{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:47:17Z","timestamp":1782928037397,"version":"3.54.5"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004628","name":"AstraZeneca UK Limited","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004628","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","resmedjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Medicine"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.rmed.2026.108913","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T23:40:53Z","timestamp":1779838853000},"page":"108913","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Acute COPD Exacerbation and long-term cardiopulmonary outcomes: Real-world EXACOS-CP evidence study in Israel"],"prefix":"10.1016","volume":"259","author":[{"given":"Samah","family":"Hayek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3188-211X","authenticated-orcid":false,"given":"Uri","family":"Gottlieb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nir","family":"Treves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roni","family":"Yahalom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsty","family":"Rhodes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Idit","family":"Livnat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adva","family":"Yarden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8796-7071","authenticated-orcid":false,"given":"Josh","family":"Silverbeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Cabrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3025-3941","authenticated-orcid":false,"given":"Donna R.","family":"Zwas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neville","family":"Berkman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.rmed.2026.108913_bib1","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.46598","article-title":"Global burden of chronic obstructive pulmonary disease through 2050","volume":"6","author":"Boers","year":"2023","journal-title":"JAMA Netw. Open"},{"issue":"10258","key":"10.1016\/j.rmed.2026.108913_bib2","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/S0140-6736(20)30925-9","article-title":"Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the global burden of disease study 2019","volume":"396","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.rmed.2026.108913_bib3","doi-asserted-by":"crossref","DOI":"10.2174\/0118743064279064231227070344","article-title":"Global initiative for chronic obstructive lung disease (GOLD) 2023 guidelines reviewed","volume":"18","author":"Sharma","year":"2024","journal-title":"Open Respir. Med. J."},{"key":"10.1016\/j.rmed.2026.108913_bib4","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.ejim.2024.04.021","article-title":"Cardiovascular events after exacerbations of chronic obstructive pulmonary disease: results from the EXAcerbations of COPD and their OutcomeS in CardioVascular diseases study in Italy","volume":"127","author":"Calabria","year":"2024","journal-title":"Eur. J. Intern. Med."},{"key":"10.1016\/j.rmed.2026.108913_bib5","article-title":"Global, regional, and national burden of chronic obstructive pulmonary disease from 1990 to 2019","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Physiol."},{"key":"10.1016\/j.rmed.2026.108913_bib6","first-page":"235","article-title":"The clinical and economic burden of chronic obstructive pulmonary disease in the USA","volume":"5","author":"Guarascio","year":"2013","journal-title":"Clinicoecon. Outcomes Res."},{"issue":"5","key":"10.1016\/j.rmed.2026.108913_bib7","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1164\/ajrccm.165.5.2104055","article-title":"The impact of chronic obstructive pulmonary disease on work loss in the United States","volume":"165","author":"Sin","year":"2002","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.rmed.2026.108913_bib8","doi-asserted-by":"crossref","DOI":"10.1136\/thoraxjnl-2021-218333","article-title":"Cardiovascular disease in chronic obstructive pulmonary disease: a narrative review","author":"Balbirsingh","year":"2022","journal-title":"Thorax"},{"issue":"4\u20135","key":"10.1016\/j.rmed.2026.108913_bib9","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1080\/14779072.2024.2333786","article-title":"Cardiovascular disease and risk in COPD: a state of the art review","volume":"22","author":"Polman","year":"2024","journal-title":"Expert Rev. Cardiovasc Ther."