{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:57:33Z","timestamp":1760144253949,"version":"build-2065373602"},"reference-count":45,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T00:00:00Z","timestamp":1661299200000},"content-version":"am","delay-in-days":357,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Revue des Maladies Respiratoires"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.rmr.2021.05.012","type":"journal-article","created":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T03:30:06Z","timestamp":1625023806000},"page":"706-720","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Combinaisons des traitements pharmacologiques au cours du sevrage tabagique. Revue syst\u00e9matique"],"prefix":"10.1016","volume":"38","author":[{"given":"M.","family":"Underner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Perriot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Peiffer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.-M.","family":"Ruppert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"de Chazeron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Jaafari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.rmr.2021.05.012_bib0230","first-page":"1217","article-title":"PHS Guideline Update Panel, Liaisons, and Staff. Treating tobacco use and dependence: update U.S.\u00a0Public Health Service Clinical Practice Guideline executive summary","volume":"53","author":"Fiore","year":"2008","journal-title":"Respir Care"},{"year":"2013","series-title":"Recommandation de bonne pratique. Arr\u00eat de la consommation de tabac\u00a0: d\u00e9pistage individuel au maintien de l\u2019abstinence en premiers recours","key":"10.1016\/j.rmr.2021.05.012_bib0235"},{"key":"10.1016\/j.rmr.2021.05.012_bib0240","series-title":"La Pneumologie fond\u00e9e sur les preuves, sous l\u2019\u00e9gide de la SPLF, coordination S.\u00a0Marchand-Adam","article-title":"Tabagisme","author":"Wirth","year":"2017"},{"key":"10.1016\/j.rmr.2021.05.012_bib0245","first-page":"CD000146","article-title":"Nicotine replacement therapy for smoking cessation","volume":"11","author":"Stead","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.rmr.2021.05.012_bib0250","first-page":"CD000146","article-title":"Nicotine replacement therapy versus control for smoking cessation","volume":"5","author":"Hartmann-Boyce","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.rmr.2021.05.012_bib0255","first-page":"CD013308","article-title":"Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation","volume":"4","author":"Lindson","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.rmr.2021.05.012_bib0260","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1164\/rccm.202005-1982ST","article-title":"Initiating pharmacologic treatment in tobacco-dependent adults. An official American Thoracic Society clinical practice guideline","volume":"202","author":"Leone","year":"2020","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.rmr.2021.05.012_bib0265","first-page":"CD008286","article-title":"Combined pharmacotherapy and behavioural interventions for smoking cessation","volume":"3","author":"Stead","year":"2016","journal-title":"Cochrane Database Syst Rev."},{"key":"10.1016\/j.rmr.2021.05.012_bib0270","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.pneumo.2018.04.008","article-title":"Sevrage tabagique: les strat\u00e9gies pharmacologiques diff\u00e9rentes des traitements standards","volume":"74","author":"Underner","year":"2018","journal-title":"Rev Pneumol Clin"},{"key":"10.1016\/j.rmr.2021.05.012_bib0275","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.rmr.2011.09.048","article-title":"Le sevrage tabagique des \u00ab\u00a0fumeurs difficiles\u00a0\u00bb","volume":"29","author":"Perriot","year":"2012","journal-title":"Rev Mal Respir"},{"key":"10.1016\/j.rmr.2021.05.012_bib0280","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s12971-016-0100-0","article-title":"Smoking cessation attempts: is it useful to treat hard core smokers?","volume":"14","author":"Joly","year":"2016","journal-title":"Tob Induc Dis"},{"key":"10.1016\/j.rmr.2021.05.012_bib0285","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1186\/s12916-014-0172-8","article-title":"Combining varenicline and nicotine patches: a randomized controlled trial study in smoking cessation","volume":"12","author":"Ramon","year":"2014","journal-title":"BMC Med"},{"key":"10.1016\/j.rmr.2021.05.012_bib0290","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1001\/jama.2014.7195","article-title":"Efficacy of varenicline combined with nicotine replacement therapy vs varenicline alone for smoking cessation: a randomized clinical trial","volume":"312","author":"Koegelenberg","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.rmr.2021.05.012_bib0295","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/1741-7015-11-140","article-title":"Is a combination of varenicline and nicotine patch more effective in helping smokers quit than varenicline alone? A randomised controlled trial","volume":"11","author":"Hajek","year":"2013","journal-title":"BMC Med"},{"key":"10.1016\/j.rmr.2021.05.012_bib0300","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1186\/s12889-015-2055-0","article-title":"Combination therapy of varenicline with nicotine replacement therapy is better