{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T07:53:30Z","timestamp":1793951610069,"version":"4.8.0"},"reference-count":22,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["rpthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research and Practice in Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.rpth.2025.102844","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:04:30Z","timestamp":1743465870000},"page":"102844","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Platelet response following dexamethasone in obese vs nonobese patients with primary, acute immune-mediated thrombocytopenia"],"prefix":"10.1016","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6482-842X","authenticated-orcid":false,"given":"Tyler","family":"Everhardt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelley","family":"Julian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell","family":"Benefield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles J.","family":"Parker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Parks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A.","family":"Gilreath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rpth.2025.102844_bib1","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1056\/NEJMcp1810479","article-title":"Immune thrombocytopenia","volume":"381","author":"Cooper","year":"2019","journal-title":"N Engl J Med"},{"key":"10.1016\/j.rpth.2025.102844_bib2","doi-asserted-by":"crossref","first-page":"3829","DOI":"10.1182\/bloodadvances.2019000966","article-title":"American Society of Hematology 2019 guidelines for immune thrombocytopenia","volume":"3","author":"Neunert","year":"2019","journal-title":"Blood Adv"},{"key":"10.1016\/j.rpth.2025.102844_bib3","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1056\/NEJM199406023302203","article-title":"Response of resistant idiopathic thrombocytopenic purpura to pulsed high-dose dexamethasone therapy","volume":"330","author":"Andersen","year":"1994","journal-title":"N Engl J Med"},{"key":"10.1016\/j.rpth.2025.102844_bib4","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1056\/NEJMoa030254","article-title":"Initial treatment of immune thrombocytopenic purpura with high-dose dexamethasone","volume":"349","author":"Cheng","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.rpth.2025.102844_bib5","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1182\/blood-2005-12-015222","article-title":"Therapy with high-dose dexamethasone (HD-DXM) in previously untreated patients affected by idiopathic thrombocytopenic purpura: a GIMEMA experience","volume":"109","author":"Mazzucconi","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2025.102844_bib6","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1182\/blood-2015-07-659656","article-title":"High-dose dexamethasone vs prednisone for treatment of adult immune thrombocytopenia: a prospective multicenter randomized trial","volume":"127","author":"Wei","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2025.102844_bib7","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1159\/000445420","article-title":"A randomized trial of daily prednisone versus pulsed dexamethasone in treatment-na\u00efve adult patients with immune thrombocytopenia: EIS 2002 study","volume":"136","author":"Matschke","year":"2016","journal-title":"Acta Haematol"},{"key":"10.1016\/j.rpth.2025.102844_bib8","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1159\/000362529","article-title":"Long-term effect of high-dose dexamethasone with or without low-dose dexamethasone maintenance in untreated immune thrombocytopenia","volume":"133","author":"Din","year":"2014","journal-title":"Acta Haematol"},{"key":"10.1016\/j.rpth.2025.102844_bib9","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s11239-013-0939-3","article-title":"Prednisone versus high-dose dexamethasone for untreated primary immune thrombocytopenia. A retrospective study of the Japan Hematology & Oncology Clinical Study Group","volume":"37","author":"Sakamoto","year":"2014","journal-title":"J Thromb Thrombolysis"},{"key":"10.1016\/j.rpth.2025.102844_bib10","doi-asserted-by":"crossref","first-page":"88","DOI":"10.4103\/jrms.JRMS_257_19","article-title":"Evaluation of treatment plan by three-period pulses of high-dose dexamethasone among patients with primary immune thrombocytopenia on platelet count response and adverse events: a randomized clinical trial","volume":"25","author":"Sadeghi","year":"2020","journal-title":"J Res Med Sci"},{"key":"10.1016\/j.rpth.2025.102844_bib11","first-page":"197","article-title":"High-dose dexamethasone therapy as the initial treatment for idiopathic thrombocytopenic purpura: protocol for a multicenter, open-label, single arm trial","volume":"72","author":"Takase","year":"2018","journal-title":"Acta Med Okayama"},{"key":"10.1016\/j.rpth.2025.102844_bib12","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1159\/000518744","article-title":"very early increased platelet count within a week after initiation of high-dose dexamethasone treatment is associated with long-term response in newly diagnosed immune thrombocytopenia patients","volume":"145","author":"Ishiyama","year":"2022","journal-title":"Acta Haematol"},{"key":"10.1016\/j.rpth.2025.102844_bib13","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1182\/bloodadvances.2023010975","article-title":"Prednisone vs high-dose dexamethasone in newly diagnosed adult primary immune thrombocytopenia: a randomized trial","volume":"8","author":"Mazzucconi","year":"2024","journal-title":"Blood Adv"},{"key":"10.1016\/j.rpth.2025.102844_bib14","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1182\/blood.2023022738","article-title":"Platelet-derived TGF-\u03b21 induces functional reprogramming of myeloid-derived suppressor cells in immune thrombocytopenia","volume":"144","author":"Wang","year":"2024","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2025.102844_bib15","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1600-0609.2006.00780.x","article-title":"Abnormality of CD4(+) CD25(+) regulatory T cells in idiopathic thrombocytopenic purpura","volume":"78","author":"Liu","year":"2007","journal-title":"Eur J Haematol"},{"key":"10.1016\/j.rpth.2025.102844_bib16","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1182\/blood-2008-07-162503","article-title":"Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group","volume":"113","author":"Rodeghiero","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2025.102844_bib18","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1182\/blood-2022-169992","article-title":"Obesity is associated with adverse outcomes in primary immune thrombocytopenia","volume":"140","author":"Xiao","year":"2022","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2025.102844_bib19","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/bjh.18997","article-title":"Obesity is associated with poor outcomes of corticosteroid treatment in patients with primary immune thrombocytopenia","volume":"203","author":"Zhang","year":"2023","journal-title":"Br J Haematol"},{"key":"10.1016\/j.rpth.2025.102844_bib20","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1111\/jth.13767","article-title":"High-dose dexamethasone or all-trans-retinoic acid restores the balance of macrophages towards M2 in immune thrombocytopenia","volume":"15","author":"Feng","year":"2017","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.rpth.2025.102844_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1215216","article-title":"Rituximab resistance in ITP and beyond","volume":"14","author":"Xiao","year":"2023","journal-title":"Front Immunol"},{"key":"10.1016\/j.rpth.2025.102844_bib22","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1182\/blood-2010-07-295477","article-title":"High-dose dexamethasone shifts the balance of stimulatory and inhibitory Fc gamma receptors on monocytes in patients with primary immune thrombocytopenia","volume":"117","author":"Liu","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2025.102844_bib23","doi-asserted-by":"crossref","first-page":"3780","DOI":"10.1182\/bloodadvances.2019000812","article-title":"Updated international consensus report on the investigation and management of primary immune thrombocytopenia","volume":"3","author":"Provan","year":"2019","journal-title":"Blood Adv"}],"container-title":["Research and Practice in Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037925001682?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037925001682?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T16:19:46Z","timestamp":1761841186000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2475037925001682"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S2475037925001682"],"URL":"https:\/\/doi.org\/10.1016\/j.rpth.2025.102844","relation":{},"ISSN":["2475-0379"],"issn-type":[{"value":"2475-0379","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Platelet response following dexamethasone in obese vs nonobese patients with primary, acute immune-mediated thrombocytopenia","name":"articletitle","label":"Article Title"},{"value":"Research and Practice in Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rpth.2025.102844","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis.","name":"copyright","label":"Copyright"}],"article-number":"102844"}}