{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:29:15Z","timestamp":1790792955151,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T00:00:00Z","timestamp":1738195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["rpthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research and Practice in Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.rpth.2025.102698","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T17:17:05Z","timestamp":1738862225000},"page":"102698","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Addressing the perimenopause: what\u2019s blood got to do with it?"],"prefix":"10.1016","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0503-9164","authenticated-orcid":false,"given":"Briony A.","family":"Cutts","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristy","family":"Fennessy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rpth.2025.102698_bib1","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1089\/jwh.2015.5556","article-title":"Perimenopause: from research to practice","volume":"25","author":"Santoro","year":"2016","journal-title":"J\u00a0Womens Health (Larchmt)"},{"key":"10.1016\/j.rpth.2025.102698_bib2","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1210\/jc.2011-3362","article-title":"Executive summary of the Stages of Reproductive Aging Workshop\u00a0+ 10: addressing the unfinished agenda of staging reproductive aging","volume":"97","author":"Harlow","year":"2012","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.rpth.2025.102698_bib3","article-title":"Management of perimenopausal and menopausal symptoms","volume":"382","author":"Duralde","year":"2023","journal-title":"BMJ"},{"key":"10.1016\/j.rpth.2025.102698_bib4","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s11920-023-01447-3","article-title":"Cognitive problems in perimenopause: a review of recent evidence","volume":"25","author":"Metcalf","year":"2023","journal-title":"Curr Psychiatry Rep"},{"key":"10.1016\/j.rpth.2025.102698_bib5","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1023\/B:QURE.0000018506.33706.05","article-title":"Well-being and menopause: an investigation of purpose in life, self-acceptance and social role in premenopausal, perimenopausal and postmenopausal women","volume":"13","author":"Deeks","year":"2004","journal-title":"Qual Life Res"},{"key":"10.1016\/j.rpth.2025.102698_bib6","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-90084-y","article-title":"Menopause impacts human brain structure, connectivity, energy metabolism, and amyloid-beta deposition","volume":"11","author":"Mosconi","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.rpth.2025.102698_bib7","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/ijgo.12666","article-title":"The two FIGO systems for normal and abnormal uterine bleeding symptoms and classification of causes of abnormal uterine bleeding in the reproductive years: 2018 revisions","volume":"143","author":"Munro","year":"2018","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1016\/j.rpth.2025.102698_bib8","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.bpobgyn.2015.11.012","article-title":"Abnormal uterine bleeding","volume":"34","author":"Whitaker","year":"2016","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"10.1016\/j.rpth.2025.102698_bib9","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.jogc.2020.10.009","article-title":"A\u00a0case series of patients with large uterine fibroids and venous thromboembolisms","volume":"43","author":"Cai","year":"2021","journal-title":"J\u00a0Obstet Gynaecol Can"},{"key":"10.1016\/j.rpth.2025.102698_bib10","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1160\/TH06-08-0452","article-title":"Extrinsic venous compression: a sufficient explanation for venous thromboembolism due to massive fibroids?","volume":"96","author":"Barsam","year":"2006","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.rpth.2025.102698_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2021.100882","article-title":"Oral tranexamic acid and thrombosis risk in women","volume":"35","author":"Meaidi","year":"2021","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.rpth.2025.102698_bib12","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1016\/S0140-6736(17)30638-4","article-title":"Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial","volume":"389","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.rpth.2025.102698_bib13","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/S0140-6736(11)60278-X","article-title":"The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial","volume":"377","author":"Roberts","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.rpth.2025.102698_bib14","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/rth2.12468","article-title":"Sexism in the management of bleeding disorders","volume":"5","author":"Weyand","year":"2021","journal-title":"Res Pract Thromb Haemost"},{"key":"10.1016\/j.rpth.2025.102698_bib15","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1111\/hae.12503","article-title":"Normal range of bleeding scores for the ISTH-BAT: adult and pediatric data from the merging project","volume":"20","author":"Elbatarny","year":"2014","journal-title":"Haemophilia"},{"key":"10.1016\/j.rpth.2025.102698_bib16","doi-asserted-by":"crossref","first-page":"153","DOI":"10.18231\/j.ijogr.2022.032","article-title":"Iron deficiency in peri-menopausal women: clinical considerations from an expert consensus","volume":"9","author":"Gandhi","year":"2022","journal-title":"Indian J Obstet Gynecol"},{"key":"10.1016\/j.rpth.2025.102698_bib17","doi-asserted-by":"crossref","first-page":"193","DOI":"10.18773\/austprescr.2021.052","article-title":"Non-anaemic iron deficiency","volume":"44","author":"Balendran","year":"2021","journal-title":"Aust Prescr"},{"key":"10.1016\/j.rpth.2025.102698_bib18","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/jha2.321","article-title":"Iron, neuro-bioavailability and depression","volume":"3","author":"Berthou","year":"2022","journal-title":"EJHaem"},{"key":"10.1016\/j.rpth.2025.102698_bib19","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.jnutbio.2014.07.003","article-title":"Iron and mechanisms of emotional behavior","volume":"25","author":"Kim","year":"2014","journal-title":"J\u00a0Nutr