{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T08:18:00Z","timestamp":1793089080224,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T00:00:00Z","timestamp":1713830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["rpthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research and Practice in Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.rpth.2024.102430","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T16:05:21Z","timestamp":1714406721000},"page":"102430","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Obstetric antiphospholipid syndrome carries an increased lifetime risk for obstetric and thrombotic complications\u2014a population-based study"],"prefix":"10.1016","volume":"8","author":[{"given":"Ariel Katherine","family":"Rhein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2710-1893","authenticated-orcid":false,"given":"Anat","family":"Rabinovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Abuhasira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shir","family":"Lubaton-Barshishat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Offer","family":"Erez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rpth.2024.102430_bib1","first-page":"675","article-title":"Pathogenesis, diagnosis and management of obstetric antiphospholipid syndrome: a comprehensive review","volume":"11","author":"Alijotas-Reig","year":"2022","journal-title":"J\u00a0Clin Med"},{"key":"10.1016\/j.rpth.2024.102430_bib2","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1016\/S0049-3848(17)30066-X","article-title":"Antiphospholipid syndrome","volume":"151","author":"Cervera","year":"2017","journal-title":"Thromb Res"},{"key":"10.1016\/j.rpth.2024.102430_bib3","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1056\/NEJMra1705454","article-title":"Diagnosis and management of the antiphospholipid syndrome","volume":"378","author":"Garcia","year":"2018","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.rpth.2024.102430_bib4","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.autrev.2014.02.003","article-title":"14th International Congress on antiphospholipid antibodies task force report on obstetric antiphospholipid syndrome","volume":"13","author":"de Jesus","year":"2014","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.rpth.2024.102430_bib5","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1136\/annrheumdis-2019-215213","article-title":"EULAR recommendations for the management of antiphospholipid syndrome in adults","volume":"78","author":"Tektonidou","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.rpth.2024.102430_bib6","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1136\/annrheumdis-2013-204838","article-title":"Morbidity and mortality in the antiphospholipid syndrome during a 10-year period: a multicentre prospective study of 1000 patients","volume":"74","author":"Cervera","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.rpth.2024.102430_bib7","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/s41584-018-0032-6","article-title":"Obstetric and vascular antiphospholipid syndrome: same antibodies but different diseases?","volume":"14","author":"Meroni","year":"2018","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.rpth.2024.102430_bib8","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1538-7836.2006.01753.x","article-title":"International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)","volume":"4","author":"Miyakis","year":"2006","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.rpth.2024.102430_bib9","doi-asserted-by":"crossref","first-page":"S656","DOI":"10.1016\/j.ajog.2017.12.210","article-title":"Individualized growth assessment: conceptual framework and practical implementation for the evaluation of fetal growth and neonatal growth outcome","volume":"218","author":"Deter","year":"2018","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.rpth.2024.102430_bib10","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/S1701-2163(15)30588-0","article-title":"Diagnosis, evaluation, and management of the hypertensive disorders of pregnancy: executive summary","volume":"36","author":"Magee","year":"2014","journal-title":"J\u00a0Obstet Gynaecol Can"},{"key":"10.1016\/j.rpth.2024.102430_bib11","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1515\/jpm-2021-0401","article-title":"Improved method for revising the Israel birthweight references","volume":"50","author":"Rubin","year":"2022","journal-title":"J\u00a0Perinat Med"},{"key":"10.1016\/j.rpth.2024.102430_bib12","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1177\/0961203309347794","article-title":"Pregnancy outcome in different clinical phenotypes of antiphospholipid syndrome","volume":"19","author":"Bramham","year":"2010","journal-title":"Lupus"},{"key":"10.1016\/j.rpth.2024.102430_bib13","doi-asserted-by":"crossref","first-page":"515","DOI":"10.3349\/ymj.2008.49.4.515","article-title":"Prognosis of neonates in pregnant women with systemic lupus erythematosus","volume":"49","author":"Kim","year":"2008","journal-title":"Yonsei Med J"},{"key":"10.1016\/j.rpth.2024.102430_bib14","doi-asserted-by":"crossref","DOI":"10.1136\/lupus-2021-000633","article-title":"Pregnancy outcomes in antiphospholipid antibody positive patients: prospective results from the AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) Clinical Database and Repository ('Registry')","volume":"9","author":"Erton","year":"2022","journal-title":"Lupus Sci Med"},{"key":"10.1016\/j.rpth.2024.102430_bib15","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/s12016-016-8569-0","article-title":"Pregnancy outcome in women with obstetric and thrombotic antiphospholipid syndrome-a retrospective analysis and a review of additional treatment in