{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:10:21Z","timestamp":1790165421254,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012425","name":"Beijing Children's Hospital","doi-asserted-by":"publisher","award":["YN2020405"],"award-info":[{"award-number":["YN2020405"]}],"id":[{"id":"10.13039\/501100012425","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","rpthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research and Practice in Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.rpth.2026.106850","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T16:06:56Z","timestamp":1784045216000},"page":"106850","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Analysis of causes and outcomes of principal secondary thrombotic microangiopathy: a 9-year cohort study from a tertiary pediatric center in China"],"prefix":"10.1016","volume":"10","author":[{"given":"Dan","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghua","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhui","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hejia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaige","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Mi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maoquan","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaorong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6133-3051","authenticated-orcid":false,"given":"Chenguang","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rpth.2026.106850_bib1","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/s41581-021-00424-4","article-title":"Thrombotic microangiopathy in aHUS and beyond: clinical clues from complement genetics","volume":"17","author":"Fakhouri","year":"2021","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.rpth.2026.106850_bib2","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.kint.2016.10.005","article-title":"Atypical hemolytic uremic syndrome and C3 glomerulopathy: conclusions from a \u201cKidney Disease: Improving Global Outcomes\u201d (KDIGO) Controversies Conference","volume":"91","author":"Goodship","year":"2017","journal-title":"Kidney Int"},{"key":"10.1016\/j.rpth.2026.106850_bib3","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1111\/jth.15006","article-title":"ISTH guidelines for the diagnosis of thrombotic thrombocytopenic purpura","volume":"18","author":"Zheng","year":"2020","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.rpth.2026.106850_bib4","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1080\/17843286.2017.1345185","article-title":"Belgian consensus statement on the diagnosis and management of patients with atypical hemolytic uremic syndrome","volume":"73","author":"Claes","year":"2018","journal-title":"Acta Clin Belg"},{"key":"10.1016\/j.rpth.2026.106850_bib5","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1146\/annurev-med-061813-013241","article-title":"ADAMTS13 and von Willebrand factor in thrombotic thrombocytopenic purpura","volume":"66","author":"Zheng","year":"2015","journal-title":"Annu Rev Med"},{"key":"10.1016\/j.rpth.2026.106850_bib6","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/bjh.18040","article-title":"TTP: from empiricism for an enigmatic disease to targeted molecular therapies","volume":"197","author":"Gra\u00e7a","year":"2022","journal-title":"Br J Haematol"},{"key":"10.1016\/j.rpth.2026.106850_bib7","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1056\/NEJMoa1806311","article-title":"Caplacizumab treatment for acquired thrombotic thrombocytopenic purpura","volume":"380","author":"Scully","year":"2019","journal-title":"N Engl J Med"},{"key":"10.1016\/j.rpth.2026.106850_bib8","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1056\/NEJMoa2314793","article-title":"Recombinant ADAMTS13 in congenital thrombotic thrombocytopenic purpura","volume":"390","author":"Scully","year":"2024","journal-title":"N Engl J Med"},{"key":"10.1016\/j.rpth.2026.106850_bib9","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/S0140-6736(17)30062-4","article-title":"Haemolytic uraemic syndrome","volume":"390","author":"Fakhouri","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.rpth.2026.106850_bib10","first-page":"149","article-title":"Guidelines on the use of therapeutic apheresis in clinical practice-evidence-based approach from the writing committee of the American Society for Apheresis: the seventh special issue","volume":"31","author":"Schwartz","year":"2016","journal-title":"J Clin Apher"},{"key":"10.1016\/j.rpth.2026.106850_bib11","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.e4565","article-title":"Validation of treatment strategies for enterohaemorrhagic Escherichia coli O104:H4 induced haemolytic uraemic syndrome: case-control study","volume":"345","author":"Menne","year":"2012","journal-title":"BMJ"},{"key":"10.1016\/j.rpth.2026.106850_bib12","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1093\/cid\/ciw099","article-title":"Shiga toxin-producing Escherichia coli infection, antibiotics, and risk of developing hemolytic uremic syndrome: a meta-analysis","volume":"62","author":"Freedman","year":"2016","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.rpth.2026.106850_bib13","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.2215\/CJN.05830519","article-title":"Complement activation and thrombotic microangiopathies","volume":"14","author":"Palomo","year":"2019","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.rpth.2026.106850_bib14","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1681\/ASN.2019040331","article-title":"Use of highly individualized complement blockade has revolutionized clinical outcomes after kidney transplantation and renal epidemiology of atypical hemolytic uremic syndrome","volume":"30","author":"Zuber","year":"2019","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.rpth.2026.106850_bib15","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.kint.2020.01.035","article-title":"The long-acting C5 inhibitor, Ravulizumab, is effective and safe in adult patients with atypical hemolytic uremic syndrome na\u00efve to complement inhibitor treatment","volume":"97","author":"Rondeau","year":"2020","journal-title":"Kidney Int"},{"key":"10.1016\/j.rpth.2026.106850_bib16","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1056\/NEJMra1312353","article-title":"Syndromes of thrombotic microangiopathy","volume":"371","author":"George","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.rpth.2026.106850_bib17","doi-asserted-by":"crossref","first-page":"E373","DOI":"10.1002\/ajh.27104","article-title":"Drug-induced thrombotic microangiopathy and thrombotic thrombocytopenic purpura: a systematic review, 2018-2023","volume":"98","author":"Khan","year":"2023","journal-title":"Am J