{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:45:33Z","timestamp":1792683933958,"version":"4.5.0"},"reference-count":59,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","rpthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research and Practice in Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.rpth.2026.106928","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T07:08:30Z","timestamp":1787814510000},"page":"106928","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genetic and hemostatic characterization of PAI-1 deficiency and isolated hyperfibrinolysis: data from the RBiN study"],"prefix":"10.1016","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5149-8864","authenticated-orcid":false,"given":"Bauke","family":"Haisma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Nieuwenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanna R.","family":"Rijpma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annet","family":"Simons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole M.A.","family":"Blijlevens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waander L.","family":"van Heerde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2423-2829","authenticated-orcid":false,"given":"Saskia E.M.","family":"Schols","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rpth.2026.106928_bib1","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1111\/jth.14160","article-title":"Hemorrhagic disorders of fibrinolysis: a clinical review","volume":"16","author":"Saes","year":"2018","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.rpth.2026.106928_bib2","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.3390\/ijms22052721","article-title":"A narrative review on plasminogen activator inhibitor-1 and its (patho)physiological role: to target or not to target?","volume":"22","author":"Sillen","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.rpth.2026.106928_bib3","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/hae.12313","article-title":"The obstetric, gynaecological and fertility implications of homozygous PAI-1 deficiency: single-centre experience","volume":"20","author":"Heiman","year":"2014","journal-title":"Haemophilia"},{"key":"10.1016\/j.rpth.2026.106928_bib4","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1111\/j.1365-2516.2008.01834.x","article-title":"Plasminogen activator inhibitor type 1 deficiency","volume":"14","author":"Mehta","year":"2008","journal-title":"Haemophilia"},{"key":"10.1016\/j.rpth.2026.106928_bib5","first-page":"286","article-title":"Four cases of bleeding diathesis in children due to congenital plasminogen activator inhibitor-1 deficiency","volume":"29","author":"Minowa","year":"1999","journal-title":"Haemostasis"},{"key":"10.1016\/j.rpth.2026.106928_bib6","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1182\/blood.V90.1.204.204_204_208","article-title":"Human plasminogen activator inhibitor-1 (PAI-1) deficiency: characterization of a large kindred with a null mutation in the PAI-1 gene","volume":"90","author":"Fay","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2026.106928_bib7","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1111\/j.1365-2516.2004.00914.x","article-title":"Haemostatic management of intraoral bleeding in patients with congenital deficiency of alpha2-plasmin inhibitor or plasminogen activator inhibitor-1","volume":"10","author":"Morimoto","year":"2004","journal-title":"Haemophilia"},{"key":"10.1016\/j.rpth.2026.106928_bib8","doi-asserted-by":"crossref","DOI":"10.1227\/01.NEU.0000345650.60160.07","article-title":"A novel association between a chronic subdural hematoma and a fibrinolytic pathway defect: case report","volume":"64","author":"Rughani","year":"2009","journal-title":"Neurosurgery"},{"key":"10.1016\/j.rpth.2026.106928_bib9","first-page":"106","article-title":"Successful arthroscopic treatment of pigmented villonodular synovitis of the knee in a patient with congenital deficiency of plasminogen activator inhibitor-1 and recurrent haemarthrosis","volume":"31","author":"Matsui","year":"2001","journal-title":"Haemostasis"},{"key":"10.1016\/j.rpth.2026.106928_bib10","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.thromres.2020.04.003","article-title":"Congenital PAI-1 deficiency results in psoas hematoma in an Indian patient","volume":"190","author":"Prabhudesai","year":"2020","journal-title":"Thromb Res"},{"key":"10.1016\/j.rpth.2026.106928_bib11","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1161\/01.CIR.79.1.101","article-title":"Diurnal variation of tissue-type plasminogen activator and its rapid inhibitor (PAI-1)","volume":"79","author":"Angleton","year":"1989","journal-title":"Circulation"},{"key":"10.1016\/j.rpth.2026.106928_bib12","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1111\/hae.13842","article-title":"Thrombin and plasmin generation in patients with plasminogen or plasminogen activator inhibitor type 1 deficiency","volume":"25","author":"Saes","year":"2019","journal-title":"Haemophilia"},{"key":"10.1016\/j.rpth.2026.106928_bib13","series-title":"GeneReviews\u00ae","article-title":"Complete plasminogen activator inhibitor 1 deficiency","author":"Heiman","year":"2017"},{"key":"10.1016\/j.rpth.2026.106928_bib14","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1056\/NEJM199212103272406","article-title":"Brief