{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T11:57:27Z","timestamp":1793620647670,"version":"4.5.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","resmedjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Medicine"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.rmed.2025.108294","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T08:14:22Z","timestamp":1754468062000},"page":"108294","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Diagnostic performance and safety of endobronchial ultrasound-guided transbronchial cryobiopsies in the diagnosis of mediastinal lesions"],"prefix":"10.1016","volume":"247","author":[{"given":"Sabina Perell\u00f3","family":"Rosell\u00f3","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Alonso-Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Becerra","family":"Anieto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Forteza","family":"Valades","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina G\u00f3mez","family":"Bellvert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borja G.","family":"Cos\u00edo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bel\u00e9n N\u00fa\u00f1ez","family":"S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Engonga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda D\u00edaz","family":"Busto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meritxell","family":"L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaume Sauleda","family":"Roig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.rmed.2025.108294_bib1","doi-asserted-by":"crossref","DOI":"10.1183\/23120541.00448-2022","article-title":"Endobronchial ultrasound-guided transbronchial mediastinal cryobiopsy in the diagnosis of mediastinal lesions: safety, feasibility and diagnostic yield \u2013 experience in 50 cases","volume":"9","author":"Ariza-Prota","year":"2023","journal-title":"ERJ Open Res."},{"issue":"10","key":"10.1016\/j.rmed.2025.108294_bib2","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.arbres.2022.05.006","article-title":"Transbronchial mediastinal cryobiopsy in the diagnosis of mediastinal lymph nodes: a case series \u2013 How to do it","volume":"58","author":"Ariza-Prota","year":"2022","journal-title":"Arch. Bronconeumol."},{"key":"10.1016\/j.rmed.2025.108294_bib3","article-title":"Endobronchial ultrasound-guided transbronchial needle aspiration (Ebus-tbna): technical updates and pathological yield","volume":"vol. 11","author":"Jaliawala","year":"2021"},{"issue":"3","key":"10.1016\/j.rmed.2025.108294_bib4","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1378\/chest.15-1216","article-title":"Technical aspects of endobronchial ultrasound-guided transbronchial needle aspiration CHEST guideline and expert panel report","volume":"149","author":"Wahidi","year":"2016","journal-title":"Chest"},{"issue":"4","key":"10.1016\/j.rmed.2025.108294_bib5","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.medcli.2024.03.011","article-title":"Cost-effectiveness and safety of mediastinal transbronchial cryobiopsy guided by endobronchial ultrasonography (CRYO-EBUS) in 110 cases","volume":"163","author":"Salcedo Lobera","year":"2024","journal-title":"Med. Clin."},{"key":"10.1016\/j.rmed.2025.108294_bib6","volume":"vol. 8","author":"Prota","year":"2024"},{"key":"10.1016\/j.rmed.2025.108294_bib7","volume":"vol. 8","author":"Ramarmuty","year":"2024"},{"issue":"6","key":"10.1016\/j.rmed.2025.108294_bib8","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00055-2021","article-title":"Transbronchial mediastinal cryobiopsy in the diagnosis of mediastinal lesions: a randomised trial","volume":"58","author":"Zhang","year":"2021","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.rmed.2025.108294_bib9","first-page":"198","article-title":"The relevance of the reference range for EGFR testing in non-small cell lung cancer patients","author":"Pisapia","year":"2024","journal-title":"Lung Cancer"},{"issue":"5","key":"10.1016\/j.rmed.2025.108294_bib10","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.pulmoe.2023.11.008","article-title":"EBUS-guided cryobiopsy in the diagnosis of thoracic disorders","volume":"30","author":"Poletti","year":"2024","journal-title":"Pulmonology"},{"key":"10.1016\/j.rmed.2025.108294_bib11","article-title":"Is the diagnostic yield of mediastinal lymph node cryobiopsy (cryoEBUS) better for diagnosing mediastinal node involvement compared to endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA)? A systematic review","volume":"218","author":"Botana-Rial","year":"2023"},{"issue":"3","key":"10.1016\/j.rmed.2025.108294_bib12","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/S2213-2600(22)00392-7","article-title":"Transbronchial needle aspiration combined with cryobiopsy in the diagnosis of mediastinal diseases: a multicentre, open-label, randomised trial","volume":"11","author":"Fan","year":"2023","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.rmed.2025.108294_bib13","article-title":"Minimally invasive sampling of mediastinal lesions","volume":"vol. 14","author":"Fantin","year":"2024"},{"issue":"1","key":"10.1016\/j.rmed.2025.108294_bib14","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/LBR.0000000000000913","article-title":"Endobronchial ultrasound-guided mediastinal lymph nodal cryobiopsy in patients with nondiagnostic\/inadequate rapid on-site evaluation A new step in the diagnostic algorithm","volume":"31","author":"Maturu","year":"2024","journal-title":"J. Bronchol. Interv. Pulmonol."