{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T08:58:59Z","timestamp":1793782739888,"version":"4.6.1"},"reference-count":25,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:00:00Z","timestamp":1696896000000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008955","name":"Wilhelmina Kinderziekenhuis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008955","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rpthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research and Practice in Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.rpth.2023.102229","type":"journal-article","created":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T02:59:02Z","timestamp":1697252342000},"page":"102229","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Heavy menstrual bleeding in adolescents: incidence, diagnostics, and management practices in primary care"],"prefix":"10.1016","volume":"7","author":[{"given":"Stella J.","family":"Van \u2018t Klooster","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"de Vaan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanette","family":"van Leeuwen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynnda","family":"Pekel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie M.","family":"van Rijn-van Kortenhof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eveline T.","family":"Engelen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willie","family":"van Greevenbroek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Huisman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathelijn","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger E.G.","family":"Schutgens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin P.M.","family":"van Galen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rpth.2023.102229_bib1","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1080\/00016340500342912","article-title":"Bleeding disorders among young women: a population-based prevalence study","volume":"85","author":"Friberg","year":"2006","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.rpth.2023.102229_bib2","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jpag.2012.11.004","article-title":"The quality of life of adolescents with menstrual problems","volume":"26","author":"Nur Azurah","year":"2013","journal-title":"J\u00a0Pediatr Adolesc Gynecol"},{"key":"10.1016\/j.rpth.2023.102229_bib3","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1111\/hae.13722","article-title":"Barriers and challenges faced by women with congenital bleeding disorders in Europe: results of a patient survey conducted by the European Hemophilia Consortium","volume":"25","author":"Noone","year":"2019","journal-title":"Haemophilia"},{"key":"10.1016\/j.rpth.2023.102229_bib4","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1111\/hae.13292","article-title":"Impact of diagnosis of von Willebrand disease on patient outcomes: analysis of medical insurance claims data","volume":"23","author":"Sidonio","year":"2017","journal-title":"Haemophilia"},{"key":"10.1016\/j.rpth.2023.102229_bib5","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.ijgo.2014.09.027","article-title":"Prevalence of heavy menstrual bleeding and experiences of affected women in a European patient survey","volume":"128","author":"Fraser","year":"2015","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1016\/j.rpth.2023.102229_bib6","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1093\/fampra\/cmx050","article-title":"Incidence and treatment of heavy menstrual bleeding in general practice","volume":"34","author":"van den Brink","year":"2017","journal-title":"Fam Pract"},{"key":"10.1016\/j.rpth.2023.102229_bib7","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1182\/bloodadvances.2020003265","article-title":"ASH ISTH NHF WFH 2021 guidelines on the diagnosis of von Willebrand disease","volume":"5","author":"James","year":"2021","journal-title":"Blood Adv"},{"key":"10.1016\/j.rpth.2023.102229_bib8","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1097\/AOG.0000000000002620","article-title":"Patterns of von Willebrand disease screening in girls and adolescents with heavy menstrual bleeding","volume":"131","author":"Jacobson","year":"2018","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.rpth.2023.102229_bib9","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.3324\/haematol.2019.225656","article-title":"Bleeding disorders in adolescents with heavy menstrual bleeding in a multicenter prospective US cohort","volume":"105","author":"Zia","year":"2020","journal-title":"Haematologica"},{"key":"10.1016\/j.rpth.2023.102229_bib10","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/hae.13330","article-title":"Differences in bleeding phenotype and provider interventions in postmenarchal adolescents when compared to adult women with bleeding disorders and heavy menstrual bleeding","volume":"24","author":"Srivaths","year":"2018","journal-title":"Haemophilia"},{"key":"10.1016\/j.rpth.2023.102229_bib11","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.1182\/bloodadvances.2020002081","article-title":"The spectrum and severity of bleeding in adolescents with low von Willebrand factor-associated heavy menstrual bleeding","volume":"4","author":"Srivaths","year":"2020","journal-title":"Blood