{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T02:34:11Z","timestamp":1755225251798,"version":"3.43.0"},"reference-count":54,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001721","name":"Rijksuniversiteit Groningen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001721","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rpthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research and Practice in Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.rpth.2025.102872","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T13:24:08Z","timestamp":1745501048000},"page":"102872","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["In vivo activation of coagulation during human liver transplantation is associated with activation of the intrinsic pathway: an observational cohort study"],"prefix":"10.1016","volume":"9","author":[{"given":"Fynn L.","family":"Elvers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jelle","family":"Adelmeijer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Bos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Coen","family":"Maas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Bernal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3503-7140","authenticated-orcid":false,"given":"Ton","family":"Lisman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.rpth.2025.102872_bib1","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1097\/MOT.0b013e3282fce79d","article-title":"The two tales of coagulation in liver transplantation","volume":"13","author":"Warnaar","year":"2008","journal-title":"Curr Opin Organ Transplant"},{"key":"10.1016\/j.rpth.2025.102872_bib2","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1055\/s-0037-1603447","article-title":"Hemostatic complications in hepatobiliary surgery","volume":"43","author":"Bos","year":"2017","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.rpth.2025.102872_bib3","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/apt.13022","article-title":"Hypercoagulability following major partial liver resection - detected by thrombomodulin-modified thrombin generation testing","volume":"41","author":"Potze","year":"2015","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.rpth.2025.102872_bib4","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/lt.20078","article-title":"Thromboelastogram monitoring in the perioperative period of hepatectomy for adult living liver donation","volume":"10","author":"Cerutti","year":"2004","journal-title":"Liver Transpl"},{"key":"10.1016\/j.rpth.2025.102872_bib5","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1160\/TH07-03-0221","article-title":"Hypercoagulability after partial liver resection","volume":"98","author":"Bezeaud","year":"2007","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.rpth.2025.102872_bib6","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1016\/j.jtha.2023.03.017","article-title":"In vivo generation of thrombin in patients with liver disease without apparent evidence of activation of the intrinsic or extrinsic pathway of coagulation","volume":"21","author":"Elvers","year":"2023","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.rpth.2025.102872_bib7","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1182\/blood-2010-02-261891","article-title":"Rebalanced hemostasis in patients with liver disease: evidence and clinical consequences","volume":"116","author":"Lisman","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2025.102872_bib8","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.amjsurg.2013.12.021","article-title":"The international normalized ratio overestimates coagulopathy in patients after major hepatectomy","volume":"207","author":"Louis","year":"2014","journal-title":"Am J Surg"},{"key":"10.1016\/j.rpth.2025.102872_bib9","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.jhep.2009.12.001","article-title":"Normal to increased thrombin generation in patients undergoing liver transplantation despite prolonged conventional coagulation tests","volume":"52","author":"Lisman","year":"2010","journal-title":"J Hepatol"},{"key":"10.1016\/j.rpth.2025.102872_bib10","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/jhbp.438","article-title":"Risk factors of serious postoperative complications after pancreaticoduodenectomy and risk calculators for predicting postoperative complications: a nationwide study of 17,564 patients in Japan","volume":"24","author":"Aoki","year":"2017","journal-title":"J Hepatobiliary Pancreat Sci"},{"key":"10.1016\/j.rpth.2025.102872_bib11","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1097\/01.coc.0000436088.69084.22","article-title":"Clinical and prognostic significance of coagulation assays in pancreatic cancer patients with absence of venous