":"93","author":"Fireman","year":"1999","journal-title":"Respir. Med."},{"key":"10.1016\/j.rmed.2020.106067_bib24","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1152\/physrev.00004.2016","article-title":"Idiopathic pulmonary fibrosis: a genetic disease that involves mucociliary dysfunction of the peripheral airways","volume":"96","author":"Evans","year":"2016","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.rmed.2020.106067_bib25","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1183\/09031936.00146306","article-title":"Eosinophilic airway inflammation and exacerbations of COPD: a randomised controlled trial","volume":"29","author":"Siva","year":"2007","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.rmed.2020.106067_bib26","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1016\/S0140-6736(02)11679-5","article-title":"Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial","volume":"360","author":"Green","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.rmed.2020.106067_bib27","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1097\/MCP.0000000000000441","article-title":"Airway remodeling in asthma","volume":"24","author":"Boulet","year":"2018","journal-title":"Curr. Opin. Pulm. Med."},{"key":"10.1016\/j.rmed.2020.106067_bib28","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1378\/chest.92.1.51","article-title":"Prognostic role of eosinophils in pulmonary fibrosis","volume":"92","author":"Peterson","year":"1987","journal-title":"Chest"},{"key":"10.1016\/j.rmed.2020.106067_bib29","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1164\/ajrccm.156.1.9605044","article-title":"A systematic evaluation of mechanisms in chronic cough","volume":"156","author":"Carney","year":"1997","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.rmed.2020.106067_bib30","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1016\/j.jaip.2019.04.048","article-title":"Cough and eosinophilia","volume":"7","author":"Diver","year":"2019","journal-title":"J Allergy Clin Immunol Pract"}],"container-title":["Respiratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611120302079?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611120302079?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T12:13:34Z","timestamp":1760616814000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0954611120302079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":30,"alternative-id":["S0954611120302079"],"URL":"https:\/\/doi.org\/10.1016\/j.rmed.2020.106067","relation":{},"ISSN":["0954-6111"],"issn-type":[{"value":"0954-6111","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sputum quantitative cytometry in patients with interstitial lung disease and chronic cough","name":"articletitle","label":"Article Title"},{"value":"Respiratory Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rmed.2020.106067","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"106067"}}