{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:15:03Z","timestamp":1788383703640,"version":"build-2803163510"},"reference-count":33,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001422","name":"American Society of Hematology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001422","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015438","name":"International Society on Thrombosis and Haemostasis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015438","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","rpthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research and Practice in Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.rpth.2026.106905","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T06:58:25Z","timestamp":1786690705000},"page":"106905","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and safety of anticoagulation for pediatric cerebral sinovenous thrombosis: systematic review and meta-analysis"],"prefix":"10.1016","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2046-8343","authenticated-orcid":false,"given":"Muayad","family":"Azzam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Kawtharany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisol","family":"Betensky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aseel","family":"Alkhader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qais","family":"Hamarsha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadi Khaled","family":"Abou Zeid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Razan","family":"Mansour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carine","family":"Tabak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Payal","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah Lamat","family":"Baghdadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel S.","family":"Bercovitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rukhmi","family":"Bhat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Biss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian R.","family":"Branchford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo R.","family":"Brand\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony K.C.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Vincent S.","family":"Faustino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Jaffray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryce A.","family":"Kerlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Kucine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riten","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Male","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Claude","family":"Pelland-Marcotte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Raffini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chittalsinh M.","family":"Raulji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Sartain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifford M.","family":"Takemoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Tarango","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Heleen","family":"Van Ommen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C.","family":"Velez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara K.","family":"Vesely","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Wiernikowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzan","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hope P.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Woods","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayesha","family":"Zia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Monagle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2091-0875","authenticated-orcid":false,"given":"Reem A.","family":"Mustafa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rpth.2026.106905_bib1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1056\/NEJM200108093450604","article-title":"Cerebral sinovenous thrombosis in children","volume":"345","author":"deVeber","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.rpth.2026.106905_bib2","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1136\/archdischild-2014-306382","article-title":"Paediatric cerebral sinovenous thrombosis: Findings of the International Paediatric Stroke Study","volume":"100","author":"Ichord","year":"2015","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.rpth.2026.106905_bib3","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1093\/brain\/awh412","article-title":"Cerebral venous sinus thrombosis in children: risk factors, presentation, diagnosis and outcome","volume":"128","author":"S\u00e9bire","year":"2005","journal-title":"Brain"},{"key":"10.1016\/j.rpth.2026.106905_bib4","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1007\/s13760-021-01807-x","article-title":"Pediatric cerebral sinus venous thrombosis: clinical characterization of a Portuguese cohort","volume":"122","author":"Rodrigues","year":"2022","journal-title":"Acta Neurol Belg"},{"key":"10.1016\/j.rpth.2026.106905_bib5","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ejpn.2023.01.009","article-title":"Post traumatic cerebral sinovenous thrombosis in children: A retrospective and multicenter study","volume":"43","author":"Roth","year":"2023","journal-title":"Eur J Paediatr Neurol"},{"key":"10.1016\/j.rpth.2026.106905_bib6","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s00247-012-2486-z","article-title":"Cerebral sinovenous thrombosis in pediatric practice","volume":"43","author":"Hedlund","year":"2013","journal-title":"Pediatric Radiology"},{"key":"10.1016\/j.rpth.2026.106905_bib7","doi-asserted-by":"crossref","first-page":"364","DOI":"10.3389\/fped.2019.00364","article-title":"Clinical Characteristics and Outcomes of Pediatric Cerebral Venous Sinus Thrombosis: An Analysis of 30 Cases in China","volume":"7","author":"Wang","year":"2019","journal-title":"Front Pediatr"},{"key":"10.1016\/j.rpth.2026.106905_bib8","first-page":"621","article-title":"[Clinical and radiological features of cerebral venous thrombosis in a children cohort]","volume":"89","author":"L\u00f3pez-Espejo","year":"2018","journal-title":"Rev Chil Pediatr"},{"key":"10.1016\/j.rpth.2026.106905_bib9","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1002\/pbc.25168","article-title":"Anticoagulant therapy in head injury-associated cerebral sinovenous thrombosis in children","volume":"61","author":"Xavier","year":"2014","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.rpth.2026.106905_bib10","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1161\/01.STR.0000117571.76197.26","article-title":"Prognosis of cerebral vein and dural sinus thrombosis: Results of the International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT)","volume":"35","author":"Ferro","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.rpth.2026.106905_bib11","doi-asserted-by":"crossref","first-page":"3292","DOI":"10.1182\/bloodadvances.2018024786","article-title":"American Society of Hematology 2018 Guidelines for management of venous thromboembolism: Treatment of pediatric venous thromboembolism","volume":"2","author":"Monagle","year":"2018","journal-title":"Blood Advances"},{"key":"10.1016\/j.rpth.2026.106905_bib12","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1182\/bloodadvances.2024015328","article-title":"American Society of Hematology\/International Society on