{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:44:05Z","timestamp":1762865045698,"version":"build-2065373602"},"reference-count":46,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T00:00:00Z","timestamp":1698105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["rpthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research and Practice in Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.rpth.2023.102244","type":"journal-article","created":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T15:11:58Z","timestamp":1698678718000},"page":"102244","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["What can historical literature on von Willebrand disease teach\u00a0us?"],"prefix":"10.1016","volume":"7","author":[{"given":"Jecko","family":"Thachil","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riitta","family":"Lassila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.rpth.2023.102244_bib1","first-page":"7","article-title":"Heredit\u00e4r pseudohemofili. Article in Swedish","volume":"67","author":"Von Willebrand","year":"1926","journal-title":"Finska L\u00e4kars\u00e4llskapets Handl"},{"key":"10.1016\/j.rpth.2023.102244_bib2","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/j.0954-6820.1931.tb18363.x","article-title":"\u00dcber heredit\u00e4re pseudoh\u00e4mophilie. Article in Swedish","volume":"76","author":"Von Willebrand","year":"1931","journal-title":"Acta Med Scand"},{"key":"10.1016\/j.rpth.2023.102244_bib3","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1046\/j.1365-2516.1999.00302.x","article-title":"Hereditary pseudohaemophilia","volume":"5","author":"Von Willebrand","year":"1999","journal-title":"Haemophilia"},{"key":"10.1016\/j.rpth.2023.102244_bib4","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1046\/j.1365-2516.1999.0320a.x","article-title":"Commentary to Erik von Willebrand\u2019s original paper from 1926 \u2018Heredit\u00e4r pseudohemofili\u2019","volume":"5","author":"Nilsson","year":"1999","journal-title":"Haemophilia"},{"first-page":"55","year":"2000","author":"Lichtman","key":"10.1016\/j.rpth.2023.102244_bib5"},{"key":"10.1016\/j.rpth.2023.102244_bib6","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/978-1-61779-307-3_8","article-title":"Clot retraction","volume":"788","author":"Tucker","year":"2012","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.rpth.2023.102244_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0560.1979.tb00300.x","article-title":"Early histopathology of the cutaneous capillary fragility test (Rumpel-Leede)","volume":"6","author":"Duncan","year":"1979","journal-title":"J\u00a0Cutan Pathol"},{"key":"10.1016\/j.rpth.2023.102244_bib8","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0049-3848(87)90191-5","article-title":"The capillary thrombometer and von Willebrand factor","volume":"45","author":"Kadota","year":"1987","journal-title":"Thromb Res"},{"key":"10.1016\/j.rpth.2023.102244_bib9","first-page":"194","article-title":"Konstitutionell thrombopati, en ny arftlig blodarsjukdom. Article in Swedish","volume":"76","author":"Von Willebrand","year":"1934","journal-title":"FLS Handl"},{"key":"10.1016\/j.rpth.2023.102244_bib10","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/hae.12243","article-title":"Erik von Willebrand","volume":"19","author":"Lassila","year":"2013","journal-title":"Haemophilia"},{"key":"10.1016\/j.rpth.2023.102244_bib11","article-title":"Willebrand-J\u00fcrgens-syndrome. Article in German","volume":"50","author":"Spannagl","year":"2001","journal-title":"Anaesthesist"},{"key":"10.1016\/j.rpth.2023.102244_bib12","first-page":"313","article-title":"Platelets in the Minot-von Willebrand syndrome","volume":"26","author":"Quick","year":"1967","journal-title":"Thromb Diath Haemorrh Suppl"},{"key":"10.1016\/j.rpth.2023.102244_bib13","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1136\/bmj.2.5415.963","article-title":"Anon. Von Willebrand\u2019s disease","volume":"2","year":"1964","journal-title":"Br Med J"},{"key":"10.1016\/j.rpth.2023.102244_bib14","first-page":"23","article-title":"ADP-induced platelet adhesiveness as a diagnostic test in von Willebrand\u2019s disease","volume":"11","author":"Odegaard","year":"1964","journal-title":"Thromb Diath Haemorrh"},{"key":"10.1016\/j.rpth.2023.102244_bib15","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1046\/j.1365-2141.2000.02246.x","article-title":"Platelet ultrastructural abnormalities in three patients with type 2B von Willebrand disease","volume":"110","author":"Nurden","year":"2000","journal-title":"Br J Haematol"},{"key":"10.1016\/j.rpth.2023.102244_bib16","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1080\/09537100500441150","article-title":"von Willebrand disease type 2B must be always considered in the differential diagnosis of genetic thrombocytopenias with giant platelets","volume":"17","author":"Loffredo","year":"2006","journal-title":"Platelets"},{"key":"10.1016\/j.rpth.2023.102244_bib17","article-title":"Low