{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T10:36:15Z","timestamp":1787654175534,"version":"build-2736575974"},"reference-count":88,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T00:00:00Z","timestamp":1673568000000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012028","name":"Trombosestichting Nederland","doi-asserted-by":"publisher","award":["2018-02"],"award-info":[{"award-number":["2018-02"]}],"id":[{"id":"10.13039\/501100012028","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rpthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research and Practice in Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.rpth.2023.100055","type":"journal-article","created":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T12:52:34Z","timestamp":1674219154000},"page":"100055","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Fibrin clot properties and thrombus composition in cirrhosis"],"prefix":"10.1016","volume":"7","author":[{"given":"Ellen G.","family":"Driever","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ton","family":"Lisman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rpth.2023.100055_bib1","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1182\/blood-2010-02-261891","article-title":"Rebalanced hemostasis in patients with liver disease: evidence and clinical consequences","volume":"116","author":"Lisman","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2023.100055_bib2","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1111\/j.1538-7836.2012.04770.x","article-title":"Intact thrombin generation and decreased fibrinolytic capacity in patients with acute liver injury or acute liver failure","volume":"10","author":"Lisman","year":"2012","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.rpth.2023.100055_bib3","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1586\/17474124.2014.934673","article-title":"Management of coagulation abnormalities in liver disease","volume":"9","author":"Potze","year":"2015","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.rpth.2023.100055_bib4","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1002\/hep.20569","article-title":"Evidence of normal thrombin generation in cirrhosis despite abnormal conventional coagulation tests","volume":"41","author":"Tripodi","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.rpth.2023.100055_bib5","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/rth2.12028","article-title":"Pathogenesis, prevention, and management of bleeding and thrombosis in patients with liver diseases","volume":"1","author":"Lisman","year":"2017","journal-title":"Res Pract Thromb Haemost"},{"key":"10.1016\/j.rpth.2023.100055_bib6","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1111\/jth.13280","article-title":"Transport physics and biorheology in the setting of hemostasis and thrombosis","volume":"14","author":"Brass","year":"2016","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.rpth.2023.100055_bib7","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1161\/ATVBAHA.120.315754","article-title":"Thrombus structural composition in cardiovascular disease","volume":"41","author":"Alkarithi","year":"2021","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.rpth.2023.100055_bib8","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1016\/S0049-3848(16)30358-9","article-title":"Novel mechanisms that regulate clot structure\/function","volume":"141","author":"Ari\u00ebns","year":"2016","journal-title":"Thromb Res"},{"key":"10.1016\/j.rpth.2023.100055_bib9","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1055\/s-0038-1676954","article-title":"Haemostatic profiles are similar across all aetiologies of cirrhosis","volume":"119","author":"Bos","year":"2019","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.rpth.2023.100055_bib10","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jcrc.2017.07.053","article-title":"Balanced haemostasis with both hypo- and hyper-coagulable features in critically ill patients with acute-on-chronic-liver failure","volume":"43","author":"Fisher","year":"2018","journal-title":"J\u00a0Crit Care"},{"key":"10.1016\/j.rpth.2023.100055_bib11","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1016\/j.jhep.2012.06.026","article-title":"Acute-on chronic liver failure","volume":"57","author":"Jalan","year":"2012","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.rpth.2023.100055_bib12","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1055\/s-0036-1571339","article-title":"Clinical features and management of congenital fibrinogen deficiencies","volume":"42","author":"Casini","year":"2016","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.rpth.2023.100055_bib13","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1002\/hep.28628","article-title":"Coagulation