{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T22:39:44Z","timestamp":1788734384222,"version":"build-2803163510"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T00:00:00Z","timestamp":1626912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","resmedjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Medicine"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.rmed.2021.106537","type":"journal-article","created":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T18:57:25Z","timestamp":1626980245000},"page":"106537","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["HLA-DRB1 alleles associate with hypercalcemia in sarcoidosis"],"prefix":"10.1016","volume":"187","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1335-6503","authenticated-orcid":false,"given":"Joanna","family":"Werner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1298-1243","authenticated-orcid":false,"given":"Natalia","family":"Rivera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Grunewald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Eklund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Iseda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pernilla","family":"Darlington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2844-4773","authenticated-orcid":false,"given":"Susanna","family":"Kullberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.rmed.2021.106537_bib1","first-page":"149","article-title":"ATS\/ERS\/WASOG statement on sarcoidosis. American thoracic society\/European respiratory society\/world association of sarcoidosis and other granulomatous disorders","volume":"16","author":"Hunninghake","year":"1999","journal-title":"Sarcoidosis Vasc. Diffuse Lung Dis."},{"issue":"8","key":"10.1016\/j.rmed.2021.106537_bib2","doi-asserted-by":"crossref","first-page":"e26","DOI":"10.1164\/rccm.202002-0251ST","article-title":"Diagnosis and detection of sarcoidosis. An official American thoracic society clinical practice guideline","volume":"201","author":"Crouser","year":"2020","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.rmed.2021.106537_bib3","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1465-9921-11-25","article-title":"Different HLA-DRB1 allele distributions in distinct clinical subgroups of sarcoidosis patients","volume":"11","author":"Grunewald","year":"2010","journal-title":"Respir. Res."},{"issue":"5","key":"10.1016\/j.rmed.2021.106537_bib4","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1183\/09031936.00025011","article-title":"HLA-DRB1* alleles and symptoms associated with Heerfordt's syndrome in sarcoidosis","volume":"38","author":"Darlington","year":"2011","journal-title":"Eur. Respir. J."},{"issue":"4","key":"10.1016\/j.rmed.2021.106537_bib5","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1086\/378097","article-title":"HLA-DRB1*1101: a significant risk factor for sarcoidosis in blacks and whites","volume":"73","author":"Rossman","year":"2003","journal-title":"Am. J. Hum. Genet."},{"issue":"4","key":"10.1016\/j.rmed.2021.106537_bib6","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/tan.12326","article-title":"HLA-alleles associated with increased risk for extra-pulmonary involvement in sarcoidosis","volume":"83","author":"Darlington","year":"2014","journal-title":"Tissue Antigens"},{"issue":"5","key":"10.1016\/j.rmed.2021.106537_bib7","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1164\/ajrccm.156.5.9704069","article-title":"HLA-DR predicts the prognosis in Scandinavian patients with pulmonary sarcoidosis","volume":"156","author":"Berlin","year":"1997","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"6","key":"10.1016\/j.rmed.2021.106537_bib8","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1164\/rccm.200303-459OC","article-title":"Human leukocyte antigen class I alleles and the disease course in sarcoidosis patients","volume":"169","author":"Grunewald","year":"2004","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"6","key":"10.1016\/j.rmed.2021.106537_bib9","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1172\/JCI101084","article-title":"Blood chemical changes IN BOECK'S sarcoid with particular reference to protein, calcium and phosphatase values","volume":"18","author":"Harrell","year":"1939","journal-title":"J. Clin. Invest."},{"issue":"10 Pt 1","key":"10.1016\/j.rmed.2021.106537_bib10","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1164\/ajrccm.164.10.2104046","article-title":"Clinical characteristics of patients in a case control study of sarcoidosis","volume":"164","author":"Baughman","year":"2001","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"2","key":"10.1016\/j.rmed.2021.106537_bib11","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1097\/MD.0b013e31819de50f","article-title":"Renal sarcoidosis: clinical, laboratory, and histologic presentation and outcome in 47 patients","volume":"88","author":"Mahevas","year":"2009","journal-title":"Medicine (Baltim.)"},{"issue":"2","key":"10.1016\/j.rmed.2021.106537_bib12","first-page":"113","article-title":"Calcium and vitamin D metabolism in sarcoidosis","volume":"30","author":"Baughman","year":"2013","journal-title":"Sarcoidosis Vasc. Diffuse Lung Dis."},{"issue":"5","key":"10.1016\/j.rmed.2021.106537_bib13","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1210\/jcem-60-5-960","article-title":"Isolation and structural identification of 1,25-dihydroxyvitamin D3 produced by cultured alveolar macrophages in sarcoidosis","volume":"60","author":"Adams","year":"1985","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"5","key":"10.1016\/j.rmed.2021.106537_bib14","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1172\/JCI111147","article-title":"Metabolism of 25-hydroxyvitamin D3 by cultured pulmonary alveolar macrophages in sarcoidosis","volume":"72","author":"Adams","year":"1983","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.rmed.2021.106537_bib15","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1210\/jcem-72-1-157","article-title":"Extrarenal production of calcitriol in normal and uremic humans","volume":"72","author":"Dusso","year":"1991","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"7","key":"10.1016\/j.rmed.2021.106537_bib16","first-page":"2222","article-title":"gamma-Interferon-induced resistance to 1,25-(OH)2 D3 in human monocytes and macrophages: a mechanism for the hypercalcemia of various granulomatoses","volume":"82","author":"Dusso","year":"1997","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"5","key":"10.1016\/j.rmed.2021.106537_bib17","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1210\/er.2016-1070","article-title":"Vitamin D-mediated hypercalcemia: mechanisms, diagnosis, and treatment","volume":"37","author":"Tebben","year":"2016","journal-title":"Endocr. Rev."