Thrombosis and Haemostasis 2024 updated guidelines for treatment of venous thromboembolism in pediatric patients","volume":"9","author":"Monagle","year":"2025","journal-title":"Blood Advances"},{"key":"10.1016\/j.rpth.2026.106905_bib13","series-title":"Cochrane Handbook for Systematic Reviews of Interventions version 6.5","author":"Higgins","year":"2024"},{"key":"10.1016\/j.rpth.2026.106905_bib14","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.rpth.2026.106905_bib15","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1111\/jth.13140","article-title":"Definition of clinically relevant non-major bleeding in studies of anticoagulants in atrial fibrillation and venous thromboembolic disease in non-surgical patients: Communication from the SSC of the ISTH","volume":"13","author":"Kaatz","year":"2015","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.rpth.2026.106905_bib16","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1111\/j.1538-7836.2005.01204.x","article-title":"Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients","volume":"3","author":"Schulman","year":"2005","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.rpth.2026.106905_bib17","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.jclinepi.2010.04.026","article-title":"GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables","volume":"64","author":"Guyatt","year":"2011","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.rpth.2026.106905_bib18","article-title":"ROBINS-I: A tool for assessing risk of bias in non-randomised studies of interventions","volume":"355","author":"Sterne","year":"2016","journal-title":"Bmj"},{"key":"10.1016\/j.rpth.2026.106905_bib19","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1093\/ecco-jcc\/jjab171","article-title":"The Incidence and Characteristics of Venous Thromboembolisms in Paediatric-Onset Inflammatory Bowel Disease: A Prospective International Cohort Study Based on the PIBD-SETQuality Safety Registry","volume":"16","author":"Aardoom","year":"2022","journal-title":"J Crohns Colitis"},{"key":"10.1016\/j.rpth.2026.106905_bib20","doi-asserted-by":"crossref","first-page":"6250","DOI":"10.1182\/bloodadvances.2020003244","article-title":"Safety and efficacy of rivaroxaban in pediatric cerebral venous thrombosis (EINSTEIN-Jr CVT)","volume":"4","author":"Connor","year":"2020","journal-title":"Blood Adv"},{"key":"10.1016\/j.rpth.2026.106905_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijporl.2023.111513","article-title":"Head and neck venous thrombosis secondary to pediatric otolaryngologic infection","volume":"168","author":"Engelhardt","year":"2023","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"10.1016\/j.rpth.2026.106905_bib22","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1212\/CPJ.0000000000000720","article-title":"Treatment and outcome of childhood cerebral sinovenous thrombosis","volume":"10","author":"Felling","year":"2020","journal-title":"Neurol Clin Pract"},{"key":"10.1016\/j.rpth.2026.106905_bib23","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jpeds.2022.05.056","article-title":"Cerebral Sinus Venous Thrombosis in Infants after Surgery for Congenital Heart Disease","volume":"248","author":"Harrar","year":"2022","journal-title":"J Pediatr"},{"key":"10.1016\/j.rpth.2026.106905_bib24","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.pediatrneurol.2021.05.001","article-title":"Clinical Profile and Long-Term Outcome in Neonatal Cerebral Sinus Venous Thrombosis","volume":"121","author":"Herman","year":"2021","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.rpth.2026.106905_bib25","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.pediatrneurol.2022.02.006","article-title":"Clinical Profile and Long-Term Outcomes in Pediatric Cavernous Sinus Thrombosis","volume":"130","author":"Karakas","year":"2022","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.rpth.2026.106905_bib26","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.amjoto.2018.03.013","article-title":"The association between otogenic lateral sinus thrombosis and thrombophilia - A long-term follow-up","volume":"39","author":"Schneider","year":"2018","journal-title":"Am J Otolaryngol"},{"key":"10.1016\/j.rpth.2026.106905_bib27","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.nrl.2022.04.006","article-title":"Cerebral venous thrombosis in children an 18-year review of a Portuguese hospital","volume":"39","author":"Tenente","year":"2024","journal-title":"Neurolog\u00eda"},{"key":"10.1016\/j.rpth.2026.106905_bib28","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s00381-016-3329-2","article-title":"Pediatric cerebral sinovenous thrombosis following cranial surgery","volume":"33","author":"Petrov","year":"2017","journal-title":"Childs Nerv Syst"},{"key":"10.1016\/j.rpth.2026.106905_bib29","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/0140-6736(91)90607-Q","article-title":"Heparin treatment in sinus venous thrombosis","volume":"338","author":"Einh\u00e4upl","year":"1991","journal-title":"Lancet"},{"key":"10.1016\/j.rpth.2026.106905_bib30","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1161\/01.STR.30.3.484","article-title":"Randomized, placebo-controlled trial of anticoagulant treatment with low-molecular-weight heparin for cerebral sinus thrombosis","volume":"30","author":"de Bruijn","year":"1999","journal-title":"Stroke"},{"key":"10.1016\/j.rpth.2026.106905_bib31","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.24953\/turkjped.2021.06.011","article-title":"Cerebral sinovenous thrombosis in children: clinical presentation, locations, and acquired and inherited prothrombotic risk factors","volume":"63","author":"Kar","year":"2021","journal-title":"Turk J Pediatr"},{"key":"10.1016\/j.rpth.2026.106905_bib32","doi-asserted-by":"crossref","first-page":"e369","DOI":"10.1097\/MPH.0000000000001149","article-title":"Cerebral Sinus Venous Thrombosis and Prothrombotic Risk Factors in Children: A Single-Center Experience From Turkey","volume":"40","author":"Ozcan","year":"2018","journal-title":"J Pediatr Hematol Oncol"},{"key":"10.1016\/j.rpth.2026.106905_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.rpth.2024.102605","article-title":"Clinical characteristics, treatment, and outcomes of provoked acute cerebral sinovenous thrombosis in patients <21 years old: findings from the Kids-DOTT Multinational Trial","volume":"8","author":"Woods","year":"2024","journal-title":"Res Pract Thromb Haemost"}],"container-title":["Research and Practice in Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037926035636?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037926035636?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T20:18:47Z","timestamp":1788380327000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2475037926035636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S2475037926035636"],"URL":"https:\/\/doi.org\/10.1016\/j.rpth.2026.106905","relation":{},"ISSN":["2475-0379"],"issn-type":[{"value":"2475-0379","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy and safety of anticoagulation for pediatric cerebral sinovenous thrombosis: systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Research and Practice in Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rpth.2026.106905","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis.","name":"copyright","label":"Copyright"}],"article-number":"106905"}}