Hematol"},{"key":"10.1016\/j.rpth.2026.106850_bib18","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1016\/j.ekir.2025.01.026","article-title":"Thrombotic microangiopathy after kidney transplantation: insights into genetic etiology and clinical outcomes","volume":"10","author":"Merzkani","year":"2025","journal-title":"Kidney Int Rep"},{"key":"10.1016\/j.rpth.2026.106850_bib19","doi-asserted-by":"crossref","first-page":"4197","DOI":"10.1182\/blood-2025-4197","article-title":"Characteristics and outcomes of pediatric hematopoietic stem cell transplantation-associated thrombotic microangiopathy: a retrospective single-center analysis","volume":"146","author":"Luckie","year":"2025","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2026.106850_bib20","doi-asserted-by":"crossref","first-page":"730","DOI":"10.3899\/jrheum.220752","article-title":"The role of complement in autoimmune disease-associated thrombotic microangiopathy and the potential for therapeutics","volume":"50","author":"Java","year":"2023","journal-title":"J Rheumatol"},{"key":"10.1016\/j.rpth.2026.106850_bib21","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1007\/s00467-008-0935-6","article-title":"Treatment and outcome of Shiga-toxin-associated hemolytic uremic syndrome (HUS)","volume":"23","author":"Scheiring","year":"2008","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.rpth.2026.106850_bib22","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1056\/NEJMra0902814","article-title":"Atypical hemolytic-uremic syndrome","volume":"361","author":"Noris","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.rpth.2026.106850_bib23","article-title":"Retrospective and systematic analysis of causes and outcomes of thrombotic microangiopathies in routine clinical practice: an 11-year study","volume":"8","author":"Henry","year":"2021","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.rpth.2026.106850_bib24","doi-asserted-by":"crossref","first-page":"557","DOI":"10.2215\/CJN.11470918","article-title":"Etiology and outcomes of thrombotic microangiopathies","volume":"14","author":"Bayer","year":"2019","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.rpth.2026.106850_bib25","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1182\/blood-2014-03-564997","article-title":"Diagnostic and risk criteria for HSCT-associated thrombotic microangiopathy: a study in children and young adults","volume":"124","author":"Jodele","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2026.106850_bib26","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1016\/j.ekir.2025.04.022","article-title":"Systematic review of the outcomes and prognostic factors of patients with systemic lupus erythematosus-associated thrombotic microangiopathy","volume":"10","author":"Gai","year":"2025","journal-title":"Kidney Int Rep"},{"key":"10.1016\/j.rpth.2026.106850_bib27","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.jpeds.2021.04.004","article-title":"Thrombotic microangiopathy associated with macrophage activation syndrome: a multinational study of 23 patients","volume":"235","author":"Minoia","year":"2021","journal-title":"J Pediatr"},{"key":"10.1016\/j.rpth.2026.106850_bib28","doi-asserted-by":"crossref","first-page":"554","DOI":"10.2215\/CJN.04760512","article-title":"Genetics and outcome of atypical hemolytic uremic syndrome: a nationwide French series comparing children and adults","volume":"8","author":"Fremeaux-Bacchi","year":"2013","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.rpth.2026.106850_bib29","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1007\/s40620-025-02366-7","article-title":"Clinical and genetic characteristics of patients diagnosed with atypical hemolytic uremic syndrome (aHUS): epidemiological data from the Belgian cohort of the Global aHUS Registry","volume":"38","author":"Massart","year":"2025","journal-title":"J Nephrol"},{"key":"10.1016\/j.rpth.2026.106850_bib30","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1007\/s10157-018-1531-0","article-title":"Clinical features in a series of 258 Japanese pediatric patients with thrombotic microangiopathy","volume":"22","author":"Ashida","year":"2018","journal-title":"Clin Exp Nephrol"},{"key":"10.1016\/j.rpth.2026.106850_bib31","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/ki.2011.339","article-title":"AKI in the ICU: definition, epidemiology, risk stratification, and outcomes","volume":"81","author":"Singbartl","year":"2012","journal-title":"Kidney Int"},{"key":"10.1016\/j.rpth.2026.106850_bib32","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1093\/ckj\/sfz066","article-title":"Relative incidence of thrombotic thrombocytopenic purpura and haemolytic uraemic syndrome in clinically suspected cases of thrombotic microangiopathy","volume":"13","author":"Sch\u00f6nermarck","year":"2020","journal-title":"Clin Kidney J"},{"key":"10.1016\/j.rpth.2026.106850_bib33","doi-asserted-by":"crossref","first-page":"881","DOI":"10.2215\/CJN.0000000000000182","article-title":"Epidemiology, outcomes, and complement gene variants in secondary thrombotic microangiopathies","volume":"18","author":"Werion","year":"2023","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.rpth.2026.106850_bib34","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1007\/s10157-020-01896-7","article-title":"A nationwide cross-sectional analysis of thrombotic microangiopathy in the Japan Renal Biopsy Registry (J-RBR)","volume":"24","author":"Katsuno","year":"2020","journal-title":"Clin Exp Nephrol"},{"key":"10.1016\/j.rpth.2026.106850_bib35","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/jha2.154","article-title":"Thrombotic microangiopathies: first report of 294 cases from a single institution experience in Argentina","volume":"2","author":"Dos Santos","year":"2021","journal-title":"EJHaem"}],"container-title":["Research and Practice in Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037926035089?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037926035089?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:58:31Z","timestamp":1790164711000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2475037926035089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S2475037926035089"],"URL":"https:\/\/doi.org\/10.1016\/j.rpth.2026.106850","relation":{},"ISSN":["2475-0379"],"issn-type":[{"value":"2475-0379","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Analysis of causes and outcomes of principal secondary thrombotic microangiopathy: a 9-year cohort study from a tertiary pediatric center in China","name":"articletitle","label":"Article Title"},{"value":"Research and Practice in Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rpth.2026.106850","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis.","name":"copyright","label":"Copyright"}],"article-number":"106850"}}