report: complete deficiency of plasminogen-activator inhibitor type 1 due to a frame-shift mutation","volume":"327","author":"Fay","year":"1992","journal-title":"N Engl J Med"},{"key":"10.1016\/j.rpth.2026.106928_bib15","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/00001721-200501000-00013","article-title":"A case of deficiency of plasma plasminogen activator inhibitor-1 related to Ala15Thr mutation in its signal peptide","volume":"16","author":"Zhang","year":"2005","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1016\/j.rpth.2026.106928_bib16","doi-asserted-by":"crossref","first-page":"575","DOI":"10.3892\/etm_00000090","article-title":"Bleeding diathesis is associated with an A15T heterozygous mutation in exon 2 of the plasminogen activator inhibitor type 1","volume":"1","author":"Jankun","year":"2010","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.rpth.2026.106928_bib17","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1111\/j.1538-7836.2011.04288.x","article-title":"Life-threatening hemorrhage and prolonged wound healing are remarkable phenotypes manifested by complete plasminogen activator inhibitor-1 deficiency in humans","volume":"9","author":"Iwaki","year":"2011","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.rpth.2026.106928_bib18","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1160\/TH16-07-0572","article-title":"Mutation in a highly conserved glycine residue in strand 5B of plasminogen activator inhibitor 1 causes polymerisation","volume":"117","author":"Iwaki","year":"2017","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.rpth.2026.106928_bib19","doi-asserted-by":"crossref","first-page":"5025","DOI":"10.1182\/bloodadvances.2020002740","article-title":"Bleeding severity in patients with rare bleeding disorders: real-life data from the RBiN study","volume":"4","author":"Saes","year":"2020","journal-title":"Blood Adv"},{"key":"10.1016\/j.rpth.2026.106928_bib20","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1093\/bioinformatics\/btp698","article-title":"Fast and accurate long-read alignment with Burrows-Wheeler transform","volume":"26","author":"Li","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.rpth.2026.106928_bib21","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1101\/gr.107524.110","article-title":"The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data","volume":"20","author":"McKenna","year":"2010","journal-title":"Genome Res"},{"key":"10.1016\/j.rpth.2026.106928_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.rpth.2024.102477","article-title":"Targeted exome analysis in patients with rare bleeding disorders: data from the Rare Bleeding disorders in the Netherlands study","volume":"8","author":"Willems","year":"2024","journal-title":"Res Pract Thromb Haemost"},{"key":"10.1016\/j.rpth.2026.106928_bib23","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1182\/blood.2018891192","article-title":"Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders","volume":"134","author":"Downes","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2026.106928_bib24","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1111\/jth.14479","article-title":"Curated disease-causing genes for bleeding, thrombotic, and platelet disorders: communication from the SSC of the ISTH","volume":"17","author":"Megy","year":"2019","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.rpth.2026.106928_bib25","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1101\/gr.138115.112","article-title":"Copy number variation detection and genotyping from exome sequence data","volume":"22","author":"Krumm","year":"2012","journal-title":"Genome Res"},{"key":"10.1016\/j.rpth.2026.106928_bib26","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet Med"},{"key":"10.1016\/j.rpth.2026.106928_bib27","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1179\/102453311X13085644680348","article-title":"A novel hemostasis assay for the simultaneous measurement of coagulation and fibrinolysis","volume":"16","author":"van Geffen","year":"2011","journal-title":"Hematology"},{"key":"10.1016\/j.rpth.2026.106928_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.thromres.2024.109045","article-title":"Comparative analysis of thrombin generation platforms for patients with coagulation factor deficiencies: a comprehensive assessment","volume":"240","author":"Haisma","year":"2024","journal-title":"Thromb Res"},{"key":"10.1016\/j.rpth.2026.106928_bib29","doi-asserted-by":"crossref","first-page":"512","DOI":"10.2174\/156652411796268678","article-title":"Val17Ile single nucleotide polymorphisms similarly as Ala15Thr could be related to the lower secretory dynamics of PAI-1 secretion: theoretical evidence","volume":"11","author":"Jankun","year":"2011","journal-title":"Curr Mol Med"},{"key":"10.1016\/j.rpth.2026.106928_bib30","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1007\/s00125-003-1170-0","article-title":"PAI-1 polymorphisms modulate phenotypes associated with the metabolic syndrome in obese and diabetic Caucasian population","volume":"46","author":"Lopes","year":"2003","journal-title":"Diabetologia"},{"key":"10.1016\/j.rpth.2026.106928_bib32","doi-asserted-by":"crossref","first-page":"37","DOI":"10.2337\/diab.44.1.37","article-title":"Determinants of plasminogen