{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T11:37:15Z","timestamp":1781005035411,"version":"3.54.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Revista de Psiquiatr\u00eda  y Salud Mental"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.rpsm.2019.01.003","type":"journal-article","created":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T09:22:10Z","timestamp":1551777730000},"page":"77-91","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Tratamiento farmacol\u00f3gico del trastorno obsesivo-compulsivo en adultos: una gu\u00eda de pr\u00e1ctica cl\u00ednica basada en el m\u00e9todo ADAPTE"],"prefix":"10.1016","volume":"12","author":[{"given":"Jose M.","family":"Menchon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Bobes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilio","family":"Alamo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pino","family":"Alonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Paz","family":"Garc\u00eda-Portilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngela","family":"Ib\u00e1\u00f1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Real","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Bouso\u00f1o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Dolores","family":"Saiz-Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeronimo","family":"Saiz-Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rpsm.2019.01.003_bib0175","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1176\/ps.2007.58.7.977","article-title":"Treatment seeking by individuals with obsessive-compulsive disorder from the british psychiatric morbidity survey of 2000","volume":"58","author":"Torres","year":"2007","journal-title":"Psychiatr Serv"},{"key":"10.1016\/j.rpsm.2019.01.003_bib0180","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1176\/ajp.2006.163.11.1978","article-title":"Obsessive-compulsive disorder: Prevalence, comorbidity, impact, and help-seeking in the British National Psychiatric Morbidity Survey of 2000","volume":"163","author":"Torres","year":"2006","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.rpsm.2019.01.003_bib0185","first-page":"131","article-title":"Obsessive-compulsive disorder: The usefulness of a pharmacological practice guideline","volume":"9","author":"Menchon","year":"2016","journal-title":"Rev Psiquiatr Salud Ment"},{"key":"10.1016\/j.rpsm.2019.01.003_bib0190","unstructured":"The ADAPTE Collaboration. The ADAPTE Process: Resource Toolkit for GUideline Adaptation. 2009. Version 2.0 [consultado 25 Jul 2018]. Disponible en: http:\/\/g-i-n.net"},{"issue":"Suppl 1","key":"10.1016\/j.rpsm.2019.01.003_bib0195","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1186\/1471-244X-14-S1-S1","article-title":"Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsessive-compulsive disorders","volume":"14","author":"Katzman","year":"2014","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.rpsm.2019.01.003_bib0200","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1177\/0269881114525674","article-title":"Evidence-based pharmacological treatment of anxiety disorders, post-traumatic stress disorder and obsessive-compulsive disorder: a revision of the 2005 guidelines from the British Association for Psychopharmacology","volume":"28","author":"Baldwin","year":"2014","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.rpsm.2019.01.003_bib0205","unstructured":"National Institute for Health and Care Excellence. Obsessive-compulsive disorder Evidence Update September 2013. National Institute for Health and Care Excellence, Manchester, 2013. 2013."},{"key":"10.1016\/j.rpsm.2019.01.003_bib0210","unstructured":"National Collaborating Centre for Mental Health. Obsessive-compulsive disorder: Core interventions in the treatment of obsessive-compulsive disorder and body dysmorphic disorder.The British Psychological Society and The Royal College of Psychiatrists, London, 2006."},{"key":"10.1016\/j.rpsm.2019.01.003_bib0215","unstructured":"Koran LM, Simpson HB. Guideline Watch (march 2013): Practice Guideline for the Treatment of Patients with Obsessive-Compulsive Disorder. 