{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T20:26:10Z","timestamp":1780604770329,"version":"3.54.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","rpthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research and Practice in Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.rpth.2025.102958","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T13:44:28Z","timestamp":1751377468000},"page":"102958","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Influence of long-distance trail running on blood hemostasis at the World Mountain Trail Running Championship 2023\u2014a pilot study"],"prefix":"10.1016","volume":"9","author":[{"given":"Wolfgang","family":"Schobersberger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Katharina","family":"Tobiasch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"D\u00fcnnwald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anika","family":"K\u00f6ck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrix","family":"Schobersberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo Emilio","family":"Adami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Garrandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephane","family":"Bermon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnter","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Irsara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedikt","family":"Treml","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietmar","family":"Fries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rpth.2025.102958_bib1","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1001\/jamainternmed.2021.7755","article-title":"Estimated number of deaths prevented through increased physical activity among US adults","volume":"182","author":"Saint-Maurice","year":"2022","journal-title":"JAMA Intern Med"},{"key":"10.1016\/j.rpth.2025.102958_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/sms.12581","article-title":"Exercise as medicine\u2014evidence for prescribing exercise as therapy in 26 different chronic diseases","volume":"25","author":"Pedersen","year":"2015","journal-title":"Scand J Med Sci Sports"},{"key":"10.1016\/j.rpth.2025.102958_bib3","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.blre.2014.10.005","article-title":"Short- and long-term exercise induced alterations in haemostasis: a review of the literature","volume":"29","author":"Posthuma","year":"2015","journal-title":"Blood Rev"},{"key":"10.1016\/j.rpth.2025.102958_bib4","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3390\/sports11040074","article-title":"The acute and chronic effects of resistance and aerobic exercise in hemostatic balance: a brief review","volume":"11","author":"Skouras","year":"2023","journal-title":"Sports (Basel)"},{"key":"10.1016\/j.rpth.2025.102958_bib5","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0268-9499(05)80074-8","article-title":"Influence of an ultramarathon race at moderate altitude on coagulation and fibrinolysis","volume":"10","author":"Schobersberger","year":"1996","journal-title":"Fibrinolysis"},{"key":"10.1016\/j.rpth.2025.102958_bib6","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1097\/MBC.0b013e328136c19b","article-title":"Blood coagulation activation and fibrinolysis during a downhill marathon run","volume":"18","author":"Sumann","year":"2007","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1016\/j.rpth.2025.102958_bib7","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.wem.2017.05.002","article-title":"Blood hemostatic changes during an ultraendurance road cycling event in a hot environment","volume":"28","author":"Kupchak","year":"2017","journal-title":"Wilderness Environ Med"},{"key":"10.1016\/j.rpth.2025.102958_bib8","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1007\/s00421-013-2709-5","article-title":"Alterations in coagulatory and fibrinolytic systems following an ultra-marathon","volume":"113","author":"Kupchak","year":"2013","journal-title":"Eur J Appl Physiol"},{"key":"10.1016\/j.rpth.2025.102958_bib9","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1055\/s-0038-1639502","article-title":"Hemostasis during extreme exertion","volume":"44","author":"Kicken","year":"2018","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.rpth.2025.102958_bib10","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1055\/s-0038-1667115","article-title":"Prothrombotic state induced by middle-distance endurance exercise in middle-aged athletes","volume":"44","author":"Lippi","year":"2018","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.rpth.2025.102958_bib11","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1055\/s-0038-1648231","article-title":"Hemostasis