{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T22:07:31Z","timestamp":1783548451526,"version":"3.55.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:00:00Z","timestamp":1759363200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["rpthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research and Practice in Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.rpth.2025.103214","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T05:24:37Z","timestamp":1760073877000},"page":"103214","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of light transmission aggregometry in patients with bleeding disorder of unknown cause and healthy blood donors"],"prefix":"10.1016","volume":"9","author":[{"given":"Lena-Theresa","family":"Fanenbruck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Metze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Weise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Federbusch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Siegemund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin Reinhard","family":"Henschler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annelie","family":"Siegemund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirak","family":"Petros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0485-7402","authenticated-orcid":false,"given":"Christian","family":"Pfrepper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rpth.2025.103214_bib1","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1055\/a-2263-5706","article-title":"Bleeding disorder of unknown cause: a diagnosis of exclusion","volume":"44","author":"Mehic","year":"2024","journal-title":"Hamostaseologie"},{"key":"10.1016\/j.rpth.2025.103214_bib2","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1016\/j.jtha.2024.03.005","article-title":"Von Willebrand Factor, Platelet Physiology, and Women\u2019s Health Issues in Thrombosis and Haemostasis. Standardization of definition and management for bleeding disorder of unknown cause: communication from the SSC of the ISTH","volume":"22","author":"Baker","year":"2024","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.rpth.2025.103214_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.rpth.2023.102305","article-title":"Association of laboratory test results with the bleeding history in patients with inherited platelet function disorders (the Bleeding Assesment Tool - LABoratory tests substudy): communication from the Platelet Physiology ISTH-SSC","volume":"8","author":"Gresele","year":"2024","journal-title":"Res Pract Thromb Haemost"},{"key":"10.1016\/j.rpth.2025.103214_bib4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1055\/s-0037-1616935","article-title":"Assessment of platelet function in the laboratory","volume":"29","author":"Harrison","year":"2009","journal-title":"Hamostaseologie"},{"key":"10.1016\/j.rpth.2025.103214_bib5","doi-asserted-by":"crossref","first-page":"e213","DOI":"10.1055\/a-1827-7025","article-title":"Influencing factors and differences in born aggregometry in specialized hemostaseological centers: results of a multicenter laboratory comparison","volume":"06","author":"Kaiser","year":"2022","journal-title":"TH Open"},{"key":"10.1016\/j.rpth.2025.103214_bib6","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/jth.12792","article-title":"Subcommittee on Platelet Physiology of the International Society on Thrombosis and Hemostasis. Diagnosis of inherited platelet function disorders: guidance from the SSC of the ISTH","volume":"13","author":"Gresele","year":"2015","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.rpth.2025.103214_bib7","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.3390\/jcm9082636","article-title":"Advances in platelet function testing\u2014light transmission aggregometry and beyond","volume":"9","author":"Le Blanc","year":"2020","journal-title":"J Clin Med"},{"key":"10.1016\/j.rpth.2025.103214_bib8","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1055\/a-2436-5318","article-title":"The diagnostic assessment of inherited platelet function defects - part 1: an overview of the diagnostic approach and laboratory methods","volume":"45","author":"Hoepner","year":"2025","journal-title":"Hamostaseologie"},{"key":"10.1016\/j.rpth.2025.103214_bib9","doi-asserted-by":"crossref","first-page":"133","DOI":"10.2147\/VHRM.S44469","article-title":"Platelet function tests: a comparative review","volume":"11","author":"Paniccia","year":"2015","journal-title":"Vasc Health Risk Manag"},{"key":"10.1016\/j.rpth.2025.103214_bib10","doi-asserted-by":"crossref","first-page":"117","DOI":"10.5603\/JTM.2023.0006","article-title":"Light transmission aggregometry in the diagnosis of thrombocytopathy","volume":"16","author":"Malarczyk","year":"2023","journal-title":"J Transfus Med"},{"key":"10.1016\/j.rpth.2025.103214_bib11","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1136\/jcp.2008.057174","article-title":"Platelet function testing: practice among UK National External Quality Assessment Scheme for Blood Coagulation participants, 2006","volume":"61","author":"Jennings","year":"2008","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.rpth.2025.103214_bib12","doi-asserted-by":"crossref","first-page":"763","DOI":"10.3390\/jcm9030763","article-title":"Strengths and weaknesses of light transmission aggregometry in diagnosing hereditary platelet function disorders","volume":"9","author":"Alessi","year":"2020","journal-title":"J Clin Med"},{"key":"10.1016\/j.rpth.2025.103214_bib13","series-title":"AWMF-Register Nr 086\u2013003","article-title":"Diagnose von Thrombozytenfunktionsst\u00f6rungen \u2013 Thrombozytopathien","year":"2024"},{"key":"10.1016\/j.rpth.2025.103214_bib14","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1111\/jth.12231","article-title":"Recommendations for the standardization of light transmission aggregometry: a