},{"issue":"2","key":"10.1016\/j.rmed.2026.108913_bib10","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.02364-2022","article-title":"Quantifying COPD as a risk factor for cardiac disease in a primary prevention cohort","volume":"62","author":"Maclagan","year":"2023","journal-title":"Eur. Respir. J."},{"issue":"4","key":"10.1016\/j.rmed.2026.108913_bib11","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1378\/chest.12-2847","article-title":"Cardiovascular comorbidity in COPD: systematic literature review","volume":"144","author":"M\u00fcllerova","year":"2013","journal-title":"Chest"},{"issue":"3","key":"10.1016\/j.rmed.2026.108913_bib12","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s41030-023-00233-z","article-title":"The 2023 GOLD report: updated guidelines for inhaled pharmacological therapy in patients with stable COPD","volume":"9","author":"Terry","year":"2023","journal-title":"Pulm. Ther."},{"key":"10.1016\/j.rmed.2026.108913_bib13","series-title":"Cardiovascular Complications of Respiratory Disorders","article-title":"Cardiovascular disease in COPD","author":"Rogliani","year":"2020"},{"issue":"2","key":"10.1016\/j.rmed.2026.108913_bib14","first-page":"128","article-title":"Atrial fibrillation and chronic obstructive pulmonary disease: diagnostic sequence and mortality risk","volume":"9","author":"Warming","year":"2023","journal-title":"Eur. Heart J. Qual. Care Clin. Outcom."},{"issue":"8","key":"10.1016\/j.rmed.2026.108913_bib15","doi-asserted-by":"crossref","first-page":"3362","DOI":"10.1007\/s12325-024-02920-y","article-title":"Increased risk of severe cardiovascular events following exacerbations of chronic obstructive pulmonary disease: results of the EXACOS-CV study in Japan","volume":"41","author":"Matsunaga","year":"2024","journal-title":"Adv. Ther."},{"issue":"1","key":"10.1016\/j.rmed.2026.108913_bib16","article-title":"GOLD report: what is new and what is noteworthy for the practicing clinician","volume":"22","author":"Kostikas","year":"2025","journal-title":"COPD J. Chronic Obstr. Pulm. Dis."},{"key":"10.1016\/j.rmed.2026.108913_bib17","doi-asserted-by":"crossref","first-page":"427","DOI":"10.2147\/COPD.S346591","article-title":"Frequency and severity of exacerbations of COPD associated with future risk of exacerbations and mortality: a UK routine health care data study","volume":"17","author":"Whittaker","year":"2022","journal-title":"Int. J. Chronic Obstr. Pulm. Dis."},{"issue":"5","key":"10.1016\/j.rmed.2026.108913_bib18","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1136\/thx.2003.008730","article-title":"Effect of exacerbations on quality of life in patients with chronic obstructive pulmonary disease: a 2 year follow up study","volume":"59","author":"Miravitlles","year":"2004","journal-title":"Thorax"},{"issue":"10","key":"10.1016\/j.rmed.2026.108913_bib19","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1136\/thorax.57.10.847","article-title":"Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease","volume":"57","author":"Donaldson","year":"2002","journal-title":"Thorax"},{"issue":"1","key":"10.1016\/j.rmed.2026.108913_bib20","article-title":"Elucidating the risk of cardiopulmonary consequences of an exacerbation of COPD: results of the EXACOS-CV study in Germany","volume":"11","author":"Vogelmeier","year":"2024","journal-title":"BMJ Open Respir. Res."},{"issue":"4","key":"10.1016\/j.rmed.2026.108913_bib21","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.cjco.2025.01.001","article-title":"The intersection of chronic obstructive pulmonary disease and cardiovascular disease: recent insights in a challenging area","volume":"7","author":"Heffernan","year":"2025","journal-title":"CJC Open"},{"key":"10.1016\/j.rmed.2026.108913_bib23","article-title":"Exacerbating the burden of cardiovascular disease: how can we address cardiopulmonary risk in individuals with chronic obstructive pulmonary disease?","author":"Shrikrishna","year":"2023","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.rmed.2026.108913_bib24","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.2147\/COPD.S466280","article-title":"Temporal dynamics of cardiovascular risk in patients with chronic obstructive pulmonary disease during stable disease and exacerbations: review of the mechanisms and implications","volume":"19","author":"Simons","year":"2024","journal-title":"Int. J. Chronic Obstr. Pulm. Dis."