{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:46:06Z","timestamp":1792683966544,"version":"4.5.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019018","name":"Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","rpthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research and Practice in Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.rpth.2026.106916","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T08:59:25Z","timestamp":1787389165000},"page":"106916","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Artificial intelligence prediction of therapy response in newly diagnosed adult severe primary immune thrombocytopenia"],"prefix":"10.1016","volume":"10","author":[{"given":"Xiaolin","family":"Zhai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saibing","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiujin","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowen","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wangsong","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sichang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueshen","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert Peter","family":"Gale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renchi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3691-4931","authenticated-orcid":false,"given":"Junren","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rpth.2026.106916_bib1","doi-asserted-by":"crossref","first-page":"4190","DOI":"10.1182\/blood-2010-08-302984","article-title":"The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopenia","volume":"117","author":"Neunert","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2026.106916_bib2","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1182\/blood-2012-09-455691","article-title":"Rituximab and dexamethasone vs dexamethasone monotherapy in newly diagnosed patients with primary immune thrombocytopenia","volume":"121","author":"Gudbrandsdottir","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2026.106916_bib3","doi-asserted-by":"crossref","first-page":"3780","DOI":"10.1182\/bloodadvances.2019000812","article-title":"Updated international consensus report on the investigation and management of primary immune thrombocytopenia","volume":"3","author":"Provan","year":"2019","journal-title":"Blood Adv"},{"key":"10.1016\/j.rpth.2026.106916_bib4","doi-asserted-by":"crossref","first-page":"3829","DOI":"10.1182\/bloodadvances.2019000966","article-title":"American society of hematology 2019 guidelines for immune thrombocytopenia","volume":"3","author":"Neunert","year":"2019","journal-title":"Blood Adv"},{"key":"10.1016\/j.rpth.2026.106916_bib5","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/bjh.16327","article-title":"Safety and efficacy of eltrombopag plus pulsed dexamethasone as first-line therapy for immune thrombocytopenia","volume":"189","author":"Zhang","year":"2020","journal-title":"Br J Haematol"},{"key":"10.1016\/j.rpth.2026.106916_bib6","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1056\/NEJMoa2100596","article-title":"Mycophenolate mofetil for first-line treatment of immune thrombocytopenia","volume":"385","author":"Bradbury","year":"2021","journal-title":"N Engl J Med"},{"key":"10.1016\/j.rpth.2026.106916_bib7","doi-asserted-by":"crossref","first-page":"e289","DOI":"10.1016\/S2352-3026(21)00030-2","article-title":"Dexamethasone plus oseltamivir versus dexamethasone in treatment-naive primary immune thrombocytopenia: a multicentre, randomised, open-label, phase 2 trial","volume":"8","author":"Sun","year":"2021","journal-title":"Lancet Haematol"},{"key":"10.1016\/j.rpth.2026.106916_bib8","doi-asserted-by":"crossref","first-page":"e688","DOI":"10.1016\/S2352-3026(21)00240-4","article-title":"All-trans retinoic acid plus high-dose dexamethasone as first-line treatment for patients with newly diagnosed immune thrombocytopenia: a multicentre, open-label, randomised, controlled, phase 2 trial","volume":"8","author":"Huang","year":"2021","journal-title":"Lancet Haematol"},{"key":"10.1016\/j.rpth.2026.106916_bib9","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/bjh.19078","article-title":"Novel therapeutics and future directions for refractory immune thrombocytopenia","volume":"203","author":"Al-Samkari","year":"2023","journal-title":"Br J Haematol"},{"key":"10.1016\/j.rpth.2026.106916_bib10","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2025-084314","article-title":"Anti-CD38 monoclonal antibody CM313 for primary immune thrombocytopenia: multicentre, randomised, placebo controlled, phase 2 trial","volume":"391","author":"Chen","year":"2025","journal-title":"BMJ"},{"key":"10.1016\/j.rpth.2026.106916_bib11","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1182\/blood-2008-07-162503","article-title":"Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group","volume":"113","author":"Rodeghiero","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2026.106916_bib12","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s12185-018-2445-z","article-title":"Chinese