than varenicline alone: a systematic review and meta-analysis of randomized controlled trials","volume":"15","author":"Chang","year":"2015","journal-title":"BMC Public Health"},{"key":"10.1016\/j.rmr.2021.05.012_bib0305","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1001\/jama.2013.283185","article-title":"Combination varenicline and bupropion SR for tobacco-dependence treatment in cigarette smokers: a randomized trial","volume":"311","author":"Ebbert","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.rmr.2021.05.012_bib0310","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1176\/appi.ajp.2014.13050595","article-title":"Combination treatment with varenicline and bupropion in an adaptive smoking cessation paradigm","volume":"171","author":"Rose","year":"2014","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.rmr.2021.05.012_bib0315","article-title":"With the combination of varenicline and bupropion for smoking cessation: clinical implications for front line use","volume":"21","author":"Cinciripini","year":"2018","journal-title":"Addiction"},{"key":"10.1016\/j.rmr.2021.05.012_bib0320","first-page":"999","article-title":"Combination Varenicline\/Bupropion treatment benefits highly dependent smokers in an adaptive smoking cessation paradigm","volume":"19","author":"Rose","year":"2017","journal-title":"Nicotine Tob Res"},{"key":"10.1016\/j.rmr.2021.05.012_bib0325","doi-asserted-by":"crossref","first-page":"152125","DOI":"10.1016\/j.comppsych.2019.152125","article-title":"Combination therapy of varenicline and bupropion in smoking cessation: A meta-analysis of the randomized controlled trials","volume":"95","author":"Zhong","year":"2019","journal-title":"Compr Psychiatry"},{"key":"10.1016\/j.rmr.2021.05.012_bib0330","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1080\/14622200701540820","article-title":"Efficacy of bupropion alone and in combination with nicotine gum","volume":"9","author":"Piper","year":"2007","journal-title":"Nicotine Tob Res"},{"key":"10.1016\/j.rmr.2021.05.012_bib0335","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/S0025-6196(11)60997-X","article-title":"Randomized comparison of a nicotine inhaler and bupropion for smoking cessation and relapse prevention","volume":"82","author":"Croghan","year":"2007","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.rmr.2021.05.012_bib0340","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1056\/NEJM199903043400903","article-title":"A controlled trial of sustained-release bupropion, a nicotine patch, or both for smoking cessation","volume":"340","author":"Jorenby","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.rmr.2021.05.012_bib0345","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/clpt.1994.105","article-title":"Mecamylamine combined with nicotine skin patch facilitates smoking cessation beyond nicotine patch treatment alone","volume":"56","author":"Rose","year":"1994","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.rmr.2021.05.012_bib0350","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1046\/j.1360-0443.2003.00524.x","article-title":"A randomized controlled trial of oral selegiline plus nicotine skin patch compared with placebo plus nicotine skin patch for smoking cessation","volume":"98","author":"Biberman","year":"2003","journal-title":"Addiction"},{"key":"10.1016\/j.rmr.2021.05.012_bib0355","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s00406-007-0726-2","article-title":"The efficacy of the combination of sertraline with buspirone for smoking cessation. A randomized clinical trial in nondepressed smokers","volume":"257","author":"Carrao","year":"2007","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"10.1016\/j.rmr.2021.05.012_bib0360","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/0165-6147(90)90242-Z","article-title":"The paradox of nicotinic acetylcholine receptor upregulation by nicotine","volume":"11","author":"Wonnacott","year":"1990","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.rmr.2021.05.012_bib0365","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1038\/npp.2012.20","article-title":"A single administration of low-dose varenicline saturates \u03b14\u03b22* nicotinic acetylcholine receptors in the human brain","volume":"37","author":"Lotfipour","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.rmr.2021.05.012_bib0370","doi-asserted-by":"crossref","first-page":"3474","DOI":"10.1021\/jm050069n","article-title":"Varenicline: an alpha4beta2\u00a0nicotinic receptor partial agonist for smoking cessation","volume":"48","author":"Coe","year":"2005","journal-title":"J Med Chem"},{"key":"10.1016\/j.rmr.2021.05.012_bib0375","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.nucmedbio.2011.11.006","article-title":"Varenicline increases in vivo striatal dopamine D2\/3\u00a0receptor binding: an ultra-high-resolution pinhole [123I]IBZM SPECT study in rats","volume":"39","author":"Crunelle","year":"2012","journal-title":"Nucl Med Biol"},{"key":"10.1016\/j.rmr.2021.05.012_bib0380","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1111\/j.1460-9568.2007.05546.x","article-title":"Chronic bupropion attenuated the anhedonic component of nicotine withdrawal in rats via inhibition of dopamine reuptake in the nucleus accumbens