},{"issue":"6","key":"10.1016\/j.rmed.2025.108294_bib15","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1164\/rccm.202401-0192ST","volume":"209","author":"Gonzalez","year":"2024","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.rmed.2025.108294_bib16","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1159\/000538609","article-title":"Endobronchial ultrasound-guided transbronchial mediastinal cryobiopsy versus endobronchial ultrasound-guided transbronchial needle aspiration for mediastinal disorders: a meta-analysis","volume":"103","author":"Zhang","year":"2024","journal-title":"Respiration"},{"key":"10.1016\/j.rmed.2025.108294_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000540859","article-title":"Comparison between endobronchial ultrasound-guided transbronchial node biopsy and transbronchial needle aspiration: a meta-analysis","volume":"13","author":"Yang","year":"2024","journal-title":"Respiration"},{"issue":"5","key":"10.1016\/j.rmed.2025.108294_bib18","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.pulmoe.2023.12.002","article-title":"Comparison of cryobiopsy and forceps biopsy for the diagnosis of mediastinal lesions: a randomised clinical trial","volume":"30","author":"Cheng","year":"2024","journal-title":"Pulmonology"},{"key":"10.1016\/j.rmed.2025.108294_bib19","first-page":"562","volume":"vol. 36","author":"Guill\u00e9n","year":"2023"},{"issue":"4","key":"10.1016\/j.rmed.2025.108294_bib20","first-page":"195","article-title":"La situaci\u00f3n del c\u00e1ncer en Espa\u00f1a 2023","volume":"56","author":"Recio-Vega","year":"2023","journal-title":"Rev. Espa\u00f1ola Patol."},{"issue":"1","key":"10.1016\/j.rmed.2025.108294_bib21","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-69702-y","article-title":"An explorative analysis on the optimal cryo-passes and freezing time of the ultrathin cryoprobe in endobronchial ultrasound-guided transbronchial mediastinal cryobiopsy","volume":"14","author":"Kho","year":"2024","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.rmed.2025.108294_bib22","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1200\/JCO.23.02744","article-title":"Therapy for stage IV non-small cell lung cancer with driver alterations: ASCO living guideline, version 2023.3","volume":"42","author":"Jaiyesimi","year":"2024","journal-title":"J. Clin. Oncol."},{"issue":"9","key":"10.1016\/j.rmed.2025.108294_bib23","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.arbres.2024.05.023","article-title":"EBUS-guided transbronchial mediastinal cryobiopsy: a novel technique for diagnosing mediastinal lesions\u2014single-center experience","volume":"60","author":"Ara\u00fajo","year":"2024","journal-title":"Arch. Bronconeumol."},{"issue":"1","key":"10.1016\/j.rmed.2025.108294_bib24","doi-asserted-by":"crossref","DOI":"10.1186\/s12890-021-01814-x","article-title":"Potential application of cryobiopsy for histo-molecular characterization of mediastinal lymph nodes in patients with thoracic malignancies: a case presentation series and implications for future developments","volume":"22","author":"Genova","year":"2022","journal-title":"BMC Pulm. Med."},{"issue":"22","key":"10.1016\/j.rmed.2025.108294_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/diagnostics13223476","article-title":"The contribution of mediastinal transbronchial nodal cryobiopsy to morpho-histological and molecular diagnosis","volume":"13","author":"Velasco-Albendea","year":"2023","journal-title":"Diagnostics"},{"issue":"2","key":"10.1016\/j.rmed.2025.108294_bib26","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/1759-7714.13770","article-title":"Comparison of adequacy between transbronchial lung cryobiopsy samples and endobronchial ultrasound-guided transbronchial needle aspiration samples for next-generation sequencing analysis","volume":"12","author":"Tone","year":"2021","journal-title":"Thorac. Cancer"},{"issue":"7","key":"10.1016\/j.rmed.2025.108294_bib27","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1200\/OP.24.00177","article-title":"Therapy for stage IV non\u2013small cell lung cancer with and without driver alterations: ASCO living guideline clinical insights","volume":"20","author":"Owen","year":"2024","journal-title":"JCO Oncol. Pract."},{"key":"10.1016\/j.rmed.2025.108294_bib28","first-page":"199","article-title":"The efficacy of continuing osimertinib with platinum pemetrexed chemotherapy upon progression in patients with metastatic non-small cell lung cancer harboring sensitizing EGFR mutations","author":"Patil","year":"2025","journal-title":"Lung Cancer"},{"key":"10.1016\/j.rmed.2025.108294_bib29","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1378\/chest.12-0317","article-title":"Learning curve for endobronchial ultrasound-guided transbronchial needle aspiration","volume":"141","author":"Medford","year":"2012","journal-title":"Chest"}],"container-title":["Respiratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611125003579?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611125003579?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T15:51:44Z","timestamp":1767714704000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0954611125003579"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":29,"alternative-id":["S0954611125003579"],"URL":"https:\/\/doi.org\/10.1016\/j.rmed.2025.108294","relation":{},"ISSN":["0954-6111"],"issn-type":[{"value":"0954-6111","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diagnostic performance and safety of endobronchial ultrasound-guided transbronchial cryobiopsies in the diagnosis of mediastinal lesions","name":"articletitle","label":"Article Title"},{"value":"Respiratory Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rmed.2025.108294","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"108294"}}