thromboembolism","volume":"38","author":"Sun","year":"2015","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.rpth.2025.102872_bib12","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1002\/lt.23668","article-title":"Intraoperative hypercoagulability during liver transplantation as demonstrated by thromboelastography","volume":"19","author":"Krzanicki","year":"2013","journal-title":"Liver Transpl"},{"key":"10.1016\/j.rpth.2025.102872_bib13","doi-asserted-by":"crossref","first-page":"3564","DOI":"10.1016\/j.transproceed.2014.09.113","article-title":"Incidence and risk factors of deep vein thrombosis after liver transplantation","volume":"46","author":"Annamalai","year":"2014","journal-title":"Transplant Proc"},{"key":"10.1016\/j.rpth.2025.102872_bib14","doi-asserted-by":"crossref","first-page":"e68","DOI":"10.1097\/TXD.0000000000000578","article-title":"Deep vein thrombosis and pulmonary embolism in liver transplant patients: Risks and Prevention","volume":"2","author":"Yip","year":"2016","journal-title":"Transplant Direct"},{"key":"10.1016\/j.rpth.2025.102872_bib15","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1007\/s11605-012-1939-x","article-title":"Venous thromboembolism after hepatic resection: analysis of 5,706 patients","volume":"16","author":"Turley","year":"2012","journal-title":"J Gastrointest Surg"},{"key":"10.1016\/j.rpth.2025.102872_bib16","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1007\/s11605-013-2432-x","article-title":"Defining incidence and risk factors of venous thromboemolism after hepatectomy","volume":"18","author":"Ejaz","year":"2014","journal-title":"J Gastrointest Surg"},{"key":"10.1016\/j.rpth.2025.102872_bib17","doi-asserted-by":"crossref","first-page":"8004","DOI":"10.3748\/wjg.v21.i26.8004","article-title":"Perioperative thrombotic complications in liver transplantation","volume":"21","author":"Feltracco","year":"2015","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.rpth.2025.102872_bib18","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/0049-3848(95)00030-5","article-title":"Plasma concentration of tissue factor and factor VII in patients after abdominal surgery","volume":"77","author":"Albrecht","year":"1995","journal-title":"Thromb Res"},{"key":"10.1016\/j.rpth.2025.102872_bib19","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s00281-021-00876-7","article-title":"The contact system in liver injury","volume":"43","author":"Rangaswamy","year":"2021","journal-title":"Semin Immunopathol"},{"key":"10.1016\/j.rpth.2025.102872_bib20","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.cell.2009.11.001","article-title":"Platelet polyphosphates are proinflammatory and procoagulant mediators in vivo","volume":"139","author":"M\u00fcller","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.rpth.2025.102872_bib21","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1182\/blood-2016-06-722298","article-title":"In vitro activation of coagulation by human neutrophil DNA and histone proteins but not neutrophil extracellular traps","volume":"129","author":"Noubouossie","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2025.102872_bib22","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.jclinepi.2007.11.008","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"61","author":"von Elm","year":"2008","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.rpth.2025.102872_bib23","doi-asserted-by":"crossref","first-page":"2840","DOI":"10.1111\/jth.15060","article-title":"Efficacy of pro- and anticoagulant strategies in plasma of patients undergoing hepatobiliary surgery","volume":"18","author":"Bos","year":"2020","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.rpth.2025.102872_bib24","doi-asserted-by":"crossref","first-page":"794","DOI":"10.3389\/fimmu.2020.00794","article-title":"Patterns of C1-inhibitor\/plasma serine protease complexes in healthy humans and in hereditary angioedema patients","volume":"11","author":"Kajd\u00e1csi","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.rpth.2025.102872_bib25","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1002\/lt.25329","article-title":"Elevated plasma levels of cell-free DNA during liver transplantation are associated with activation of coagulation","volume":"24","author":"von Meijenfeldt","year":"2018","journal-title":"Liver Transpl"},{"key":"10.1016\/j.rpth.2025.102872_bib26","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1002\/hep.1840120317","article-title":"A hypercoagulable state follows orthotopic liver transplantation","volume":"12","author":"Stahl","year":"1990","journal-title":"Hepatology"},{"key":"10.1016\/j.rpth.2025.102872_bib27","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1177\/0310057X1103900508","article-title":"Markers of coagulation activation after hepatic resection for cancer: evidence of sustained upregulation of