{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T08:25:07Z","timestamp":1773044707160,"version":"3.50.1"},"reference-count":31,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,25]],"date-time":"2023-03-25T00:00:00Z","timestamp":1679702400000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["rpthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research and Practice in Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.rpth.2023.100139","type":"journal-article","created":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T23:24:04Z","timestamp":1680218644000},"page":"100139","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["A comparative study in patients with type 2 von Willebrand disease using 4 different platelet-dependent von Willebrand factor assays"],"prefix":"10.1016","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4180-6011","authenticated-orcid":false,"given":"Paola","family":"Colpani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1186-6005","authenticated-orcid":false,"given":"Luciano","family":"Baronciani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5214-0580","authenticated-orcid":false,"given":"Francesca","family":"Stufano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0267-3773","authenticated-orcid":false,"given":"Giovanna","family":"Cozzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1917-5535","authenticated-orcid":false,"given":"Marco","family":"Boscarino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0778-2271","authenticated-orcid":false,"given":"Maria Teresa","family":"Pagliari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1818-3872","authenticated-orcid":false,"given":"Eugenia","family":"Biguzzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7423-9864","authenticated-orcid":false,"given":"Flora","family":"Peyvandi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.rpth.2023.100139_bib1","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1182\/blood.V69.2.454.454","article-title":"Epidemiological investigation of the prevalence of von Willebrand's disease","volume":"69","author":"Rodeghiero","year":"1987","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2023.100139_bib2","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1056\/NEJMra1601561","article-title":"Von Willebrand\u2019s disease","volume":"375","author":"Leebeek","year":"2016","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.rpth.2023.100139_bib3","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1111\/j.1538-7836.2006.02146.x","article-title":"Update on the pathophysiology and classification of von Willebrand disease: a report of the Subcommittee on von Willebrand factor","volume":"4","author":"Sadler","year":"2006","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.rpth.2023.100139_bib4","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1365-2516.2007.01643.x","article-title":"von Willebrand disease (VWD): evidence-based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA)","volume":"14","author":"Nichols","year":"2008","journal-title":"Haemophilia"},{"key":"10.1016\/j.rpth.2023.100139_bib5","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.thromres.2019.07.010","article-title":"How we make an accurate diagnosis of von Willebrand disease","volume":"196","author":"Baronciani","year":"2020","journal-title":"Thromb Res"},{"key":"10.1016\/j.rpth.2023.100139_bib6","first-page":"41","article-title":"Perils, problems, and progress in laboratory diagnosis of von Willebrand disease","volume":"40","author":"Flood","year":"2014","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.rpth.2023.100139_bib7","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1182\/blood-2014-08-528398","article-title":"Diagnostic approach to von Willebrand disease","volume":"125","author":"Ng","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2023.100139_bib8","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1182\/blood.V41.5.687.687","article-title":"Ristocetin: a means of differentiating von Willebrand\u2019s disease into two groups","volume":"41","author":"Howard","year":"1973","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2023.100139_bib9","doi-asserted-by":"crossref","first-page":"E25","DOI":"10.1177\/1076029610379848","article-title":"Evaluation of an automated von Willebrand factor activity assay in von Willebrand disease","volume":"17","author":"Trossa\u00ebrt","year":"2011","journal-title":"Clin Appl Thromb Hemost"},{"key":"10.1016\/j.rpth.2023.100139_bib10","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1111\/jth.12964","volume":"13","author":"Bod\u00f3","year":"2015","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.rpth.2023.100139_bib11","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/hae.12264","article-title":"A\u00a0two-centre comparative evaluation of new automated assays for von Willebrand factor ristocetin cofactor activity and antigen","volume":"20","author":"Stufano","year":"2014","journal-title":"Haemophilia"},{"key":"10.1016\/j.rpth.2023.100139_bib12","doi-asserted-by":"crossref","first-page":"712","DOI":"10.3324\/haematol.10766","article-title":"Evaluation of a new turbidimetric assay for von Willebrand factor activity useful in the general screening of von Willebrand disease","volume":"92","author":"Pi\u00f1ol","year":"2007","journal-title":"Haematologica"},{"key":"10.1016\/j.rpth.2023.100139_bib13","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1182\/blood-2010-08-299016","article-title":"Gain-of-function GPIb ELISA assay for VWF activity in the Zimmerman Program for the molecular and clinical biology of VWD","volume":"117","author":"Flood","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2023.100139_bib14","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1097\/MBC.0000000000000169","article-title":"Performance evaluation and multicentre study of a von Willebrand factor activity assay based on GPIb binding in the absence of ristocetin","volume":"25","author":"Patzke","year":"2014","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1016\/j.rpth.2023.100139_bib15","doi-asserted-by":"crossref","first-page":"610","DOI":"10.3324\/haematol.2009.005751","article-title":"Clinical and laboratory versus molecular markers for a correct