{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T11:15:08Z","timestamp":1781954108716,"version":"3.54.5"},"reference-count":53,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021856","name":"Ministero dell&apos;Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rpthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research and Practice in Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.rpth.2025.103233","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T02:46:50Z","timestamp":1761187610000},"page":"103233","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Deep molecular modeling and mechanistic insights into type 2A von Willebrand disease with von Willebrand factor A2 domain mutations"],"prefix":"10.1016","volume":"9","author":[{"given":"Omid","family":"Seidizadeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Mollica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Giana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"Baronciani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Colpani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea","family":"Sicuro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Cairo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7423-9864","authenticated-orcid":false,"given":"Flora","family":"Peyvandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rpth.2025.103233_bib1","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1055\/s-0037-1615883","article-title":"Structure and function of von Willebrand factor","volume":"82","author":"Ruggeri","year":"1999","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.rpth.2025.103233_bib2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/s41572-024-00536-8","article-title":"von Willebrand disease","volume":"10","author":"Seidizadeh","year":"2024","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.rpth.2025.103233_bib3","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1111\/j.1538-7836.2006.02146.x","article-title":"Working Party on von Willebrand Disease Classification. Update on the pathophysiology and classification of von Willebrand disease: a report of the Subcommittee on von Willebrand Factor","volume":"4","author":"Sadler","year":"2006","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.rpth.2025.103233_bib4","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/s41525-023-00375-8","article-title":"Population-based prevalence and mutational landscape of von Willebrand disease using large-scale genetic databases","volume":"8","author":"Seidizadeh","year":"2023","journal-title":"NPJ Genom Med"},{"key":"10.1016\/j.rpth.2025.103233_bib5","author":"Seidizadeh"},{"key":"10.1016\/j.rpth.2025.103233_bib6","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s00894-004-0194-9","article-title":"Molecular modeling of the von Willebrand factor A2 Domain and the effects of associated type 2A von Willebrand disease mutations","volume":"10","author":"Sutherland","year":"2004","journal-title":"J Mol Model"},{"key":"10.1016\/j.rpth.2025.103233_bib7","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1055\/s-0036-1579641","article-title":"Type 2M and type 2A von Willebrand disease: similar but different","volume":"42","author":"Favaloro","year":"2016","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.rpth.2025.103233_bib8","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1182\/blood-2009-03-210369","article-title":"Force-induced cleavage of single VWFA1A2A3 tridomains by ADAMTS-13","volume":"115","author":"Wu","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2025.103233_bib9","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1126\/science.1170905","article-title":"Mechanoenzymatic cleavage of the ultralarge vascular protein von Willebrand factor","volume":"324","author":"Zhang","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.rpth.2025.103233_bib10","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.bpj.2015.12.023","article-title":"Shear-Induced Unfolding and enzymatic cleavage of full-length VWF multimers","volume":"110","author":"Lippok","year":"2016","journal-title":"Biophys J"},{"key":"10.1016\/j.rpth.2025.103233_bib11","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1111\/j.1538-7836.2012.04661.x","article-title":"Different bleeding risk in type 2A and 2M von Willebrand disease: a 2-year prospective study in 107 patients","volume":"10","author":"Castaman","year":"2012","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.rpth.2025.103233_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0045207","article-title":"Structural basis of type 2A von Willebrand disease investigated by molecular dynamics simulations and