consensus of the working party from the platelet physiology subcommittee of SSC\/ISTH","volume":"11","author":"Cattaneo","year":"2013","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.rpth.2025.103214_bib15","doi-asserted-by":"crossref","first-page":"201","DOI":"10.5482\/HAMO-13-04-0024","article-title":"Diagnose angeborener St\u00f6rungen der Thrombozytenfunktion: Interdisziplin\u00e4re S2K-Leitlinie der St\u00e4ndigen Kommission P\u00e4diatrie der Gesellschaft f\u00fcr Thrombose- und H\u00e4mostaseforschung e","volume":"34","author":"Kn\u00f6fler","year":"2014","journal-title":"V. Hamostaseologie"},{"key":"10.1016\/j.rpth.2025.103214_bib16","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1055\/s-0029-1220324","article-title":"Light transmission aggregometry and ATP release for the diagnostic assessment of platelet function","volume":"35","author":"Cattaneo","year":"2009","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.rpth.2025.103214_bib17","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1177\/107602960401000301","article-title":"A practical concept for preoperative identification of patients with impaired primary hemostasis","volume":"10","author":"Koscielny","year":"2004","journal-title":"Clin Appl Thromb"},{"key":"10.1016\/j.rpth.2025.103214_bib18","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1111\/j.1538-7836.2010.03975.x","article-title":"ISTH\/SSC bleeding assessment tool: a standardized questionnaire and a proposal for a new bleeding score for inherited bleeding disorders","volume":"8","author":"Rodeghiero","year":"2010","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.rpth.2025.103214_bib19","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.clinbiochem.2012.08.002","article-title":"Effectiveness of practices to reduce blood sample hemolysis in EDs: a laboratory medicine best practices systematic review and meta-analysis","volume":"45","author":"Heyer","year":"2012","journal-title":"Clin Biochem"},{"key":"10.1016\/j.rpth.2025.103214_bib20","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1002\/ajh.22112","article-title":"Laboratory evaluation of clopidogrel responsiveness by platelet function and genetic methods","volume":"86","author":"Smock","year":"2011","journal-title":"Am J Hematol"},{"key":"10.1016\/j.rpth.2025.103214_bib21","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1016\/j.jtha.2023.05.027","article-title":"Multicenter evaluation of light transmission platelet aggregation reagents: communication from the ISTH SSC Subcommittee on Platelet Physiology","volume":"21","author":"Alessi","year":"2023","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.rpth.2025.103214_bib22","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1055\/s-0039-1688791","volume":"119","author":"Althaus","year":"2019","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.rpth.2025.103214_bib23","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1080\/09537104.2020.1771549","article-title":"Harmonizing light transmission aggregometry in the Netherlands by implementation of the SSC-ISTH guideline","volume":"32","author":"Munnix","year":"2021","journal-title":"Platelets"},{"key":"10.1016\/j.rpth.2025.103214_bib24","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1007\/s11239-009-0436-x","article-title":"Gender differences in platelet aggregation in healthy individuals","volume":"30","author":"Otahbachi","year":"2010","journal-title":"J Thromb Thrombolysis"},{"key":"10.1016\/j.rpth.2025.103214_bib25","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1055\/s-0038-1646620","article-title":"ADP-induced platelet aggregation as a function of age in healthy humans","volume":"61","author":"Vil\u00e9n","year":"1989","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.rpth.2025.103214_bib26","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1111\/jth.15263","article-title":"The ISTH bleeding assessment tool as predictor of bleeding events in inherited platelet disorders: communication from the ISTH SSC Subcommittee on Platelet Physiology","volume":"19","author":"Gresele","year":"2021","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.rpth.2025.103214_bib27","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1111\/jth.12332","article-title":"Utility of the ISTH bleeding assessment tool in predicting platelet defects in participants with suspected inherited platelet function disorders","volume":"11","author":"Lowe","year":"2013","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.rpth.2025.103214_bib28","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/hae.14376","article-title":"Preoperative bleeding risk assessment with ISTH-BAT and laboratory tests in patients undergoing elective surgery: a prospective cohort study","volume":"27","author":"Ambaglio","year":"2021","journal-title":"Haemophilia"}],"container-title":["Research and Practice in Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037925005382?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037925005382?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T02:45:06Z","timestamp":1767062706000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2475037925005382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":28,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S2475037925005382"],"URL":"https:\/\/doi.org\/10.1016\/j.rpth.2025.103214","relation":{},"ISSN":["2475-0379"],"issn-type":[{"value":"2475-0379","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of light transmission aggregometry in patients with bleeding disorder of unknown cause and healthy blood donors","name":"articletitle","label":"Article Title"},{"value":"Research and Practice in Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rpth.2025.103214","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis.","name":"copyright","label":"Copyright"}],"article-number":"103214"}}