classification of von Willebrand disease","volume":"94","author":"Federici","year":"2009","journal-title":"Haematologica"},{"key":"10.1016\/j.rpth.2023.100139_bib16","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1182\/bloodadvances.2020003265","article-title":"ASH ISTH NHF WFH 2021 guidelines on the diagnosis of von Willebrand disease","volume":"5","author":"James","year":"2021","journal-title":"Blood Adv"},{"key":"10.1016\/j.rpth.2023.100139_bib17","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1097\/00001721-200408000-00011","article-title":"A\u00a0rapid assay for ristocetin cofactor activity using an automated coagulometer (ACL 9000)","volume":"15","author":"Lattuada","year":"2004","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1016\/j.rpth.2023.100139_bib19","author":"Cooper"},{"key":"10.1016\/j.rpth.2023.100139_bib20","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1159\/000214853","volume":"121","author":"Gadisseur","year":"2009","journal-title":"Acta Haematol"},{"key":"10.1016\/j.rpth.2023.100139_bib21","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1160\/TH15-07-0604","article-title":"Genotype-phenotype correlation in a cohort of Portuguese patients comprising the entire spectrum of VWD types: impact of NGS","volume":"116","author":"Fidalgo","year":"2016","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.rpth.2023.100139_bib22","doi-asserted-by":"crossref","first-page":"e3038","DOI":"10.1097\/MD.0000000000003038","article-title":"A\u00a0laboratory phenotype\/genotype correlation of 1167 French patients from 670 families with von Willebrand disease: a new epidemiologic picture","volume":"95","author":"Veyradier","year":"2016","journal-title":"Med (Baltim)"},{"key":"10.1016\/j.rpth.2023.100139_bib23","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/j.1538-7836.2009.03482.x","article-title":"Genetic testing for von Willebrand disease: the case against","volume":"8","author":"Favaloro","year":"2010","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.rpth.2023.100139_bib24","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/jth.15129","article-title":"Laboratory variability in the diagnosis of type 2 VWD variants","volume":"19","author":"DiGiandomenico","year":"2021","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.rpth.2023.100139_bib25","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.3324\/haematol.2017.168765","article-title":"Molecular and clinical profile of von Willebrand disease in Spain (PCM-EVW-ES): comprehensive genetic analysis by next-generation sequencing of 480 patients","volume":"102","author":"Borr\u00e0s","year":"2017","journal-title":"Haematologica"},{"key":"10.1016\/j.rpth.2023.100139_bib26","doi-asserted-by":"crossref","first-page":"4031","DOI":"10.1182\/bloodadvances.2022007216","article-title":"Phenotypic and genetic characterizations of the Milan cohort of von Willebrand disease type 2","volume":"6","author":"Seidizadeh","year":"2022","journal-title":"Blood Adv"},{"key":"10.1016\/j.rpth.2023.100139_bib27","first-page":"77","article-title":"A\u00a0sensitive ristocetin co-factor activity assay with recombinant glycoprotein Ib\u03b1 for the diagnosis of patients with low von Willebrand factor levels","volume":"89","author":"Federici","year":"2004","journal-title":"Haematologica"},{"key":"10.1016\/j.rpth.2023.100139_bib28","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1111\/jth.13062","article-title":"Evaluation of an heterogeneous group of patients with von Willebrand disease using an assay alternative to ristocetin induced platelet agglutination","volume":"13","author":"Stufano","year":"2015","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.rpth.2023.100139_bib29","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1056\/NEJM198005083021902","article-title":"Heightened interaction between platelets and factor VIII\/von Willebrand factor in a new subtype of von Willebrand's disease","volume":"302","author":"Ruggeri","year":"1980","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.rpth.2023.100139_bib30","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1182\/blood.V68.1.149.149","article-title":"A\u00a0new von Willebrand variant (type I, New York): increased ristocetin-induced platelet aggregation and plasma von Willebrand factor containing the full range of multimers","volume":"68","author":"Weiss","year":"1986","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2023.100139_bib31","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1111\/jth.14971","article-title":"Comparison of von Willebrand factor platelet-binding activity assays: ELISA overreads type 2B with loss of HMW multimers","volume":"18","author":"Szederjesi","year":"2020","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.rpth.2023.100139_bib32","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1111\/jth.14319","article-title":"Clinically relevant differences between assays for von Willebrand factor activity","volume":"16","author":"Boender","year":"2018","journal-title":"J\u00a0Thromb Haemost"}],"updated-by":[{"DOI":"10.1016\/j.rpth.2023.102141","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000}}],"container-title":["Research and Practice in Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037923001127?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037923001127?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T16:50:55Z","timestamp":1684774255000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2475037923001127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["S2475037923001127"],"URL":"https:\/\/doi.org\/10.1016\/j.rpth.2023.100139","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.rpth.2023.102141","asserted-by":"object"}]},"ISSN":["2475-0379"],"issn-type":[{"value":"2475-0379","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A comparative study in patients with type 2 von Willebrand disease using 4 different platelet-dependent von Willebrand factor assays","name":"articletitle","label":"Article Title"},{"value":"Research and Practice in Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rpth.2023.100139","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis.","name":"copyright","label":"Copyright"}],"article-number":"100139"}}