experiments","volume":"7","author":"Interlandi","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.rpth.2025.103233_bib13","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1055\/s-0041-1726097","article-title":"Type 2A and 2M von Willebrand disease: differences in phenotypic parameters according to the affected domain by disease-causing variants and assessment of pathophysiological mechanisms","volume":"47","author":"Woods","year":"2021","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.rpth.2025.103233_bib14","doi-asserted-by":"crossref","first-page":"19274","DOI":"10.1073\/pnas.0909755106","article-title":"Crystal structures of the noncatalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor","volume":"106","author":"Akiyama","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.rpth.2025.103233_bib15","doi-asserted-by":"crossref","first-page":"30136","DOI":"10.1074\/jbc.M305331200","article-title":"Cleavage of von Willebrand factor requires the spacer domain of the metalloprotease ADAMTS13","volume":"278","author":"Zheng","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.rpth.2025.103233_bib16","doi-asserted-by":"crossref","first-page":"18578","DOI":"10.1073\/pnas.1411979112","article-title":"Conformational activation of ADAMTS13","volume":"111","author":"South","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.rpth.2025.103233_bib17","doi-asserted-by":"crossref","first-page":"19099","DOI":"10.1073\/pnas.0607264104","article-title":"Exosite interactions contribute to tension-induced cleavage of von Willebrand factor by the antithrombotic ADAMTS13 metalloprotease","volume":"103","author":"Gao","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.rpth.2025.103233_bib18","doi-asserted-by":"crossref","first-page":"9226","DOI":"10.1073\/pnas.0903679106","article-title":"Structural specializations of A2, a force-sensing domain in the ultralarge vascular protein von Willebrand factor","volume":"106","author":"Zhang","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.rpth.2025.103233_bib19","doi-asserted-by":"crossref","first-page":"5791","DOI":"10.1038\/s41598-018-24212-6","article-title":"Prediction of spacer-\u03b16 complex: a novel insight into binding of ADAMTS13 with A2 domain of von Willebrand factor under forces","volume":"8","author":"Fang","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.rpth.2025.103233_bib20","doi-asserted-by":"crossref","first-page":"4031","DOI":"10.1182\/bloodadvances.2022007216","article-title":"Phenotypic and genetic characterizations of the Milan cohort of von Willebrand disease type 2","volume":"6","author":"Seidizadeh","year":"2022","journal-title":"Blood Adv"},{"key":"10.1016\/j.rpth.2025.103233_bib21","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1182\/bloodadvances.2024012626","article-title":"Type 2M\/2A von Willebrand disease: a shared phenotype between type 2M and 2A","volume":"8","author":"Seidizadeh","year":"2024","journal-title":"Blood Adv"},{"key":"10.1016\/j.rpth.2025.103233_bib22","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1182\/blood-2008-04-152280","article-title":"Clinical and molecular predictors of thrombocytopenia and risk of bleeding in patients with von Willebrand disease type 2B: a cohort study of 67 patients","volume":"113","author":"Federici","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2025.103233_bib23","doi-asserted-by":"crossref","first-page":"2428","DOI":"10.1073\/pnas.92.7.2428","article-title":"Platelet von Willebrand factor in inherited and acquired bleeding disorders","volume":"92","author":"Mannucci","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.rpth.2025.103233_bib24","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1182\/blood.V66.4.796.796","article-title":"Heterogeneity of type I von Willebrand disease: evidence for a subgroup with an abnormal von Willebrand factor","volume":"66","author":"Mannucci","year":"1985","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2025.103233_bib25","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.jtha.2023.01.012","article-title":"Genetic determinants of enhanced von Willebrand factor clearance from plasma","volume":"21","author":"Seidizadeh","year":"2023","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.rpth.2025.103233_bib26","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1055\/s-0038-1660481","article-title":"Evaluation of the utility of von Willebrand factor propeptide in the differential diagnosis of von Willebrand disease and acquired von Willebrand syndrome","volume":"45","author":"Stufano","year":"2019","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.rpth.2025.103233_bib27","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1016\/j.jtha.2024.05.006","article-title":"Application of genetic testing for the