parameters and major bleeding in critically ill patients with cirrhosis","volume":"64","author":"Drolz","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.rpth.2023.100055_bib14","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1055\/a-1355-3716","article-title":"Transfusion with cryoprecipitate for very low fibrinogen levels does not affect bleeding or survival in critically ill cirrhosis patients","volume":"121","author":"Budnick","year":"2021","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.rpth.2023.100055_bib15","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1111\/liv.15132","article-title":"Fibrin clot quality in acutely ill cirrhosis patients: relation with outcome and improvement with coagulation factor concentrates","volume":"42","author":"Blasi","year":"2022","journal-title":"Liver Int"},{"key":"10.1016\/j.rpth.2023.100055_bib16","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1111\/jth.13167","article-title":"Ex\u00a0vivo addition of fibrinogen concentrate improves the fibrin network structure in plasma samples taken during liver transplantation","volume":"13","author":"Groeneveld","year":"2015","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.rpth.2023.100055_bib17","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1055\/s-0036-1571340","article-title":"Laboratory and genetic investigation of mutations accounting for congenital fibrinogen disorders","volume":"42","author":"Neerman-Arbez","year":"2016","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.rpth.2023.100055_bib18","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/978-3-030-58971-4_15","article-title":"Fibrinogen and fibrin","volume":"96","author":"Litvinov","year":"2021","journal-title":"Subcell Biochem"},{"key":"10.1016\/j.rpth.2023.100055_bib19","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/0167-4838(89)90140-4","article-title":"Native fibrin gel networks observed by 3D microscopy, permeation and turbidity","volume":"997","author":"Blomb\u00e4ck","year":"1989","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.rpth.2023.100055_bib20","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/0049-3848(94)90227-5","article-title":"Fibrin in human plasma: gel architectures governed by rate and nature of fibrinogen activation","volume":"75","author":"Blomb\u00e4ck","year":"1994","journal-title":"Thromb Res"},{"key":"10.1016\/j.rpth.2023.100055_bib21","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.transci.2007.12.005","article-title":"Thrombin generation, fibrin clot formation and hemostasis","volume":"38","author":"Wolberg","year":"2008","journal-title":"Transfus Apher Sci"},{"key":"10.1016\/j.rpth.2023.100055_bib22","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.thromres.2020.01.001","article-title":"Fibrin clot formation under diverse clotting conditions: comparing turbidimetry and thromboelastography","volume":"187","author":"Zeng","year":"2020","journal-title":"Thromb Res"},{"key":"10.1016\/j.rpth.2023.100055_bib23","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.thromres.2014.07.010","article-title":"Thrombomodulin-modified thrombin generation testing detects a hypercoagulable state in patients with cirrhosis regardless of the exact experimental conditions","volume":"134","author":"Groeneveld","year":"2014","journal-title":"Thromb Res"},{"key":"10.1016\/j.rpth.2023.100055_bib24","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/rth2.12037","article-title":"Thromboelastography does not predict outcome in different etiologies of cirrhosis","volume":"1","author":"Hugenholtz","year":"2017","journal-title":"Res Pract Thromb Haemost"},{"key":"10.1016\/j.rpth.2023.100055_bib25","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1172\/JCI108773","article-title":"Dysfibrinogenemia associated with liver disease","volume":"60","author":"Palascak","year":"1977","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.rpth.2023.100055_bib26","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1136\/jcp.35.6.667","article-title":"Acquired dysfibrinogenaemia in liver disease","volume":"35","author":"Francis","year":"1982","journal-title":"J\u00a0Clin Pathol"},{"key":"10.1016\/j.rpth.2023.100055_bib27","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1172\/JCI108964","article-title":"Abnormal sialic acid content of the dysfibrinogenemia associated with liver disease","volume":"61","author":"Martinez","year":"1978","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.rpth.2023.100055_bib28","doi-asserted-by":"crossref","first-page":"15104","DOI":"10.1016\/S0021-9258(18)63817-7","article-title":"Fibrinogen sialic acid residues are low affinity calcium-binding sites that influence fibrin