Biochem"},{"key":"10.1016\/j.rpth.2025.102698_bib20","doi-asserted-by":"crossref","first-page":"S243","DOI":"10.1192\/j.eurpsy.2023.559","article-title":"Psychiatric manifestations of iron deficiency anemia-a literature review","volume":"66","author":"Arshad","year":"2023","journal-title":"Eur Psychiatry"},{"key":"10.1016\/j.rpth.2025.102698_bib21","doi-asserted-by":"crossref","first-page":"602","DOI":"10.3390\/medicina55090602","article-title":"The controversial history of hormone replacement therapy","volume":"55","author":"Cagnacci","year":"2019","journal-title":"Medicina (Kaunas)"},{"key":"10.1016\/j.rpth.2025.102698_bib22","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1111\/j.1471-0528.1973.tb15981.x","article-title":"Speculations about mortality trends from venous thromboembolic disease in England and Wales and their relation to the pattern of oral contraceptive usage","volume":"80","author":"Vessey","year":"1973","journal-title":"J\u00a0Obstet Gynaecol Br Commonw"},{"key":"10.1016\/j.rpth.2025.102698_bib23","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.thromres.2020.05.008","article-title":"Estrogen and thrombosis: a bench to bedside review","volume":"192","author":"Abou-Ismail","year":"2020","journal-title":"Thromb Res"},{"key":"10.1016\/j.rpth.2025.102698_bib24","doi-asserted-by":"crossref","first-page":"18S","DOI":"10.1002\/j.1552-4604.1995.tb04143.x","article-title":"Pharmacokinetic and pharmacologic variation between different estrogen products","volume":"35","author":"O'Connell","year":"1995","journal-title":"J\u00a0Clin Pharmacol"},{"key":"10.1016\/j.rpth.2025.102698_bib25","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1056\/NEJM197512042932303","article-title":"Increased risk of endometrial carcinoma among users of conjugated estrogens","volume":"293","author":"Ziel","year":"1975","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.rpth.2025.102698_bib26","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1001\/jama.280.7.605","article-title":"Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen\/progestin Replacement Study (HERS) Research Group","volume":"280","author":"Hulley","year":"1998","journal-title":"JAMA"},{"key":"10.1016\/j.rpth.2025.102698_bib27","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1056\/NEJMoa030808","article-title":"Estrogen plus progestin and the risk of coronary heart disease","volume":"349","author":"Manson","year":"2003","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.rpth.2025.102698_bib28","author":"Bjugstad"},{"key":"10.1016\/j.rpth.2025.102698_bib29","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1177\/2053369120957514","article-title":"The British Menopause Society & Women's Health Concern 2020 recommendations on hormone replacement therapy in menopausal women","volume":"26","author":"Hamoda","year":"2020","journal-title":"Post Reprod Health"},{"key":"10.1016\/j.rpth.2025.102698_bib30","doi-asserted-by":"crossref","first-page":"680","DOI":"10.7326\/0003-4819-136-9-200205070-00011","article-title":"Postmenopausal estrogen replacement and risk for venous thromboembolism: a systematic review and meta-analysis for the U.S. Preventive Services Task Force","volume":"136","author":"Miller","year":"2002","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.rpth.2025.102698_bib31","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1080\/13697137.2018.1446931","article-title":"Progestogens and venous thromboembolism in menopausal women: an updated oral versus transdermal estrogen meta-analysis","volume":"21","author":"Scarabin","year":"2018","journal-title":"Climacteric"},{"key":"10.1016\/j.rpth.2025.102698_bib32","article-title":"Use of hormone replacement therapy and risk of venous thromboembolism: nested case-control studies using the QResearch and CPRD databases","volume":"364","author":"Vinogradova","year":"2019","journal-title":"BMJ"},{"key":"10.1016\/j.rpth.2025.102698_bib33","doi-asserted-by":"crossref","first-page":"e12","DOI":"10.3324\/haematol.2015.134882","article-title":"Risk of recurrent venous thromboembolism on progestin-only contraception: a cohort study","volume":"101","author":"Le Moigne","year":"2016","journal-title":"Haematologica"},{"key":"10.1016\/j.rpth.2025.102698_bib34","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1097\/AOG.0000000000005137","article-title":"Heavy menstrual bleeding treatment with a levonorgestrel 52-mg intrauterine device","volume":"141","author":"Creinin","year":"2023","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.rpth.2025.102698_bib37","doi-asserted-by":"crossref","first-page":"7101","DOI":"10.1182\/bloodadvances.2023010177","article-title":"American Society of Hematology 2023 guidelines for management of venous thromboembolism: thrombophilia testing","volume":"7","author":"Middeldorp","year":"2023","journal-title":"Blood Adv"},{"key":"10.1016\/j.rpth.2025.102698_bib38","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1177\/20533691221148036","article-title":"Hormone replacement therapy in women with history of thrombosis or a thrombophilia","volume":"29","author":"Morris","year":"2023","journal-title":"Post Reprod Health"},{"issue":"Suppl 2","key":"10.1016\/j.rpth.2025.102698_bib39","article-title":"Genome-wide investigation of exogenous female hormones, genetic variation, and venous thromboembolism risk: the INVENT Consortium [abstract]","volume":"8","author":"Smith","year":"2024","journal-title":"Res Pract Thromb Haemost"}],"container-title":["Research and Practice in Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037925000226?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037925000226?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T19:50:10Z","timestamp":1751399410000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2475037925000226"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["S2475037925000226"],"URL":"https:\/\/doi.org\/10.1016\/j.rpth.2025.102698","relation":{},"ISSN":["2475-0379"],"issn-type":[{"value":"2475-0379","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Addressing the perimenopause: what\u2019s blood got to do with it?","name":"articletitle","label":"Article Title"},{"value":"Research and Practice in Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rpth.2025.102698","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis.","name":"copyright","label":"Copyright"}],"article-number":"102698"}}