{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:50:28Z","timestamp":1791330628974,"version":"4.3.1"},"reference-count":54,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","rpthjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research and Practice in Thrombosis and Haemostasis"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.rpth.2026.106940","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:18:03Z","timestamp":1788448683000},"page":"106940","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiovascular and comorbid risk factors for thrombosis in primary immune thrombocytopenia: a single-center retrospective study"],"prefix":"10.1016","volume":"10","author":[{"given":"Ping","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yitong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1403-1882","authenticated-orcid":false,"given":"Yu","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rpth.2026.106940_bib1","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1056\/NEJMcp1810479","article-title":"Immune thrombocytopenia","volume":"381","author":"Cooper","year":"2019","journal-title":"N Engl J Med"},{"key":"10.1016\/j.rpth.2026.106940_bib2","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/ajh.24702","article-title":"Newly diagnosed immune thrombocytopenia adults: clinical epidemiology, exposure to treatments, and evolution. Results of the CARMEN multicenter prospective cohort","volume":"92","author":"Moulis","year":"2017","journal-title":"Am J Hematol"},{"key":"10.1016\/j.rpth.2026.106940_bib3","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1111\/bjh.17390","article-title":"Thrombosis in immune thrombocytopenia\u2014current status and future perspectives","volume":"194","author":"Swan","year":"2021","journal-title":"Br J Haematol"},{"key":"10.1016\/j.rpth.2026.106940_bib4","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/ajh.24234","article-title":"Is ITP a thrombophilic disorder?","volume":"91","author":"Rodeghiero","year":"2016","journal-title":"Am J Hematol"},{"key":"10.1016\/j.rpth.2026.106940_bib5","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1111\/bjh.13787","article-title":"Risk of arterial thrombotic and venous thromboembolic events in patients with primary chronic immune thrombocytopenia: a Scandinavian population-based cohort study","volume":"174","author":"N\u00f8rgaard","year":"2016","journal-title":"Br J Haematol"},{"key":"10.1016\/j.rpth.2026.106940_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.thromres.2024.109109","article-title":"The immune thrombocytopenia paradox: Should we be concerned about thrombosis in ITP?","volume":"241","author":"Saldanha","year":"2024","journal-title":"Thromb Res"},{"key":"10.1016\/j.rpth.2026.106940_bib7","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1111\/ejh.14154","article-title":"Risk-based and individualised management of bleeding and thrombotic events in adults with primary immune thrombocytopenia (ITP)","volume":"112","author":"Lambert","year":"2024","journal-title":"Eur J Haematol"},{"key":"10.1016\/j.rpth.2026.106940_bib8","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/j.1365-2141.2010.08418.x","article-title":"Risk of venous thromboembolism in patients with primary chronic immune thrombocytopenia: a Danish population-based cohort study","volume":"152","author":"Severinsen","year":"2011","journal-title":"Br J Haematol"},{"key":"10.1016\/j.rpth.2026.106940_bib9","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1365-2141.2012.09231.x","article-title":"Risk of arterial thrombosis in patients with primary chronic immune thrombocytopenia: a Danish population-based cohort study","volume":"159","author":"N\u00f8rgaard","year":"2012","journal-title":"Br J Haematol"},{"key":"10.1016\/j.rpth.2026.106940_bib10","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1111\/jth.13940","article-title":"The association between idiopathic thrombocytopenic purpura and cardiovascular disease: a retrospective cohort study","volume":"16","author":"Chandan","year":"2018","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.rpth.2026.106940_bib11","doi-asserted-by":"crossref","first-page":"E181","DOI":"10.1002\/ajh.25127","article-title":"Cardiovascular risk factors in immune thrombocytopenia adults: results from the CARMEN registry","volume":"93","author":"Moulis","year":"2018","journal-title":"Am J Hematol"},{"key":"10.1016\/j.rpth.2026.106940_bib12","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/bjh.12869","article-title":"Twenty-year mortality of adult patients with primary immune thrombocytopenia: a Danish population-based cohort study","volume":"166","author":"Frederiksen","year":"2014","journal-title":"Br J Haematol"},{"key":"10.1016\/j.rpth.2026.106940_bib13","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1182\/blood-2022-169640","article-title":"Arterial thromboembolism is prevalent and