{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T09:12:15Z","timestamp":1784365935852,"version":"3.55.0"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":731,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007509","name":"Sociedad Espa\u00f1ola de Neumolog\u00eda y Cirug\u00eda Tor\u00e1cica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007509","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002924","name":"Federaci\u00f3n Espa\u00f1ola de Enfermedades Raras","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022302","name":"Societat Catalana de Pneumologia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022302","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022766","name":"Fundaci\u00f3n Contra la Hipertensi\u00f3n Pulmonar","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022766","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI17\/1515"],"award-info":[{"award-number":["PI17\/1515"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI21\/555"],"award-info":[{"award-number":["PI21\/555"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","resmedjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Medicine"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.rmed.2022.107070","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T18:24:10Z","timestamp":1670264650000},"page":"107070","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Does arterial oxygenation during exercise add prognostic value in pulmonary arterial hypertension?"],"prefix":"10.1016","volume":"206","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5536-6099","authenticated-orcid":false,"given":"Xavier","family":"Alsina-Restoy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Torres-Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda","family":"Torralba-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felip","family":"Burgos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan Albert","family":"Barber\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c0lvar","family":"Agust\u00ed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Blanco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rmed.2022.107070_bib1","article-title":"2022 ESC\/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension","author":"Humbert","year":"2022","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.rmed.2022.107070_bib2","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/1756-185X.13001","article-title":"Pulmonary hypertension in connective tissue diseases: an update","volume":"20","author":"Aithala","year":"2017","journal-title":"Int. J. Rheum. Dis."},{"key":"10.1016\/j.rmed.2022.107070_bib3","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1086\/682432","article-title":"Heart rate recovery is an important predictor of outcomes in patients with connective tissue disease\u2013associated pulmonary hypertension","volume":"5","author":"Minai","year":"2015","journal-title":"Pulm. Circ."},{"key":"10.1016\/j.rmed.2022.107070_bib4","first-page":"292","article-title":"Exercise tolerance estimated from simple walk tests in patients with pulmonary arterial hypertension","volume":"33","author":"Irisawa","year":"2012","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.rmed.2022.107070_bib5","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1164\/ajrccm.161.2.9906015","article-title":"Clinical correlates and prognostic significance of six-minute walk test in patients with primary pulmonary hypertension: comparison with cardiopulmonary exercise testing","volume":"161","author":"Miyamoto","year":"2000","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.rmed.2022.107070_bib6","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.arbres.2009.12.005","article-title":"[Peak oxygen uptake during the six-minute walk test in diffuse interstitial lung disease and pulmonary hypertension]","volume":"46","author":"Blanco","year":"2010","journal-title":"Arch. Bronconeumol."},{"key":"10.1016\/j.rmed.2022.107070_bib7","first-page":"1235","article-title":"Application of a new parameter in the 6-minute walk test for manifold analysis of exercise capacity in patients with COPD","volume":"9","author":"Ijiri","year":"2014","journal-title":"Int. J. Chronic Obstr. Pulm. Dis."},{"key":"10.1016\/j.rmed.2022.107070_bib8","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.2147\/COPD.S143477","article-title":"Usefulness of the desaturation-distance ratio from the six-minute walk test for patients with COPD","volume":"12","author":"Fujimoto","year":"2017","journal-title":"Int. J. COPD."},{"key":"10.1016\/j.rmed.2022.107070_bib9","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1590\/S1807-59322010000900005","article-title":"Desaturation - distance ratio: a new concept for a functional assessment of interstitial lung diseases","volume":"65","author":"Pimenta","year":"2010","journal-title":"Clinics"},{"key":"10.1016\/j.rmed.2022.107070_bib10","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.arbres.2021.04.017","article-title":"A new and more sensitive method to integrate the desaturation distance ratio during a 6-minute walking test in chronic respiratory diseases: physiological correlates","volume":"58","author":"Alsina-Restoy","year":"2022","journal-title":"Arch. Bronconeumol."},{"key":"10.1016\/j.rmed.2022.107070_bib11","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/j.rmed.2015.06.013","article-title":"Prognostic value of variables derived from the six-minute walk test in patients with COPD: results from the ECLIPSE study","volume":"109","author":"Andrianopoulos","year":"2015","journal-title":"Respir. Med."},{"key":"10.1016\/j.rmed.2022.107070_bib12","doi-asserted-by":"crossref","first-page":"3168","DOI":"10.21037\/jtd.2017.08.53","article-title":"Distance-saturation product of the 6-minute walk test predicts mortality of patients with non-cystic fibrosis bronchiectasis","volume":"9","author":"Hsieh","year":"2017","journal-title":"J. Thorac. Dis."