diagnosis of von Willebrand disease","volume":"22","author":"Seidizadeh","year":"2024","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.rpth.2025.103233_bib28","doi-asserted-by":"crossref","first-page":"W382","DOI":"10.1093\/nar\/gki387","article-title":"The FoldX web server: an online force field","volume":"33","author":"Schymkowitz","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.rpth.2025.103233_bib29","doi-asserted-by":"crossref","first-page":"12759","DOI":"10.1021\/jp401587e","article-title":"Population based reweighting of scaled molecular dynamics","volume":"117","author":"Sinko","year":"2013","journal-title":"J Phys Chem B"},{"key":"10.1016\/j.rpth.2025.103233_bib30","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.softx.2015.06.001","article-title":"GROMACS: high performance molecular simulations through multi-level parallelism from laptops to supercomputers","volume":"1\u20132","author":"Abraham","year":"2015","journal-title":"SoftwareX"},{"key":"10.1016\/j.rpth.2025.103233_bib31","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1021\/acs.jcim.7b00680","article-title":"BiKi life sciences: a new suite for molecular dynamics and related methods in drug discovery","volume":"58","author":"Decherchi","year":"2018","journal-title":"J Chem Inf Model"},{"key":"10.1016\/j.rpth.2025.103233_bib32","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1002\/prot.22711","article-title":"Improved side-chain torsion potentials for the Amber ff99SB protein force field","volume":"78","author":"Lindorff-Larsen","year":"2010","journal-title":"Proteins"},{"key":"10.1016\/j.rpth.2025.103233_bib33","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1063\/1.445869","article-title":"Comparison of simple potential functions for simulating liquid water","volume":"79","author":"Jorgensen","year":"1983","journal-title":"J Chem Phys"},{"key":"10.1016\/j.rpth.2025.103233_bib34","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1063\/1.447334","article-title":"A unified formulation of the constant temperature molecular dynamics methods","volume":"81","author":"Nos\u00e9","year":"1984","journal-title":"The J Chem Phys"},{"key":"10.1016\/j.rpth.2025.103233_bib35","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1002\/(SICI)1096-987X(199709)18:12<1463::AID-JCC4>3.0.CO;2-H","article-title":"LINCS: a linear constraint solver for molecular simulations","volume":"18","author":"Hess","year":"1997","journal-title":"J Comput Chem"},{"key":"10.1016\/j.rpth.2025.103233_bib36","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1021\/ja026939x","article-title":"HADDOCK: a protein-protein docking approach based on biochemical or biophysical information","volume":"125","author":"Dominguez","year":"2003","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.rpth.2025.103233_bib37","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1107\/S0907444998003254","article-title":"Crystallography & NMR system: a new software suite for macromolecular structure determination","volume":"54","author":"Br\u00fcnger","year":"1998","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"10.1016\/j.rpth.2025.103233_bib38","doi-asserted-by":"crossref","first-page":"3212","DOI":"10.1182\/blood-2011-02-306597","article-title":"Unraveling the scissile bond: how ADAMTS13 recognizes and cleaves von Willebrand factor","volume":"118","author":"Crawley","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2025.103233_bib39","doi-asserted-by":"crossref","DOI":"10.1002\/wcms.1448","article-title":"Computational prediction of protein\u2013protein binding affinities","volume":"10","author":"Siebenmorgen","year":"2020","journal-title":"WIREs Comput Mol Sci"},{"key":"10.1016\/j.rpth.2025.103233_bib40","doi-asserted-by":"crossref","first-page":"6281","DOI":"10.1021\/acs.jctc.1c00645","article-title":"gmx_MMPBSA: a new tool to perform end-state free energy calculations with GROMACS","volume":"17","author":"Vald\u00e9s-Tresanco","year":"2021","journal-title":"J Chem Theory Comput"},{"key":"10.1016\/j.rpth.2025.103233_bib41","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1021\/ct4010917","article-title":"Introducing charge hydration asymmetry into the generalized Born model","volume":"10","author":"Mukhopadhyay","year":"2014","journal-title":"J Chem Theory Comput"},{"key":"10.1016\/j.rpth.2025.103233_bib42","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1002\/bip.22321","article-title":"Protein folding and unfolding under force","volume":"99","author":"Jagannathan","year":"2013","journal-title":"Biopolymers"},{"key":"10.1016\/j.rpth.2025.103233_bib43","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.3324\/haematol.2017.168765","article-title":"Molecular and clinical