{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T02:23:52Z","timestamp":1767666232371,"version":"build-2065373602"},"reference-count":43,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T00:00:00Z","timestamp":1674604800000},"content-version":"am","delay-in-days":389,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Revue des Maladies Respiratoires"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.rmr.2021.11.004","type":"journal-article","created":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T12:50:50Z","timestamp":1642078250000},"page":"26-33","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Adaptation \u00e0 l\u2019altitude dans les maladies respiratoires"],"prefix":"10.1016","volume":"39","author":[{"given":"B.","family":"Wuyam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Baillieul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Doutreleau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Verg\u00e8s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.rmr.2021.11.004_bib0220","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1159\/000486450","article-title":"Exercise performance of lowlanders with COPD at 2,590\u00a0m: data from a randomized trial","volume":"95","author":"Furian","year":"2018","journal-title":"Respiration"},{"key":"10.1016\/j.rmr.2021.11.004_bib0225","first-page":"40","article-title":"Respiratory changes during initial days of acclimatization to increasing altitudes","volume":"67","author":"Basu","year":"1996","journal-title":"Aviat Space Environ Med"},{"issue":"7\u00a0Suppl","key":"10.1016\/j.rmr.2021.11.004_bib0230","doi-asserted-by":"crossref","first-page":"S647","DOI":"10.1097\/00005768-200107001-00002","article-title":"Ventilatory limitations in chronic obstructive pulmonary disease","volume":"33","author":"O\u2019Donnell","year":"2001","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.rmr.2021.11.004_bib0235","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1139\/H07-119","article-title":"Ventilatory constraints and dyspnea during exercise in chronic obstructive pulmonary disease","volume":"32","author":"Laveneziana","year":"2007","journal-title":"Appl Physiol Nutr Metab"},{"key":"10.1016\/j.rmr.2021.11.004_bib0240","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1164\/ajrccm.156.1.9607090","article-title":"Inhomogeneities of ventilation and the diffusing capacity to perfusion in various chronic lung diseases","volume":"156","author":"Yamaguchi","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.rmr.2021.11.004_bib0245","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1152\/jappl.1987.63.6.2348","article-title":"Operation Everest II: pulmonary gas exchange during a simulated ascent of Mt. Everest","volume":"63","author":"Wagner","year":"1987","journal-title":"J Appl Physiol (1985)"},{"key":"10.1016\/j.rmr.2021.11.004_bib0250","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1001\/jama.1978.03290140033017","article-title":"Short-term adaptation to moderate altitude. Patients with chronic obstructive pulmonary disease","volume":"240","author":"Graham","year":"1978","journal-title":"JAMA"},{"key":"10.1016\/j.rmr.2021.11.004_bib0255","doi-asserted-by":"crossref","first-page":"3529","DOI":"10.2147\/COPD.S173039","article-title":"Exercise performance and symptoms in lowlanders with COPD ascending to moderate altitude: randomized trial","volume":"13","author":"Furian","year":"2018","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"issue":"4\u00a0Pt 3","key":"10.1016\/j.rmr.2021.11.004_bib0260","first-page":"4S24","article-title":"What are the general principles and management of patients presenting with respiratory diseases and preparing for air travel? How to evaluate the respiratory risk before air travel?","volume":"24","author":"Chambellan","year":"2007","journal-title":"Rev Mal Respir"},{"key":"10.1016\/j.rmr.2021.11.004_bib0265","first-page":"4S7S68","article-title":"Voyage a\u00e9rien et maladies respiratoires","volume":"24","author":"Similowski","year":"2007","journal-title":"Rev Mal Respir"},{"key":"10.1016\/j.rmr.2021.11.004_bib0270","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1136\/thorax.57.4.289","article-title":"Managing passengers with respiratory disease planning air travel: British Thoracic Society recommendations","volume":"57","year":"2002","journal-title":"Thorax"},{"issue":"148","key":"10.1016\/j.rmr.2021.11.004_bib0275","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0030-2018","article-title":"Should I stay or should I go?. COPD and air travel","volume":"27","author":"Ergan","year":"2018","journal-title":"Eur Respir Rev"},{"key":"10.1016\/j.rmr.2021.11.004_bib0280","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1183\/09031936.00052606","article-title":"Travel to high altitude with pre-existing lung disease","volume":"29","author":"Luks","year":"2007","journal-title":"Eur Respir J"},{"key":"10.1016\/j.rmr.2021.11.004_bib0285","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1159\/000492898","article-title":"Right and Left Heart Function