{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T10:52:25Z","timestamp":1785754345796,"version":"3.56.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T00:00:00Z","timestamp":1723161600000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008907","name":"Oklahoma Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008907","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rpthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research and Practice in Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.rpth.2024.102550","type":"journal-article","created":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T23:46:06Z","timestamp":1723851966000},"page":"102550","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Antipolyphosphate monoclonal antibodies derived from autoimmune mice"],"prefix":"10.1016","volume":"8","author":[{"given":"Josepha C.","family":"Sedzro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie A.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Travers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Hemp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chase N.","family":"Morse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1570-1569","authenticated-orcid":false,"given":"James H.","family":"Morrissey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rpth.2024.102550_bib1","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1161\/CIRCRESAHA.118.313155","article-title":"Antithrombotic agents","volume":"124","author":"Chan","year":"2019","journal-title":"Circ Res"},{"key":"10.1016\/j.rpth.2024.102550_bib2","article-title":"Inhibitors of polyphosphate and neutrophil extracellular traps","author":"Vappala","year":"2023","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.rpth.2024.102550_bib3","doi-asserted-by":"crossref","first-page":"44250","DOI":"10.1074\/jbc.M406261200","article-title":"Human platelet dense granules contain polyphosphate and are similar to acidocalcisomes of bacteria and unicellular eukaryotes","volume":"279","author":"Ruiz","year":"2004","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.rpth.2024.102550_bib4","doi-asserted-by":"crossref","first-page":"28435","DOI":"10.1074\/jbc.M112.385823","article-title":"Polyphosphate is a novel pro-inflammatory regulator of mast cells and is located in acidocalcisomes","volume":"287","author":"Moreno-Sanchez","year":"2012","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.rpth.2024.102550_bib5","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1146\/annurev.biochem.77.083007.093039","article-title":"Inorganic polyphosphate: essential for growth and survival","volume":"78","author":"Rao","year":"2009","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.rpth.2024.102550_bib6","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1073\/pnas.0507195103","article-title":"Polyphosphate modulates blood coagulation and fibrinolysis","volume":"103","author":"Smith","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.rpth.2024.102550_bib7","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.cell.2009.11.001","article-title":"Platelet polyphosphates are proinflammatory and procoagulant mediators in\u00a0vivo","volume":"139","author":"M\u00fcller","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.rpth.2024.102550_bib8","doi-asserted-by":"crossref","first-page":"6963","DOI":"10.1182\/blood-2011-07-368811","article-title":"Polyphosphate is a cofactor for the activation of factor XI by thrombin","volume":"118","author":"Choi","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2024.102550_bib9","doi-asserted-by":"crossref","first-page":"3962","DOI":"10.1182\/blood-2012-12-473629","article-title":"The dimeric structure of factor XI and zymogen activation","volume":"121","author":"Geng","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2024.102550_bib10","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.1182\/blood-2008-03-145755","article-title":"Polyphosphate enhances fibrin clot structure","volume":"112","author":"Smith","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2024.102550_bib11","doi-asserted-by":"crossref","first-page":"3980","DOI":"10.1182\/blood-2009-11-254029","article-title":"Polyphosphate modifies the fibrin network and down-regulates fibrinolysis by attenuating binding of tPA and plasminogen to fibrin","volume":"115","author":"Mutch","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2024.102550_bib12","doi-asserted-by":"crossref","first-page":"4353","DOI":"10.1182\/blood-2010-01-266791","article-title":"Polyphosphate exerts differential effects on blood clotting, depending on polymer size","volume":"116","author":"Smith","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2024.102550_bib13","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1182\/blood-2013-01-481549","article-title":"Inositol hexakisphosphate