{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T03:40:20Z","timestamp":1793072420377,"version":"4.5.0"},"reference-count":53,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,18]],"date-time":"2022-12-18T00:00:00Z","timestamp":1671321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017885","name":"Queen Elisabeth Medical Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017885","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek Vlaanderen","doi-asserted-by":"publisher","award":["1509216N"],"award-info":[{"award-number":["1509216N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek Vlaanderen","doi-asserted-by":"publisher","award":["G.0785.17"],"award-info":[{"award-number":["G.0785.17"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek Vlaanderen","doi-asserted-by":"publisher","award":["G.0A86.13"],"award-info":[{"award-number":["G.0A86.13"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","award":["ISP\/14\/02L2"],"award-info":[{"award-number":["ISP\/14\/02L2"]}],"id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","award":["OT\/14\/099"],"award-info":[{"award-number":["OT\/14\/099"]}],"id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022601","name":"Fondation M\u00e9dicale Reine Elisabeth","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022601","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rpthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research and Practice in Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.rpth.2022.100028","type":"journal-article","created":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T20:09:04Z","timestamp":1676318944000},"page":"100028","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Spatiotemporal profile of neutrophil extracellular trap formation in a mouse model of ischemic stroke"],"prefix":"10.1016","volume":"7","author":[{"given":"Maaike","family":"De Wilde","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Desender","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Tersteeg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Vanhoorelbeke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon F.","family":"De Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rpth.2022.100028_bib1","first-page":"153","article-title":"Heart disease and stroke statistics\u20142022 update: a report from the American Heart Association","volume":"146","author":"Tsao","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.rpth.2022.100028_bib2","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1161\/STROKEAHA.115.012577","article-title":"Eligibility and predictors for acute revascularization procedures in a stroke center","volume":"47","author":"Vanacker","year":"2016","journal-title":"Stroke"},{"key":"10.1016\/j.rpth.2022.100028_bib3","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1001\/jama.2015.3058","article-title":"Acute stroke intervention: a systematic review","volume":"313","author":"Prabhakaran","year":"2015","journal-title":"JAMA"},{"key":"10.1016\/j.rpth.2022.100028_bib4","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1161\/STROKEAHA.117.017286","article-title":"Targeting reperfusion injury in the age of mechanical thrombectomy","volume":"49","author":"Mizuma","year":"2018","journal-title":"Stroke"},{"key":"10.1016\/j.rpth.2022.100028_bib5","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1161\/01.STR.0000144051.32131.09","article-title":"Evidence of reperfusion injury, exacerbated by thrombolytic therapy, in human focal brain ischemia using a novel imaging marker of early blood-brain barrier disruption","volume":"35","author":"Warach","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.rpth.2022.100028_bib6","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1177\/0271678X20954929","article-title":"Tissue no-reflow despite full recanalization following thrombectomy for anterior circulation stroke with proximal occlusion: a clinical study","volume":"41","author":"Schiphorst","year":"2021","journal-title":"J\u00a0Cereb Blood Flow Metab"},{"key":"10.1016\/j.rpth.2022.100028_bib7","first-page":"1","article-title":"Ischemia-reperfusion injury in the brain: mechanisms and potential therapeutic strategies","volume":"5","author":"Lin","year":"2016","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.rpth.2022.100028_bib8","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1083\/jcb.200606027","article-title":"Novel cell death program leads to neutrophil extracellular traps","volume":"204","author":"Fuchs","year":"2007","journal-title":"J\u00a0Cell Biol"},{"key":"10.1016\/j.rpth.2022.100028_bib9","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1182\/blood-2013-10-463646","article-title":"Thrombosis: tangled up in