guidelines for treatment of adult primary immune thrombocytopenia","volume":"107","author":"Liu","year":"2018","journal-title":"Int J Hematol"},{"key":"10.1016\/j.rpth.2026.106916_bib13","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1111\/bjh.18670","article-title":"Biomarkers for predicting response to corticosteroid therapy for immune thrombocytopenic purpura","volume":"201","author":"Nakamura","year":"2023","journal-title":"Br J Haematol"},{"key":"10.1016\/j.rpth.2026.106916_bib14","doi-asserted-by":"crossref","DOI":"10.1097\/HS9.0000000000000960","article-title":"Prediction of the clinical course of immune thrombocytopenia in children by platelet kinetics","volume":"7","author":"Lejeune","year":"2023","journal-title":"Hemasphere"},{"key":"10.1016\/j.rpth.2026.106916_bib15","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1111\/bjh.19615","article-title":"A novel scoring model for predicting efficacy and guiding individualised treatment in immune thrombocytopaenia","volume":"205","author":"Xu","year":"2024","journal-title":"Br J Haematol"},{"key":"10.1016\/j.rpth.2026.106916_bib16","doi-asserted-by":"crossref","DOI":"10.1080\/16078454.2024.2304486","article-title":"Lymphocyte subpopulations: a potential predictor of a response in patients with immune thrombocytopenia","volume":"29","author":"Zibridova","year":"2024","journal-title":"Hematology"},{"key":"10.1016\/j.rpth.2026.106916_bib17","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1111\/bjh.19391","article-title":"Metabolomics profile and machine learning prediction of treatment responses in immune thrombocytopenia: a prospective cohort study","volume":"204","author":"Li","year":"2024","journal-title":"Br J Haematol"},{"key":"10.1016\/j.rpth.2026.106916_bib18","article-title":"Correlation between fecal microbiota and corticosteroid responsiveness in primary immune thrombocytopenia: an exploratory study","volume":"12","author":"Liu","year":"2025","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.rpth.2026.106916_bib19","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s41586-024-08264-5","article-title":"Haematological setpoints are a stable and patient-specific deep phenotype","volume":"637","author":"Foy","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.rpth.2026.106916_bib20","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/s43588-022-00213-4","article-title":"Dynamic forecasting of severe acute graft-versus-host disease after transplantation","volume":"2","author":"Liu","year":"2022","journal-title":"Nat Comput Sci"},{"key":"10.1016\/j.rpth.2026.106916_bib21","doi-asserted-by":"crossref","first-page":"8391","DOI":"10.1038\/s41467-025-62926-0","article-title":"Autonomous artificial intelligence prescribing a drug to prevent severe acute graft-versus-host disease in HLA-haploidentical transplants","volume":"16","author":"Chen","year":"2025","journal-title":"Nat Commun"},{"key":"10.1016\/j.rpth.2026.106916_bib22","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1182\/blood-2012-07-442392","article-title":"Standardization of bleeding assessment in immune thrombocytopenia: report from the International working group","volume":"121","author":"Rodeghiero","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2026.106916_bib23","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1056\/NEJMoa0904084","article-title":"Dose of prophylactic platelet transfusions and prevention of hemorrhage","volume":"362","author":"Slichter","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.rpth.2026.106916_bib24","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1182\/blood.V88.1.3.3","article-title":"Idiopathic thrombocytopenic purpura: a practice guideline developed by explicit methods for the American Society of Hematology","volume":"88","author":"George","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2026.106916_bib25","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1053\/j.seminhematol.2010.04.001","article-title":"Overview of platelet transfusion","volume":"47","author":"McCullough","year":"2010","journal-title":"Semin Hematol"},{"key":"10.1016\/j.rpth.2026.106916_bib26","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.1182\/blood.2020004858","article-title":"Identification of occult cerebral microbleeds in adults with immune thrombocytopenia","volume":"136","author":"Cooper","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2026.106916_bib27","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1055\/s-0039-1700512","article-title":"Immune thrombocytopenia in adults: modern approaches to diagnosis and treatment","volume":"46","author":"Al-Samkari","year":"2020","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.rpth.2026.106916_bib28","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.3892\/mmr.2016.5504","article-title":"Role