{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:10:38Z","timestamp":1789726238329,"version":"4.0.1"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","resmedjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Medicine"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.rmed.2025.108136","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T02:48:40Z","timestamp":1746499720000},"page":"108136","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Inhaled tobramycin in non-cystic fibrosis bronchiectasis: A meta-analysis of randomized controlled trials"],"prefix":"10.1016","volume":"243","author":[{"given":"Zhaoshuang","family":"Zhong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9625-6048","authenticated-orcid":false,"given":"Shuyue","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.rmed.2025.108136_bib1","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1164\/rccm.201309-1575OC","article-title":"The bronchiectasis severity index. An international derivation and validation study","volume":"189","author":"Chalmers","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.rmed.2025.108136_bib2","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.rmed.2016.06.007","article-title":"Challenges in managing Pseudomonas aeruginosa in non-cystic fibrosis bronchiectasis","volume":"117","author":"Wilson","year":"2016","journal-title":"Respir. Med."},{"key":"10.1016\/j.rmed.2025.108136_bib3","doi-asserted-by":"crossref","first-page":"3211","DOI":"10.2147\/COPD.S137578","article-title":"Inflammation and chronic colonization of Haemophilus influenzae in sputum in COPD patients related to the degree of emphysema and bronchiectasis in high-resolution computed tomography","volume":"12","author":"Tufvesson","year":"2017","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"issue":"3","key":"10.1016\/j.rmed.2025.108136_bib4","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.cmi.2020.04.007","article-title":"Pseudomonas aeruginosa and lung function decline in patients with bronchiectasis","volume":"27","author":"Martinez-Garcia","year":"2021","journal-title":"Clin. Microbiol. Infect."},{"issue":"2","key":"10.1016\/j.rmed.2025.108136_bib5","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01953-2017","article-title":"The independent contribution of Pseudomonas aeruginosa infection to long-term clinical outcomes in bronchiectasis","volume":"51","author":"Araujo","year":"2018","journal-title":"Eur. Respir. J."},{"issue":"10","key":"10.1016\/j.rmed.2025.108136_bib6","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/S2213-2600(19)30185-7","article-title":"The efficacy and safety of inhaled antibiotics for the treatment of bronchiectasis in adults: a systematic review and meta-analysis","volume":"7","author":"Laska","year":"2019","journal-title":"Lancet Respir. Med."},{"issue":"3","key":"10.1016\/j.rmed.2025.108136_bib7","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1080\/13543784.2018.1439919","article-title":"Inhaled medication therapy for bronchiectasis: status quo and the next frontier","volume":"27","author":"Chen","year":"2018","journal-title":"Expert Opin Investig Drugs"},{"issue":"3","key":"10.1016\/j.rmed.2025.108136_bib8","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00629-2017","article-title":"European Respiratory Society guidelines for the management of adult bronchiectasis","volume":"50","author":"Polverino","year":"2017","journal-title":"Eur. Respir. J."},{"issue":"3","key":"10.1016\/j.rmed.2025.108136_bib9","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1513\/AnnalsATS.201311-395FR","article-title":"Inhaled antibiotics for lower airway infections","volume":"11","author":"Quon","year":"2014","journal-title":"Ann Am Thorac Soc"},{"key":"10.1016\/j.rmed.2025.108136_bib10","doi-asserted-by":"crossref","first-page":"30","DOI":"10.2174\/1874306401509010030","article-title":"Evidence of inhaled tobramycin in non-cystic fibrosis bronchiectasis","volume":"9","author":"Vendrell","year":"2015","journal-title":"Open Respir. Med. J."},{"issue":"5","key":"10.1016\/j.rmed.2025.108136_bib11","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.jcf.2012.03.010","article-title":"A network meta-analysis of the efficacy of inhaled antibiotics for chronic Pseudomonas infections in cystic fibrosis","volume":"11","author":"Littlewood","year":"2012","journal-title":"J. Cyst. Fibros."},{"issue":"4","key":"10.1016\/j.rmed.2025.108136_bib12","first-page":"1420","article-title":"A pilot study of the safety and efficacy of tobramycin solution for inhalation in patients with severe bronchiectasis","volume":"127","author":"Scheinberg","year":"2005","journal-title":"Chest"},{"key":"10.1016\/j.rmed.2025.108136_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.rmed.2021.106728","article-title":"Bronchiectasis and inhaled tobramycin: a literature review","volume":"192","author":"Elborn","year":"2022","journal-title":"Respir. Med."},{"key":"10.1016\/j.rmed.2025.108136_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.rmed.2020.106283","article-title":"Inhaled tobramycin for chronic infection with pseudomonas aeruginosa in non-cystic fibrosis bronchiectasis: a systematic review and meta-analysis","volume":"176","author":"Sangiovanni","year":"2021","journal-title":"Respir. Med."},{"issue":"1","key":"10.1016\/j.rmed.2025.108136_bib15","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s13643-021-01626-4","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"10","author":"Page","year":"2021","journal-title":"Syst. Rev."},{"key":"10.1016\/j.rmed.2025.108136_bib16","article-title":"RoB 2: a revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne","year":"2019","journal-title":"BMJ"},{"key":"10.1016\/j.rmed.2025.108136_bib17","first-page":"ED000142","article-title":"Updated guidance for trusted systematic reviews: a new edition of the Cochrane Handbook for Systematic Reviews of Interventions","volume":"10","author":"Cumpston","year":"2019","journal-title":"Cochrane Database Syst. Rev."