NETs","volume":"123","author":"Martinod","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2022.100028_bib10","article-title":"Extracellular DNA traps promote thrombosis","volume":"107","author":"Tobias","year":"2010","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.rpth.2022.100028_bib11","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s40478-019-0747-x","article-title":"Neutrophil extracellular trap induced by HMGB1 exacerbates damages in the ischemic brain","volume":"7","author":"Kim","year":"2019","journal-title":"Acta Neuropathol Commun"},{"key":"10.1016\/j.rpth.2022.100028_bib12","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1038\/s41467-020-16191-y","article-title":"Neutrophil extracellular traps released by neutrophils impair revascularization and vascular remodeling after stroke","volume":"11","author":"Kang","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.rpth.2022.100028_bib13","doi-asserted-by":"crossref","DOI":"10.1172\/JCI154225","article-title":"Neutrophil extracellular traps regulate ischemic stroke brain injury","volume":"132","author":"Denorme","year":"2022","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.rpth.2022.100028_bib14","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1159\/000089591","article-title":"Nucleosomes in serum of patients with early cerebral stroke","volume":"21","author":"Geiger","year":"2006","journal-title":"Cerebrovasc Dis"},{"key":"10.1016\/j.rpth.2022.100028_bib15","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.resuscitation.2005.05.021","article-title":"Plasma DNA as a prognostic marker for stroke patients with negative neuroimaging within the first 24 h of symptom onset","volume":"68","author":"Lam","year":"2006","journal-title":"Resuscitation"},{"key":"10.1016\/j.rpth.2022.100028_bib16","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1373\/49.4.562","article-title":"Prognostic use of circulating plasma nucleic acid concentrations in patients with acute stroke","volume":"49","author":"Rainer","year":"2003","journal-title":"Clin Chem"},{"key":"10.1016\/j.rpth.2022.100028_bib17","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.cca.2010.11.036","article-title":"The value of serial plasma nuclear and mitochondrial DNA levels in\u00a0patients with acute ischemic stroke","volume":"412","author":"Tsai","year":"2011","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.rpth.2022.100028_bib18","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1160\/TH17-02-0130","article-title":"Neutrophil extracellular traps are increased in patients with acute ischemic stroke: Prognostic significance","volume":"117","author":"Valles","year":"2017","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.rpth.2022.100028_bib19","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1161\/ATVBAHA.112.250993","article-title":"Extracellular chromatin is an important mediator of ischemic stroke in mice","volume":"32","author":"De Meyer","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.rpth.2022.100028_bib20","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202100471RR","article-title":"Neutrophil extracellular traps contribute to tissue plasminogen activator resistance in acute ischemic stroke","volume":"35","author":"Zhang","year":"2021","journal-title":"FASEB J"},{"key":"10.1016\/j.rpth.2022.100028_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2020.135383","article-title":"Neutrophil extracellular traps increased by hyperglycemia exacerbate ischemic brain damage","volume":"738","author":"Deng","year":"2020","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.rpth.2022.100028_bib22","doi-asserted-by":"crossref","first-page":"3228","DOI":"10.1161\/STROKEAHA.119.026848","article-title":"Pharmacological modulation of neutrophil extracellular traps reverses thrombotic stroke tpa (tissue-type plasminogen activator) resistance","volume":"50","author":"Pe\u00f1a-Mart\u00ednez","year":"2019","journal-title":"Stroke"},{"key":"10.1016\/j.rpth.2022.100028_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.790002","article-title":"Neutrophil extracellular trap targeting protects against ischemic damage after fibrin-rich thrombotic stroke despite non-reperfusion","volume":"13","author":"Pe\u00f1a-Mart\u00ednez","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.rpth.2022.100028_bib24","doi-asserted-by":"crossref","first-page":"819","DOI":"10.3324\/haematol.2019.241042","article-title":"The von Willebrand Factor A1 domain mediates thromboinflammation, aggravating ischemic stroke outcome in mice","volume":"106","author":"Denorme","year":"2020","journal-title":"Haematologica"},{"key":"10.1016\/j.rpth.2022.100028_bib25","doi-asserted-by":"crossref","first-page":"4712","DOI":"10.1182\/blood-2010-03-276311","article-title":"von Willebrand