often suboptimally managed in immune thrombocytopenia","volume":"140","author":"Wang","year":"2022","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2026.106940_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.rpth.2024.102342","article-title":"Thrombosis in patients with immune thrombocytopenia: incidence, risk, and clinical outcomes","volume":"8","author":"Goncalves","year":"2024","journal-title":"Res Pract Thromb Haemost"},{"key":"10.1016\/j.rpth.2026.106940_bib15","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s12959-023-00509-z","article-title":"Risk of thrombotic events in immune thrombocytopenia patients treated with thrombopoietic agents: a systematic review and meta-analysis","volume":"21","author":"Dong","year":"2023","journal-title":"Thromb J"},{"key":"10.1016\/j.rpth.2026.106940_bib16","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.3324\/haematol.2018.212845","article-title":"Thrombopoietin receptor agonists: ten years later","volume":"104","author":"Ghanima","year":"2019","journal-title":"Haematologica"},{"key":"10.1016\/j.rpth.2026.106940_bib17","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1007\/s12026-018-9047-y","article-title":"Intravenous immunoglobulins for rheumatic disorders and thromboembolic events\u2014a case series and review of the literature","volume":"66","author":"Lidar","year":"2018","journal-title":"Immunol Res"},{"key":"10.1016\/j.rpth.2026.106940_bib18","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1001\/jamainternmed.2013.122","article-title":"Use of glucocorticoids and risk of venous thromboembolism: a nationwide population-based case-control study","volume":"173","author":"Johannesdottir","year":"2013","journal-title":"JAMA Intern Med"},{"key":"10.1016\/j.rpth.2026.106940_bib19","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1111\/jth.12636","article-title":"Thrombotic risk in patients with primary immune thrombocytopenia is only mildly increased and explained by personal and treatment-related risk factors","volume":"12","author":"Ruggeri","year":"2014","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.rpth.2026.106940_bib20","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000005098","article-title":"Long-term complications of splenectomy in adult immune thrombocytopenia","volume":"95","author":"Thai","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.rpth.2026.106940_bib21","doi-asserted-by":"crossref","first-page":"4782","DOI":"10.1182\/blood-2012-12-467068","article-title":"Splenectomy and the incidence of venous thromboembolism and sepsis in patients with immune thrombocytopenia","volume":"121","author":"Boyle","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2026.106940_bib22","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1111\/bjh.17709","article-title":"Risk factors of hospitalisation for thrombosis in adults with primary immune thrombocytopenia, including disease-specific treatments: a French nationwide cohort study","volume":"195","author":"Lafaurie","year":"2021","journal-title":"Br J Haematol"},{"key":"10.1016\/j.rpth.2026.106940_bib23","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1111\/j.1538-7836.2010.03849.x","article-title":"Risk of venous thromboembolism in splenectomized patients compared with the general population and appendectomized patients: a 10-year nationwide cohort study","volume":"8","author":"Thomsen","year":"2010","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.rpth.2026.106940_bib24","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.3324\/haematol.2009.018390","article-title":"Thromboembolic events among adult patients with primary immune thrombocytopenia in the United Kingdom general practice research database","volume":"95","author":"Sarpatwari","year":"2010","journal-title":"Haematologica"},{"key":"10.1016\/j.rpth.2026.106940_bib25","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1111\/jth.14446","article-title":"Cardiovascular and bleeding outcomes in a population-based cohort of patients with chronic immune thrombocytopenia","volume":"17","author":"Adelborg","year":"2019","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.rpth.2026.106940_bib26","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.thromres.2019.04.016","article-title":"Impact of risk factors on the occurrence of arterial thrombosis and venous thromboembolism in adults with primary immune thrombocytopenia\u2014results from two nationwide cohorts","volume":"178","author":"Ekstrand","year":"2019","journal-title":"Thromb Res"},{"key":"10.1016\/j.rpth.2026.106940_bib27","doi-asserted-by":"crossref","first-page":"3780","DOI":"10.1182\/bloodadvances.2019000812","article-title":"Updated international consensus report on the investigation and management of primary immune thrombocytopenia","volume":"3","author":"Provan","year":"2019","journal-title":"Blood