},{"key":"10.1016\/j.rmed.2026.108913_bib25","first-page":"1091","article-title":"The sustained increase of cardiovascular risk following COPD exacerbations: meta-analyses of the EXACOS-CV studies","volume":"27","author":"Nordon","year":"2024","journal-title":"ERJ Open Res."},{"issue":"15","key":"10.1016\/j.rmed.2026.108913_bib26","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1056\/NEJMoa2101765","article-title":"BNT162b2 mRNA Covid-19 vaccine in a nationwide mass vaccination setting","volume":"384","author":"Dagan","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.rmed.2026.108913_bib22","doi-asserted-by":"crossref","first-page":"225","DOI":"10.2147\/COPD.S438893","article-title":"Risk of death and cardiovascular events following an exacerbation of COPD: the EXACOS-CV US study","volume":"19","author":"Daniels","year":"2024","journal-title":"Int. J. Chronic Obstr. Pulm. Dis."},{"issue":"4","key":"10.1016\/j.rmed.2026.108913_bib27","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2022-070022","article-title":"EXAcerbations of COPD and their OutcomeS on CardioVascular diseases (EXACOS-CV) programme: protocol of multicountry observational cohort studies","volume":"13","author":"Nordon","year":"2023","journal-title":"BMJ Open"},{"issue":"2","key":"10.1016\/j.rmed.2026.108913_bib28","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1002\/pds.4448","article-title":"GOLD assessment of COPD severity in the clinical practice research datalink (CPRD)","volume":"28","author":"Rebordosa","year":"2019","journal-title":"Pharmacoepidemiol. Drug Saf."},{"issue":"1","key":"10.1016\/j.rmed.2026.108913_bib29","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1186\/s12931-023-02601-4","article-title":"Risk of cardiovascular events after an exacerbation of chronic obstructive pulmonary disease: results from the EXACOS-CV cohort study using the PHARMO data network in the Netherlands","volume":"24","author":"Swart","year":"2023","journal-title":"Respir. Res."},{"issue":"7","key":"10.1016\/j.rmed.2026.108913_bib30","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2024-097006","article-title":"Future exacerbations and mortality rates among patients experiencing COPD exacerbations: a meta-analysis of results from the EXACOS\/AVOIDEX programme","volume":"15","author":"Rhodes","year":"2025","journal-title":"BMJ Open"},{"key":"10.1016\/j.rmed.2026.108913_bib31","doi-asserted-by":"crossref","DOI":"10.1177\/17534666221113647","article-title":"Association of COPD exacerbations and acute cardiovascular events: a systematic review and meta-analysis","volume":"16","author":"M\u00fcllerov\u00e1","year":"2022","journal-title":"Ther. Adv. Respir. Dis."},{"key":"10.1016\/j.rmed.2026.108913_bib32","unstructured":"Yang J, Schupp CW, Harrati A. Developing an area-based socioeconomic measure from American community survey data. Fremont."},{"issue":"1","key":"10.1016\/j.rmed.2026.108913_bib33","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1164\/rccm.201711-2239OC","article-title":"Exacerbations of chronic obstructive pulmonary disease and cardiac events. A post hoc cohort analysis from the SUMMIT randomized clinical trial","volume":"198","author":"Kunisaki","year":"2018","journal-title":"Am. J. Respir. Crit. Care Med."}],"container-title":["Respiratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611126002817?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611126002817?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:03:51Z","timestamp":1782925431000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0954611126002817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":33,"alternative-id":["S0954611126002817"],"URL":"https:\/\/doi.org\/10.1016\/j.rmed.2026.108913","relation":{},"ISSN":["0954-6111"],"issn-type":[{"value":"0954-6111","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acute COPD Exacerbation and long-term cardiopulmonary outcomes: Real-world EXACOS-CP evidence study in Israel","name":"articletitle","label":"Article Title"},{"value":"Respiratory Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rmed.2026.108913","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108913"}}