{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:09:04Z","timestamp":1792807744347,"version":"4.5.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["rpthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research and Practice in Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.rpth.2025.103225","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:09:38Z","timestamp":1760551778000},"page":"103225","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Specific reversal agents for direct oral anticoagulants in neurosurgical emergencies \u2013 a systematic review"],"prefix":"10.1016","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9273-6756","authenticated-orcid":false,"given":"Laura","family":"Zeller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Rohr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Brandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Globas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Kaserer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Greutmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tilman","family":"Schubert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan-Dirk","family":"Studt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Geiling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Regli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menno R.","family":"Germans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rpth.2025.103225_bib1","series-title":"Neurointensive care unit. Current clinical neurology","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/978-3-030-36548-6_15","article-title":"Neurosurgical Emergencies","author":"Lee","year":"2020"},{"key":"10.1016\/j.rpth.2025.103225_bib2","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1161\/STROKEAHA.116.013343","article-title":"Anticoagulant-associated intracranial hemorrhage in the era of reversal agents","volume":"48","author":"Steiner","year":"2017","journal-title":"Stroke"},{"key":"10.1016\/j.rpth.2025.103225_bib3","doi-asserted-by":"crossref","first-page":"E275","DOI":"10.1055\/s-0043-108836","article-title":"Acute management of anticoagulation-associated intracerebral hemorrhage","volume":"1","author":"Kuramatsu","year":"2017","journal-title":"Neurol Int Open"},{"key":"10.1016\/j.rpth.2025.103225_bib4","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.006022","article-title":"Association of atrial fibrillation and oral anticoagulant use with perioperative outcomes after major noncardiac surgery","volume":"6","author":"Ge","year":"2017","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.rpth.2025.103225_bib5","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1161\/CIRCULATIONAHA.111.090464","article-title":"Periprocedural bleeding and thromboembolic events with dabigatran compared with warfarin: results from the Randomized Evaluation of Long-Term Anticoagulation Therapy (RE-LY) randomized trial","volume":"126","author":"Healey","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.rpth.2025.103225_bib6","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.thromres.2016.01.004","article-title":"Urgent surgery or procedures in patients taking dabigatran or warfarin: analysis of perioperative outcomes from the RE-LY trial","volume":"139","author":"Douketis","year":"2016","journal-title":"Thromb Res"},{"key":"10.1016\/j.rpth.2025.103225_bib7","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1111\/jth.13305","article-title":"Periprocedural management of patients receiving a vitamin K antagonist or a direct oral anticoagulant requiring an elective procedure or surgery","volume":"14","author":"Spyropoulos","year":"2016","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.rpth.2025.103225_bib10","doi-asserted-by":"crossref","DOI":"10.57187\/smw.2023.40113","article-title":"Recommendations for the use of andexanet alfa in the management of bleeding in patients on oral factor Xa inhibitors in Switzerland: guideline from the Working Party Hemostasis of the Swiss Society of Hematology","volume":"153","author":"Angelillo-Scherrer","year":"2023","journal-title":"Swiss Med Wkly"},{"key":"10.1016\/j.rpth.2025.103225_bib11","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1161\/CIRCULATIONAHA.121.057844","article-title":"Final study report of andexanet alfa for major bleeding with factor Xa inhibitors","volume":"147","author":"Milling","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.rpth.2025.103225_bib12","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1056\/NEJMoa1707278","article-title":"Idarucizumab for dabigatran reversal - full cohort analysis","volume":"377","author":"Pollack","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.rpth.2025.103225_bib13","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1136\/emermed-2015-205372.9","article-title":"Initial