{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T18:34:14Z","timestamp":1785004454475,"version":"3.55.0"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"vor","delay-in-days":731,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","resmedjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Medicine"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.rmed.2022.106793","type":"journal-article","created":{"date-parts":[[2022,2,26]],"date-time":"2022-02-26T16:15:12Z","timestamp":1645892112000},"page":"106793","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["The German severe asthma patient: Baseline characteristics of patients in the German Severe Asthma Registry, and relationship with exacerbations and control"],"prefix":"10.1016","volume":"195","author":[{"given":"Stephanie","family":"Korn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2914-8773","authenticated-orcid":false,"given":"Katrin","family":"Milger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Skowasch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hartmut","family":"Timmermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Taube","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Idzko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans Werner","family":"Vo\u00df","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Holtdirk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eckard","family":"Hamelmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Buhl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rmed.2022.106793_bib1","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1183\/09031936.00202013","article-title":"International ERS\/ATS guidelines on definition, evaluation and treatment of severe asthma","volume":"43","author":"Chung","year":"2014","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.rmed.2022.106793_bib2","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jaip.2015.08.003","article-title":"Utilization and costs of severe uncontrolled asthma in a managed-care setting","volume":"4","author":"Zeiger","year":"2016","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"10.1016\/j.rmed.2022.106793_bib3","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jaip.2017.05.026","article-title":"Drivers of health care costs for adults with persistent asthma","volume":"6","author":"Zeiger","year":"2018","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"10.1016\/j.rmed.2022.106793_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40733-016-0029-3","article-title":"Asthma costs and social impact","volume":"3","author":"Nunes","year":"2017","journal-title":"Asthma Res. Pract."},{"key":"10.1016\/j.rmed.2022.106793_bib5","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.jaci.2012.01.039","article-title":"Effect of asthma exacerbations on health care costs among asthmatic patients with moderate and severe persistent asthma","volume":"129","author":"Ivanova","year":"2012","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.rmed.2022.106793_bib6","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1164\/rccm.201107-1317PP","article-title":"Severe asthma. Lessons learned from the national heart, lung, and blood institute severe asthma research program","volume":"185","author":"Jarjour","year":"2012","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.rmed.2022.106793_bib7","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1136\/thx.2010.137414","article-title":"On behalf of the British Thoracic Society Difficult Asthma Network, Refractory asthma in the UK: cross-sectional findings from a UK multicentre registry","volume":"65","author":"Heaney","year":"2010","journal-title":"Thorax"},{"key":"10.1016\/j.rmed.2022.106793_bib8","first-page":"2936","article-title":"Cross-sectional analysis of the Belgian severe asthma registry (BSAR)","volume":"44","author":"Schleich","year":"2014","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.rmed.2022.106793_bib9","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1111\/all.13342","article-title":"On behalf of the AGAVE Group, RItA: the Italian severe\/uncontrolled asthma registry","volume":"73","author":"Maio","year":"2018","journal-title":"Allergy"},{"key":"10.1016\/j.rmed.2022.106793_bib10","doi-asserted-by":"crossref","first-page":"1842117","DOI":"10.1080\/20018525.2020.1842117","article-title":"The Danish severe asthma register: an electronic platform for severe asthma management and research","volume":"8","author":"Hansen","year":"2021","journal-title":"Eur. Clin. Respir. J."},{"key":"10.1016\/j.rmed.2022.106793_bib11","doi-asserted-by":"crossref","first-page":"296","DOI":"10.3109\/02770903.2012.757780","article-title":"Effects of omalizumab in non-atopic asthma: results from a Spanish multicenter registry","volume":"50","author":"de Llano","year":"2013","journal-title":"J. Asthma"},{"key":"10.1016\/j.rmed.2022.106793_bib12","doi-asserted-by":"crossref","first-page":"1801671","DOI":"10.1183\/13993003.01671-2018","article-title":"The severe heterogeneous asthma research collaboration, patient-centred (SHARP) ERS clinical research collaboration: a new dawn in asthma research","volume":"52","author":"Djukanovic","year":"2018","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.rmed.2022.106793_bib13","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/s12874-020-01065-0","article-title":"International severe asthma registry (ISAR): protocol for a global registry","volume":"20","author":"FitzGerald","year":"2020","journal-title":"BMC Med. Res. Methodol."},{"key":"10.1016\/j.rmed.2022.106793_bib14","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.chest.2019.10.051","article-title":"International severe asthma registry: mission statement","volume":"157","author":"Canonica","year":"2020","journal-title":"Chest"},{"key":"10.1016\/j.rmed.2022.106793_bib15","doi-asserted-by":"crossref","first-page":"105858","DOI":"10.1016\/j.rmed.2019.105858","article-title":"Age- and sex-dependent differences in patients with severe asthma included in the German Asthma Net cohort","volume":"162","author":"Milger","year":"2020","journal-title":"Respir. Med."},{"key":"10.1016\/j.rmed.2022.106793_bib16","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1213\/ANE.0000000000002864","article-title":"Correlation coefficients: appropriate use and interpretation","volume":"126","author":"Schober","year":"2018","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.rmed.2022.106793_bib17","series-title":"Global Strategy for Asthma Management and Prevention","author":"Global Initiative For Asthma","year":"2021"},{"key":"10.1016\/j.rmed.2022.106793_bib18","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1164\/rccm.200711-1754OC","article-title":"Cluster analysis and clinical asthma phenotypes","volume":"178","author":"Haldar","year":"2008","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.rmed.2022.106793_bib19","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s12890-017-0409-3","article-title":"The frequency of asthma exacerbations and healthcare utilization in patients with asthma from the UK and USA","volume":"17","author":"Suruki","year":"2017","journal-title":"BMC Pulm. Med."},{"key":"10.1016\/j.rmed.2022.106793_bib20","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.jaci.2013.06.007","article-title":"Exhaled nitric oxide levels and blood eosinophil counts independently associate with wheeze and asthma events in National Health and Nutrition Examination Survey subjects","volume":"132","author":"Malinovschi","year":"2013","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.rmed.2022.106793_bib21","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jaip.2016.07.015","article-title":"Blood eosinophil count and outcomes in severe uncontrolled asthma: a prospective study","volume":"5","author":"Zeiger","year":"2017","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"10.1016\/j.rmed.2022.106793_bib22","doi-asserted-by":"crossref","first-page":"1700634","DOI":"10.1183\/13993003.00634-2017","article-title":"Severe eosinophilic asthma: a roadmap to consensus","volume":"49","author":"Buhl","year":"2017","journal-title":"Eur. Respir. J."}],"updated-by":[{"DOI":"10.1016\/j.rmed.2022.106827","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000}}],"container-title":["Respiratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611122000580?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611122000580?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T02:07:51Z","timestamp":1711937271000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0954611122000580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":22,"alternative-id":["S0954611122000580"],"URL":"https:\/\/doi.org\/10.1016\/j.rmed.2022.106793","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.rmed.2022.106827","asserted-by":"object"}]},"ISSN":["0954-6111"],"issn-type":[{"value":"0954-6111","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The German severe asthma patient: Baseline characteristics of patients in the German Severe Asthma Registry, and relationship with exacerbations and control","name":"articletitle","label":"Article Title"},{"value":"Respiratory Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rmed.2022.106793","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"106793"}}