assembly","volume":"264","author":"Dang","year":"1989","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.rpth.2023.100055_bib29","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/978-3-319-49674-0_13","article-title":"Fibrin formation, structure and properties","volume":"82","author":"Weisel","year":"2017","journal-title":"Subcell Biochem"},{"key":"10.1016\/j.rpth.2023.100055_bib30","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1055\/s-0036-1572353","article-title":"The (patho)physiology of fibrinogen \u03b3","volume":"42","author":"Macrae","year":"2016","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.rpth.2023.100055_bib31","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1111\/jth.13278","article-title":"Procoagulant changes in fibrin clot structure in patients with cirrhosis are associated with oxidative modifications of fibrinogen","volume":"14","author":"Hugenholtz","year":"2016","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.rpth.2023.100055_bib32","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.1161\/ATVBAHA.117.308564","article-title":"Fibrinogen and fibrin in hemostasis and thrombosis","volume":"37","author":"Kattula","year":"2017","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.rpth.2023.100055_bib33","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1182\/bloodadvances.2017011890","article-title":"Factor XIII in plasma, but not in platelets, mediates red blood cell retention in clots and venous thrombus size in mice","volume":"2","author":"Kattula","year":"2018","journal-title":"Blood Adv"},{"key":"10.1016\/j.rpth.2023.100055_bib34","doi-asserted-by":"crossref","first-page":"3590","DOI":"10.1172\/JCI75386","article-title":"Factor XIII activity mediates red blood cell retention in venous thrombi","volume":"124","author":"Aleman","year":"2014","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.rpth.2023.100055_bib35","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/j.hoc.2021.07.011","article-title":"Disorders of fibrinogen and fibrinolysis","volume":"35","author":"May","year":"2021","journal-title":"Hematol Oncol Clin North Am"},{"key":"10.1016\/j.rpth.2023.100055_bib36","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1161\/ATVBAHA.119.313626","article-title":"Effects of post-translational modifications of fibrinogen on clot formation, clot structure, and fibrinolysis: a systematic review","volume":"40","author":"de Vries","year":"2020","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.rpth.2023.100055_bib37","doi-asserted-by":"crossref","first-page":"7965","DOI":"10.1007\/s00216-018-1418-7","article-title":"Fast and facile analysis of glycosylation and phosphorylation of fibrinogen from human plasma\u2014correlation with liver cancer and liver cirrhosis","volume":"410","author":"Nagel","year":"2018","journal-title":"Anal Bioanal Chem"},{"key":"10.1016\/j.rpth.2023.100055_bib38","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/j.1749-6632.1983.tb23259.x","article-title":"The abnormal carbohydrate composition of the dysfibrinogenemia associated with liver disease","volume":"408","author":"Martinez","year":"1983","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.rpth.2023.100055_bib39","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1055\/s-0036-1572327","article-title":"Alterations in fibrin structure in patients with liver diseases","volume":"42","author":"Lisman","year":"2016","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.rpth.2023.100055_bib40","doi-asserted-by":"crossref","first-page":"15056","DOI":"10.1016\/S0021-9258(18)68145-1","article-title":"Deglycosylation of fibrinogen accelerates polymerization and increases lateral aggregation of fibrin fibers","volume":"263","author":"Langer","year":"1988","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.rpth.2023.100055_bib41","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1182\/blood.2020007415","article-title":"Factor XIII cross-links fibrin(ogen) independent of fibrin polymerization in experimental acute liver injury","volume":"137","author":"Poole","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2023.100055_bib42","doi-asserted-by":"crossref","first-page":"8820","DOI":"10.1074\/jbc.M306101200","article-title":"Pro-thrombotic state induced by post-translational modification of fibrinogen by reactive nitrogen species","volume":"279","author":"Vadseth","year":"2004","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.rpth.2023.100055_bib43","doi-asserted-by":"crossref","first-page":"33846","DOI":"10.1074\/jbc.M805522200","article-title":"Fibrinogen \u03b2-chain tyrosine nitration is a prothrombotic risk factor","volume":"283","author":"Parastatidis","year":"2008","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.rpth.2023.100055_bib44","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1161\/ATVBAHA.114.303785","article-title":"Oxidative modification of