results of the RE-VERSE AD trial: idarucizumab reverses the anticoagulant effects of dabigatran in patients in an emergency setting of major bleeding, urgent surgery, or interventions","volume":"32","author":"Pollack","year":"2015","journal-title":"Emerg Med J"},{"key":"10.1016\/j.rpth.2025.103225_bib14","doi-asserted-by":"crossref","first-page":"6637","DOI":"10.3390\/jcm12206637","article-title":"Challenges in coagulation management in neurosurgical diseases: a scoping review, development, and implementation of coagulation management strategies","volume":"12","author":"Germans","year":"2023","journal-title":"J Clin Med"},{"key":"10.1016\/j.rpth.2025.103225_bib15","article-title":"PRISMA2020: an R package and Shiny app for producing PRISMA 2020-compliant flow diagrams, with interactivity for optimised digital transparency and Open Synthesis","volume":"18","author":"Haddaway","year":"2022","journal-title":"Campbell Syst Rev"},{"key":"10.1016\/j.rpth.2025.103225_bib16","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.recesp.2021.06.016","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"74","author":"Page","year":"2021","journal-title":"Rev Esp Cardiol (Engl Ed)"},{"key":"10.1016\/j.rpth.2025.103225_bib18","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s40119-020-00165-8","article-title":"Idarucizumab for emergency reversal of anticoagulant effects of dabigatran: interim results of a Japanese post-marketing surveillance study","volume":"9","author":"Yasaka","year":"2020","journal-title":"Cardiol Ther"},{"key":"10.1016\/j.rpth.2025.103225_bib19","doi-asserted-by":"crossref","first-page":"E278","DOI":"10.1002\/ajh.25587","article-title":"Coordinating emergent procedures after andexanet alfa","volume":"94","author":"Culbreth","year":"2019","journal-title":"Am J Hematol"},{"key":"10.1016\/j.rpth.2025.103225_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.clineuro.2020.106070","article-title":"An 18-month single-center observational study of real-world use of andexanet alfa in patients with factor Xa inhibitor associated intracranial hemorrhage","volume":"195","author":"Giovino","year":"2020","journal-title":"Clin Neurol Neurosurg"},{"key":"10.1016\/j.rpth.2025.103225_bib21","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.thromres.2020.11.010","article-title":"Real-world experience with reversal of dabigatran by idarucizumab","volume":"197","author":"Haastrup","year":"2021","journal-title":"Thromb Res"},{"key":"10.1016\/j.rpth.2025.103225_bib22","doi-asserted-by":"crossref","first-page":"e204","DOI":"10.1097\/SLA.0000000000003638","article-title":"Dabigatran reversal with idarucizumab in patients requiring urgent surgery: a subanalysis of the RE-VERSE AD study","volume":"274","author":"Levy","year":"2021","journal-title":"Ann Surg"},{"key":"10.1016\/j.rpth.2025.103225_bib23","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1002\/phar.2727","article-title":"Reversal of apixaban and rivaroxaban with andexanet alfa prior to invasive or surgical procedures","volume":"42","author":"Bradshaw","year":"2022","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.rpth.2025.103225_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.clineuro.2023.107621","article-title":"Emergent external ventricular drain placement in patients with factor Xa inhibitor-associated intracerebral hemorrhage after reversal with andexanet alfa","volume":"226","author":"Ammar","year":"2023","journal-title":"Clin Neurol Neurosurg"},{"key":"10.1016\/j.rpth.2025.103225_bib25","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1007\/s40119-023-00333-6","article-title":"Idarucizumab for emergency reversal of the anticoagulant effects of dabigatran: final results of a Japanese postmarketing surveillance study","volume":"12","author":"Yasaka","year":"2023","journal-title":"Cardiol Ther"},{"key":"10.1016\/j.rpth.2025.103225_bib26","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1515\/cclm-2014-0767","article-title":"Recent guidelines and recommendations for laboratory assessment of the direct oral anticoagulants (DOACs): is there consensus?","volume":"53","author":"Lippi","year":"2015","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.rpth.2025.103225_bib27","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1055\/a-1450-8178","article-title":"2021 update of the International Council for Standardization in Haematology recommendations for laboratory measurement of direct oral anticoagulants","volume":"121","author":"Douxfils","year":"2021","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.rpth.2025.103225_bib28","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1111\/anae.14816","article-title":"Impact