coagulation","volume":"39","author":"Weinberg","year":"2011","journal-title":"Anaesth Intensive Care"},{"key":"10.1016\/j.rpth.2025.102872_bib28","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1002\/hep.510250332","article-title":"Coagulation and fibrinolysis in primary biliary cirrhosis compared with other liver disease and during orthotopic liver transplantation","volume":"25","author":"Segal","year":"1997","journal-title":"Hepatology"},{"key":"10.1016\/j.rpth.2025.102872_bib29","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1055\/s-0038-1651542","article-title":"Intravascular coagulation in liver transplantation--is it present or not? A comparison between orthotopic and heterotopic liver transplantation","volume":"69","author":"Bakker","year":"1993","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.rpth.2025.102872_bib30","first-page":"51","article-title":"Prothrombin fragment 1 + 2 and thrombin-antithrombin complex measurements indicate continuous and progressive intraoperative thrombin generation in liver transplantation","volume":"23","author":"Monteagudo","year":"1993","journal-title":"Haemostasis"},{"key":"10.1016\/j.rpth.2025.102872_bib31","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1111\/j.1399-0012.2005.00425.x","article-title":"Coagulation and fibrinolytic profiles and appropriate use of heparin after living-donor liver transplantation","volume":"19","author":"Kaneko","year":"2005","journal-title":"Clin Transplant"},{"key":"10.1016\/j.rpth.2025.102872_bib32","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1002\/hep.510260509","article-title":"The prophylactic effect of aprotinin on intraoperative bleeding in liver transplantation: a randomized clinical study","volume":"26","author":"Garc\u00eda-Huete","year":"1997","journal-title":"Hepatology"},{"key":"10.1016\/j.rpth.2025.102872_bib33","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/00024382-200115040-00003","article-title":"Coagulopathy following major liver resection: the effect of rBPI21 and the role of decreased synthesis of regulating proteins by the liver","volume":"15","author":"Meijer","year":"2001","journal-title":"Shock"},{"key":"10.1016\/j.rpth.2025.102872_bib34","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1213\/00000539-199704000-00032","article-title":"Aprotinin reduces blood loss in patients undergoing elective liver resection","volume":"84","author":"Lentschener","year":"1997","journal-title":"Anesth Analg"},{"key":"10.1016\/j.rpth.2025.102872_bib35","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1155\/1993\/91843","article-title":"Factors relating to coagulation, fibrinolysis and hepatic damage after liver resection","volume":"7","author":"Oguro","year":"1993","journal-title":"HPB Surg"},{"key":"10.1016\/j.rpth.2025.102872_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ajh.2830470102","article-title":"Thrombomodulin: a marker for endothelial damage during orthotopic liver transplantation","volume":"47","author":"Himmelreich","year":"1994","journal-title":"Am J Hematol"},{"key":"10.1016\/j.rpth.2025.102872_bib37","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1097\/00007890-199206000-00017","article-title":"Diminished anticoagulant and fibrinolytic activity following liver transplantation","volume":"53","author":"Velasco","year":"1992","journal-title":"Transplantation"},{"key":"10.1016\/j.rpth.2025.102872_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0165390","article-title":"Tumor-specific D-dimer concentration ranges and influencing factors: a cross-sectional study","volume":"11","author":"Yu","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.rpth.2025.102872_bib39","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1002\/1097-0142(19921015)70:8<2067::AID-CNCR2820700809>3.0.CO;2-A","article-title":"Coagulation inhibition and activation in pancreatic cancer. Changes during progress of disease","volume":"70","author":"Lindahl","year":"1992","journal-title":"Cancer"},{"key":"10.1016\/j.rpth.2025.102872_bib40","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1055\/a-1839-0355","article-title":"Perioperative coagulation profile in major liver resection for cancer: a prospective observational study","volume":"122","author":"Tzimas","year":"2022","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.rpth.2025.102872_bib41","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.thromres.2015.05.023","article-title":"The temporal pattern of postoperative coagulation status in patients undergoing major liver surgery","volume":"136","author":"Dumitrescu","year":"2015","journal-title":"Thromb Res"},{"key":"10.1016\/j.rpth.2025.102872_bib42","doi-asserted-by":"crossref","first-page":"4108","DOI":"10.1080\/02648725.2023.2205199","article-title":"Analysis of risk factors of lower extremity deep venous thrombosis in patients