Adv"},{"key":"10.1016\/j.rpth.2023.102229_bib12","author":"Meijer"},{"key":"10.1016\/j.rpth.2023.102229_bib13","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1186\/s12913-018-3528-5","article-title":"Routine primary care data for scientific research, quality of care programs and educational purposes: the Julius General Practitioners\u2019 Network (JGPN)","volume":"18","author":"Smeets","year":"2018","journal-title":"BMC Health Serv Res"},{"key":"10.1016\/j.rpth.2023.102229_bib14","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s12978-017-0293-6","article-title":"Mapping the knowledge and understanding of menarche, menstrual hygiene and menstrual health among adolescent girls in low- and middle-income countries","volume":"14","author":"Chandra-Mouli","year":"2017","journal-title":"Reprod Health"},{"key":"10.1016\/j.rpth.2023.102229_bib15","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.jpag.2019.08.007","article-title":"Status and factors of menstrual knowledge, attitudes, behaviors and their correlation with psychological stress in adolescent girls","volume":"32","author":"Borjigen","year":"2019","journal-title":"J\u00a0Pediatr Adolesc Gynecol"},{"key":"10.1016\/j.rpth.2023.102229_bib16","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12905-017-0502-z","article-title":"Menstrual health and school absenteeism among adolescent girls in Uganda (MENISCUS): a feasibility study","volume":"18","author":"Miiro","year":"2018","journal-title":"BMC Womens Health"},{"key":"10.1016\/j.rpth.2023.102229_bib17","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1111\/jth.14997","article-title":"Prospective evaluation of ISTH-BAT as a predictor of bleeding disorder in adolescents presenting with heavy menstrual bleeding in a multidisciplinary hematology clinic","volume":"18","author":"Jain","year":"2020","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.rpth.2023.102229_bib18","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/hae.13501","article-title":"Women with bleeding disorders: clinical and psychological issues","volume":"24","author":"McLintock","year":"2018","journal-title":"Haemophilia"},{"key":"10.1016\/j.rpth.2023.102229_bib19","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1080\/03630241003705037","article-title":"Questioning our questions: do frequently asked questions adequately cover the aspects of women\u2019s lives most affected by abnormal uterine bleeding? Opinions of women with abnormal uterine bleeding participating in focus group discussions","volume":"50","author":"Matteson","year":"2010","journal-title":"Women Health"},{"key":"10.1016\/j.rpth.2023.102229_bib20","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1002\/ccr3.1529","article-title":"Iron deficiency without anemia \u2013 a clinical challenge","volume":"6","author":"Soppi","year":"2018","journal-title":"Clin Case Rep"},{"key":"10.1016\/j.rpth.2023.102229_bib21","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2017-019240","article-title":"Efficacy of iron supplementation on fatigue and physical capacity in non-anaemic iron-deficient adults: a systematic review of randomised controlled trials","volume":"8","author":"Houston","year":"2018","journal-title":"BMJ Open"},{"key":"10.1016\/j.rpth.2023.102229_bib22","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1080\/17474086.2018.1502081","article-title":"Impact and management of iron deficiency and iron deficiency anemia in women\u2019s health","volume":"11","author":"Mirza","year":"2018","journal-title":"Expert Rev Hematol"},{"key":"10.1016\/j.rpth.2023.102229_bib23","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1055\/s-2006-947869","article-title":"The utility of the PFA-100 in the identification of von Willebrand disease: a concise review","volume":"32","author":"Favaloro","year":"2006","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.rpth.2023.102229_bib24","doi-asserted-by":"crossref","DOI":"10.1002\/rth2.12763","article-title":"Hormonal therapies and venous thrombosis: considerations for prevention and management","volume":"6","author":"LaVasseur","year":"2022","journal-title":"Res Pract Thromb Haemost"},{"key":"10.1016\/j.rpth.2023.102229_bib25","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1111\/hae.12503","article-title":"Normal range of bleeding scores for the ISTH-BAT: adult and pediatric data from the merging project","volume":"20","author":"Elbatarny","year":"2014","journal-title":"Haemophilia"}],"container-title":["Research and Practice in Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037923004880?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037923004880?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:30:18Z","timestamp":1762864218000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2475037923004880"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["S2475037923004880"],"URL":"https:\/\/doi.org\/10.1016\/j.rpth.2023.102229","relation":{},"ISSN":["2475-0379"],"issn-type":[{"value":"2475-0379","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Heavy menstrual bleeding in adolescents: incidence, diagnostics, and management practices in primary care","name":"articletitle","label":"Article Title"},{"value":"Research and Practice in Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rpth.2023.102229","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis.","name":"copyright","label":"Copyright"}],"article-number":"102229"}}