in Lowlanders with COPD at Altitude: Data from a Randomized Study","volume":"97","author":"Lichtblau","year":"2018","journal-title":"Respiration"},{"key":"10.1016\/j.rmr.2021.11.004_bib0290","doi-asserted-by":"crossref","first-page":"752","DOI":"10.3389\/fphys.2018.00752","article-title":"Postural Control in Lowlanders With COPD Traveling to 3100\u00a0m: Data From a Randomized Trial Evaluating the Effect of Preventive Dexamethasone Treatment","volume":"9","author":"Muralt","year":"2018","journal-title":"Front Physiol"},{"key":"10.1016\/j.rmr.2021.11.004_bib0295","doi-asserted-by":"crossref","first-page":"160","DOI":"10.4103\/2045-8932.109949","article-title":"Mechanisms of development of chronic obstructive pulmonary disease-associated pulmonary hypertension","volume":"3","author":"Barbera","year":"2013","journal-title":"Pulm Circ"},{"key":"10.1016\/j.rmr.2021.11.004_bib0300","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1186\/cc1049","article-title":"Pulmonary hypertension associated with COPD","volume":"5","author":"Naeije","year":"2001","journal-title":"Crit Care"},{"key":"10.1016\/j.rmr.2021.11.004_bib0305","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0188-4409(01)00302-2","article-title":"The influence of altitude in bronchial asthma","volume":"32","author":"Gourgoulianis","year":"2001","journal-title":"Arch Med Res"},{"issue":"6","key":"10.1016\/j.rmr.2021.11.004_bib0310","doi-asserted-by":"crossref","first-page":"511","DOI":"10.3109\/02770909909054557","article-title":"Asthma and geographical altitude: an inverse relationship in Mexico","volume":"36","author":"Vargas","year":"1999","journal-title":"J Asthma"},{"key":"10.1016\/j.rmr.2021.11.004_bib0315","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1089\/ham.2016.0137","article-title":"Geographic variation in mentally unhealthy days: air pollution and altitude perspectives","volume":"18","author":"Ha","year":"2017","journal-title":"High Alt Med Biol"},{"key":"10.1016\/j.rmr.2021.11.004_bib0320","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1111\/j.1365-2222.2007.02781.x","article-title":"Prevalence and severity of asthma and allergies in schoolchildren in Lhasa, Tibet","volume":"37","author":"Droma","year":"2007","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.rmr.2021.11.004_bib0325","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1164\/rccm.200112-142BC","article-title":"Racing Alaskan sled dogs as a model of \u201cski asthma\u201d","volume":"166","author":"Davis","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.rmr.2021.11.004_bib0330","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1067\/mai.2000.109822","article-title":"The mechanism of exercise-induced asthma is","volume":"106","author":"Anderson","year":"2000","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.rmr.2021.11.004_bib0335","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.iac.2013.02.002","article-title":"Pathogenesis of exercise-induced bronchoconstriction","volume":"33","author":"Kippelen","year":"2013","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1016\/j.rmr.2021.11.004_bib0340","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1136\/thx.52.5.453","article-title":"Effect of acute alterations in inspired oxygen tension on methacholine induced bronchoconstriction in patients with asthma","volume":"52","author":"Dagg","year":"1997","journal-title":"Thorax"},{"key":"10.1016\/j.rmr.2021.11.004_bib0345","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1152\/jappl.1964.19.4.745","article-title":"Effect of Alterations in End-Tidal Co2\u00a0Tension on Flow Resistance","volume":"19","author":"Newhouse","year":"1964","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.rmr.2021.11.004_bib0350","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1136\/thx.46.1.28","article-title":"Effects of hypercapnia and hypocapnia on respiratory resistance in normal and asthmatic subjects","volume":"46","author":"van den Elshout","year":"1991","journal-title":"Thorax"},{"key":"10.1016\/j.rmr.2021.11.004_bib0355","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1152\/jappl.2000.89.1.120","article-title":"Characterization of pharyngeal resistance during sleep in a spectrum of sleep-disordered breathing","volume":"89","author":"Tamisier","year":"2000","journal-title":"J Appl Physiol (1985)"},{"key":"10.1016\/j.rmr.2021.11.004_bib0360","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1136\/thx.2009.125849","article-title":"Exacerbation of sleep apnoea by frequent central events in patients with the obstructive sleep apnoea syndrome at altitude: a randomised trial","volume":"65","author":"Nussbaumer-Ochsner","year":"2010","journal-title":"Thorax"},{"key":"10.1016\/j.rmr.2021.11.004_bib0365","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1183\/09031936.00073111","article-title":"Altitude illness is related to low hypoxic chemoresponse and low oxygenation during sleep","volume":"40","author":"Nespoulet","year":"2012","journal-title":"Eur Respir