},{"key":"10.1016\/j.rmed.2022.107070_bib13","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1016\/j.rmed.2006.02.004","article-title":"The distance-saturation product predicts mortality in idiopathic pulmonary fibrosis","volume":"100","author":"Lettieri","year":"2006","journal-title":"Respir. Med."},{"key":"10.1016\/j.rmed.2022.107070_bib14","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1111\/crj.13141","article-title":"Prognostic ability of the distance-saturation product in the 6-minute walk test in patients with chronic obstructive pulmonary disease","volume":"14","author":"Gurbani","year":"2020","journal-title":"Clin. Res. J."},{"key":"10.1016\/j.rmed.2022.107070_bib15","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1183\/09031936.05.00034905","article-title":"Standardisation of the single-breath determination of carbon monoxide uptake in the lung","volume":"26","author":"MacIntyre","year":"2005","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.rmed.2022.107070_bib16","first-page":"511","article-title":"Standardization of the measurement of lung volumes","author":"Wagner","year":"2015","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.rmed.2022.107070_bib17","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1183\/09031936.05.00034805","article-title":"Standardisation of spirometry","volume":"26","author":"Miller","year":"2005","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.rmed.2022.107070_bib18","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1164\/ajrccm\/141.4_Pt_1.1026","article-title":"Single breath carbon monoxide diffusing capacity prediction equations from a mediterranean population","volume":"141","author":"Roca","year":"1989","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/j.rmed.2022.107070_bib19","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/S0954-6111(98)90291-8","article-title":"Prediction equations for plethysmographic lung volumes","volume":"92","author":"Roca","year":"1998","journal-title":"Respir. Med."},{"key":"10.1016\/j.rmed.2022.107070_bib20","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1183\/09031936.98.11061354","article-title":"References values for forced spirometry","volume":"11","author":"Roca","year":"1998","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.rmed.2022.107070_bib21","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1183\/09031936.00150314","article-title":"An official European respiratory society\/American thoracic society technical standard: field walking tests in chronic respiratory disease","volume":"44","author":"Holland","year":"2014","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.rmed.2022.107070_bib22","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1164\/ajrccm.158.5.9710086","article-title":"Reference equations for the six-minute walk in healthy adults","volume":"158","author":"Enright","year":"1998","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.rmed.2022.107070_bib23","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1183\/09031936.00101211","article-title":"Survival in pulmonary hypertension in Spain: insights from the Spanish registry","volume":"40","author":"Escribano-Subias","year":"2012","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.rmed.2022.107070_bib24","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1007\/s12325-021-01898-1","article-title":"Long-term survival, safety and tolerability with selexipag in patients with pulmonary arterial hypertension: results from GRIPHON and its open-label extension","volume":"39","author":"Gali\u00e8","year":"2022","journal-title":"Adv. Ther."},{"key":"10.1016\/j.rmed.2022.107070_bib25","first-page":"55","article-title":"Comprehensive exercise capacity and quality of life assessments predict mortality in patients with pulmonary arterial hypertension","volume":"35","author":"Chen","year":"2019","journal-title":"Acta Cardiol. Sin."},{"key":"10.1016\/j.rmed.2022.107070_bib26","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1183\/09031936.00155009","article-title":"The role of per cent predicted 6-min walk distance in pulmonary arterial hypertension","volume":"36","author":"Lee","year":"2010","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.rmed.2022.107070_bib27","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01908-2018","article-title":"Clinical trial design and new therapies for pulmonary arterial hypertension","volume":"53","author":"Sitbon","year":"2019","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.rmed.2022.107070_bib28","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1164\/ajrccm\/143.2.219","article-title":"Mechanisms of gas-exchange impairment in idiopathic pulmonary fibrosis","volume":"143","author":"Agust\u00ed","year":"1991","journal-title":"Am. Rev. Respir. Dis."}],"container-title":["Respiratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611122003353?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611122003353?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T19:04:54Z","timestamp":1735758294000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0954611122003353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":28,"alternative-id":["S0954611122003353"],"URL":"https:\/\/doi.org\/10.1016\/j.rmed.2022.107070","relation":{},"ISSN":["0954-6111"],"issn-type":[{"value":"0954-6111","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Does arterial oxygenation during exercise add prognostic value in pulmonary arterial hypertension?","name":"articletitle","label":"Article Title"},{"value":"Respiratory Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rmed.2022.107070","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"107070"}}