},{"issue":"4","key":"10.1016\/j.rmed.2025.108136_bib18","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.2307\/2533446","article-title":"Operating characteristics of a rank correlation test for publication bias","volume":"50","author":"Begg","year":"1994","journal-title":"Biometrics"},{"issue":"8","key":"10.1016\/j.rmed.2025.108136_bib19","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1111\/crj.13663","article-title":"Treatment with inhaled antibiotics in bronchiectasis, side effects, and evaluation of the tolerance test; analysis from the BATTLE randomized controlled trial","volume":"17","author":"Terpstra","year":"2023","journal-title":"Clin Respir J"},{"issue":"1","key":"10.1016\/j.rmed.2025.108136_bib20","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.chest.2022.07.007","article-title":"A Double-blind randomized placebo-controlled phase 3 trial of tobramycin inhalation solution in adults with bronchiectasis with Pseudomonas aeruginosa infection","volume":"163","author":"Guan","year":"2023","journal-title":"Chest"},{"issue":"1","key":"10.1016\/j.rmed.2025.108136_bib21","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1186\/s12931-022-02243-y","article-title":"Effects of long-term tobramycin inhalation solution (TIS) once daily on exacerbation rate in patients with non-cystic fibrosis bronchiectasis","volume":"23","author":"Terpstra","year":"2022","journal-title":"Respir. Res."},{"issue":"1","key":"10.1016\/j.rmed.2025.108136_bib22","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01451-2020","article-title":"Efficacy and safety of TOBI Podhaler in Pseudomonas aeruginosa-infected bronchiectasis patients: iBEST study","volume":"57","author":"Loebinger","year":"2021","journal-title":"Eur. Respir. J."},{"issue":"4","key":"10.1016\/j.rmed.2025.108136_bib23","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1159\/000438490","article-title":"Eradication therapy against Pseudomonas aeruginosa in non-cystic fibrosis bronchiectasis","volume":"90","author":"Orriols","year":"2015","journal-title":"Respiration"},{"issue":"5","key":"10.1016\/j.rmed.2025.108136_bib24","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1378\/chest.130.5.1503","article-title":"Addition of inhaled tobramycin to ciprofloxacin for acute exacerbations of Pseudomonas aeruginosa infection in adult bronchiectasis","volume":"130","author":"Bilton","year":"2006","journal-title":"Chest"},{"issue":"1","key":"10.1016\/j.rmed.2025.108136_bib25","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1345\/aph.1E099","article-title":"Inhaled tobramycin in non-cystic fibrosis patients with bronchiectasis and chronic bronchial infection with Pseudomonas aeruginosa","volume":"39","author":"Drobnic","year":"2005","journal-title":"Ann. Pharmacother."},{"issue":"2 Pt 1","key":"10.1016\/j.rmed.2025.108136_bib26","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1164\/ajrccm.162.2.9910086","article-title":"Tobramycin solution for inhalation reduces sputum Pseudomonas aeruginosa density in bronchiectasis","volume":"162","author":"Barker","year":"2000","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"7","key":"10.1016\/j.rmed.2025.108136_bib27","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/S0954-6111(99)90090-2","article-title":"Inhaled antibiotic therapy in non-cystic fibrosis patients with bronchiectasis and chronic bronchial infection by Pseudomonas aeruginosa","volume":"93","author":"Orriols","year":"1999","journal-title":"Respir. Med."},{"issue":"8","key":"10.1016\/j.rmed.2025.108136_bib28","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1183\/09031936.96.09081601","article-title":"Lung function in bronchiectasis: the influence of Pseudomonas aeruginosa","volume":"9","author":"Evans","year":"1996","journal-title":"Eur. Respir. J."},{"issue":"8","key":"10.1016\/j.rmed.2025.108136_bib29","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1183\/09031936.97.10081754","article-title":"Effect of sputum bacteriology on the quality of life of patients with bronchiectasis","volume":"10","author":"Wilson","year":"1997","journal-title":"Eur. Respir. J."},{"issue":"9","key":"10.1016\/j.rmed.2025.108136_bib30","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1136\/thx.56.9.669","article-title":"Anti-Pseudomonas aeruginosa antibody detection in patients with bronchiectasis without cystic fibrosis","volume":"56","author":"Caballero","year":"2001","journal-title":"Thorax"},{"issue":"Suppl 1","key":"10.1016\/j.rmed.2025.108136_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/thoraxjnl-2018-212463","article-title":"British Thoracic society guideline for bronchiectasis in adults","volume":"74","author":"Hill","year":"2019","journal-title":"Thorax"},{"issue":"6","key":"10.1016\/j.rmed.2025.108136_bib32","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01289-2017","article-title":"Standardised classification of the aetiology of bronchiectasis using an objective algorithm","volume":"50","author":"Araujo","year":"2017","journal-title":"Eur. Respir. J."}],"container-title":["Respiratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611125001982?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611125001982?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T23:24:49Z","timestamp":1762039489000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0954611125001982"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":32,"alternative-id":["S0954611125001982"],"URL":"https:\/\/doi.org\/10.1016\/j.rmed.2025.108136","relation":{},"ISSN":["0954-6111"],"issn-type":[{"value":"0954-6111","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhaled tobramycin in non-cystic fibrosis bronchiectasis: A meta-analysis of randomized controlled trials","name":"articletitle","label":"Article Title"},{"value":"Respiratory Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rmed.2025.108136","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108136"}}