von Willebrand factor: sometimes a risk factor and sometimes a disease","volume":"106\u201312","author":"Sadler","year":"2009","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"10.1016\/j.rpth.2023.102244_bib18","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/bjh.13064","article-title":"The diagnosis and management of von Willebrand disease: a United Kingdom Haemophilia Centre Doctors Organization guideline approved by the British Committee for Standards in Haematology","volume":"167","author":"Laffan","year":"2014","journal-title":"Br J Haematol"},{"key":"10.1016\/j.rpth.2023.102244_bib19","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1055\/s-0031-1300952","article-title":"New insights into von Willebrand disease and platelet function","volume":"38","author":"Sz\u00e1nt\u00f3","year":"2012","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.rpth.2023.102244_bib20","first-page":"1","article-title":"Critical review: the normal haemostatic mechanism and its failure in the haemorrhagic states","volume":"10","author":"MacFarlane","year":"1941","journal-title":"Quart J Med"},{"key":"10.1016\/j.rpth.2023.102244_bib21","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1182\/blood.V1.6.504.504","volume":"1","author":"Estren","year":"1946","journal-title":"Pseudohemophilia. Blood"},{"key":"10.1016\/j.rpth.2023.102244_bib22","first-page":"173","article-title":"Hereditary capillary purpura (von Willebrand\u2019s disease)","volume":"27","author":"Horler","year":"1958","journal-title":"Q\u00a0J Med"},{"key":"10.1016\/j.rpth.2023.102244_bib23","first-page":"347","article-title":"Vascular hemophilia; a familial hemorrhagic disease in males and females characterized by combined antihemophilic globulin deficiency and vascular abnormality","volume":"18","author":"Erlandson","year":"1956","journal-title":"Pediatrics"},{"key":"10.1016\/j.rpth.2023.102244_bib24","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1097\/00000441-195610000-00009","article-title":"Vascular hemophilia: the association of a vascular defect with a deficiency of antihemophilic globulin","volume":"232","author":"Finch","year":"1956","journal-title":"Am J Med Sci"},{"key":"10.1016\/j.rpth.2023.102244_bib25","first-page":"35","article-title":"Angiohemophilia. Article in German","volume":"30","author":"Landbeck","year":"1968","journal-title":"Thromb Diath Haemorrh Suppl"},{"key":"10.1016\/j.rpth.2023.102244_bib26","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1160\/TH13-11-0952","article-title":"Gastrointestinal angiodysplasia and bleeding in von Willebrand disease","volume":"112","author":"Franchini","year":"2014","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.rpth.2023.102244_bib27","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1182\/hematology.2022000390","article-title":"Special considerations in GI bleeding in VWD patients","volume":"2022","author":"Chornenki","year":"2022","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"10.1016\/j.rpth.2023.102244_bib28","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1182\/blood-2012-06-435727","article-title":"Cellular and molecular basis of von Willebrand disease: studies on blood outgrowth endothelial cells","volume":"121","author":"Starke","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2023.102244_bib29","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1182\/blood.2019000510","article-title":"The heparin binding domain of von Willebrand factor binds to growth factors and promotes angiogenesis in wound healing","volume":"133","author":"Ishihara","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2023.102244_bib30","first-page":"757","article-title":"Analysis of the relationship of von Willebrand disease (vWD) and hereditary hemorrhagic telangiectasia and identification of a potential type IIA vWD mutation (IIe865 to Thr)","volume":"48","author":"Iannuzzi","year":"1991","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.rpth.2023.102244_bib31","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1111\/jth.15410","article-title":"Vascular abnormalities in patients with von Willebrand disease: a scoping review","volume":"19","author":"Chornenki","year":"2021","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.rpth.2023.102244_bib32","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1097\/00005537-200404000-00021","article-title":"Hormonal and antihormonal therapy for epistaxis in hereditary hemorrhagic telangiectasia","volume":"114","author":"Jameson","year":"2004","journal-title":"Laryngoscope"},{"key":"10.1016\/j.rpth.2023.102244_bib33","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1046\/j.1365-2516.1998.440665.x","article-title":"Females with von Willebrand disease: 72 years as the silent majority","volume":"4","author":"Kouides","year":"1998","journal-title":"Haemophilia"},{"key":"10.1016\/j.rpth.2023.102244_bib34","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0002-9343(82)90729-X","article-title":"Estrogens