fibrinogen is associated with altered function and structure in the subacute phase of myocardial infarction","volume":"34","author":"Becatti","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.rpth.2023.100055_bib45","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.freeradbiomed.2009.10.044","article-title":"Increased thrombin-induced polymerization of fibrinogen associated with high protein carbonyl levels in plasma from patients post myocardial infarction","volume":"48","author":"Paton","year":"2010","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.rpth.2023.100055_bib46","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1111\/jth.15313","article-title":"PAD4 takes charge during neutrophil activation: impact of PAD4 mediated NET formation on immune-mediated disease","volume":"19","author":"Liu","year":"2021","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.rpth.2023.100055_bib47","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1055\/s-0040-1715474","article-title":"Netting liver disease: neutrophil extracellular traps in the initiation and exacerbation of liver pathology","volume":"46","author":"Meijenfeldt","year":"2020","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.rpth.2023.100055_bib48","doi-asserted-by":"crossref","first-page":"4177","DOI":"10.4049\/jimmunol.166.6.4177","article-title":"The major synovial targets of the rheumatoid arthritis-specific antifilaggrin autoantibodies are deiminated forms of the \u03b1- and \u03b2-chains of fibrin","volume":"166","author":"Masson-Bessi\u00e8re","year":"2001","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.rpth.2023.100055_bib49","doi-asserted-by":"crossref","first-page":"2862","DOI":"10.1111\/jth.15875","article-title":"Citrullinated fibrinogen forms densely packed clots with decreased permeability","volume":"20","author":"Varj\u00fa","year":"2022","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.rpth.2023.100055_bib50","doi-asserted-by":"crossref","first-page":"e251","DOI":"10.1016\/j.thromres.2012.03.014","article-title":"Monomeric C-reactive protein alters fibrin clot properties on endothelial cells","volume":"129","author":"Li","year":"2012","journal-title":"Thromb Res"},{"key":"10.1016\/j.rpth.2023.100055_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.jprot.2020.103946","article-title":"Plasma fibrin clot proteomics in patients with acute pulmonary embolism: association with clot properties","volume":"229","author":"Bryk","year":"2020","journal-title":"J\u00a0Proteomics"},{"key":"10.1016\/j.rpth.2023.100055_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.jprot.2019.103487","article-title":"Plasma fibrin clot proteomics in healthy subjects: relation to clot permeability and lysis time","volume":"208","author":"Z\u0105bczyk","year":"2019","journal-title":"J\u00a0Proteomics"},{"key":"10.1016\/j.rpth.2023.100055_bib53","first-page":"330","article-title":"Fibrinolysis in chronic hepatic insufficiency","volume":"25","author":"Goodpasture","year":"1914","journal-title":"Bull Johns Hopkins Hosp"},{"key":"10.1016\/j.rpth.2023.100055_bib54","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1053\/jhep.2003.50277","article-title":"Deficiency of thrombin activatable fibrinolysis inhibitor in cirrhosis is associated with increased plasma fibrinolysis","volume":"38","author":"Colucci","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.rpth.2023.100055_bib55","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1016\/0016-5085(91)90092-Y","article-title":"A\u00a0shift in balance between profibrinolytic and antifibrinolytic factors causes enhanced fibrinolysis in cirrhosis","volume":"101","author":"Leebeek","year":"1991","journal-title":"Gastroenterology"},{"key":"10.1016\/j.rpth.2023.100055_bib56","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1053\/gast.2001.25481","article-title":"Thrombin-activatable fibrinolysis inhibitor deficiency in cirrhosis is not associated with increased plasma fibrinolysis","volume":"121","author":"Lisman","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.rpth.2023.100055_bib57","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1055\/s-0035-1550437","article-title":"The fibrinolytic status in liver diseases","volume":"41","author":"Leebeek","year":"2015","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.rpth.2023.100055_bib58","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1055\/s-0040-1718924","article-title":"Fibrinolysis in patients with liver disease","volume":"47","author":"von Meijenfeldt","year":"2021","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.rpth.2023.100055_bib59","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1111\/j.1538-7836.2012.04901.x","article-title":"Evidence for an enhanced fibrinolytic capacity in cirrhosis as measured with two different