pregnancy","volume":"53","author":"Mayer-Pickel","year":"2017","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.rpth.2024.102430_bib16","doi-asserted-by":"crossref","first-page":"525.e1","DOI":"10.1016\/j.ajog.2017.01.026","article-title":"Antiphospholipid antibody profile based obstetric outcomes of primary antiphospholipid syndrome: the PREGNANTS study","volume":"216","author":"Saccone","year":"2017","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.rpth.2024.102430_bib17","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s13075-021-02515-w","article-title":"Clinical characteristics and prognosis of patients with isolated thrombotic vs. obstetric antiphospholipid syndrome: a prospective cohort study","volume":"23","author":"Jiang","year":"2021","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.rpth.2024.102430_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232112819","article-title":"Differences in antiphospholipid antibody profile between patients with obstetric and thrombotic antiphospholipid syndrome","volume":"23","author":"Anunciaci\u00f3n-Llunell","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.rpth.2024.102430_bib19","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s11239-017-1526-9","article-title":"Obstetric antiphospholipid syndrome and long term arterial thrombosis risk","volume":"44","author":"Drozdinsky","year":"2017","journal-title":"J\u00a0Thromb Thrombolysis"},{"key":"10.1016\/j.rpth.2024.102430_bib20","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.1182\/blood-2011-09-381913","article-title":"Comparative incidence of a first thrombotic event in purely obstetric antiphospholipid syndrome with pregnancy loss: the NOH-APS observational study","volume":"119","author":"Gris","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2024.102430_bib21","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.autrev.2018.12.006","article-title":"The European Registry on Obstetric Antiphospholipid Syndrome (EUROAPS): a survey of 1000 consecutive cases","volume":"18","author":"Alijotas-Reig","year":"2019","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.rpth.2024.102430_bib22","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.autrev.2014.12.010","article-title":"The European Registry on Obstetric Antiphospholipid Syndrome (EUROAPS): a survey of 247 consecutive cases","volume":"14","author":"Alijotas-Reig","year":"2015","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.rpth.2024.102430_bib23","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1007\/s11239-018-1672-8","article-title":"Antiphospholipid antibody profile-based outcome of purely vascular and purely obstetric antiphospholipid syndrome","volume":"46","author":"Rottenstreich","year":"2018","journal-title":"J\u00a0Thromb Thrombolysis"},{"key":"10.1016\/j.rpth.2024.102430_bib24","doi-asserted-by":"crossref","first-page":"B2","DOI":"10.1016\/j.ajog.2023.04.039","article-title":"Society for Maternal-Fetal Medicine Special Statement: prophylactic low-dose aspirin for preeclampsia prevention-quality metric and opportunities for quality improvement","volume":"229","author":"Kumar","year":"2023","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.rpth.2024.102430_bib25","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1182\/blood-2013-08-522623","article-title":"Comparative incidence of pregnancy outcomes in treated obstetric antiphospholipid syndrome: the NOH-APS observational study","volume":"123","author":"Bouvier","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2024.102430_bib26","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1093\/rheumatology\/ker139","article-title":"Risk factors for pregnancy failure in patients with anti-phospholipid syndrome treated with conventional therapies: a multicentre, case-control study","volume":"50","author":"Ruffatti","year":"2011","journal-title":"Rheumatology"},{"key":"10.1016\/j.rpth.2024.102430_bib27","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/s11239-023-02789-8","article-title":"Management and outcomes of women with antiphospholipid syndrome during pregnancy","volume":"55","author":"Tao","year":"2023","journal-title":"J\u00a0Thromb Thrombolysis"},{"key":"10.1016\/j.rpth.2024.102430_bib28","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1002\/art.34402","article-title":"Prediction of adverse pregnancy outcome by the presence of lupus anticoagulant, but not anticardiolipin antibody, in patients with antiphospholipid antibodies","volume":"64","author":"Lockshin","year":"2012","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.rpth.2024.102430_bib29","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1002\/1529-0131(200106)44:6<1466::AID-ART242>3.0.CO;2-C","article-title":"High thrombosis rate after fetal loss in antiphospholipid syndrome: effective prophylaxis with aspirin","volume":"44","author":"Erkan","year":"2001","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.rpth.2024.102430_bib30","doi-asserted-by":"crossref","first-page":"S1006","DOI":"10.1016\/j.ajog.2020.10.052","article-title":"Preeclampsia has two phenotypes which require different treatment strategies","volume":"226","author":"Masini","year":"2022","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.rpth.2024.102430_bib31","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.placenta.2022.03.009","article-title":"Early pathways, biomarkers, and four distinct molecular subclasses of preeclampsia: the intersection of clinical, pathological, and high-dimensional biology studies","volume":"125","author":"Than","year":"2022","journal-title":"Placenta"},{"key":"10.1016\/j.rpth.2024.102430_bib32","doi-asserted-by":"crossref","first-page":"S844","DOI":"10.1016\/j.ajog.2021.11.1356","article-title":"The etiology of preeclampsia","volume":"226","author":"Jung","year":"2022","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.rpth.2024.102430_bib33","doi-asserted-by":"crossref","first-page":"S786","DOI":"10.1016\/j.ajog.2021.12.001","article-title":"Preeclampsia