{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:17:52Z","timestamp":1787242672616,"version":"build-2736575974"},"reference-count":18,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","rpthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research and Practice in Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.rpth.2026.103361","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T16:46:11Z","timestamp":1768841171000},"page":"103361","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prothrombin complex concentrate for oral factor Xa inhibitor-associated intracerebral hemorrhage"],"prefix":"10.1016","volume":"10","author":[{"given":"Mohammad","family":"Shamiea","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Sbehi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadim Abu","family":"Rashed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Awan","family":"Kashua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feda","family":"Fanadka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eilam","family":"Rabina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Osnis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilad","family":"Itchaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orly","family":"Avnery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osnat","family":"Jarchowsky-Dolberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Ellis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rpth.2026.103361_bib1","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1161\/CIR.0000000000001193","article-title":"2023 ACC\/AHA\/ACCP\/HRS guideline for the diagnosis and management of atrial fibrillation: a report of the American College of Cardiology\/American Heart Association Joint Committee on clinical practice guidelines","volume":"149","author":"Joglar","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.rpth.2026.103361_bib2","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1055\/a-2451-4014","article-title":"Direct oral anticoagulants: quick primer on when to use and when to avoid","volume":"125","author":"Bejjani","year":"2025","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.rpth.2026.103361_bib3","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s12325-022-02333-9","article-title":"Risk and management of bleeding complications with direct oral anticoagulants in patients with atrial fibrillation and venous thromboembolism: a narrative review","volume":"40","author":"Ballestri","year":"2023","journal-title":"Adv Ther"},{"key":"10.1016\/j.rpth.2026.103361_bib4","doi-asserted-by":"crossref","first-page":"325","DOI":"10.2147\/VHRM.S121661","article-title":"Evaluation of bleeding in patients receiving direct oral anticoagulants","volume":"13","author":"Hellenbart","year":"2017","journal-title":"Vasc Health Risk Manag"},{"key":"10.1016\/j.rpth.2026.103361_bib5","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.amjcard.2021.09.011","article-title":"Risk of intracranial hemorrhage caused by direct oral anticoagulants for stroke prevention in patients with atrial fibrillation (from a network meta-analysis of randomized controlled trials)","volume":"162","author":"Lv","year":"2022","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.rpth.2026.103361_bib6","article-title":"Risks and benefits of direct oral anticoagulants versus warfarin in a real world setting: cohort study in primary care","volume":"362","author":"Vinogradova","year":"2018","journal-title":"BMJ"},{"key":"10.1016\/j.rpth.2026.103361_bib7","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1111\/bcp.14362","article-title":"Major bleeding risk associated with oral anticoagulant in real clinical practice. A multicentre 3-year period population-based prospective cohort study","volume":"86","author":"Bouget","year":"2020","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.rpth.2026.103361_bib8","doi-asserted-by":"crossref","first-page":"e1143","DOI":"10.1212\/WNL.0000000000005207","article-title":"Comparing intracerebral hemorrhages associated with direct oral anticoagulants or warfarin","volume":"90","author":"Kurogi","year":"2018","journal-title":"Neurology"},{"key":"10.1016\/j.rpth.2026.103361_bib9","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.12.013","article-title":"Characteristics of acute spontaneous intracerebral hemorrhage in patients receiving oral anticoagulants","volume":"28","author":"Suda","year":"2019","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"10.1016\/j.rpth.2026.103361_bib10","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1056\/NEJMoa1707278","article-title":"Idarucizumab for dabigatran reversal - full cohort analysis","volume":"377","author":"Pollack","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.rpth.2026.103361_bib11","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1056\/NEJMoa2313040","article-title":"Andexanet for factor Xa inhibitor\u2013associated acute intracerebral hemorrhage","volume":"390","author":"Connolly","year":"2024","journal-title":"N Engl J Med"},{"key":"10.1016\/j.rpth.2026.103361_bib12","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1007\/s12028-024-02130-y","article-title":"Efficacy and safety of andexanet alfa versus four factor prothrombin complex concentrate for emergent reversal of factor Xa inhibitor associated intracranial hemorrhage: a systematic review and meta-analysis","volume":"42","author":"Sarhan","year":"2025","journal-title":"Neurocrit Care"},{"key":"10.1016\/j.rpth.2026.103361_bib13","doi-asserted-by":"crossref","first-page":"e1202","DOI":"10.1097\/CCM.0000000000006656","article-title":"Reversal of factor Xa inhibitor-related intracranial hemorrhage: a multicenter, retrospective, observational study comparing the efficacy and safety of andexanet and prothrombin complex concentrates","volume":"53","author":"Panos","year":"2025","journal-title":"Crit Care Med"},{"key":"10.1016\/j.rpth.2026.103361_bib14","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1186\/s13054-022-04043-8","article-title":"Andexanet alfa versus four-factor prothrombin complex concentrate for the reversal of apixaban- or rivaroxaban-associated intracranial hemorrhage: a propensity score-overlap weighted analysis","volume":"26","author":"Costa","year":"2022","journal-title":"Crit Care"},{"key":"10.1016\/j.rpth.2026.103361_bib15","doi-asserted-by":"crossref","first-page":"e1025","DOI":"10.1097\/CCM.0000000000005059","article-title":"Andexanet alfa or prothrombin complex concentrate for factor Xa inhibitor reversal in acute major bleeding: a systematic review and meta-analysis","volume":"49","author":"Nederpelt","year":"2021","journal-title":"Crit Care Med"},{"key":"10.1016\/j.rpth.2026.103361_bib16","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1111\/jth.14838","article-title":"Evaluation of andexanet alfa and four-factor prothrombin complex concentrate (4F-PCC) for reversal of rivaroxaban- and apixaban-associated intracranial hemorrhages","volume":"18","author":"Barra","year":"2020","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.rpth.2026.103361_bib17","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1016\/j.jtha.2024.07.009","article-title":"Reversal of direct oral anticoagulants: guidance from the SSC of the ISTH","volume":"22","author":"Levy","year":"2024","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.rpth.2026.103361_bib18","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s11239-019-01973-z","article-title":"Cost comparison of andexanet versus prothrombin complex concentrates for direct factor Xa inhibitor reversal after hemorrhage","volume":"49","author":"Frontera","year":"2020","journal-title":"J Thromb Thrombolysis"}],"container-title":["Research and Practice in Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037926000191?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037926000191?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T01:53:55Z","timestamp":1778896435000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2475037926000191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S2475037926000191"],"URL":"https:\/\/doi.org\/10.1016\/j.rpth.2026.103361","relation":{},"ISSN":["2475-0379"],"issn-type":[{"value":"2475-0379","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prothrombin complex concentrate for oral factor Xa inhibitor-associated intracerebral hemorrhage","name":"articletitle","label":"Article Title"},{"value":"Research and Practice in Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rpth.2026.103361","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis.","name":"copyright","label":"Copyright"}],"article-number":"103361"}}