{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:26:16Z","timestamp":1787739976895,"version":"build-2784847793"},"reference-count":42,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["rpthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research and Practice in Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.rpth.2023.100100","type":"journal-article","created":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T17:03:07Z","timestamp":1678208587000},"page":"100100","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Sepsis-induced coagulopathy in preterm neonates with Gram-positive sepsis presents with hypercoagulation and reduced platelet activation compared with healthy preterm neonates"],"prefix":"10.1016","volume":"7","author":[{"given":"Dimitra","family":"Gialamprinou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos-Georgios","family":"Kontovazainitis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham","family":"Pouliakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Fleva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Markopoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria\u2013Elina","family":"Bessina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios N.","family":"Katsaras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilias","family":"Chatziioannidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Giannakou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Roilides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisavet","family":"Diamanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Mitsiakos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rpth.2023.100100_bib1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S2213-2600(18)30063-8","article-title":"The global burden of paediatric and neonatal sepsis: a systematic review","volume":"6","author":"Fleischmann-Struzek","year":"2018","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.rpth.2023.100100_bib2","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1542\/peds.103.2.446","article-title":"Causes of death in the extremely low birth weight infant","volume":"103","author":"Barton","year":"1999","journal-title":"Pediatrics"},{"key":"10.1016\/j.rpth.2023.100100_bib3","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41390-020-0785-x","article-title":"Challenges in developing a consensus definition of neonatal sepsis","volume":"88","author":"McGovern","year":"2020","journal-title":"Pediatr Res"},{"key":"10.1016\/j.rpth.2023.100100_bib4","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.rpth.2023.100100_bib5","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1056\/NEJMra1208623","article-title":"Severe sepsis and septic shock","volume":"369","author":"Angus","year":"2013","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.rpth.2023.100100_bib6","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.4049\/jimmunol.1101094","article-title":"Protective roles for fibrin, tissue factor, plasminogen activator inhibitor-1, and thrombin activatable fibrinolysis inhibitor, but not factor XI, during defense against the gram-negative bacterium Yersinia enterocolitica","volume":"187","author":"Luo","year":"2011","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.rpth.2023.100100_bib7","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nri3345","article-title":"Thrombosis as an intravascular effector of innate immunity","volume":"13","author":"Engelmann","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.rpth.2023.100100_bib8","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.chom.2012.06.011","article-title":"Intravascular neutrophil extracellular traps capture bacteria from the bloodstream during sepsis","volume":"12","author":"McDonald","year":"2012","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.rpth.2023.100100_bib9","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/j.1365-2141.2009.07600.x","article-title":"Guidelines for the diagnosis and management of disseminated intravascular coagulation. British committee for standards in haematology","volume":"145","author":"Levi","year":"2009","journal-title":"Br J Haematol"},{"key":"10.1016\/j.rpth.2023.100100_bib10","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1111\/jth.14578","article-title":"Diagnosis and management of sepsis-induced coagulopathy and disseminated intravascular coagulation","volume":"17","author":"Iba","year":"2019","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.rpth.2023.100100_bib11","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.clp.2010.04.002","article-title":"Pathophysiology and treatment of septic shock in neonates","volume":"37","author":"Wynn","year":"2010","journal-title":"Clin Perinatol"},{"key":"10.1016\/j.rpth.2023.100100_bib12","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1046\/j.1365-2141.2002.03674.x","article-title":"The investigation and management of neonatal haemostasis and thrombosis","volume":"119","author":"Williams","year":"2002","journal-title":"Br J Haematol"},{"key":"10.1016\/j.rpth.2023.100100_bib13","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1160\/TH05-01-0047","article-title":"Developmental haemostasis. Impact for clinical haemostasis laboratories","volume":"95","author":"Monagle","year":"2006","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.rpth.2023.100100_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0183042","article-title":"Comprehensive comparison of neonate and adult human platelet transcriptomes","volume":"12","author":"Caparr\u00f3s-P\u00e9rez","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.rpth.2023.100100_bib15","series-title":"Report on the Expert Meeting on Neonatal and Paediatric Sepsis 8 June 2010","year":"2010"},{"key":"10.1016\/j.rpth.2023.100100_bib16","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/s41390-020-0850-5","article-title":"Neonatal sepsis: need for consensus definition, collaboration and core outcomes","volume":"88","author":"Molloy","year":"2020","journal-title":"Pediatr Res"},{"key":"10.1016\/j.rpth.2023.100100_bib17","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1067\/mpd.2001.109608","article-title":"SNAP-II and SNAPPE-II: simplified newborn illness severity and mortality risk scores","volume":"138","author":"Richardson","year":"2001","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.rpth.2023.100100_bib18","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/BF00442511","article-title":"Early diagnosis of septicemia in the newborn. Clinical studies and sepsis score","volume":"138","author":"T\u00f6llner","year":"1982","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.rpth.2023.100100_bib19","doi-asserted-by":"crossref","first-page":"e178","DOI":"10.1002\/cpz1.178","article-title":"Immunophenotypic analysis of platelets by flow cytometry","volume":"1","author":"Spurgeon","year":"2021","journal-title":"Curr Protoc"},{"key":"10.1016\/j.rpth.2023.100100_bib20","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/BF01372152","article-title":"Prediction of neonatal sepsis by thromboelastography","volume":"12","author":"Grant","year":"1997","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.rpth.2023.100100_bib21","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s00431-017-3072-z","article-title":"Thromboelastometry for diagnosis of neonatal sepsis-associated coagulopathy: an observational