{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T04:00:32Z","timestamp":1781755232244,"version":"3.54.5"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T00:00:00Z","timestamp":1662076800000},"content-version":"vor","delay-in-days":731,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","resmedjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Medicine"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.rmed.2020.106115","type":"journal-article","created":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T12:03:24Z","timestamp":1597665804000},"page":"106115","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["sIL-2R levels predict the spontaneous remission in sarcoidosis"],"prefix":"10.1016","volume":"171","author":[{"given":"Ying","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuhong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.rmed.2020.106115_bib1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1164\/ajrccm\/145.1.187","article-title":"Lung-restricted activation of the alveolar macrophage\/monocyte system in pulmonary sarcoidosis","volume":"145","author":"Muller-Quernheim","year":"1992","journal-title":"Am. Rev. Respir. Dis."},{"issue":"11","key":"10.1016\/j.rmed.2020.106115_bib2","doi-asserted-by":"crossref","first-page":"3475","DOI":"10.4049\/jimmunol.137.11.3475","article-title":"Compartmentalized activation of the interleukin 2 gene by lung T lymphocytes in active pulmonary sarcoidosis","volume":"137","author":"Muller-Quernheim","year":"1986","journal-title":"J. Immunol."},{"issue":"4 Pt 1","key":"10.1016\/j.rmed.2020.106115_bib3","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1164\/ajrccm.149.4.8143052","article-title":"Outcome of the treatment for sarcoidosis","volume":"149","author":"Hunninghake","year":"1994","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"4","key":"10.1016\/j.rmed.2020.106115_bib4","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1080\/17476348.2020.1721284","article-title":"Therapeutic strategies for pulmonary sarcoidosis","volume":"14","author":"James","year":"2020","journal-title":"Expet Rev. Respir. Med."},{"issue":"2","key":"10.1016\/j.rmed.2020.106115_bib5","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1164\/ajrccm.160.2.ats4-99","volume":"160","year":"1999","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"5261","key":"10.1016\/j.rmed.2020.106115_bib6","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1136\/bmj.2.5261.1165","article-title":"Prognosis of intrathoracic sarcoidosis in England. A review of 136 cases after five years' observation","volume":"2","author":"Scadding","year":"1961","journal-title":"Br. Med. J."},{"issue":"1","key":"10.1016\/j.rmed.2020.106115_bib7","first-page":"19","article-title":"The WASOG Sarcoidosis Organ Assessment Instrument: an update of a previous clinical tool","volume":"31","author":"Judson","year":"2014","journal-title":"Sarcoidosis Vasc. Diffuse Lung Dis."},{"key":"10.1016\/j.rmed.2020.106115_bib8","doi-asserted-by":"crossref","DOI":"10.1177\/1753466619868935","article-title":"Contemporary optimized practice in the management of pulmonary sarcoidosis","volume":"13","author":"Aryal","year":"2019","journal-title":"Ther. Adv. Respir. Dis."},{"issue":"3","key":"10.1016\/j.rmed.2020.106115_bib9","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1183\/09031936.98.12030716","article-title":"Sarcoidosis: immunopathogenetic concepts and their clinical application","volume":"12","author":"Muller-Quernheim","year":"1998","journal-title":"Eur. Respir. J."},{"issue":"4","key":"10.1016\/j.rmed.2020.106115_bib10","first-page":"634","article-title":"Role of interleukin-2 release by lung T-cells in active pulmonary sarcoidosis","volume":"128","author":"Hunninghake","year":"1983","journal-title":"Am. Rev. Respir. Dis."},{"issue":"5","key":"10.1016\/j.rmed.2020.106115_bib11","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1378\/chest.98.5.1125","article-title":"Serum concentration of soluble interleukin-2 receptor as a sensitive parameter of disease activity in sarcoidosis","volume":"98","author":"Keicho","year":"1990","journal-title":"Chest"},{"issue":"2","key":"10.1016\/j.rmed.2020.106115_bib12","first-page":"61","article-title":"Cytokines assay in peripheral blood and bronchoalveolar lavage in the diagnosis and staging of pulmonary granulomatous diseases","volume":"13","author":"Belli","year":"2000","journal-title":"Int. J. Immunopathol. Pharmacol."},{"issue":"4","key":"10.1016\/j.rmed.2020.106115_bib13","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1164\/ajrccm\/137.4.759","article-title":"Elevated concentrations of soluble interleukin-2 receptors in serum samples and bronchoalveolar lavage fluids in active sarcoidosis","volume":"137","author":"Lawrence","year":"1988","journal-title":"Am. Rev. Respir. Dis."