activator inhibitor 1 activity in treated NIDDM and its relation to a polymorphism in the plasminogen activator inhibitor 1 gene","volume":"44","author":"Panahloo","year":"1995","journal-title":"Diabetes"},{"key":"10.1016\/j.rpth.2026.106928_bib33","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1073\/pnas.92.6.1851","article-title":"Allele-specific increase in basal transcription of the plasminogen-activator inhibitor 1 gene is associated with myocardial infarction","volume":"92","author":"Eriksson","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.rpth.2026.106928_bib34","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1159\/000047656","article-title":"4G\/5G polymorphism of the plasminogen activator inhibitor-1 gene and insertion\/deletion polymorphism of the tissue-type plasminogen activator gene in atherothrombotic stroke","volume":"11","author":"Bang","year":"2001","journal-title":"Cerebrovasc Dis"},{"key":"10.1016\/j.rpth.2026.106928_bib35","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1055\/s-0037-1615395","article-title":"4G\/5G polymorphism of PAI-1 gene promoter and fibrinolytic capacity in patients with deep vein thrombosis","volume":"80","author":"Sartori","year":"1998","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.rpth.2026.106928_bib36","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1160\/TH04-09-0560","article-title":"The plasminogen activator inhibitor (PAI-1) 4G\/5G promoter polymorphism and PAI-1 levels in ischemic stroke. A case-control study","volume":"93","author":"van Goor","year":"2005","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.rpth.2026.106928_bib37","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1016\/S0735-1097(99)00424-6","article-title":"Lack of association of a common polymorphism of the plasminogen activator inhibitor-1 gene with coronary artery disease and myocardial infarction","volume":"34","author":"Anderson","year":"1999","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.rpth.2026.106928_bib38","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1055\/s-0037-1614639","article-title":"The 4G\/5G polymorphism in the plasminogen activator inhibitor-1 gene is not associated with myocardial infarction","volume":"82","author":"Doggen","year":"1999","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.rpth.2026.106928_bib39","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1055\/s-0038-1656042","article-title":"Plasminogen activator inhibitor-1 (PAI-1) 4G\/5G promoter polymorphism and levels in subjects with cerebrovascular disease","volume":"77","author":"Catto","year":"1997","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.rpth.2026.106928_bib40","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1161\/01.CIR.95.1.59","article-title":"Arterial and venous thrombosis is not associated with the 4G\/5G polymorphism in the promoter of the plasminogen activator inhibitor gene in a large cohort of US men","volume":"95","author":"Ridker","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.rpth.2026.106928_bib41","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1055\/s-0037-1615105","article-title":"The 4G\/5G sequence polymorphism in the promoter of plasminogen activator inhibitor-1 (PAI-1) gene: relationship to plasma PAI-1 level in venous thromboembolism","volume":"79","author":"Stegnar","year":"1998","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.rpth.2026.106928_bib42","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1538-7836.2005.01709.x","article-title":"Evaluation of low PAI-1 activity as a risk factor for hemorrhagic diathesis","volume":"4","author":"Agren","year":"2006","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.rpth.2026.106928_bib43","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0049-3848(96)00211-3","article-title":"A novel G\/A and the 4G\/5G polymorphism within the promoter of the plasminogen activator inhibitor-1 gene in patients with deep vein thrombosis","volume":"84","author":"Grubic","year":"1996","journal-title":"Thromb Res"},{"key":"10.1016\/j.rpth.2026.106928_bib44","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1161\/01.ATV.17.5.851","article-title":"Five frequent polymorphisms of the PAI-1 gene: lack of association between genotypes, PAI activity, and triglyceride levels in a healthy population","volume":"17","author":"Henry","year":"1997","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.rpth.2026.106928_bib45","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jstrokecerebrovasdis.2007.02.002","article-title":"Association of PAI-1 4G\/5G and -844G\/A gene polymorphism and changes in PAI-1\/tPA levels in stroke: a case-control study","volume":"16","author":"Saidi","year":"2007","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"10.1016\/j.rpth.2026.106928_bib46","first-page":"122","article-title":"PAI-1 promoter 4G\/5G genotype as an additional risk factor for venous thrombosis in subjects with genetic thrombophilic defects","volume":"111","author":"Segu\u00ed","year":"2000","journal-title":"Br J Haematol"},{"key":"10.1016\/j.rpth.2026.106928_bib47","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1046\/j.1365-2141.2000.02152.x","article-title":"Influence of the -675 4G\/5G dimorphism of the plasminogen activator inhibitor 1 promoter on thrombotic risk