},{"issue":"5","key":"10.1016\/j.rmed.2021.106537_bib18","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1097\/00063198-200009000-00010","article-title":"Hypercalcemia in granulomatous disorders: a clinical review","volume":"6","author":"Sharma","year":"2000","journal-title":"Curr. Opin. Pulm. Med."},{"issue":"5","key":"10.1016\/j.rmed.2021.106537_bib19","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1183\/09031936.98.11051015","article-title":"Ionized calcium and 1,25-dihydroxyvitamin D concentration in serum of patients with sarcoidosis","volume":"11","author":"Hamada","year":"1998","journal-title":"Eur. Respir. J."},{"issue":"1","key":"10.1016\/j.rmed.2021.106537_bib20","doi-asserted-by":"crossref","first-page":"59","DOI":"10.7326\/0003-4819-100-1-59","article-title":"Vitamin D conversion by sarcoid lymph node homogenate","volume":"100","author":"Mason","year":"1984","journal-title":"Ann. Intern. Med."},{"issue":"4","key":"10.1016\/j.rmed.2021.106537_bib21","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.rmed.2009.12.004","article-title":"Elevated 1, 25-dihydroxyvitamin D levels are associated with protracted treatment in sarcoidosis","volume":"104","author":"Kavathia","year":"2010","journal-title":"Respir. Med."},{"issue":"11","key":"10.1016\/j.rmed.2021.106537_bib22","first-page":"Cs133","article-title":"Hypercalcemia as a result of sarcoidosis with normal serum concentrations of vitamin D","volume":"13","author":"Falk","year":"2007","journal-title":"Med. Sci. Mon. Int. Med. J. Exp. Clin. Res."},{"issue":"3","key":"10.1016\/j.rmed.2021.106537_bib23","first-page":"186","article-title":"Calcium metabolism in sarcoidosis. A follow-up study with respect to parathyroid hormone and vitamin D metabolites","volume":"68","author":"Alberts","year":"1986","journal-title":"Eur. J. Respir. Dis."},{"key":"10.1016\/j.rmed.2021.106537_bib24","article-title":"Sarcoidosis-related hypercalcaemia due to production of parathyroid hormone-related peptide","volume":"2015","author":"van Raalte","year":"2015","journal-title":"BMJ Case Rep."},{"issue":"1","key":"10.1016\/j.rmed.2021.106537_bib25","first-page":"17","article-title":"Parathyroid-hormone-related protein in sarcoidosis","volume":"152","author":"Zeimer","year":"1998","journal-title":"Am. J. Pathol."},{"issue":"2","key":"10.1016\/j.rmed.2021.106537_bib26","first-page":"125","article-title":"Hla and environmental interactions IN sarcoidosis","volume":"25","author":"Rossman","year":"2008","journal-title":"Sarcoidosis Vasc. Diffuse Lung Dis."},{"issue":"2","key":"10.1016\/j.rmed.2021.106537_bib27","first-page":"483","article-title":"Amounts of angiotensin-converting enzyme mRNA reflect the burden of granulomas in granulomatous lung disease","volume":"148","author":"Gilbert","year":"1993"},{"issue":"21","key":"10.1016\/j.rmed.2021.106537_bib28","doi-asserted-by":"crossref","first-page":"4296","DOI":"10.1093\/hmg\/ddq342","article-title":"Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels","volume":"19","author":"O'Seaghdha","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.rmed.2021.106537_bib29","doi-asserted-by":"crossref","first-page":"42691","DOI":"10.1038\/srep42691","article-title":"A Mendelian randomization study of the effect of calcium on coronary artery disease, myocardial infarction and their risk factors","volume":"7","author":"Xu","year":"2017","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.rmed.2021.106537_bib30","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0198-8859(98)00009-3","article-title":"HLA-A*24-B*07-DRB1*01 haplotype implicated with genetic disposition of peak bone mass in healthy young Japanese women","volume":"59","author":"Tsuji","year":"1998","journal-title":"Hum. Immunol."},{"issue":"6","key":"10.1016\/j.rmed.2021.106537_bib31","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/0002-9343(74)90160-0","article-title":"Course and prognosis of sarcoidosis around the world","volume":"57","author":"Siltzbach","year":"1974","journal-title":"Am. J. Med."},{"issue":"6","key":"10.1016\/j.rmed.2021.106537_bib32","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1183\/13993003.00477-2016","article-title":"Sarcoidosis incidence and prevalence: a nationwide register-based assessment in Sweden","volume":"48","author":"Arkema","year":"2016","journal-title":"Eur. Respir. J."},{"issue":"10","key":"10.1016\/j.rmed.2021.106537_bib33","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2013-003562","article-title":"Randomised controlled trial of vitamin D supplementation in sarcoidosis","volume":"3","author":"Bolland","year":"2013","journal-title":"BMJ Open"},{"issue":"11","key":"10.1016\/j.rmed.2021.106537_bib34","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1002\/jbmr.2262","article-title":"Calcium and vitamin D in sarcoidosis: is supplementation safe?","volume":"29","author":"Kamphuis","year":"2014","journal-title":"J. Bone Miner. Res."}],"container-title":["Respiratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611121002432?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611121002432?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T12:19:44Z","timestamp":1760617184000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0954611121002432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":34,"alternative-id":["S0954611121002432"],"URL":"https:\/\/doi.org\/10.1016\/j.rmed.2021.106537","relation":{},"ISSN":["0954-6111"],"issn-type":[{"value":"0954-6111","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HLA-DRB1 alleles associate with hypercalcemia in sarcoidosis","name":"articletitle","label":"Article Title"},{"value":"Respiratory Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rmed.2021.106537","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"106537"}}