kinase 1 maintains hemostasis in mice by regulating platelet polyphosphate levels","volume":"122","author":"Ghosh","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2024.102550_bib14","doi-asserted-by":"crossref","first-page":"12938","DOI":"10.1073\/pnas.1204928109","article-title":"Nucleic acid scavengers inhibit thrombosis without increasing bleeding","volume":"109","author":"Jain","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.rpth.2024.102550_bib15","doi-asserted-by":"crossref","first-page":"5103","DOI":"10.1182\/blood-2012-07-444935","article-title":"Inhibition of polyphosphate as a novel strategy for preventing thrombosis and inflammation","volume":"120","author":"Smith","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2024.102550_bib16","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.1182\/blood-2014-05-577932","article-title":"Nontoxic polyphosphate inhibitors reduce thrombosis while sparing hemostasis","volume":"124","author":"Travers","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2024.102550_bib17","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1038\/s41467-023-37709-0","article-title":"Smart thrombosis inhibitors without bleeding side effects via charge tunable ligand design","volume":"14","author":"La","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.rpth.2024.102550_bib18","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3009427","article-title":"Affinity-based design of a synthetic universal reversal agent for heparin anticoagulants","volume":"6","author":"Shenoi","year":"2014","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.rpth.2024.102550_bib19","first-page":"2327","article-title":"Pharmacokinetics of therapeutic monoclonal antibodies used in oncology","volume":"25","author":"Lev\u00eaque","year":"2005","journal-title":"Anticancer Res"},{"key":"10.1016\/j.rpth.2024.102550_bib20","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1001\/jama.1966.03100040091025","article-title":"NZB\/NZW mice as a model of systemic lupus erythematosus","volume":"195","author":"Dubois","year":"1966","journal-title":"JAMA"},{"key":"10.1016\/j.rpth.2024.102550_bib21","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3389\/fmed.2018.00107","article-title":"Ability of polyphosphate and nucleic acids to trigger blood clotting: some observations and caveats","volume":"5","author":"Smith","year":"2018","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.rpth.2024.102550_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0237849","article-title":"Diversification of polyphosphate end-labeling via bridging molecules","volume":"15","author":"Baker","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.rpth.2024.102550_bib23","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1002\/elps.201800227","article-title":"DNA ladders can be used to size polyphosphate resolved by polyacrylamide gel electrophoresis","volume":"39","author":"Smith","year":"2018","journal-title":"Electrophoresis"},{"key":"10.1016\/j.rpth.2024.102550_bib24","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/S0021-9258(19)35429-8","article-title":"The interaction of a Ca2+-dependent monoclonal antibody with the protein C activation peptide region. Evidence for obligatory Ca2+ binding to both antigen and antibody","volume":"263","author":"Stearns","year":"1988","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.rpth.2024.102550_bib25","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/BF00376096","article-title":"Interleukin-6 is antiproliferative to a mouse hybridoma cell line and promotive for its antibody productivity","volume":"10","author":"Makishima","year":"1992","journal-title":"Cytotechnology"},{"key":"10.1016\/j.rpth.2024.102550_bib26","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1111\/j.1538-7836.2008.03104.x","article-title":"Polyphosphate as a general procoagulant agent","volume":"6","author":"Smith","year":"2008","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.rpth.2024.102550_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0233644","article-title":"Heparin and non-anticoagulant heparin attenuate histone-induced inflammatory responses in whole blood","volume":"15","author":"Hogwood","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.rpth.2024.102550_bib28","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.biochi.2007.09.007","article-title":"Multifaceted roles of human elafin and secretory leukocyte proteinase inhibitor (SLPI), two serine protease inhibitors of the chelonianin family","volume":"90","author":"Moreau","year":"2008","journal-title":"Biochimie"},{"key":"10.1016\/j.rpth.2024.102550_bib29","doi-asserted-by":"crossref","first-page":"8285","DOI":"10.1021\/bi00150a023","article-title":"Heparin-induced conformational change and activation of mucus proteinase