in patients with factor V Leiden","volume":"110","author":"Visanji","year":"2000","journal-title":"Br J Haematol"},{"key":"10.1016\/j.rpth.2026.106928_bib48","first-page":"83","article-title":"Effect of plasminogen activator inhibitor-1 4G\/5G polymorphism in Turkish deep vein thromboembolic patients with and without prothrombin 20210 G-A","volume":"21","author":"Y\u0131lmaz","year":"2004","journal-title":"Turk J Haematol"},{"key":"10.1016\/j.rpth.2026.106928_bib49","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1161\/01.ATV.20.5.1387","article-title":"The A -844G polymorphism in the PAI-1 gene is associated with a higher risk of venous thrombosis in factor V Leiden carriers","volume":"20","author":"Morange","year":"2000","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.rpth.2026.106928_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.rpth.2024.102604","article-title":"Enhanced thrombin and plasmin generation profiles in alpha-2-antiplasmin-deficient patients: data from the Rare Bleeding disorders in the Netherlands study","volume":"8","author":"Haisma","year":"2024","journal-title":"Res Pract Thromb Haemost"},{"key":"10.1016\/j.rpth.2026.106928_bib51","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1111\/j.1538-7836.2007.02430.x","article-title":"TAFIa, PAI-1 and alpha-antiplasmin: complementary roles in regulating lysis of thrombi and plasma clots","volume":"5","author":"Mutch","year":"2007","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.rpth.2026.106928_bib52","doi-asserted-by":"crossref","first-page":"16603","DOI":"10.1074\/jbc.271.28.16603","article-title":"TAFI, or plasma procarboxypeptidase B, couples the coagulation and fibrinolytic cascades through the thrombin-thrombomodulin complex","volume":"271","author":"Bajzar","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.rpth.2026.106928_bib53","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1046\/j.1538-7836.2003.00383.x","article-title":"Thrombus lysis by uPA, scuPA and tPA is regulated by plasma TAFI","volume":"1","author":"Mutch","year":"2003","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.rpth.2026.106928_bib54","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1471-2253-12-27","article-title":"PAI-1 and t-PA\/PAI-1 complex potential markers of fibrinolytic bleeding after cardiac surgery employing cardiopulmonary bypass","volume":"12","author":"Ozolina","year":"2012","journal-title":"BMC Anesthesiol"},{"key":"10.1016\/j.rpth.2026.106928_bib55","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0125069","article-title":"Increased plasma clot permeability and susceptibility to lysis are associated with heavy menstrual bleeding of unknown cause: a case-control study","volume":"10","author":"Szczepaniak","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.rpth.2026.106928_bib56","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.thromres.2018.12.004","article-title":"Assessment and determinants of whole blood and plasma fibrinolysis in patients with mild bleeding symptoms","volume":"174","author":"Vries","year":"2019","journal-title":"Thromb Res"},{"key":"10.1016\/j.rpth.2026.106928_bib57","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s00277-016-2893-6","article-title":"Fibrinolysis in patients with a mild-to-moderate bleeding tendency of unknown cause","volume":"96","author":"Gebhart","year":"2017","journal-title":"Ann Hematol"},{"key":"10.1016\/j.rpth.2026.106928_bib58","doi-asserted-by":"crossref","DOI":"10.1128\/MCB.00565-20","article-title":"MicroRNA 617 targeting SERPINE1 inhibited the progression of oral squamous cell carcinoma","volume":"41","author":"Zhao","year":"2021","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.rpth.2026.106928_bib59","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0044532","article-title":"miR-421 and miR-30c inhibit SERPINE 1 gene expression in human endothelial cells","volume":"7","author":"Marchand","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.rpth.2026.106928_bib60","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1186\/s13578-022-00901-8","article-title":"Aberrant methylation of Serpine1 mediates lung injury in neonatal mice prenatally exposed to intrauterine inflammation","volume":"12","author":"Yao","year":"2022","journal-title":"Cell Biosci"}],"container-title":["Research and Practice in Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037926035867?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037926035867?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:25:19Z","timestamp":1792682719000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2475037926035867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":59,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S2475037926035867"],"URL":"https:\/\/doi.org\/10.1016\/j.rpth.2026.106928","relation":{},"ISSN":["2475-0379"],"issn-type":[{"value":"2475-0379","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic and hemostatic characterization of PAI-1 deficiency and isolated hyperfibrinolysis: data from the RBiN study","name":"articletitle","label":"Article Title"},{"value":"Research and Practice in Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rpth.2026.106928","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis.","name":"copyright","label":"Copyright"}],"article-number":"106928"}}