2013 [consultado 25 Jul 2018]. Disponible en: https:\/\/psychiatryonline.org\/pb\/assets\/raw\/sitewide\/practice_guidelines\/guidelines\/ocd-watch.pdf"},{"key":"10.1016\/j.rpsm.2019.01.003_bib0220","unstructured":"American Psychiatric Association. Practice guideline for the treatment of patients with obsessive-compulsive disorder. Arlington, VA: American Psychiatric Association, 2007 [consultado 25 Jul 2018]. Disponible en: http\/\/www.psych.org\/psych_pract\/treatg\/pg\/prac_ guide.cfm"},{"key":"10.1016\/j.rpsm.2019.01.003_bib0225","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s11920-012-0268-9","article-title":"A 2012 evidence-based algorithm for the pharmacotherapy for obsessive-compulsive disorder","volume":"14","author":"Stein","year":"2012","journal-title":"Curr Psychiatry Rep"},{"key":"10.1016\/j.rpsm.2019.01.003_bib0230","first-page":"606","article-title":"Obsessive-compulsive disorder--the role of the GP","volume":"42","author":"Johnson","year":"2013","journal-title":"Aust Fam Physician"},{"key":"10.1016\/j.rpsm.2019.01.003_bib0235","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1177\/070674370004500304","article-title":"On the pharmacotherapy of obsessive-compulsive disorder: Is a consensus possible?","volume":"45","author":"Todorov","year":"2000","journal-title":"Can J Psychiatry"},{"key":"10.1016\/j.rpsm.2019.01.003_bib0240","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3109\/13651501.2012.667114","article-title":"Guidelines for the pharmacological treatment of anxiety disorders, obsessive-compulsive disorder and posttraumatic stress disorder in primary care","volume":"16","author":"Bandelow","year":"2012","journal-title":"Int J Psychiatry Clin Pract"},{"key":"10.1016\/j.rpsm.2019.01.003_bib0245","doi-asserted-by":"crossref","first-page":"E839","DOI":"10.1503\/cmaj.090449","article-title":"AGREE II: Advancing guideline development, reporting and evaluation in healthcare","volume":"182","author":"Brouwers","year":"2010","journal-title":"CMAJ"},{"key":"10.1016\/j.rpsm.2019.01.003_bib0250","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.rpsm.2016.02.001","article-title":"Are we considering the QTc interval of our patients?","volume":"10","author":"Muquebil Ali Al Shaban Rodr\u00edguez","year":"2017","journal-title":"Rev Psiquiatr Salud Ment"},{"key":"10.1016\/j.rpsm.2019.01.003_bib0255","doi-asserted-by":"crossref","first-page":"e441","DOI":"10.4088\/JCP.13r08672","article-title":"Meta-analysis of selective serotonin reuptake inhibitor-associated QTc prolongation","volume":"75","author":"Beach","year":"2014","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.rpsm.2019.01.003_bib0260","doi-asserted-by":"crossref","first-page":"e011200","DOI":"10.1136\/bmjopen-2016-011200","article-title":"Antidepressants and the risk of hyponatremia: A Danish register-based population study","volume":"6","author":"Leth-M\u00f8ller","year":"2016","journal-title":"BMJ Open"},{"key":"10.1016\/j.rpsm.2019.01.003_bib0265","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.amjmed.2017.07.025","article-title":"Differences in Associations of Antidepressants and Hospitalization Due to Hyponatremia","volume":"131","author":"Farmand","year":"2018","journal-title":"Am J Med"},{"key":"10.1016\/j.rpsm.2019.01.003_bib0270","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.rpsm.2017.07.001","article-title":"Safety in the use of antidepressants: Vortioxetine-induce hyponatremia in a case report","volume":"10","author":"Pelayo-Ter\u00e1n","year":"2017","journal-title":"Rev Psiquiatr Salud Ment"},{"key":"10.1016\/j.rpsm.2019.01.003_bib0275","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1001\/archpsyc.1994.03950070051010","article-title":"A multicenter investigation of fixed-dose fluoxetine in the treatment of obsessive-compulsive disorder","volume":"51","author":"Tollefson","year":"1994","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.rpsm.2019.01.003_bib0280","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1001\/archpsyc.1995.03950160039008","article-title":"Double-blind parallel comparison of three dosages of sertraline and placebo in outpatients with obsessive-compulsive disorder","volume":"52","author":"Greist","year":"1995","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.rpsm.2019.01.003_bib0285","first-page":"439","article-title":"Efficacy of fluoxetine in Austrian patients with obsessive-compulsive disorder","volume":"111","author":"Zitterl","year":"1999","journal-title":"Wien Klin Wochenschr"},{"key":"10.1016\/j.rpsm.2019.01.003_bib0290","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/00004850-200103000-00002","article-title":"Citalopram 20mg, 40mg and 60mg are all effective and well