{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T06:58:24Z","timestamp":1770965904708,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research in Veterinary Science"],"published-print":{"date-parts":[[2007,4]]},"DOI":"10.1016\/j.rvsc.2006.07.008","type":"journal-article","created":{"date-parts":[[2006,10,3]],"date-time":"2006-10-03T08:04:53Z","timestamp":1159862693000},"page":"181-186","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Elevated cAMP levels reverse Brucella melitensis-induced lipid peroxidation and stimulate IL-10 transcription in rats"],"prefix":"10.1016","volume":"82","author":[{"given":"S.","family":"Erdogan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Celik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Aslantas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Kontas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Ocak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.rvsc.2006.07.008_bib1","first-page":"305","article-title":"Kakoma I. Evaluation of the Sprague-Dawley rat as a model for vertical transmission of Brucella abortus","volume":"69","author":"Baek","year":"2005","journal-title":"Canadian Journal of Veterinary Research"},{"key":"10.1016\/j.rvsc.2006.07.008_bib2","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Analytical Biochemistry"},{"key":"10.1016\/j.rvsc.2006.07.008_bib3","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1093\/clinchem\/36.8.1440","article-title":"Determination of inorganic nitrate in serum and urine by a kinetic cadmium-reduction method","volume":"36","author":"Cortas","year":"1990","journal-title":"Clinical Chemistry"},{"key":"10.1016\/j.rvsc.2006.07.008_bib4","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1042\/bj3210165","volume":"321","author":"Erdogan","year":"1997","journal-title":"Biochemical Journal"},{"key":"10.1016\/j.rvsc.2006.07.008_bib5","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S1567-5769(01)00159-X","article-title":"Inhibition of endotoxemia-induced nitric oxide synthase expression by cyclosporin A enhances hepatocyte injury in rats: amelioration by NO donors","volume":"2","author":"Farghali","year":"2002","journal-title":"International Immunopharmacology"},{"key":"10.1016\/j.rvsc.2006.07.008_bib6","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0378-1135(02)00367-X","article-title":"Intracellular survival of Brucella: defining the link with persistence","volume":"92","author":"Ficht","year":"2003","journal-title":"Veterinary Microbiology"},{"key":"10.1016\/j.rvsc.2006.07.008_bib7","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.micpath.2003.09.003","article-title":"Impairment of Brucella growth in human macrophagic cells that produce nitric oxide","volume":"36","author":"Gross","year":"2004","journal-title":"Microbial Pathogenesis"},{"key":"10.1016\/j.rvsc.2006.07.008_bib8","doi-asserted-by":"crossref","first-page":"5607","DOI":"10.4049\/jimmunol.170.11.5607","article-title":"Subversion and utilization of the host cell cyclic adenosine 5\u2032-monophosphate\/protein kinase A pathway by Brucella during macrophage infection","volume":"170","author":"Gross","year":"2003","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.rvsc.2006.07.008_bib9","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1096\/fasebj.6.9.1612291","article-title":"Regulation of antioxidant enzymes","volume":"6","author":"Harris","year":"1992","journal-title":"The FASEB Journal"},{"key":"10.1016\/j.rvsc.2006.07.008_bib10","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S1286-4579(02)00076-X","article-title":"Delayed type hypersensitivity-associated disruption of splenic periarteriolar lymphatic sheaths coincides with temporary loss of IFN-gamma production and impaired eradication of bacteria in Brucella abortus-infected mice","volume":"5","author":"Hort","year":"2003","journal-title":"Microbes and Infection"},{"key":"10.1016\/j.rvsc.2006.07.008_bib11","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/S1359-6446(05)03622-6","article-title":"Phosphodiesterase-4 as a therapeutic target","volume":"10","author":"Houslay","year":"2005","journal-title":"Drug Discovery Today"},{"key":"10.1016\/j.rvsc.2006.07.008_bib12","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1006\/cimm.1993.1241","article-title":"Macrophage control of Brucella abortus: role of reactive oxygen intermediates and nitric oxide","volume":"151","author":"Jiang","year":"1993","journal-title":"Cellular