inhibitor","volume":"31","author":"Faller","year":"1992","journal-title":"Biochemistry"},{"key":"10.1016\/j.rpth.2024.102550_bib30","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1111\/j.1476-5381.1995.tb15892.x","article-title":"Pharmacological activity of the C-terminal and N-terminal domains of secretory leukoprotease inhibitor in\u00a0vitro","volume":"115","author":"Masuda","year":"1995","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.rpth.2024.102550_bib31","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1006\/abbi.1996.0095","article-title":"Inhibition of human mast cell chymase by secretory leukocyte proteinase inhibitor: enhancement of the interaction by heparin","volume":"327","author":"Walter","year":"1996","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.rpth.2024.102550_bib32","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jbiotec.2011.12.025","article-title":"Secretory leukocyte protease inhibitor (SLPI) might contaminate murine monoclonal antibodies after purification on protein G","volume":"158","author":"Schenk","year":"2012","journal-title":"J\u00a0Biotechnol"},{"key":"10.1016\/j.rpth.2024.102550_bib33","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12616","article-title":"Neutralizing blood-borne polyphosphate in\u00a0vivo provides safe thromboprotection","volume":"7","author":"Labberton","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.rpth.2024.102550_bib34","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1042\/BST20230257","article-title":"Inorganic polyphosphate: from basic research to diagnostic and therapeutic opportunities in ALS\/FTD","volume":"52","author":"Garc\u00e9s","year":"2024","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.rpth.2024.102550_bib35","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3389\/fmed.2019.00076","article-title":"Polyphosphate as a target for interference with inflammation and thrombosis","volume":"6","author":"Mailer","year":"2019","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.rpth.2024.102550_bib36","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.201900385","article-title":"Molecular characterization of CHAD domains as inorganic polyphosphate-binding modules","volume":"2","author":"Lorenzo-Orts","year":"2019","journal-title":"Life Sci Alliance"},{"key":"10.1016\/j.rpth.2024.102550_bib37","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.cca.2021.12.029","article-title":"Laboratory evaluation of anti-dsDNA antibodies","volume":"528","author":"Cockx","year":"2022","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.rpth.2024.102550_bib38","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1002\/bp0700051","article-title":"Genome-wide analysis of mouse myeloma cell lines expressing therapeutic antibodies","volume":"23","author":"Dorai","year":"2007","journal-title":"Biotechnol Prog"},{"key":"10.1016\/j.rpth.2024.102550_bib39","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1128\/IAI.66.6.2447-2452.1998","article-title":"Lipopolysaccharide-related stimuli induce expression of the secretory leukocyte protease inhibitor, a macrophage-derived lipopolysaccharide inhibitor","volume":"66","author":"Jin","year":"1998","journal-title":"Infect Immun"},{"key":"10.1016\/j.rpth.2024.102550_bib40","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0021-9673(00)01013-X","article-title":"Comparison of hydrophobic charge induction chromatography with affinity chromatography on protein A for harvest and purification of antibodies","volume":"908","author":"Schwart","year":"2001","journal-title":"J\u00a0Chromatogr A"},{"key":"10.1016\/j.rpth.2024.102550_bib41","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1182\/blood-2016-09-741298","article-title":"Platelets and neutrophil extracellular traps collaborate to promote intravascular coagulation during sepsis in mice","volume":"129","author":"McDonald","year":"2017","journal-title":"Blood"}],"container-title":["Research and Practice in Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037924002450?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037924002450?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T23:25:06Z","timestamp":1728602706000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2475037924002450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["S2475037924002450"],"URL":"https:\/\/doi.org\/10.1016\/j.rpth.2024.102550","relation":{},"ISSN":["2475-0379"],"issn-type":[{"value":"2475-0379","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antipolyphosphate monoclonal antibodies derived from autoimmune mice","name":"articletitle","label":"Article Title"},{"value":"Research and Practice in Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rpth.2024.102550","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis.","name":"copyright","label":"Copyright"}],"article-number":"102550"}}