{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T12:06:13Z","timestamp":1784549173747,"version":"3.55.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004326","name":"Bayer AG","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004326","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","rpthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research and Practice in Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.rpth.2026.106616","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T02:28:46Z","timestamp":1777602526000},"page":"106616","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Validation of electronic health record-based International Society on Thrombosis and Haemostasis bleeding algorithms in a US health system"],"prefix":"10.1016","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3161-5732","authenticated-orcid":false,"given":"Jaejin","family":"An","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Hartenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon Kyu","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernadine","family":"Dizon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susie","family":"Flores","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Sum","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Hocum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Vogtl\u00e4nder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Abdelgawwad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rpth.2026.106616_bib1","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.1093\/eurheartj\/ehae176","article-title":"2024 ESC Guidelines for the management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS)","volume":"45","author":"Van Gelder","year":"2024","journal-title":"Eur Heart J"},{"key":"10.1016\/j.rpth.2026.106616_bib2","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1161\/CIR.0000000000001193","article-title":"2023 ACC\/AHA\/ACCP\/HRS guideline for the diagnosis and management of atrial fibrillation: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"149","author":"Joglar","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.rpth.2026.106616_bib3","doi-asserted-by":"crossref","first-page":"4899","DOI":"10.1093\/eurheartj\/ehac587","article-title":"Bleeding and ischaemic events after first bleed in anticoagulated atrial fibrillation patients: risk and timing","volume":"43","author":"Meyre","year":"2022","journal-title":"Eur Heart J"},{"key":"10.1016\/j.rpth.2026.106616_bib4","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1111\/j.1538-7836.2005.01204.x","volume":"3","author":"Schulman","year":"2005","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.rpth.2026.106616_bib5","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1111\/jth.13140","article-title":"Definition of clinically relevant non-major bleeding in studies of anticoagulants in atrial fibrillation and venous thromboembolic disease in non-surgical patients: communication from the SSC of the ISTH","volume":"13","author":"Kaatz","year":"2015","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.rpth.2026.106616_bib6","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s11239-020-02135-2","article-title":"Incidence and consequences of resuming oral anticoagulant therapy following hematuria and risks of ischemic stroke and major bleeding in patients with atrial fibrillation","volume":"51","author":"Wang","year":"2021","journal-title":"J Thromb Thrombolysis"},{"key":"10.1016\/j.rpth.2026.106616_bib7","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/S0140-6736(13)62343-0","article-title":"Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials","volume":"383","author":"Ruff","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.rpth.2026.106616_bib8","first-page":"387","article-title":"Clinically relevant non-major bleeding with oral anticoagulants: non-major may not be trivial","volume":"16","author":"Franco","year":"2018","journal-title":"Blood Transfus"},{"key":"10.1016\/j.rpth.2026.106616_bib9","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.ijcard.2016.05.059","article-title":"Safety and efficacy of oral factor-Xa inhibitors versus Vitamin K antagonist in patients with non-valvular atrial fibrillation: meta-analysis of phase II and III randomized controlled trials","volume":"218","author":"Garg","year":"2016","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.rpth.2026.106616_bib10","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1161\/CIRCULATIONAHA.118.036248","article-title":"Major bleeding rates in atrial fibrillation patients on single, dual, or triple antithrombotic therapy","volume":"139","author":"van Rein","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.rpth.2026.106616_bib11","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.115.001921","article-title":"Stroke and bleeding risk associated with antithrombotic therapy for patients with nonvalvular atrial fibrillation in clinical practice","volume":"4","author":"An","year":"2015","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.rpth.2026.106616_bib12","first-page":"2144","article-title":"Identification of International Society on Thrombosis and Haemostasis major and clinically relevant non-major bleed events from electronic health records: a novel algorithm to enhance data utilisation from real-world sources","volume":"8","author":"Hartenstein","year":"2023","journal-title":"Int J Popul Data Sci"},{"key":"10.1016\/j.rpth.2026.106616_bib13","doi-asserted-by":"crossref","first-page":"87","DOI":"10.7812\/TPP\/22.172","article-title":"Comparing Kaiser Permanente members to the general population: implications for generalizability of research","volume":"27","author":"Davis","year":"2023","journal-title":"Perm J"},{"key":"10.1016\/j.rpth.2026.106616_bib14","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.121.021601","article-title":"Long-term medication adherence trajectories to direct oral anticoagulants and clinical outcomes in patients with atrial