Immunology"},{"key":"10.1016\/j.rvsc.2006.07.008_bib13","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/S0022-3565(24)29287-9","article-title":"Phosphodiesterase 4 inhibitors prevent cytokine secretion by T lymphocytes by inhibiting nuclear factor-kappaB and nuclear factor of activated T cells activation","volume":"299","author":"Jimenez","year":"2001","journal-title":"The Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.rvsc.2006.07.008_bib14","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.taap.2005.01.006","article-title":"Elastolytic activity and alveolar epithelial type-1 cell damage after chronic LPS inhalation: effects of dexamethasone and rolipram","volume":"207","author":"Johnson","year":"2005","journal-title":"Toxicology and Applied Pharmacology"},{"key":"10.1016\/j.rvsc.2006.07.008_bib15","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0147-9571(01)00029-7","article-title":"Study of interleukin-10 and interleukin-12 productions in response to lipopolysaccharides extracted from two different Brucella strains","volume":"25","author":"Kariminia","year":"2002","journal-title":"Comparative Immunology, Microbiology and Infectious Diseases"},{"key":"10.1016\/j.rvsc.2006.07.008_bib16","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s10238-005-0075-2","article-title":"Lipid peroxidation levels in patients with acute brucellosis","volume":"5","author":"Kilic","year":"2005","journal-title":"Clinical Experimental Medicine"},{"key":"10.1016\/j.rvsc.2006.07.008_bib17","doi-asserted-by":"crossref","first-page":"3861","DOI":"10.1128\/IAI.68.7.3861-3866.2000","article-title":"Regulation of Brucella abortus catalase","volume":"68","author":"Kim","year":"2000","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.rvsc.2006.07.008_bib18","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0014-2999(03)01830-2","article-title":"Effects of phosphodiesterase inhibitors on l-arginine pathways in rat alveolar macrophages","volume":"471","author":"Koschorreck","year":"2003","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.rvsc.2006.07.008_bib19","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1006\/jmcc.1997.0544","article-title":"Altered expression of PDE1 and PDE4 cyclic nucleotide phosphodiesterase isoforms in 7-oxo-prostacyclin-preconditioned rat heart","volume":"29","author":"Kostic","year":"1997","journal-title":"Journal of Molecular and Cellular Cardiology"},{"key":"10.1016\/j.rvsc.2006.07.008_bib20","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1128\/IAI.68.3.1740-1745.2000","article-title":"Lipopolysaccharides of Brucella abortus and Brucella melitensis induce nitric oxide synthesis in rat peritoneal macrophages","volume":"68","author":"Lopez-Urrutia","year":"2000","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.rvsc.2006.07.008_bib21","doi-asserted-by":"crossref","first-page":"6370","DOI":"10.1016\/S0021-9258(18)42704-4","article-title":"Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line","volume":"267","author":"Lyons","year":"1992","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.rvsc.2006.07.008_bib22","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev.immunol.15.1.323","article-title":"Nitric oxide and macrophage function","volume":"15","author":"MacMicking","year":"1997","journal-title":"Annual Review of Immunology"},{"key":"10.1016\/j.rvsc.2006.07.008_bib23","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.cca.2005.02.010","article-title":"Reduction of diabetes-induced oxidative stress by phosphodiesterase inhibitors in rats","volume":"140","author":"Milani","year":"2005","journal-title":"Comparative Biochemistry and Physiology C, Comparative Pharmacology and Toxicology"},{"key":"10.1016\/j.rvsc.2006.07.008_bib24","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1211\/0022357023565","article-title":"Protection against doxorubicin cardiomyopathy in rats: role of phosphodiesterase inhibitors type 4","volume":"56","author":"Mohamed","year":"2004","journal-title":"The Journal of Pharmacy and Pharmacology"},{"key":"10.1016\/j.rvsc.2006.07.008_bib25","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1146\/annurev.me.38.020187.002221","article-title":"Endotoxins and disease mechanisms","volume":"38","author":"Morris","year":"1987","journal-title":"Annual Review of Medicine"},{"key":"10.1016\/j.rvsc.2006.07.008_bib26","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1093\/intimm\/7.4.517","article-title":"Up-regulation of monocytic IL-10 by tumor necrosis factor-alpha