and eclampsia: the conceptual evolution of a syndrome","volume":"226","author":"Erez","year":"2022","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.rpth.2024.102430_bib34","doi-asserted-by":"crossref","first-page":"835","DOI":"10.3324\/haematol.2016.155184","article-title":"Obstetric antiphospholipid syndrome: early variations of angiogenic factors are associated with adverse outcomes","volume":"102","author":"Cochery-Nouvellon","year":"2017","journal-title":"Haematologica"},{"key":"10.1016\/j.rpth.2024.102430_bib35","doi-asserted-by":"crossref","first-page":"108.e1","DOI":"10.1016\/j.ajog.2015.09.066","article-title":"Angiogenic factor imbalance early in pregnancy predicts adverse outcomes in patients with lupus and antiphospholipid antibodies: results of the PROMISSE study","volume":"214","author":"Kim","year":"2016","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.rpth.2024.102430_bib36","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/s10238-021-00764-2","article-title":"Angiogenic markers could predict adverse pregnancy outcomes","volume":"22","author":"Xing","year":"2022","journal-title":"Clin Exp Med"},{"key":"10.1016\/j.rpth.2024.102430_bib37","doi-asserted-by":"crossref","first-page":"432.e1","DOI":"10.1016\/j.ajog.2021.03.039","article-title":"Is the presence of antiphospholipid antibodies a poor prognostic factor for patients with hemolysis, elevated liver enzymes, and low platelet count syndrome?","volume":"225","author":"P\u00e9court","year":"2021","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.rpth.2024.102430_bib38","doi-asserted-by":"crossref","DOI":"10.1177\/10760296221088576","article-title":"The pathophysiology of the antiphospholipid syndrome: a perspective from the blood coagulation system","volume":"28","author":"Arreola-Diaz","year":"2022","journal-title":"Clin Appl Thromb Hemost"},{"key":"10.1016\/j.rpth.2024.102430_bib39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0158757","article-title":"Identification of a monoclonal antibody that attenuates antiphospholipid syndrome-related pregnancy complications and thrombosis","volume":"11","author":"Mineo","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.rpth.2024.102430_bib40","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1111\/aji.12341","article-title":"Purified IgG from patients with obstetric but not IgG from non-obstetric antiphospholipid syndrome inhibit trophoblast invasion","volume":"73","author":"Poulton","year":"2015","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.rpth.2024.102430_bib41","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1055\/s-2007-994176","article-title":"Placental pathology and antiphospholipid antibodies: a descriptive study","volume":"14","author":"Salafia","year":"1997","journal-title":"Am J Perinatol"},{"key":"10.1016\/j.rpth.2024.102430_bib42","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1016\/j.jacc.2017.02.058","article-title":"Antiphospholipid syndrome: role of vascular endothelial cells and implications for risk stratification and targeted therapeutics","volume":"69","author":"Corban","year":"2017","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.rpth.2024.102430_bib43","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.jtha.2022.12.002","article-title":"Targeting thromboinflammation in antiphospholipid syndrome","volume":"21","author":"Salet","year":"2023","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.rpth.2024.102430_bib44","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1136\/ard.2010.135525","article-title":"Global effects of fluvastatin on the prothrombotic status of patients with antiphospholipid syndrome","volume":"70","author":"L\u00f3pez-Pedrera","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.rpth.2024.102430_bib45","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.thromres.2022.05.001","article-title":"Association between neutrophil extracellular traps (NETs) and thrombosis in antiphospholipid syndrome","volume":"214","author":"Mazetto","year":"2022","journal-title":"Thromb Res"},{"key":"10.1016\/j.rpth.2024.102430_bib46","doi-asserted-by":"crossref","first-page":"2990","DOI":"10.1002\/art.39247","article-title":"Release of neutrophil extracellular traps by neutrophils stimulated with antiphospholipid antibodies: a newly identified mechanism of thrombosis in the antiphospholipid syndrome","volume":"67","author":"Yalavarthi","year":"2015","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.rpth.2024.102430_bib47","article-title":"1201 IMPACT Study: Preliminary results of a trial with a biologic to prevent preeclampsia in women with antiphospholipid syndrome","volume":"9","author":"Salmon","year":"2022","journal-title":"Lupus Sci Med"}],"container-title":["Research and Practice in Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037924001195?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037924001195?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,28]],"date-time":"2024-07-28T05:33:03Z","timestamp":1722144783000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2475037924001195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":47,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["S2475037924001195"],"URL":"https:\/\/doi.org\/10.1016\/j.rpth.2024.102430","relation":{},"ISSN":["2475-0379"],"issn-type":[{"value":"2475-0379","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Obstetric antiphospholipid syndrome carries an increased lifetime risk for obstetric and thrombotic complications\u2014a population-based study","name":"articletitle","label":"Article Title"},{"value":"Research and Practice in Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rpth.2024.102430","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis.","name":"copyright","label":"Copyright"}],"article-number":"102430"}}