and thrombosis in extreme temperatures (hypo- and hyperthermia)","volume":"44","author":"Levi","year":"2018","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.rpth.2025.102958_bib12","doi-asserted-by":"crossref","first-page":"8531","DOI":"10.3390\/ijms21228531","article-title":"Impact of trail running races on blood viscosity and its determinants: effects of distance","volume":"21","author":"Robert","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.rpth.2025.102958_bib13","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jsams.2016.01.007","article-title":"The impact of exercise-induced core body temperature elevations on coagulation responses","volume":"20","author":"Veltmeijer","year":"2017","journal-title":"J Sci Med Sport"},{"key":"10.1016\/j.rpth.2025.102958_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.813550","article-title":"The Influence of environmental hypoxia on hemostasis-a systematic review","volume":"9","author":"Treml","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.rpth.2025.102958_bib15","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3390\/metabo13020179","article-title":"Effects of a maximal exercise followed by a submaximal exercise performed in normobaric hypoxia (2500 m), on blood rheology, red blood cell senescence, and coagulation in well-trained cyclists","volume":"13","author":"Carin","year":"2023","journal-title":"Metabolites"},{"key":"10.1016\/j.rpth.2025.102958_bib16","doi-asserted-by":"crossref","first-page":"171","DOI":"10.33549\/physiolres.934768","article-title":"Combined effect of acute altitude exposure and vigorous exercise on platelet activation","volume":"71","author":"Lackermair","year":"2022","journal-title":"Physiol Res"},{"key":"10.1016\/j.rpth.2025.102958_bib17","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.jshs.2023.09.007","article-title":"Immune consequences of exercise in hypoxia: a narrative review","volume":"13","author":"Burtscher","year":"2024","journal-title":"J Sport Health Sci"},{"key":"10.1016\/j.rpth.2025.102958_bib18","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1213\/ANE.0000000000006888","article-title":"Sepsis-induced coagulopathy: a comprehensive narrative review of pathophysiology, clinical presentation, diagnosis, and management strategies","volume":"138","author":"Williams","year":"2024","journal-title":"Anesth Analg"},{"key":"10.1016\/j.rpth.2025.102958_bib19","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1056\/NEJMra1808137","article-title":"Acute infection and myocardial infarction","volume":"380","author":"Musher","year":"2019","journal-title":"N Engl J Med"},{"key":"10.1016\/j.rpth.2025.102958_bib20","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.thromres.2019.09.029","article-title":"The current status of viscoelastic testing in septic coagulopathy","volume":"183","author":"Scarlatescu","year":"2019","journal-title":"Thromb Res"},{"key":"10.1016\/j.rpth.2025.102958_bib21","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.3390\/medicina58091311","volume":"58","author":"Chang","year":"2022","journal-title":"Medicina (Kaunas)"},{"key":"10.1016\/j.rpth.2025.102958_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.838069","article-title":"Changes in cytokines concentration following long-distance running: a systematic review and meta-analysis","volume":"13","author":"Alves","year":"2022","journal-title":"Front Physiol"},{"key":"10.1016\/j.rpth.2025.102958_bib23","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.23736\/S0022-4707.21.12752-5","article-title":"Wearable and telemedicine innovations for Olympic events and elite sport","volume":"61","author":"Muniz-Pardos","year":"2021","journal-title":"J Sports Med Phys Fitness"},{"key":"10.1016\/j.rpth.2025.102958_bib24","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1123\/ijspp.2021-0451","article-title":"Defining training and performance caliber: a participant classification framework","volume":"17","author":"McKay","year":"2022","journal-title":"Int J Sports Physiol Perform"},{"key":"10.1016\/j.rpth.2025.102958_bib25","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1111\/sms.13869","article-title":"Effect of marathon and ultra-marathon on inflammation and iron homeostasis","volume":"31","author":"Kaufmann","year":"2021","journal-title":"Scand J Med Sci Sports"},{"key":"10.1016\/j.rpth.2025.102958_bib26","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.maturitas.2003.10.015","article-title":"Crosstalk between inflammation and