study","volume":"177","author":"Sokou","year":"2018","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.rpth.2023.100100_bib22","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1182\/blood-2015-01-624023","article-title":"P-selectin promotes neutrophil extracellular trap formation in mice","volume":"126","author":"Etulain","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2023.100100_bib23","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3324\/haematol.2016.142471","article-title":"Propagation of thrombosis by neutrophils and extracellular nucleosome networks","volume":"102","author":"Pfeiler","year":"2017","journal-title":"Haematologica"},{"key":"10.1016\/j.rpth.2023.100100_bib24","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1126\/science.1092385","article-title":"Neutrophil extracellular traps kill bacteria","volume":"303","author":"Brinkmann","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.rpth.2023.100100_bib25","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1471-2431-11-16","article-title":"Thrombocytopenia in neonates and the risk of intraventricular hemorrhage: a retrospective cohort study","volume":"11","author":"von Lindern","year":"2011","journal-title":"BMC Pediatr"},{"key":"10.1016\/j.rpth.2023.100100_bib26","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/j.1365-3148.2012.01171.x","article-title":"Severe thrombocytopenia and patterns of bleeding in neonates: results from a prospective observational study and implications for use of platelet transfusions","volume":"22","author":"Muthukumar","year":"2012","journal-title":"Transfus Med"},{"key":"10.1016\/j.rpth.2023.100100_bib27","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1038\/s41390-019-0316-9","article-title":"Flow cytometry for near-patient testing in premature neonates reveals variation in platelet function: a novel approach to guide platelet transfusion","volume":"85","author":"Waller","year":"2019","journal-title":"Pediatr Res"},{"key":"10.1016\/j.rpth.2023.100100_bib28","doi-asserted-by":"crossref","first-page":"535","DOI":"10.3109\/09537104.2016.1148129","article-title":"Human platelet activation by Escherichia coli: roles for Fc\u03b3RIIA and integrin \u03b1IIb\u03b23","volume":"27","author":"Watson","year":"2016","journal-title":"Platelets"},{"key":"10.1016\/j.rpth.2023.100100_bib29","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nrmicro3521","article-title":"Staphylococcal manipulation of host immune responses","volume":"13","author":"Thammavongsa","year":"2015","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.rpth.2023.100100_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002355","article-title":"Novel anti-bacterial activities of \u03b2-defensin 1 in human platelets: suppression of pathogen growth and signaling of neutrophil extracellular trap formation","volume":"7","author":"Kraemer","year":"2011","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.rpth.2023.100100_bib31","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1182\/blood-2011-03-343061","article-title":"Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4","volume":"118","author":"Semeraro","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2023.100100_bib32","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nrmicro1425","article-title":"The interaction of bacterial pathogens with platelets","volume":"4","author":"Fitzgerald","year":"2006","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.rpth.2023.100100_bib33","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1080\/09537100400016862","article-title":"Neonatal platelets from cord blood and peripheral blood","volume":"16","author":"Sitaru","year":"2005","journal-title":"Platelets"},{"key":"10.1016\/j.rpth.2023.100100_bib34","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1080\/09537104.2020.1786040","article-title":"Platelet count and function in umbilical cord blood versus peripheral blood in term neonates","volume":"32","author":"Grevsen","year":"2021","journal-title":"Platelets"},{"key":"10.1016\/j.rpth.2023.100100_bib35","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1055\/s-0038-1648990","article-title":"Neonatal platelets are less reactive than adult platelets to physiological agonists in whole blood","volume":"72","author":"Rajasekhar","year":"1994","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.rpth.2023.100100_bib36","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/s41390-018-0184-8","article-title":"Impaired platelet activity and hypercoagulation in healthy term and moderately preterm newborns during the early neonatal period","volume":"85","author":"Koltsova","year":"2019","journal-title":"Pediatr Res"},{"key":"10.1016\/j.rpth.2023.100100_bib37","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1111\/jth.13414","article-title":"Dynamic platelet function on von Willebrand factor is different in preterm neonates and full-term neonates: changes in neonatal platelet function","volume":"14","author":"Cowman","year":"2016","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.rpth.2023.100100_bib38","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1080\/09537100701882046","article-title":"The effect of gestational age on platelet surface expression of CD62P in preterm newborns","volume":"19","author":"Wasiluk","year":"2008","journal-title":"Platelets"},{"key":"10.1016\/j.rpth.2023.100100_bib39","doi-asserted-by":"crossref","DOI":"10.1002\/rth2.12751","article-title":"Reduced platelet function in preterm neonates compared with term neonates","volume":"6","author":"Hovgesen","year":"2022","journal-title":"Res Pract Thromb Haemost"},{"key":"10.1016\/j.rpth.2023.100100_bib40","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1055\/s-2007-996049","article-title":"Platelet function in the newborn","volume":"24","author":"Michelson","year":"1998","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.rpth.2023.100100_bib41","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.thromres.2008.10.004","article-title":"The platelet hyporeactivity of extremely low birth weight neonates is age-dependent","volume":"124","author":"Bednarek","year":"2009","journal-title":"Thromb Res"},{"key":"10.1016\/j.rpth.2023.100100_bib42","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/jth.15567","article-title":"Not one, but many forms of thrombosis proteins","volume":"20","author":"Pijning","year":"2022","journal-title":"J\u00a0Thromb Haemost"}],"container-title":["Research and Practice in Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037923000699?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037923000699?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:26:25Z","timestamp":1762863985000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2475037923000699"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["S2475037923000699"],"URL":"https:\/\/doi.org\/10.1016\/j.rpth.2023.100100","relation":{},"ISSN":["2475-0379"],"issn-type":[{"value":"2475-0379","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sepsis-induced coagulopathy in preterm neonates with Gram-positive sepsis presents with hypercoagulation and reduced platelet activation compared with healthy preterm neonates","name":"articletitle","label":"Article Title"},{"value":"Research and Practice in Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rpth.2023.100100","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis.","name":"copyright","label":"Copyright"}],"article-number":"100100"}}