profile of von Willebrand disease in Spain (PCM-EVW-ES): comprehensive genetic analysis by next-generation sequencing of 480 patients","volume":"102","author":"Borr\u00e0s","year":"2017","journal-title":"Haematologica"},{"key":"10.1016\/j.rpth.2025.103233_bib44","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000003038","article-title":"French Reference Center for von Willebrand disease. A laboratory phenotype\/genotype correlation of 1167 French patients from 670 families with von Willebrand disease: a new epidemiologic picture","volume":"95","author":"Veyradier","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.rpth.2025.103233_bib45","doi-asserted-by":"crossref","unstructured":"Seidizadeh O, Ciavarella A, Baronciani L, Colpani P, Cairo A, Siboni SM, et al. Genetic determinants of clinical variability in type 2 von Willebrand disease: bridging genotype and phenotype. Haematologica. In press. https:\/\/doi.org\/10.3324\/haematol.2025.288342","DOI":"10.3324\/haematol.2025.288342"},{"key":"10.1016\/j.rpth.2025.103233_bib46","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0161310","article-title":"Diagnostic value of measuring platelet von Willebrand factor in von Willebrand disease","volume":"11","author":"Casonato","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.rpth.2025.103233_bib47","doi-asserted-by":"crossref","first-page":"4424","DOI":"10.1016\/S0021-9258(18)42852-9","article-title":"Impaired intracellular transport produced by a subset of type IIA von Willebrand disease mutations","volume":"267","author":"Lyons","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1016\/j.rpth.2025.103233_bib48","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1160\/TH12-07-0475","article-title":"Characterisation of mutations and molecular studies of type 2 von Willebrand disease","volume":"109","author":"Ahmad","year":"2013","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.rpth.2025.103233_bib49","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1111\/j.1538-7836.2004.00732.x","article-title":"A novel type 2A (Group II) von Willebrand disease mutation (L1503Q) associated with loss of the highest molecular weight von Willebrand factor multimers","volume":"2","author":"O\u2019Brien","year":"2004","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.rpth.2025.103233_bib50","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1182\/blood-2014-09-603241","article-title":"von Willebrand factor propeptide and the phenotypic classification of von Willebrand disease","volume":"125","author":"Sanders","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2025.103233_bib51","doi-asserted-by":"crossref","first-page":"4543","DOI":"10.1182\/blood-2011-06-360875","article-title":"Intersection of mechanisms of type 2A VWD through defects in VWF multimerization, secretion, ADAMTS-13 susceptibility, and regulated storage","volume":"119","author":"Jacobi","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2025.103233_bib52","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0188405","article-title":"A common mechanism by which type 2A von Willebrand disease mutations enhance ADAMTS13 proteolysis revealed with a von Willebrand factor A2 domain FRET construct","volume":"12","author":"Lynch","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.rpth.2025.103233_bib53","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.1110\/ps.0222702","article-title":"Side-chain conformational entropy at protein-protein interfaces","volume":"11","author":"Cole","year":"2002","journal-title":"Protein Sci"}],"updated-by":[{"DOI":"10.1016\/j.rpth.2025.103300","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000}}],"container-title":["Research and Practice in Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037925005576?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037925005576?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T09:14:50Z","timestamp":1768468490000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2475037925005576"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":53,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S2475037925005576"],"URL":"https:\/\/doi.org\/10.1016\/j.rpth.2025.103233","relation":{},"ISSN":["2475-0379"],"issn-type":[{"value":"2475-0379","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deep molecular modeling and mechanistic insights into type 2A von Willebrand disease with von Willebrand factor A2 domain mutations","name":"articletitle","label":"Article Title"},{"value":"Research and Practice in Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rpth.2025.103233","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis.","name":"copyright","label":"Copyright"}],"article-number":"103233"}}