{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T09:50:54Z","timestamp":1792230654297,"version":"4.4.0"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":731,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","resmedjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Medicine"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.rmed.2023.107299","type":"journal-article","created":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T11:41:45Z","timestamp":1685360505000},"page":"107299","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Development of a diagnostic score using FeNO and symptoms to predict asthma"],"prefix":"10.1016","volume":"215","author":[{"given":"Benjamin","family":"Brunn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6765-6352","authenticated-orcid":false,"given":"Alexander","family":"Hapfelmeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf A.","family":"J\u00f6rres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konrad","family":"Schultz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2847-8626","authenticated-orcid":false,"given":"Antonius","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rmed.2023.107299_bib3","series-title":"Kassen\u00e4rztliche Bundesvereinigung (KBV), Arbeitsgemeinschaft Der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF)","year":"2020"},{"issue":"2","key":"10.1016\/j.rmed.2023.107299_bib4","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1136\/thoraxjnl-2016-208704","article-title":"Accuracy of FENO for diagnosing asthma: a systematic review","volume":"72","author":"Karrasch","year":"2017","journal-title":"Thorax"},{"issue":"6","key":"10.1016\/j.rmed.2023.107299_bib5","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.rmed.2014.02.005","article-title":"Current evidence and future research needs for FeNO measurement in respiratory diseases","volume":"108","author":"Bjermer","year":"2014","journal-title":"Respir. Med."},{"issue":"5","key":"10.1016\/j.rmed.2023.107299_bib6","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/nm.2678","article-title":"Asthma phenotypes: the evolution from clinical to molecular approaches","volume":"18","author":"Wenzel","year":"2012","journal-title":"Nat. Med."},{"issue":"11","key":"10.1016\/j.rmed.2023.107299_bib7","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2015-009676","article-title":"Influence of the practice setting on diagnostic prediction rules using FENO measurement in combination with clinical signs and symptoms of asthma","volume":"5","author":"Schneider","year":"2015","journal-title":"BMJ Open"},{"key":"10.1016\/j.rmed.2023.107299_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2022.101533","article-title":"Diagnostic accuracy of FeNO in asthma and predictive value for inhaled corticosteroid responsiveness: a prospective, multicentre study","volume":"50","author":"Schneider","year":"2022","journal-title":"EClinicalMedicine"},{"issue":"7","key":"10.1016\/j.rmed.2023.107299_bib9","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.rmed.2008.02.012","article-title":"Exhaled nitric oxide: independent effects of atopy, smoking, respiratory tract infection, gender and height","volume":"102","author":"Dressel","year":"2008","journal-title":"Respir. Med."},{"issue":"2","key":"10.1016\/j.rmed.2023.107299_bib10","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1053\/rmed.2000.1010","article-title":"Increased nitric oxide in exhaled air after intake of a nitrate-rich meal","volume":"95","author":"Olin","year":"2001","journal-title":"Respir. Med."},{"issue":"4","key":"10.1016\/j.rmed.2023.107299_bib11","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1034\/j.1399-3003.1999.14d29.x","article-title":"Development and validation of a questionnaire to measure asthma control","volume":"14","author":"Juniper","year":"1999","journal-title":"Eur. Respir. J."},{"issue":"8","key":"10.1016\/j.rmed.2023.107299_bib12","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1164\/rccm.200406-710ST","article-title":"European Respiratory Society ATS\/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005","volume":"171","year":"2005","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"2","key":"10.1016\/j.rmed.2023.107299_bib13","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2020-045420","article-title":"Evaluation of the diagnostic accuracy of fractional exhaled nitric oxide (FeNO) in patients with suspected asthma: study protocol for a prospective diagnostic study","volume":"11","author":"Kellerer","year":"2021","journal-title":"BMJ Open"},{"issue":"4","key":"10.1016\/j.rmed.2023.107299_bib14","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.rmed.2008.10.010","article-title":"Development of a 1-concentration-4-step dosimeter protocol for methacholine testing","volume":"103","author":"Merget","year":"2009","journal-title":"Respir. Med."},{"issue":"1","key":"10.1016\/j.rmed.2023.107299_bib15","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1164\/ajrccm.161.1.ats11-99","article-title":"Guidelines for methacholine and exercise challenge testing-1999. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, July 1999","volume":"161","author":"Crapo","year":"2000","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"7","key":"10.1016\/j.rmed.2023.107299_bib16","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.rmed.2011.02.006","article-title":"Body plethysmography\u2013its principles and clinical use","volume":"105","author":"Criee","year":"2011","journal-title":"Respir. Med."},{"issue":"9","key":"10.1016\/j.rmed.2023.107299_bib17","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S2213-2600(13)70184-X","article-title":"Contribution of four common pulmonary function tests to diagnosis of patients with respiratory symptoms: a prospective cohort study","volume":"1","author":"Decramer","year":"2013","journal-title":"Lancet Respir. Med."},{"issue":"24","key":"10.1016\/j.rmed.2023.107299_bib18","first-page":"405","article-title":"Whole-body plethysmography in suspected asthma: a prospective study of its added diagnostic value in 302 patients","volume":"112","author":"Schneider","year":"2015","journal-title":"Dtsch Arztebl Int"},{"issue":"1","key":"10.1016\/j.rmed.2023.107299_bib19","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1093\/bioinformatics\/btr597","article-title":"MissForest - nonparametric missing value imputation for mixed-type data","volume":"28","author":"Stekhoven","year":"2012","journal-title":"Bioinformatics"},{"issue":"1","key":"10.1016\/j.rmed.2023.107299_bib20","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1378\/chest.104.1.149","article-title":"Diagnostic value of the bronchial provocation test with methacholine in asthma. A Bayesian analysis approach","volume":"104","author":"Perpi\u00f1\u00e1","year":"1993","journal-title":"Chest"},{"issue":"2","key":"10.1016\/j.rmed.2023.107299_bib21","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.rmed.2012.10.003","article-title":"FENO measurement and sputum analysis for diagnosing asthma in clinical practice","volume":"107","author":"Schneider","year":"2013","journal-title":"Respir. Med."},{"issue":"5","key":"10.1016\/j.rmed.2023.107299_bib22","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1378\/chest.114.5.1343","article-title":"Questionnaire items that predict asthma and other respiratory conditions in adults","volume":"114","author":"Bai","year":"1998","journal-title":"Chest"},{"issue":"7","key":"10.1016\/j.rmed.2023.107299_bib23","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.rmed.2008.02.012","article-title":"Exhaled nitric oxide: independent effects of atopy, smoking, respiratory tract infection, gender and height","author":"Dressel","year":"2008","journal-title":"Respir. Med."},{"issue":"5","key":"10.1016\/j.rmed.2023.107299_bib24","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.rmed.2010.11.002","article-title":"Exhaled nitric oxide and influencing factors in a random population sample","author":"Karrasch","year":"2011","journal-title":"Respir. Med."}],"container-title":["Respiratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611123001877?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611123001877?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T02:21:07Z","timestamp":1754014867000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0954611123001877"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":22,"alternative-id":["S0954611123001877"],"URL":"https:\/\/doi.org\/10.1016\/j.rmed.2023.107299","relation":{},"ISSN":["0954-6111"],"issn-type":[{"value":"0954-6111","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of a diagnostic score using FeNO and symptoms to predict asthma","name":"articletitle","label":"Article Title"},{"value":"Respiratory Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rmed.2023.107299","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"107299"}}