J"},{"key":"10.1016\/j.rmr.2021.11.004_bib0370","doi-asserted-by":"crossref","first-page":"123","DOI":"10.5935\/1984-0063.20180023","article-title":"Effectiveness of a lightweight portable auto-CPAP device for the treatment of sleep apnea during high altitude stages of the Dakar Rally: a case report","volume":"11","author":"Lebret","year":"2018","journal-title":"Sleep Sci"},{"key":"10.1016\/j.rmr.2021.11.004_bib0375","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1177\/1753465816677006","article-title":"The effect of acetazolamide on sleep apnea at high altitude: a systematic review and meta-analysis","volume":"11","author":"Liu","year":"2017","journal-title":"Ther Adv Respir Dis"},{"key":"10.1016\/j.rmr.2021.11.004_bib0380","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1378\/chest.120.2.369","article-title":"The obesity-hypoventilation syndrome revisited: a prospective study of 34\u00a0consecutive cases","volume":"120","author":"Kessler","year":"2001","journal-title":"Chest"},{"key":"10.1016\/j.rmr.2021.11.004_bib0385","doi-asserted-by":"crossref","first-page":"253","DOI":"10.7326\/0003-4819-139-4-200308190-00007","article-title":"Obesity: associations with acute mountain sickness","volume":"139","author":"Ri-Li","year":"2003","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.rmr.2021.11.004_bib0390","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1089\/ham.2017.0164","article-title":"The 2018\u00a0Lake Louise Acute Mountain Sickness Score","volume":"19","author":"Roach","year":"2018","journal-title":"High Alt Med Biol"},{"key":"10.1016\/j.rmr.2021.11.004_bib0395","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1056\/NEJM198005083021907","article-title":"High-altitude pulmonary edema in persons without the right pulmonary artery","volume":"302","author":"Hackett","year":"1980","journal-title":"N Engl J Med"},{"key":"10.1016\/j.rmr.2021.11.004_bib0400","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/(SICI)1099-0496(199708)24:2<111::AID-PPUL6>3.0.CO;2-R","article-title":"Unilateral agenesis of the pulmonary artery and high-altitude pulmonary edema (HAPE) at moderate altitude","volume":"24","author":"Sebbane","year":"1997","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.rmr.2021.11.004_bib0405","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1378\/chest.96.6.1422","article-title":"Recurrent high-altitude illness associated with right pulmonary artery occlusion from granulomatous mediastinitis","volume":"96","author":"Torrington","year":"1989","journal-title":"Chest"},{"key":"10.1016\/j.rmr.2021.11.004_bib0410","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1152\/jappl.1993.75.3.1097","article-title":"Stress failure of pulmonary capillaries in racehorses with exercise-induced pulmonary hemorrhage","volume":"75","author":"West","year":"1993","journal-title":"J Appl Physiol (1985)"},{"key":"10.1016\/j.rmr.2021.11.004_bib0415","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1183\/09031936.05.10087304","article-title":"Lung function in adults with cystic fibrosis at altitude: impact on air travel","volume":"25","author":"Fischer","year":"2005","journal-title":"Eur Respir J"},{"key":"10.1016\/j.rmr.2021.11.004_bib0420","first-page":"9","article-title":"Blood gas-analyses in patients with cystic fibrosis to estimate hypoxemia during exposure to high altitudes in a hypobaric-chamber","volume":"5","author":"Rose","year":"2000","journal-title":"Eur J Med Res"},{"key":"10.1016\/j.rmr.2021.11.004_bib0425","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0954-6111(06)80150-2","article-title":"Exacerbations of cystic fibrosis after holidays at high altitude--a cautionary tale","volume":"86","author":"Speechly-Dick","year":"1992","journal-title":"Respir Med"},{"key":"10.1016\/j.rmr.2021.11.004_bib0215","doi-asserted-by":"crossref","first-page":"1802454","DOI":"10.1183\/13993003.02454-2018","article-title":"Household air pollution as an important factor in the complex relationship between altitude and COPD","volume":"53","author":"Basagana","year":"2019","journal-title":"Eur Respir J"}],"container-title":["Revue des Maladies Respiratoires"],"original-title":[],"language":"fr","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0761842521004150?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0761842521004150?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:22:22Z","timestamp":1760106142000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0761842521004150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["S0761842521004150"],"URL":"https:\/\/doi.org\/10.1016\/j.rmr.2021.11.004","relation":{},"ISSN":["0761-8425"],"issn-type":[{"type":"print","value":"0761-8425"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adaptation \u00e0 l\u2019altitude dans les maladies respiratoires","name":"articletitle","label":"Article Title"},{"value":"Revue des Maladies Respiratoires","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rmr.2021.11.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 SPLF. Published by Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}