global fibrinolysis tests","volume":"10","author":"Rijken","year":"2012","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.rpth.2023.100055_bib60","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/j.jhep.2016.06.001","article-title":"Preserved hemostatic status in patients with non-alcoholic fatty liver disease","volume":"65","author":"Potze","year":"2016","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.rpth.2023.100055_bib61","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1002\/hep.30915","article-title":"Mixed fibrinolytic phenotypes in decompensated cirrhosis and acute-on-chronic liver failure with hypofibrinolysis in those with complications and poor survival","volume":"71","author":"Blasi","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.rpth.2023.100055_bib62","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.thromres.2016.11.007","article-title":"Coagulation and sepsis","volume":"149","author":"Levi","year":"2017","journal-title":"Thromb Res"},{"key":"10.1016\/j.rpth.2023.100055_bib63","first-page":"2002","article-title":"Impaired fibrinolysis in patients with isolated aortic stenosis is associated with enhanced oxidative stress","volume":"9","author":"Siudut","year":"2020","journal-title":"J\u00a0Clin Med"},{"key":"10.1016\/j.rpth.2023.100055_bib64","doi-asserted-by":"crossref","first-page":"e88","DOI":"10.1161\/ATVBAHA.111.230631","article-title":"Fibrin clot structure and function: a role in the pathophysiology of arterial and venous thromboembolic diseases","volume":"31","author":"Undas","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.rpth.2023.100055_bib65","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1039\/C9SM01973A","article-title":"Poroelasticity of (bio)polymer networks during compression: theory and experiment","volume":"16","author":"Punter","year":"2020","journal-title":"Soft Matter"},{"key":"10.1016\/j.rpth.2023.100055_bib66","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1155\/2009\/591317","article-title":"Abnormal hematological indices in cirrhosis","volume":"23","author":"Qamar","year":"2009","journal-title":"Can J Gastroenterol"},{"key":"10.1016\/j.rpth.2023.100055_bib67","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1097\/MBC.0b013e328335d0e4","article-title":"Thrombocytopenia affects plasmatic coagulation as measured by thrombelastography","volume":"21","author":"Roeloffzen","year":"2010","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1016\/j.rpth.2023.100055_bib68","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1182\/blood-2017-03-745349","article-title":"Red blood cells in thrombosis","volume":"130","author":"Byrnes","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2023.100055_bib69","doi-asserted-by":"crossref","first-page":"5112","DOI":"10.1038\/s41598-020-59526-x","article-title":"The distinctive structure and composition of arterial and venous thrombi and pulmonary emboli","volume":"10","author":"Chernysh","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.rpth.2023.100055_bib70","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-35849-8","article-title":"Shape changes of erythrocytes during blood clot contraction and the structure of polyhedrocytes","volume":"8","author":"Tutwiler","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.rpth.2023.100055_bib71","doi-asserted-by":"crossref","first-page":"e104","DOI":"10.1055\/s-0038-1635572","article-title":"Reduced contraction of blood clots in venous thromboembolism is a potential thrombogenic and embologenic mechanism","volume":"2","author":"Peshkova","year":"2018","journal-title":"TH Open"},{"key":"10.1016\/j.rpth.2023.100055_bib72","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/jth.14370","article-title":"Blood clot contraction differentially modulates internal and external fibrinolysis","volume":"17","author":"Tutwiler","year":"2019","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.rpth.2023.100055_bib73","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1002\/hep.32169","article-title":"Non-malignant portal vein thrombi in patients with cirrhosis consist of intimal fibrosis with or without a fibrin-rich thrombus","volume":"75","author":"Driever","year":"2022","journal-title":"Hepatology"},{"key":"10.1016\/j.rpth.2023.100055_bib74","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1007\/s00392-019-01425-x","article-title":"Polyhedral erythrocytes in intracoronary thrombus and their association with reperfusion in myocardial infarction","volume":"108","author":"Zalewski","year":"2019","journal-title":"Clin Res Cardiol"},{"key":"10.1016\/j.rpth.2023.100055_bib75","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1136\/gut.19.9.844","article-title":"Membrane lipid composition of red blood cells in liver disease: regression of spur cell anaemia