thrombosis","volume":"47","author":"Esmon","year":"2004","journal-title":"Maturitas"},{"key":"10.1016\/j.rpth.2025.102958_bib27","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.3389\/fimmu.2019.02536","article-title":"DAMPs and NETs in sepsis","volume":"10","author":"Denning","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.rpth.2025.102958_bib28","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.bja.2020.12.010","article-title":"Impaired fibrinolysis in critically ill COVID-19 patients","volume":"126","author":"Bachler","year":"2021","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.rpth.2025.102958_bib29","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13613-019-0499-6","article-title":"Acute fibrinolysis shutdown occurs early in septic shock and is associated with increased morbidity and mortality: results of an observational pilot study","volume":"9","author":"Schmitt","year":"2019","journal-title":"Ann Intensive Care"},{"key":"10.1016\/j.rpth.2025.102958_bib30","doi-asserted-by":"crossref","first-page":"634","DOI":"10.3389\/fphys.2018.00634","article-title":"Physiology and pathophysiology in ultra-marathon running","volume":"9","author":"Knechtle","year":"2018","journal-title":"Front Physiol"},{"key":"10.1016\/j.rpth.2025.102958_bib31","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s40279-024-02127-9","article-title":"Decoding ultramarathon: muscle damage as the main impediment to performance","volume":"55","author":"Tiller","year":"2025","journal-title":"Sports Med"},{"key":"10.1016\/j.rpth.2025.102958_bib32","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1152\/japplphysiol.00412.2024","article-title":"Acute cardiovascular responses to the 100-mi Western States Endurance Run","volume":"137","author":"Babcock","year":"2024","journal-title":"J Appl Physiol (1985)"},{"key":"10.1016\/j.rpth.2025.102958_bib33","doi-asserted-by":"crossref","first-page":"96","DOI":"10.3390\/jfmk6040096","article-title":"Eccentric exercise: adaptations and applications for health and performance","volume":"6","author":"Harris-Love","year":"2021","journal-title":"J Funct Morphol Kinesiol"},{"key":"10.1016\/j.rpth.2025.102958_bib34","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1139\/apnm-2022-0376","article-title":"Eccentric, but not concentric muscle contraction induce inflammation and impairs fibrinolysis in healthy young men","volume":"48","author":"Teixeira","year":"2023","journal-title":"Appl Physiol Nutr Metab"},{"key":"10.1016\/j.rpth.2025.102958_bib35","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/593938","article-title":"Influence of acute normobaric hypoxia on hemostasis in volunteers with and without acute mountain sickness","volume":"2015","author":"Schaber","year":"2015","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.rpth.2025.102958_bib36","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.thromres.2023.12.018","article-title":"Exercise and hypoxia-induced hypercoagulability is counterbalanced in women in part by decreased platelet reactivity","volume":"234","author":"Ninivaggi","year":"2024","journal-title":"Thromb Res"},{"key":"10.1016\/j.rpth.2025.102958_bib37","doi-asserted-by":"crossref","DOI":"10.1136\/bmjmed-2022-000239","article-title":"Exertional heat stroke: pathophysiology and risk factors","volume":"1","author":"Garcia","year":"2022","journal-title":"BMJ Med"},{"key":"10.1016\/j.rpth.2025.102958_bib38","article-title":"A potential driver of disseminated intravascular coagulation in heat stroke mice: neutrophil extracellular traps","volume":"19","author":"Zhang","year":"2022","journal-title":"Int J Environ Res Public Health"}],"container-title":["Research and Practice in Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037925002821?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037925002821?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T14:16:18Z","timestamp":1773843378000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2475037925002821"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S2475037925002821"],"URL":"https:\/\/doi.org\/10.1016\/j.rpth.2025.102958","relation":{},"ISSN":["2475-0379"],"issn-type":[{"value":"2475-0379","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Influence of long-distance trail running on blood hemostasis at the World Mountain Trail Running Championship 2023\u2014a pilot study","name":"articletitle","label":"Article Title"},{"value":"Research and Practice in Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rpth.2025.102958","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis.","name":"copyright","label":"Copyright"}],"article-number":"102958"}}