and cAMP elevating drugs","volume":"7","author":"Platzer","year":"1995","journal-title":"International Immunology"},{"key":"10.1016\/j.rvsc.2006.07.008_bib27","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.pharmthera.2004.12.001","article-title":"PDE4 inhibitors as new anti-inflammatory drugs: effects on cell trafficking and cell adhesion molecules expression","volume":"106","author":"Sanz","year":"2005","journal-title":"Pharmacology and Therapeutics"},{"key":"10.1016\/j.rvsc.2006.07.008_bib28","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1093\/humrep\/17.7.1709","article-title":"Different mechanisms for the induction of copper\u2013zinc superoxide dismutase and manganese superoxide dismutase by progesterone in human endometrial stromal cells","volume":"17","author":"Sugino","year":"2002","journal-title":"Human Reproduction"},{"key":"10.1016\/j.rvsc.2006.07.008_bib29","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/clinchem\/34.3.497","article-title":"A simple method for clinical assay of superoxide dismutase","volume":"34","author":"Sun","year":"1988","journal-title":"Clinical Chemistry"},{"key":"10.1016\/j.rvsc.2006.07.008_bib30","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.4049\/jimmunol.161.6.3019","article-title":"Prostaglandin E2 protects against liver injury after Escherichia coli infection but hampers the resolution of the infection in mice","volume":"161","author":"Takano","year":"1998","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.rvsc.2006.07.008_bib31","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0165-5728(96)00199-3","article-title":"Competitive PCR quantification of pro- and anti-inflammatory cytokine mRNA in the central nervous system during autoimmune encephalomyelitis","volume":"73","author":"Tanuma","year":"1997","journal-title":"Journal of Neuroimmunology"},{"key":"10.1016\/j.rvsc.2006.07.008_bib32","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1128\/iai.60.7.2863-2869.1992","article-title":"Construction of Cu\u2013Zn superoxide dismutase deletion mutants of Brucella abortus: analysis of survival in vitro in epithelial and phagocytic cells and in vivo in mice","volume":"60","author":"Tatum","year":"1992","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.rvsc.2006.07.008_bib33","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/0002-9378(79)90708-7","article-title":"Lipid peroxidation in maternal and cord blood and protective mechanism against active-oxygen toxicity in the blood","volume":"135","author":"Yoshoiko","year":"1979","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"10.1016\/j.rvsc.2006.07.008_bib34","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1093\/clinids\/5.5.821","article-title":"Human brucellosis","volume":"5","author":"Young","year":"1983","journal-title":"Reviews of Infectious Diseases"},{"key":"10.1016\/j.rvsc.2006.07.008_bib35","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0928-8244(03)00257-8","article-title":"The effects of streptozotocin-induced diabetes on brucellosis of rats","volume":"39","author":"Yumuk","year":"2003","journal-title":"FEMS Immunology and Medical Microbiology"},{"key":"10.1016\/j.rvsc.2006.07.008_bib36","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/S0028-3908(01)00174-5","article-title":"Suppressive effects of phosphodiesterase type IV inhibitors on rat cultured microglial cells: comparison with other types of cAMP-elevating agents","volume":"42","author":"Zhang","year":"2002","journal-title":"Neuropharmacology"}],"container-title":["Research in Veterinary Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034528806001421?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034528806001421?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T03:37:34Z","timestamp":1758512254000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0034528806001421"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["S0034528806001421"],"URL":"https:\/\/doi.org\/10.1016\/j.rvsc.2006.07.008","relation":{},"ISSN":["0034-5288"],"issn-type":[{"value":"0034-5288","type":"print"}],"subject":[],"published":{"date-parts":[[2007,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Elevated cAMP levels reverse Brucella melitensis-induced lipid peroxidation and stimulate IL-10 transcription in rats","name":"articletitle","label":"Article Title"},{"value":"Research in Veterinary Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rvsc.2006.07.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}