after infusion of polyunsaturated phosphatidylcholine","volume":"19","author":"Salvioli","year":"1978","journal-title":"Gut"},{"key":"10.1016\/j.rpth.2023.100055_bib76","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/S0022-2275(20)38181-5","article-title":"Decreased erythrocyte membrane fluidity and altered lipid composition in human liver disease","volume":"23","author":"Owen","year":"1982","journal-title":"J\u00a0Lipid Res"},{"key":"10.1016\/j.rpth.2023.100055_bib77","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2478\/jtim-2018-0001","article-title":"Timing of anticoagulation for portal vein thrombosis in liver cirrhosis: a US hepatologist\u2019s perspective","volume":"6","author":"Northup","year":"2018","journal-title":"J\u00a0Transl Int Med"},{"key":"10.1016\/j.rpth.2023.100055_bib78","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1055\/s-0042-1742438","article-title":"Effects of inflammation on hemostasis in acutely ill patients with liver disease","volume":"48","author":"Driever","year":"2022","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.rpth.2023.100055_bib79","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jhep.2019.09.030","article-title":"Von Willebrand factor delays liver repair after acetaminophen-induced acute liver injury in mice","volume":"72","author":"Groeneveld","year":"2020","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.rpth.2023.100055_bib80","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1002\/hep.21779","article-title":"Role of the coagulation system in acetaminophen-induced hepatotoxicity in mice","volume":"46","author":"Ganey","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.rpth.2023.100055_bib81","article-title":"Dysregulated fibrinogen \u03b3-chain cross-linking in Fib\u03b3\u03945 mice drives acute liver injury after acetaminophen overdose [Abstract]","volume":"6","author":"Poole","year":"2022","journal-title":"Res Pract Thromb Haemost"},{"key":"10.1016\/j.rpth.2023.100055_bib82","article-title":"Both \u03b1- and \u03b3-chain crosslinks mediated by FXIIIa affect fibrin fibre resistance to rupture","volume":"6","author":"Feller","year":"2022","journal-title":"Res Pract Thromb Haemost"},{"key":"10.1016\/j.rpth.2023.100055_bib83","article-title":"A\u00a0new mouse model of impaired fibrin \u03b1-chain crosslinking shows increased venous thromboembolism [Abstract]","volume":"6","author":"Duval","year":"2022","journal-title":"Res Pract Thromb Haemost"},{"key":"10.1016\/j.rpth.2023.100055_bib84","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2103226118","article-title":"Elimination of fibrin \u03b3-chain cross-linking by FXIIIa increases pulmonary embolism arising from murine inferior vena cava thrombi","volume":"118","author":"Duval","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.rpth.2023.100055_bib85","article-title":"A\u00a0zebrafish model of dysfibrinogenemia caused by hotspot mutations in the human fibrinogen gamma chain [Abstract]","volume":"6","author":"Fish","year":"2022","journal-title":"Res Pract Thromb Haemost"},{"key":"10.1016\/j.rpth.2023.100055_bib86","article-title":"Antithrombin deficiency is associated with more compact plasma fibrin clot structure and impaired susceptibility to fibrinolysis [Abstract]","volume":"6","author":"Klajmon","year":"2022","journal-title":"Res Pract Thromb Haemost"},{"key":"10.1016\/j.rpth.2023.100055_bib87","article-title":"Neutrophil cathepsin G cleaves fibrinogen affecting clot structure [Abstract]","volume":"6","author":"Smith","year":"2022","journal-title":"Res Pract Thromb Haemost"},{"key":"10.1016\/j.rpth.2023.100055_bib88","article-title":"Effects of clot contraction on clot degradation: a mathematical and experimental approach [Abstract]","volume":"6","author":"Risman","year":"2022","journal-title":"Res Pract Thromb Haemost"}],"container-title":["Research and Practice in Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037923000201?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037923000201?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:25:43Z","timestamp":1762863943000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2475037923000201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":88,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["S2475037923000201"],"URL":"https:\/\/doi.org\/10.1016\/j.rpth.2023.100055","relation":{},"ISSN":["2475-0379"],"issn-type":[{"value":"2475-0379","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fibrin clot properties and thrombus composition in cirrhosis","name":"articletitle","label":"Article Title"},{"value":"Research and Practice in Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rpth.2023.100055","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis.","name":"copyright","label":"Copyright"}],"article-number":"100055"}}