undergoing hepatobiliary surgery","volume":"40","author":"Song","year":"2024","journal-title":"Biotechnol Genet Eng Rev"},{"key":"10.1016\/j.rpth.2025.102872_bib43","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1089\/lap.2023.0455","article-title":"Analysis of related influencing factors of portal vein thrombosis after hepatectomy","volume":"34","author":"Qi","year":"2024","journal-title":"J Laparoendosc Adv Surg Tech A"},{"key":"10.1016\/j.rpth.2025.102872_bib44","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1080\/10408363.2018.1529734","article-title":"D-dimer: preanalytical, analytical, postanalytical variables, and clinical applications","volume":"55","author":"Favresse","year":"2018","journal-title":"Crit Rev Clin Lab Sci"},{"key":"10.1016\/j.rpth.2025.102872_bib45","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1097\/MBC.0b013e32832a5fe6","article-title":"Kinetics of D-dimer after general surgery","volume":"20","author":"Dindo","year":"2009","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1016\/j.rpth.2025.102872_bib46","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1172\/JCI111360","article-title":"Inactivation of factor XII active fragment in normal plasma. Predominant role of C-1-inhibitor","volume":"73","author":"de Agostini","year":"1984","journal-title":"J Clin Invest"},{"key":"10.1016\/j.rpth.2025.102872_bib47","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1097\/00007890-199507150-00007","article-title":"Activation of the plasma contact system and hemodynamic changes after graft revascularization in liver transplantation","volume":"60","author":"Scholz","year":"1995","journal-title":"Transplantation"},{"key":"10.1016\/j.rpth.2025.102872_bib48","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1097\/00007890-199502000-00011","article-title":"Changes in the contact system during orthotopic liver transplantation with and without aprotinin","volume":"59","author":"Segal","year":"1995","journal-title":"Transplantation"},{"key":"10.1016\/j.rpth.2025.102872_bib49","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1055\/s-0031-1276586","article-title":"The plasma contact system 2.0","volume":"37","author":"Maas","year":"2011","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.rpth.2025.102872_bib50","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.5858\/2002-126-1382-TCS","article-title":"The contact system","volume":"126","author":"Kitchens","year":"2002","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.rpth.2025.102872_bib51","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/jth.13235","article-title":"Contact system revisited: an interface between inflammation, coagulation, and innate immunity","volume":"14","author":"Long","year":"2016","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.rpth.2025.102872_bib52","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1182\/blood.V128.22.258.258","article-title":"Stimulated platelets but not endothelium generate thrombin via a factor XIIa-dependent mechanism requiring phosphatidylserine exposure","volume":"128","author":"Bendapudi","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2025.102872_bib53","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0185685","article-title":"Inflammatory response and oxidative stress during liver resection","volume":"12","author":"Schwarz","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.rpth.2025.102872_bib54","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1182\/hematology.2022000386","article-title":"Coming soon to a pharmacy near you? FXI and FXII inhibitors to prevent or treat thromboembolism","volume":"2022","author":"Cohen","year":"2022","journal-title":"Hematology Am Soc Hematol Educ Program"}],"container-title":["Research and Practice in Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037925001967?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037925001967?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T08:37:44Z","timestamp":1755074264000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2475037925001967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":54,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S2475037925001967"],"URL":"https:\/\/doi.org\/10.1016\/j.rpth.2025.102872","relation":{},"ISSN":["2475-0379"],"issn-type":[{"type":"print","value":"2475-0379"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vivo activation of coagulation during human liver transplantation is associated with activation of the intrinsic pathway: an observational cohort study","name":"articletitle","label":"Article Title"},{"value":"Research and Practice in Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rpth.2025.102872","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis.","name":"copyright","label":"Copyright"}],"article-number":"102872"}}