Advances"},{"key":"10.1016\/j.rpth.2026.106940_bib28","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/bjh.18997","article-title":"Obesity is associated with poor outcomes of corticosteroid treatment in patients with primary immune thrombocytopenia","volume":"203","author":"Zhang","year":"2023","journal-title":"Br J Haematol"},{"key":"10.1016\/j.rpth.2026.106940_bib29","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0140-6736(21)00798-4","article-title":"Body-mass index and obesity in urban and rural China: findings from consecutive nationally representative surveys during 2004-18","volume":"398","author":"Wang","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.rpth.2026.106940_bib30","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1093\/ije\/dyv337","article-title":"Cohort Profile: The Framingham Heart Study (FHS): overview of milestones in cardiovascular epidemiology","volume":"44","author":"Tsao","year":"2015","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.rpth.2026.106940_bib31","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1001\/archinte.1997.00440420033005","article-title":"The sixth report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure","volume":"157","year":"1997","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.rpth.2026.106940_bib32","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s12185-016-1974-6","article-title":"Thromboembolism in patients with immune thrombocytopenia (ITP): a meta-analysis of observational studies","volume":"103","author":"Langeberg","year":"2016","journal-title":"Int J Hematol"},{"key":"10.1016\/j.rpth.2026.106940_bib33","doi-asserted-by":"crossref","DOI":"10.1177\/20406207211010875","article-title":"Assessment of thrombotic risk during long-term treatment of immune thrombocytopenia with fostamatinib","volume":"12","author":"Cooper","year":"2021","journal-title":"Ther Adv Hematol"},{"key":"10.1016\/j.rpth.2026.106940_bib34","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s12185-010-0636-3","article-title":"Comorbidities in patients with persistent or chronic immune thrombocytopenia","volume":"92","author":"Enger","year":"2010","journal-title":"Int J Hematol"},{"key":"10.1016\/j.rpth.2026.106940_bib35","doi-asserted-by":"crossref","first-page":"436","DOI":"10.21037\/atm.2019.09.04","article-title":"Prevalence of hypertension, diabetes, and dyslipidemia, and their additive effects on myocardial infarction and stroke: a cross-sectional study in Nanjing, China","volume":"7","author":"Lu","year":"2019","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.rpth.2026.106940_bib36","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1161\/01.STR.0000158925.12740.87","article-title":"Blood pressure control and risk of stroke","volume":"36","author":"Li","year":"2005","journal-title":"Stroke"},{"key":"10.1016\/j.rpth.2026.106940_bib37","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1136\/bmj.321.7258.405","article-title":"Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study","volume":"321","author":"Stratton","year":"2000","journal-title":"BMJ"},{"key":"10.1016\/j.rpth.2026.106940_bib38","doi-asserted-by":"crossref","DOI":"10.1002\/jcsm.70028","article-title":"Dual roles of HbA1c variability and body composition for cardiovascular risk: a cohort study of 8224 adults with type 2 diabetes mellitus","volume":"16","author":"Kim","year":"2025","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.rpth.2026.106940_bib39","doi-asserted-by":"crossref","first-page":"4204","DOI":"10.1093\/eurheartj\/ehae576","article-title":"Intensive early and sustained lowering of non-high-density lipoprotein cholesterol after myocardial infarction and prognosis: the SWEDEHEART registry","volume":"45","author":"Schubert","year":"2024","journal-title":"Eur Heart J"},{"key":"10.1016\/j.rpth.2026.106940_bib40","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.125.041416","article-title":"Statin use and recurrent atherosclerotic cardiovascular disease events in patients with coronary artery intervention: a retrospective analysis from a large health care network","volume":"15","author":"Ahmed","year":"2026","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.rpth.2026.106940_bib41","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1182\/blood-2017-09-742353","article-title":"Splenectomy for immune thrombocytopenia: down but not out","volume":"131","author":"Chaturvedi","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2026.106940_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.htct.2025.104981","article-title":"Assessment of thrombotic risk and pathophysiological mechanisms of splenectomy-associated hypercoagulability in patients with immune thrombocytopenia","volume":"47","author":"Saldanha","year":"2025","journal-title":"Hematol Transfus Cell Ther"},{"key":"10.1016\/j.rpth.2026.106940_bib43","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1111\/imj.14269","article-title":"Characteristics, risk