of platelet function and platelet membrane glycoproteins in children with primary immune thrombocytopenia","volume":"14","author":"Liu","year":"2016","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.rpth.2026.106916_bib29","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1159\/000510460","article-title":"Pretreatment immature platelet fraction as a surrogate of reticulated platelets predicts the response to corticosteroids in adults with immune thrombocytopenia","volume":"144","author":"Takami","year":"2021","journal-title":"Acta Haematol"},{"key":"10.1016\/j.rpth.2026.106916_bib30","doi-asserted-by":"crossref","first-page":"3287","DOI":"10.1038\/s41598-025-33069-5","article-title":"Immature platelet fraction and bone marrow findings in hematology","volume":"16","author":"Yamasaki","year":"2025","journal-title":"Sci Rep"},{"key":"10.1016\/j.rpth.2026.106916_bib31","doi-asserted-by":"crossref","first-page":"325","DOI":"10.3233\/CH-131745","article-title":"Association of red blood cell distribution width, inflammation markers and morphological as well as rheological erythrocyte parameters with target organ damage in hypertension","volume":"56","author":"Fornal","year":"2014","journal-title":"Clin Hemorheol Microcirc"},{"key":"10.1016\/j.rpth.2026.106916_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104552","article-title":"Cellular and molecular biomarkers of long COVID: a scoping review","volume":"91","author":"Espin","year":"2023","journal-title":"EBioMedicine"},{"key":"10.1016\/j.rpth.2026.106916_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e22896","article-title":"Hematological, inflammatory, and novel biomarkers assessment as an eminent strategy for clinical management of COVID-19","volume":"9","author":"Rezaeian","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.rpth.2026.106916_bib34","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1080\/17474086.2022.2082936","article-title":"Alternatives for managing patients with newly diagnosed immune thrombocytopenia: a narrative review","volume":"15","author":"Gomez-Almaguer","year":"2022","journal-title":"Expert Rev Hematol"},{"key":"10.1016\/j.rpth.2026.106916_bib35","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1182\/hematology.2024000596","article-title":"On the horizon: upcoming new agents for the management of ITP","volume":"2024","author":"Lambert","year":"2024","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"10.1016\/j.rpth.2026.106916_bib36","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1111\/bjh.17884","article-title":"CD4(+) T cells from patients with glucocorticoid-refractory immune thrombocytopenia have altered cytokine expression","volume":"196","author":"Stimpson","year":"2022","journal-title":"Br J Haematol"},{"key":"10.1016\/j.rpth.2026.106916_bib37","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/bjh.19070","article-title":"Complement in immune thrombocytopenia (ITP): the role of complement in refractory ITP","volume":"203","author":"Weitz","year":"2023","journal-title":"Br J Haematol"},{"key":"10.1016\/j.rpth.2026.106916_bib38","article-title":"The gut-immune axis in primary immune thrombocytopenia (ITP): a paradigm shifts in treatment approaches","volume":"16","author":"Guo","year":"2025","journal-title":"Front Immunol"},{"key":"10.1016\/j.rpth.2026.106916_bib39","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1182\/blood.2025029769","article-title":"Integrin alphavbeta8-mediated TGF-beta1 activation regulates the sustained response in immune thrombocytopenia after TPO-RA withdrawal","volume":"147","author":"Mei","year":"2026","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2026.106916_bib40","doi-asserted-by":"crossref","first-page":"2958","DOI":"10.1182\/blood.2025032255","article-title":"Complement activation profile in adult primary immune thrombocytopenia","volume":"147","author":"Nakata","year":"2026","journal-title":"Blood"}],"container-title":["Research and Practice in Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037926035740?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037926035740?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:24:40Z","timestamp":1792682680000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2475037926035740"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S2475037926035740"],"URL":"https:\/\/doi.org\/10.1016\/j.rpth.2026.106916","relation":{},"ISSN":["2475-0379"],"issn-type":[{"value":"2475-0379","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Artificial intelligence prediction of therapy response in newly diagnosed adult severe primary immune thrombocytopenia","name":"articletitle","label":"Article Title"},{"value":"Research and Practice in Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rpth.2026.106916","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis.","name":"copyright","label":"Copyright"}],"article-number":"106916"}}