of a Patient Blood Management monitoring and feedback programme on allogeneic blood transfusions and related costs","volume":"74","author":"Kaserer","year":"2019","journal-title":"Anaesthesia"},{"key":"10.1016\/j.rpth.2025.103225_bib29","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1111\/ijlh.13591","article-title":"Measuring residual anti-Xa activity of direct factor Xa inhibitors after reversal with andexanet alfa","volume":"43","author":"Bourdin","year":"2021","journal-title":"Int J Lab Hematol"},{"key":"10.1016\/j.rpth.2025.103225_bib30","doi-asserted-by":"crossref","first-page":"E304","DOI":"10.1093\/neuros\/nyy333","article-title":"Venous thromboembolism in patients with spontaneous intracerebral hemorrhage: a multicenter study","volume":"84","author":"Ding","year":"2019","journal-title":"Neurosurgery"},{"key":"10.1016\/j.rpth.2025.103225_bib31","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1097\/01.PHM.0000064725.62897.A5","article-title":"Prevalence of venous thromboembolism in acute hemorrhagic and thromboembolic stroke","volume":"82","author":"Gregory","year":"2003","journal-title":"Am J Phys Med Rehabil"},{"key":"10.1016\/j.rpth.2025.103225_bib32","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2022.40145","article-title":"Evaluation of direct oral anticoagulant reversal agents in intracranial hemorrhage: a systematic review and meta-analysis","volume":"5","author":"Chaudhary","year":"2022","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.rpth.2025.103225_bib33","first-page":"773","article-title":"Andexanet for factor Xa inhibitor-associated acute intracerebral hemorrhage","volume":"391","author":"Wong","year":"2024","journal-title":"N Engl J Med"},{"key":"10.1016\/j.rpth.2025.103225_bib34","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.54916","article-title":"Prothrombin complex concentrate vs conservative management in ICH associated with direct oral anticoagulants","volume":"7","author":"Ip","year":"2024","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.rpth.2025.103225_bib35","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1097\/ACO.0000000000001275","article-title":"Direct oral anticoagulants and their antagonists in perioperative practice","volume":"36","author":"Levy","year":"2023","journal-title":"Curr Opin Anaesthesiol"},{"key":"10.1016\/j.rpth.2025.103225_bib36","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.annemergmed.2019.09.001","article-title":"Anticoagulant reversal strategies in the emergency department setting: recommendations of a multidisciplinary expert panel","volume":"76","author":"Baugh","year":"2020","journal-title":"Ann Emerg Med"},{"key":"10.1016\/j.rpth.2025.103225_bib37","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.jacc.2020.04.053","article-title":"2020 ACC expert consensus decision pathway on management of bleeding in patients on oral anticoagulants: a report of the American College of Cardiology Solution Set Oversight Committee","volume":"76","author":"Tomaselli","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.rpth.2025.103225_bib38","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1177\/2396987319849763","article-title":"European Stroke Organisation guideline on reversal of oral anticoagulants in acute intracerebral haemorrhage","volume":"4","author":"Christensen","year":"2019","journal-title":"Eur Stroke J"},{"key":"10.1016\/j.rpth.2025.103225_bib39","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1016\/j.jtha.2024.07.009","article-title":"Reversal of direct oral anticoagulants: guidance from the SSC of the ISTH","volume":"22","author":"Levy","year":"2024","journal-title":"J Thromb Haemost"}],"container-title":["Research and Practice in Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037925005497?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037925005497?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T07:32:51Z","timestamp":1766129571000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2475037925005497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":36,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S2475037925005497"],"URL":"https:\/\/doi.org\/10.1016\/j.rpth.2025.103225","relation":{},"ISSN":["2475-0379"],"issn-type":[{"value":"2475-0379","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Specific reversal agents for direct oral anticoagulants in neurosurgical emergencies \u2013 a systematic review","name":"articletitle","label":"Article Title"},{"value":"Research and Practice in Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rpth.2025.103225","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis.","name":"copyright","label":"Copyright"}],"article-number":"103225"}}