factor promotes leukocyte extravasation","volume":"116","author":"Petri","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2022.100028_bib26","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1111\/j.1538-7836.2012.04822.x","article-title":"ADAMTS13 reduces VWF-mediated acute inflammation following focal cerebral ischemia in mice","volume":"10","author":"Khan","year":"2012","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.rpth.2022.100028_bib27","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1182\/blood.2020008345","article-title":"Impaired adhesion of neutrophils expressing Slc44a2\/HNA-3b to VWF protects against NETosis under venous shear rates","volume":"137","author":"Zirka","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2022.100028_bib28","doi-asserted-by":"crossref","first-page":"9524","DOI":"10.1073\/pnas.95.16.9524","article-title":"A\u00a0mouse model of severe von Willebrand disease: defects in hemostasis and thrombosis","volume":"95","author":"Denis","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"10.1016\/j.rpth.2022.100028_bib29","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/2040-7378-3-9","article-title":"Platelet glycoprotein Ib\u03b1 is an important mediator of ischemic stroke in mice","volume":"3","author":"De Meyer","year":"2011","journal-title":"Exp Transl Stroke Med"},{"key":"10.1016\/j.rpth.2022.100028_bib30","doi-asserted-by":"crossref","first-page":"3600","DOI":"10.1182\/blood-2008-09-180695","article-title":"Deficiency of von Willebrand\u00a0factor protects mice from ischemic stroke","volume":"113","author":"Kleinschnitz","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2022.100028_bib31","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1182\/blood-2009-03-213264","article-title":"vonWillebrand factor-cleaving protease ADAMTS13 reduces ischemic brain injury in experimental stroke","volume":"114","author":"Zhao","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2022.100028_bib32","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s40478-019-0747-x","article-title":"Neutrophil extracellular trap induced by HMGB1 exacerbates damages in the ischemic brain","volume":"7","author":"Kim","year":"2019","journal-title":"Acta Neuropathol Commun"},{"key":"10.1016\/j.rpth.2022.100028_bib33","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1161\/STROKEAHA.118.023837","article-title":"Location of neutrophils in different compartments of the damaged mouse brain after severe ischemia\/reperfusion","volume":"50","author":"Otxoa-De-Amezaga","year":"2019","journal-title":"Stroke"},{"key":"10.1016\/j.rpth.2022.100028_bib34","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1007\/s12975-019-00694-y","article-title":"Functional dynamics of neutrophils after ischemic stroke","volume":"11","author":"Cai","year":"2020","journal-title":"Transl Stroke Res"},{"key":"10.1016\/j.rpth.2022.100028_bib35","first-page":"239","article-title":"Neutrophil recruitment to the brain in mouse and human ischemic stroke","volume":"129","author":"Perez-de-Puig","year":"2015","journal-title":"Pathol Mech Neurol Dis"},{"key":"10.1016\/j.rpth.2022.100028_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12974-019-1557-6","article-title":"All trans-retinoic acid protects against acute ischemic stroke by modulating neutrophil functions through STAT1 signaling","volume":"16","author":"Cai","year":"2019","journal-title":"J\u00a0Neuroinflammation"},{"key":"10.1016\/j.rpth.2022.100028_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jneumeth.2008.12.028","article-title":"TTC, Fluoro-Jade B and NeuN staining confirm evolving phases of infarction induced by middle cerebral artery occlusion","volume":"179","author":"Liu","year":"2009","journal-title":"J\u00a0Neurosci Methods"},{"key":"10.1016\/j.rpth.2022.100028_bib38","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1177\/0271678X20914179","article-title":"Dynamic capillary stalls in reperfused ischemic penumbra contribute to injury: A hyperacute role for neutrophils in persistent traffic jams","volume":"41","author":"Erdener","year":"2021","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.rpth.2022.100028_bib39","first-page":"776427","article-title":"Neutrophil-mediated dynamic capillary stalls in ischemic penumbra: persistent traffic jams after reperfusion contribute to injury","author":"Erdener","year":"2019","journal-title":"bioRxiv"},{"key":"10.1016\/j.rpth.2022.100028_bib40","doi-asserted-by":"crossref","first-page":"108260","DOI":"10.1016\/j.celrep.2020.108260","article-title":"Neutrophils Obstructing Brain Capillaries Are a Major Cause of No-Reflow in Ischemic Stroke","volume":"33","author":"El Amki","year":"2020","journal-title":"Cell