},{"issue":"2","key":"10.1016\/j.rmed.2020.106115_bib14","first-page":"102","article-title":"Soluble interleukin-2 receptor in blood from patients with sarcoidosis and idiopathic pulmonary fibrosis","volume":"11","author":"Tsutsumi","year":"1994","journal-title":"Sarcoidosis"},{"issue":"1","key":"10.1016\/j.rmed.2020.106115_bib15","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1378\/chest.124.1.186","article-title":"Serum soluble interleukin-2 receptor measurement in patients with sarcoidosis: a clinical evaluation","volume":"124","author":"Grutters","year":"2003","journal-title":"Chest"},{"issue":"3","key":"10.1016\/j.rmed.2020.106115_bib16","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1164\/rccm.200705-742OC","article-title":"Phenotyping sarcoidosis from a pulmonary perspective","volume":"177","author":"Prasse","year":"2008","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"1","key":"10.1016\/j.rmed.2020.106115_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0147258","article-title":"Interleukin-2 receptor and angiotensin-converting enzyme as markers for ocular sarcoidosis","volume":"11","author":"Gundlach","year":"2016","journal-title":"PloS One"},{"issue":"7","key":"10.1016\/j.rmed.2020.106115_bib18","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1111\/1346-8138.13792","article-title":"Serum soluble interleukin-2 receptor level is more sensitive than angiotensin-converting enzyme or lysozyme for diagnosis of sarcoidosis and may be a marker of multiple organ involvement","volume":"44","author":"Thi","year":"2017","journal-title":"J. Dermatol."},{"issue":"3","key":"10.1016\/j.rmed.2020.106115_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/biom8030084","article-title":"YKL-40, soluble IL-2 receptor, angiotensin converting enzyme and C-reactive protein: comparison of markers of sarcoidosis activity","volume":"8","author":"Uysal","year":"2018","journal-title":"Biomolecules"},{"issue":"2","key":"10.1016\/j.rmed.2020.106115_bib20","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1183\/09031936.00055213","article-title":"Prediction of relapse after discontinuation of infliximab therapy in severe sarcoidosis","volume":"43","author":"Vorselaars","year":"2014","journal-title":"Eur. Respir. J."},{"issue":"5","key":"10.1016\/j.rmed.2020.106115_bib21","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1164\/ajrccm.156.5.97-02050","article-title":"Sarcoidosis: TNF-alpha release from alveolar macrophages and serum level of sIL-2R are prognostic markers","volume":"156","author":"Ziegenhagen","year":"1997","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"6","key":"10.1016\/j.rmed.2020.106115_bib22","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1378\/chest.09-1975","article-title":"Comparative evaluation of serum markers in pulmonary sarcoidosis","volume":"137","author":"Miyoshi","year":"2010","journal-title":"Chest"},{"issue":"3","key":"10.1016\/j.rmed.2020.106115_bib23","first-page":"325","article-title":"Sarcoidosis: a review for the internist","volume":"13","author":"Bargagli","year":"2018","journal-title":"Int. Emerg. Med."},{"issue":"10","key":"10.1016\/j.rmed.2020.106115_bib24","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1016\/j.rmed.2007.05.008","article-title":"Chitotriosidase activity in patients with interstitial lung diseases","volume":"101","author":"Bargagli","year":"2007","journal-title":"Respir. Med."},{"key":"10.1016\/j.rmed.2020.106115_bib25","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.rmed.2019.04.005","article-title":"Serum CXCL11 correlates with pulmonary outcomes and disease burden in sarcoidosis","volume":"152","author":"Arger","year":"2019","journal-title":"Respir. Med."},{"issue":"3","key":"10.1016\/j.rmed.2020.106115_bib26","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1159\/000505653","article-title":"The role of urinary calcium and chitotriosidase in a cohort of chronic sarcoidosis patients","volume":"99","author":"Cameli","year":"2020","journal-title":"Respiration"}],"container-title":["Respiratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611120302559?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611120302559?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T12:19:46Z","timestamp":1760617186000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0954611120302559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":26,"alternative-id":["S0954611120302559"],"URL":"https:\/\/doi.org\/10.1016\/j.rmed.2020.106115","relation":{},"ISSN":["0954-6111"],"issn-type":[{"value":"0954-6111","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"sIL-2R levels predict the spontaneous remission in sarcoidosis","name":"articletitle","label":"Article Title"},{"value":"Respiratory Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rmed.2020.106115","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"106115"}}