shell","volume":"250","author":"Paterson","year":"2007","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.rmr.2021.05.012_bib0385","first-page":"395","article-title":"Bupropion: a review of its mechanism of antidepressant activity","volume":"56","author":"Ascher","year":"1995","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.rmr.2021.05.012_bib0390","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0091-3057(92)90086-U","article-title":"Concurrent agonist-antagonist administration for the analysis and treatment of drug dependence","volume":"41","author":"Rose","year":"1992","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.rmr.2021.05.012_bib0395","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.jad.2013.06.027","article-title":"Placing transdermal selegiline for major depressive disorder into clinical context: number needed to treat, number needed to harm, and likelihood to be helped or harmed","volume":"151","author":"Citrome","year":"2013","journal-title":"J Affect Disord"},{"key":"10.1016\/j.rmr.2021.05.012_bib0400","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/379733a0","article-title":"Inhibition of monoamine oxidase B in the brains of smokers","volume":"379","author":"Fowler","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.rmr.2021.05.012_bib0405","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1300\/J069v17n01_03","article-title":"Neuropharmacological actions of cigarette smoke: brain monoamine oxidase B (MAO B) inhibition","volume":"17","author":"Fowler","year":"1998","journal-title":"J Addict Dis"},{"key":"10.1016\/j.rmr.2021.05.012_bib0410","first-page":"222","article-title":"Seven-year update","volume":"55","author":"Buspirone:","year":"1994","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.rmr.2021.05.012_bib0415","first-page":"27","article-title":"Strategies for treatment of generalized anxiety in the primary care setting","volume":"58","author":"Schweizer","year":"1997","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.rmr.2021.05.012_bib0420","doi-asserted-by":"crossref","first-page":"3S85","DOI":"10.1016\/S0761-8425(06)73419-2","article-title":"La conduite de l\u2019aide au sevrage tabagique","volume":"23","author":"Perriot","year":"2006","journal-title":"Rev Mal Respir"},{"key":"10.1016\/j.rmr.2021.05.012_bib0425","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1001\/archgenpsychiatry.2011.1465","article-title":"Sex differences in availability of \u03b22*-nicotinic acetylcholine receptors in recently abstinent tobacco smokers","volume":"69","author":"Cosgrove","year":"2012","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.rmr.2021.05.012_bib0430","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1017\/S1461145711001957","article-title":"Sex differences in striatal dopamine D2\/D3\u00a0receptor availability in smokers and non-smokers","volume":"15","author":"Brown","year":"2012","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.rmr.2021.05.012_bib0435","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.biopsych.2006.01.008","article-title":"Sex differences in striatal dopamine release in healthy adults","volume":"59","author":"Munro","year":"2006","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.rmr.2021.05.012_bib0440","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1001\/jamapsychiatry.2014.138","article-title":"Brain nicotinic acetylcholine receptor availability and response to smoking cessation treatment: a randomized trial","volume":"71","author":"Brody","year":"2014","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.rmr.2021.05.012_bib0445","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1124\/mol.104.001313","article-title":"Enantioselective effects of hydroxy metabolites of bupropion on behavior and on function of monoamine transporters and nicotinic receptors","volume":"66","author":"Damaj","year":"2004","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.rmr.2021.05.012_bib0225","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.rmr.2017.01.001","article-title":"Practical guidelines on e-cigarettes for practitioners and others health professionals. A French 2016\u00a0expert's statement","volume":"34","author":"Dautzenberg","year":"2017","journal-title":"Rev Mal Respir"}],"container-title":["Revue des Maladies Respiratoires"],"original-title":[],"language":"fr","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0761842521003053?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0761842521003053?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:21:21Z","timestamp":1760106081000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0761842521003053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":45,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["S0761842521003053"],"URL":"https:\/\/doi.org\/10.1016\/j.rmr.2021.05.012","relation":{},"ISSN":["0761-8425"],"issn-type":[{"type":"print","value":"0761-8425"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Combinaisons des traitements pharmacologiques au cours du sevrage tabagique. Revue syst\u00e9matique","name":"articletitle","label":"Article Title"},{"value":"Revue des Maladies Respiratoires","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rmr.2021.05.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 SPLF. Published by Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}