and surgery in women with von Willebrand's disease","volume":"73","author":"Alperin","year":"1982","journal-title":"Am J Med"},{"key":"10.1016\/j.rpth.2023.102244_bib35","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/ajh.2830410410","article-title":"Angiodysplasia and von Willebrand\u2019s disease type IIB treated with estrogen\/progesterone therapy","volume":"41","author":"Chey","year":"1992","journal-title":"Am J Hematol"},{"key":"10.1016\/j.rpth.2023.102244_bib36","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/ajh.2830460325","article-title":"Von Willebrand\u2019s disease, digestive angiodysplasia, and estrogen-progesterone treatment","volume":"46","author":"Lavabre-Bertrand","year":"1994","journal-title":"Am J Hematol"},{"key":"10.1016\/j.rpth.2023.102244_bib37","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1182\/blood.2019003702","article-title":"How I treat gastrointestinal bleeding in congenital and acquired von Willebrand disease","volume":"136","author":"Biguzzi","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2023.102244_bib38","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1182\/blood.V63.3.657.657","article-title":"Estrogen stimulates von Willebrand factor production by cultured endothelial cells","volume":"63","author":"Harrison","year":"1984","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2023.102244_bib39","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1161\/ATVBAHA.108.182279","article-title":"Estrogen and mechanisms of vascular protection","volume":"29","author":"Xing","year":"2009","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.rpth.2023.102244_bib40","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1124\/pr.107.08002","article-title":"Vascular actions of estrogens: functional implications","volume":"60","author":"Miller","year":"2008","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.rpth.2023.102244_bib41","doi-asserted-by":"crossref","first-page":"3024","DOI":"10.1016\/j.jtha.2023.05.009","article-title":"Role of red blood cells in clinically relevant bleeding tendencies and complications","volume":"21","author":"Lassila","year":"2023","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.rpth.2023.102244_bib42","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1046\/j.1365-2516.2003.00756.x","article-title":"Medical, reproductive and psychosocial experiences of women diagnosed with von Willebrand\u2019s disease receiving care in haemophilia treatment centres: a case-control study","volume":"9","author":"Kirtava","year":"2003","journal-title":"Haemophilia"},{"key":"10.1016\/j.rpth.2023.102244_bib43","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1111\/jth.13273","article-title":"Assessing the clinical severity of type 1 von Willebrand disease patients with a microchip flow-chamber system","volume":"14","author":"Nogami","year":"2016","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.rpth.2023.102244_bib44","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1046\/j.1538-7836.2003.00190.x","article-title":"Cellular mechanisms of the hemostatic effects of desmopressin (DDAVP)","volume":"1","author":"Kaufmann","year":"2003","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.rpth.2023.102244_bib45","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1182\/blood.V67.1.203.203","article-title":"Human thrombocytopenia is associated with structural abnormalities of the endothelium that are ameliorated by glucocorticosteroid administration","volume":"67","author":"Kitchens","year":"1986","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2023.102244_bib46","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/j.1365-2141.2007.06907.x","article-title":"Polymorphisms in von Willebrand factor gene promoter influence the glucocorticoid-induced increase in von Willebrand factor: the lesson learned from Cushing syndrome","volume":"140","author":"Casonato","year":"2008","journal-title":"Br J Haematol"}],"container-title":["Research and Practice in Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037923005046?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037923005046?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:28:46Z","timestamp":1762864126000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2475037923005046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":46,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["S2475037923005046"],"URL":"https:\/\/doi.org\/10.1016\/j.rpth.2023.102244","relation":{},"ISSN":["2475-0379"],"issn-type":[{"type":"print","value":"2475-0379"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"What can historical literature on von Willebrand disease teach\u00a0us?","name":"articletitle","label":"Article Title"},{"value":"Research and Practice in Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rpth.2023.102244","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis.","name":"copyright","label":"Copyright"}],"article-number":"102244"}}