tolerated compared with placebo in obsessive-compulsive disorder","volume":"16","author":"Montgomery","year":"2001","journal-title":"Int Clin Psychopharmacol"},{"key":"10.1016\/j.rpsm.2019.01.003_bib0295","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1097\/YIC.0b013e32833119d8","article-title":"Open-label study of high (30 mg) and moderate (20mg) dose escitalopram for the treatment of obsessive-compulsive disorder","volume":"24","author":"Dougherty","year":"2009","journal-title":"Int Clin Psychopharmacol"},{"key":"10.1016\/j.rpsm.2019.01.003_bib0300","first-page":"315","article-title":"A score for predicting response to pharmacotherapy in obsessive-compulsive disorder","volume":"18","author":"Denys","year":"2003","journal-title":"Int Clin Psychopharmacol"},{"key":"10.1016\/j.rpsm.2019.01.003_bib0305","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.rpsm.2017.04.003","article-title":"Biomarkers in Psychiatry: Between myth and clinical reality","volume":"10","author":"Meana","year":"2017","journal-title":"Rev Psiquiatr Salud Ment"},{"key":"10.1016\/j.rpsm.2019.01.003_bib0310","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1177\/0269881117699361","article-title":"British Association for Psychopharmacology consensus guidance on the use of psychotropic medication preconception, in pregnancy and postpartum 2017","volume":"31","author":"McAllister-Williams","year":"2017","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.rpsm.2019.01.003_bib0315","unstructured":"M\u00e1rquez-Gonz\u00e1lez M, Romero-Moreno R, Fern\u00e1ndez Marcos T, Ortega Otero M. Gu\u00eda para la Intervenci\u00f3n Psicol\u00f3gica en el Trastorno Obsesivo-Compulsivo [consultado 25 Jul 2018]. Disponible en: https:\/\/www.uam.es\/centros\/psicologia\/paginas\/cpa\/paginas\/doc\/documentacion\/rincon\/protocolo_TOC.pdf"},{"key":"10.1016\/j.rpsm.2019.01.003_bib0320","article-title":"New Directions in the Use of Brain Stimulation Interventions in Patients with Obsessive-Compulsive Disorder","author":"Dell\u2019Osso","year":"2017","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.rpsm.2019.01.003_bib0325","doi-asserted-by":"crossref","first-page":"e0133591","DOI":"10.1371\/journal.pone.0133591","article-title":"Deep Brain Stimulation for Obsessive-Compulsive Disorder: A Meta-Analysis of Treatment Outcome and Predictors of Response","volume":"10","author":"Alonso","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.rpsm.2019.01.003_bib0330","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1097\/YCT.0000000000000335","article-title":"Transcranial Magnetic Stimulation for Obsessive-Compulsive Disorder: An Updated Systematic Review and Meta-analysis","volume":"32","author":"Trevizol","year":"2016","journal-title":"J ECT"},{"key":"10.1016\/j.rpsm.2019.01.003_bib0335","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1136\/qshc.4.1.55","article-title":"Developing and implementing clinical practice guidelines","volume":"4","author":"Grimshaw","year":"1995","journal-title":"Qual Health Care"},{"key":"10.1016\/j.rpsm.2019.01.003_bib0340","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1136\/bmj.317.7162.858","article-title":"Attributes of clinical guidelines that influence use of guidelines in general practice: Observational study","volume":"317","author":"Grol","year":"1998","journal-title":"BMJ"}],"container-title":["Revista de Psiquiatr\u00eda  y Salud Mental"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1888989119300205?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1888989119300205?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:32:30Z","timestamp":1761823950000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1888989119300205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["S1888989119300205"],"URL":"https:\/\/doi.org\/10.1016\/j.rpsm.2019.01.003","relation":{},"ISSN":["1888-9891"],"issn-type":[{"value":"1888-9891","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tratamiento farmacol\u00f3gico del trastorno obsesivo-compulsivo en adultos: una gu\u00eda de pr\u00e1ctica cl\u00ednica basada en el m\u00e9todo ADAPTE","name":"articletitle","label":"Article Title"},{"value":"Revista de Psiquiatr\u00eda  y Salud Mental","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rpsm.2019.01.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Espa\u00f1a, S.L.U. on behalf of SEP y SEPB.","name":"copyright","label":"Copyright"}]}}