factors and management of venous thromboembolism in immune thrombocytopenia: a retrospective multicentre study","volume":"49","author":"Le Guenno","year":"2019","journal-title":"Intern Med J"},{"key":"10.1016\/j.rpth.2026.106940_bib44","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1111\/j.1538-7836.2010.04044.x","article-title":"A risk assessment model for the identification of hospitalized medical patients at risk for venous thromboembolism: the Padua Prediction Score","volume":"8","author":"Barbar","year":"2010","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.rpth.2026.106940_bib45","doi-asserted-by":"crossref","DOI":"10.2147\/JBM.S570135","article-title":"Development and validation of a novel thrombosis prediction model for adult immune thrombocytopenia (ITP-THROMBO)","volume":"17","author":"Yan","year":"2026","journal-title":"J Blood Med"},{"key":"10.1016\/j.rpth.2026.106940_bib46","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.3324\/haematol.2009.018390","article-title":"Thromboembolic events among adult patients with primary immune thrombocytopenia in the United Kingdom general practice research database","volume":"95","author":"Ameet","year":"2010","journal-title":"Haematologica"},{"key":"10.1016\/j.rpth.2026.106940_bib47","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1182\/blood-2023-185866","article-title":"High risk of thrombosis in a prospective cohort of adults with primary immune thrombocytopenia","volume":"142","author":"Rast","year":"2023","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2026.106940_bib48","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1182\/blood-2025-1251","article-title":"Comparative risk of thrombosis in adults with primary immune thrombocytopenia treated with eltrombopag versus romiplostim: a target trial emulation in the french adult immune thrombocytopenia (FAITH) cohort","volume":"146","author":"Zordan","year":"2025","journal-title":"Blood"},{"key":"10.1016\/j.rpth.2026.106940_bib49","doi-asserted-by":"crossref","first-page":"5902","DOI":"10.1182\/bloodadvances.2025017902","article-title":"Beyond platelet counts: assessing safety of postsplenectomy TPO-RA use in ITP","volume":"9","author":"Alyamany","year":"2025","journal-title":"Blood Adv"},{"key":"10.1016\/j.rpth.2026.106940_bib50","doi-asserted-by":"crossref","DOI":"10.1080\/16078454.2025.2472461","article-title":"A retrospective study of risk factors for thrombosis in patients with ITP","volume":"30","author":"Zhou","year":"2025","journal-title":"Hematology"},{"key":"10.1016\/j.rpth.2026.106940_bib51","article-title":"A practical guide to the management of immune thrombocytopenia co-existing with acute coronary syndrome","volume":"11","author":"Rahhal","year":"2024","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.rpth.2026.106940_bib52","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/pbc.22968","article-title":"Cerebral sinus thrombosis following IV immunoglobulin therapy of immune thrombocytopenia purpura","volume":"57","author":"Al-Riyami","year":"2011","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.rpth.2026.106940_bib53","doi-asserted-by":"crossref","first-page":"869","DOI":"10.4103\/ijccm.IJCCM_308_17","article-title":"Cerebral venous thrombosis after intravenous immunoglobulin therapy in immune thrombocytopenic purpura","volume":"21","author":"James","year":"2017","journal-title":"Indian J Crit Care Med"},{"key":"10.1016\/j.rpth.2026.106940_bib54","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.1182\/blood-2018-08-868406","article-title":"Managing antithrombotic therapy in immune thrombocytopenia: development of the TH2 risk assessment score","volume":"132","author":"Balitsky","year":"2018","journal-title":"Blood"}],"container-title":["Research and Practice in Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037926035983?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2475037926035983?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:01:34Z","timestamp":1791327694000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2475037926035983"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":54,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S2475037926035983"],"URL":"https:\/\/doi.org\/10.1016\/j.rpth.2026.106940","relation":{},"ISSN":["2475-0379"],"issn-type":[{"value":"2475-0379","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardiovascular and comorbid risk factors for thrombosis in primary immune thrombocytopenia: a single-center retrospective study","name":"articletitle","label":"Article Title"},{"value":"Research and Practice in Thrombosis and Haemostasis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rpth.2026.106940","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of International Society on Thrombosis and Haemostasis.","name":"copyright","label":"Copyright"}],"article-number":"106940"}}