fibrillation","volume":"10","author":"An","year":"2021","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.rpth.2026.106616_bib15","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1161\/CIRCOUTCOMES.111.962688","article-title":"Incidence and prevalence of atrial fibrillation and associated mortality among Medicare beneficiaries, 1993-2007","volume":"5","author":"Piccini","year":"2012","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"10.1016\/j.rpth.2026.106616_bib16","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.014527","article-title":"Impact of different electronic cohort definitions to identify patients with atrial fibrillation from the electronic medical record","volume":"9","author":"Shah","year":"2020","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.rpth.2026.106616_bib17","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"Harris","year":"2009","journal-title":"J Biomed Inform"},{"key":"10.1016\/j.rpth.2026.106616_bib18","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/pds.4701","article-title":"Conditional validation sampling for consistent risk estimation with binary outcome data subject to misclassification","volume":"28","author":"Gravel","year":"2019","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"10.1016\/j.rpth.2026.106616_bib19","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1378\/chest.09-1584","article-title":"Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach: the Euro Heart Survey on atrial fibrillation","volume":"137","author":"Lip","year":"2010","journal-title":"Chest"},{"key":"10.1016\/j.rpth.2026.106616_bib20","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1161\/STROKEAHA.110.590257","article-title":"Identifying patients at high risk for stroke despite anticoagulation: a comparison of contemporary stroke risk stratification schemes in an anticoagulated atrial fibrillation cohort","volume":"41","author":"Lip","year":"2010","journal-title":"Stroke"},{"key":"10.1016\/j.rpth.2026.106616_bib21","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1378\/chest.10-0134","article-title":"A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation: the Euro Heart Survey","volume":"138","author":"Pisters","year":"2010","journal-title":"Chest"},{"key":"10.1016\/j.rpth.2026.106616_bib22","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jacc.2010.09.024","volume":"57","author":"Lip","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.rpth.2026.106616_bib23","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1097\/01.mlr.0000182534.19832.83","article-title":"Coding algorithms for defining comorbidities in ICD-9-CM and ICD-10 administrative data","volume":"43","author":"Quan","year":"2005","journal-title":"Med Care"},{"key":"10.1016\/j.rpth.2026.106616_bib24","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1002\/(SICI)1097-0258(19981130)17:22<2635::AID-SIM954>3.0.CO;2-C","article-title":"Improved confidence intervals for the difference between binomial proportions based on paired data","volume":"17","author":"Newcombe","year":"1998","journal-title":"Stat Med"},{"key":"10.1016\/j.rpth.2026.106616_bib25","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1002\/sim.2677","article-title":"Confidence intervals for predictive values with an emphasis to case-control studies","volume":"26","author":"Mercaldo","year":"2007","journal-title":"Stat Med"},{"key":"10.1016\/j.rpth.2026.106616_bib26","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s12916-019-1438-y","article-title":"Bleeding in cardiac patients prescribed antithrombotic drugs: electronic health record phenotyping algorithms, incidence, trends and prognosis","volume":"17","author":"Pasea","year":"2019","journal-title":"BMC Med"},{"key":"10.1016\/j.rpth.2026.106616_bib27","doi-asserted-by":"crossref","DOI":"10.1002\/pds.5875","article-title":"Validation of a major and clinically relevant nonmajor bleeding phenotyping algorithm on electronic health records","volume":"33","author":"Yap","year":"2024","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"10.1016\/j.rpth.2026.106616_bib28","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1186\/s12874-019-0841-6","article-title":"Sensitivity and specificity of an algorithm based on medico-administrative data to identify hospitalized patients with major bleeding presenting to an emergency department","volume":"19","author":"Oger","year":"2019","journal-title":"BMC Med Res Methodol"},{"key":"10.1016\/j.rpth.2026.106616_bib29","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1002\/pds.2109","article-title":"An automated database case definition for serious bleeding related to oral anticoagulant use","volume":"20","author":"Cunningham","year":"2011","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"10.1016\/j.rpth.2026.106616_bib30","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1160\/TH16-05-0400","article-title":"Usefulness of health registers for detection of bleeding events in outcome studies","volume":"116","author":"Friberg","year":"2016","journal-title":"Thromb Haemost"}],"container-title":["Research and Practice in Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037926032747?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037926032747?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:21:45Z","timestamp":1784546505000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2475037926032747"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S2475037926032747"],"URL":"https:\/\/doi.org\/10.1016\/j.rpth.2026.106616","relation":{},"ISSN":["2475-0379"],"issn-type":[{"value":"2475-0379","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Validation of electronic health record-based International Society on Thrombosis and Haemostasis bleeding algorithms in a US health system","name":"articletitle","label":"Article Title"},{"value":"Research and Practice in Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rpth.2026.106616","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis.","name":"copyright","label":"Copyright"}],"article-number":"106616"}}