Rep"},{"key":"10.1016\/j.rpth.2022.100028_bib41","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.thromres.2016.01.009","article-title":"NETosis promotes cancer-associated arterial microthrombosis presenting as ischemic stroke with troponin elevation","volume":"139","author":"Th\u00e5lin","year":"2016","journal-title":"Thromb Res"},{"key":"10.1016\/j.rpth.2022.100028_bib42","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1093\/cvr\/cvab217","article-title":"Culprit site extracellular DNA and microvascular obstruction in ST-elevation myocardial infarction","volume":"118","author":"Mangold","year":"2021","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.rpth.2022.100028_bib43","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/nm.2184","article-title":"Reciprocal coupling of coagulation and innate\u00a0immunity via neutrophil serine proteases","volume":"16","author":"Steffen","year":"2010","journal-title":"Nat Med"},{"key":"10.1016\/j.rpth.2022.100028_bib44","first-page":"1","article-title":"Adenosine triphosphate accumulated following cerebral ischemia induces neutrophil extracellular trap formation","volume":"21","author":"Kim","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.rpth.2022.100028_bib45","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0032366","article-title":"Neutrophil extracellular traps directly induce epithelial and endothelial cell death: a predominant role of histones","volume":"7","author":"Saffarzadeh","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.rpth.2022.100028_bib46","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1016\/j.bbrc.2018.07.069","article-title":"Citrullinated histone 3 causes endothelial barrier dysfunction","volume":"503","author":"Meegan","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.rpth.2022.100028_bib47","first-page":"1","article-title":"Neutrophil extracellular traps exacerbate ischemic brain damage","author":"Li","year":"2021","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.rpth.2022.100028_bib48","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1182\/bloodadvances.2019000979","article-title":"von Willebrand factor\/ADAMTS13 ratio at presentation of acute ischemic brain injury is predictive of outcome","volume":"4","author":"Taylor","year":"2020","journal-title":"Blood Adv"},{"key":"10.1016\/j.rpth.2022.100028_bib49","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1161\/ATVBAHA.110.208918","article-title":"Binding of von Willebrand factor to collagen and glycoprotein Ib\u03b1, but not to glycoprotein IIb\/IIIa, contributes to ischemic stroke in mice-brief report","volume":"30","author":"De Meyer","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.rpth.2022.100028_bib50","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.53353","article-title":"Activated \u03b1iib\u03b23 on platelets mediates flow-dependent netosis via slc44a2","volume":"9","author":"Constantinescu-Bercu","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.rpth.2022.100028_bib51","doi-asserted-by":"crossref","DOI":"10.1172\/JCI154225","article-title":"Neutrophil extracellular traps regulate ischemic stroke brain injury","volume":"132","author":"Denorme","year":"2022","journal-title":"J\u00a0Clin Investig"},{"key":"10.1016\/j.rpth.2022.100028_bib52","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1182\/blood-2015-01-624023","article-title":"P-selectin promotes neutrophil extracellular trap formation in mice","volume":"126","author":"Etulain","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2022.100028_bib53","doi-asserted-by":"crossref","first-page":"4072","DOI":"10.1073\/pnas.061307098","article-title":"Defect in regulated secretion of P-selectin affects leukocyte recruitment in von Willebrand factor-deficient mice","volume":"98","author":"Denis","year":"2001","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Research and Practice in Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037922022798?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037922022798?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:24:59Z","timestamp":1762863899000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2475037922022798"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["S2475037922022798"],"URL":"https:\/\/doi.org\/10.1016\/j.rpth.2022.100028","relation":{},"ISSN":["2475-0379"],"issn-type":[{"value":"2475-0379","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Spatiotemporal profile of neutrophil extracellular trap formation in a mouse model of ischemic stroke","name":"articletitle","label":"Article Title"},{"value":"Research and Practice in Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rpth.2022.100028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis.","name":"copyright","label":"Copyright"}],"article-number":"100028"}}