{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T03:01:52Z","timestamp":1770433312090,"version":"3.49.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research in Veterinary Science"],"published-print":{"date-parts":[[2008,6]]},"DOI":"10.1016\/j.rvsc.2007.05.012","type":"journal-article","created":{"date-parts":[[2007,7,17]],"date-time":"2007-07-17T07:18:31Z","timestamp":1184656711000},"page":"444-451","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["In vitro effects of bethanechol on smooth muscle preparations from abomasal fundus, corpus, and antrum of dairy cows"],"prefix":"10.1016","volume":"84","author":[{"given":"M.","family":"Buehler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Steiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Meylan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.J.","family":"Portier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Mevissen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.rvsc.2007.05.012_bib1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0163-7258(93)90027-B","article-title":"Muscarinic receptors \u2013 characterization, coupling and function","volume":"58","author":"Caulfield","year":"1993","journal-title":"Pharmacology and Therapeutics"},{"key":"10.1016\/j.rvsc.2007.05.012_bib2","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0031-6997(24)01362-0","article-title":"International Union of Pharmacology. XVII. Classification of muscarinic acetylcholine receptors","volume":"50","author":"Caulfield","year":"1998","journal-title":"Pharmacological Reviews"},{"key":"10.1016\/j.rvsc.2007.05.012_bib3","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.2460\/ajvr.1992.53.7.1184","article-title":"Risk factors for abomasal volvulus and left abomasal displacement in cattle","volume":"53","author":"Constable","year":"1992","journal-title":"American Journal of Veterinary Research"},{"key":"10.1016\/j.rvsc.2007.05.012_bib4","first-page":"27","article-title":"Review of the clinical pharmacology of the equine digestive system","volume":"1","author":"Davis","year":"1977","journal-title":"Journal of Equine Medicine Surgery"},{"key":"10.1016\/j.rvsc.2007.05.012_bib5","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1161\/01.CIR.102.16.1883","article-title":"Domperidone should not be considered a no-risk alternative to cisapride in the treatment of gastrointestinal motility disorders","volume":"102","author":"Drolet","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.rvsc.2007.05.012_bib6","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1016\/S0024-3205(01)01054-2","article-title":"Muscarinic receptors and gastrointestinal tract smooth muscle function","volume":"68","author":"Eglen","year":"2001","journal-title":"Life Sciences"},{"key":"10.1016\/j.rvsc.2007.05.012_bib7","first-page":"1357","article-title":"Selective inactivation of muscarinic receptor subtypes","volume":"26","author":"Eglen","year":"1994","journal-title":"The International Journal of Biochemistry and Cell Biology"},{"key":"10.1016\/j.rvsc.2007.05.012_bib8","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0031-6997(25)06957-1","article-title":"Muscarinic receptor subtypes and smooth muscle function","volume":"48","author":"Eglen","year":"1996","journal-title":"Pharmacological Reviews"},{"key":"10.1016\/j.rvsc.2007.05.012_bib9","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/00001813-199204000-00001","article-title":"Selectivity of 5-HT3 receptor antagonists and anti-emetic mechanisms of action","volume":"3","author":"Freeman","year":"1992","journal-title":"Anticancer Drugs"},{"key":"10.1016\/j.rvsc.2007.05.012_bib10","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1439-0442.1995.tb00375.x","article-title":"Abomasal displacement in the bovine \u2013 a review on character, occurrence, aetiology and pathogenesis","volume":"42","author":"Geishauser","year":"1995","journal-title":"Zentralblatt f\u00fcr Veterin\u00e4rmedizin A"},{"key":"10.1016\/j.rvsc.2007.05.012_bib11","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1046\/j.1365-2982.1998.00119.x","article-title":"In vitro motility disorders associated with displaced abomasum in dairy cows","volume":"10","author":"Geishauser","year":"1998","journal-title":"Neurogastroenterology and Motility"},{"key":"10.1016\/j.rvsc.2007.05.012_bib12","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1439-0442.2004.00626.x","article-title":"Relationships between lactational incidence of displaced abomasum and milk production traits in German Holstein cows","volume":"51","author":"Hamann","year":"2004","journal-title":"Journal of Veterinary Medicine A, Physiology, Pathology, Clinical Medicine"},{"key":"10.1016\/j.rvsc.2007.05.012_bib13","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1016\/0024-3205(86)90409-1","article-title":"Binding profile of a novel cardioselective muscarine receptor antagonist, AF-DX 116, to membranes of peripheral tissues and brain in the rat","volume":"38","author":"Hammer","year":"1986","journal-title":"Life Sciences"},{"key":"10.1016\/j.rvsc.2007.05.012_bib14","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1159\/000137725","article-title":"Drugs increasing gastrointestinal motility","volume":"25","author":"Kilbinger","year":"1982","journal-title":"Pharmacology"},{"key":"10.1016\/j.rvsc.2007.05.012_bib15","first-page":"G1228","article-title":"Cholinergic stimulation enhances colonic motor activity, transit, and sensation in humans","volume":"281","author":"Law","year":"2001","journal-title":"American Journal of Physiology: Gastrointestinal and Liver Physiology"},{"key":"10.1016\/j.rvsc.2007.05.012_bib16","doi-asserted-by":"crossref","first-page":"320","DOI":"10.2460\/ajvr.1998.59.03.320","article-title":"Effect of alpha 2-adrenergic, cholinergic, and non-steroidal anti-inflammatory drugs on myoelectric activity of ileum, caecum, and right ventral colon and on cecal emptying of radiolabeled markers in clinically normal ponies","volume":"59","author":"Lester","year":"1998","journal-title":"American Journal of Veterinary Research"},{"key":"10.1016\/j.rvsc.2007.05.012_bib17","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ejphar.2003.10.008","article-title":"Muscarinic receptor subtypes in the human colon: lack of evidence for atypical subtypes","volume":"482","author":"Mansfield","year":"2003","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.rvsc.2007.05.012_bib18","doi-asserted-by":"crossref","first-page":"9579","DOI":"10.1073\/pnas.97.17.9579","article-title":"Multiple functional defects in peripheral autonomic organs in mice lacking muscarinic acetylcholine receptor gene for the M3 subtype","volume":"97","author":"Matsui","year":"2000","journal-title":"Proceedings National Academy of Science"},{"key":"10.1016\/j.rvsc.2007.05.012_bib19","first-page":"631","article-title":"General pharmacology of the four gastrointestinal motility stimulants bethanechol, metoclopramide, trimebutine, and cisapride","volume":"41","author":"Megens","year":"1991","journal-title":"Arzneimittelforschung"},{"key":"10.1016\/j.rvsc.2007.05.012_bib20","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1046\/j.0140-7783.2003.00528.x","article-title":"In vitro effects of cisapride, metoclopramide and bethanechol on smooth muscle preparations from abomasal antrum and duodenum of dairy cows","volume":"26","author":"Michel","year":"2003","journal-title":"Journal of Veterinary Pharmacology and Therapeutics"},{"key":"10.1016\/j.rvsc.2007.05.012_bib21","doi-asserted-by":"crossref","first-page":"295","DOI":"10.2165\/00003495-199243030-00002","article-title":"Pharmacological agents affecting emesis. A review (Part I)","volume":"43","author":"Mitchelson","year":"1992","journal-title":"Drugs"},{"key":"10.1016\/j.rvsc.2007.05.012_bib22","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1038\/sj.bjp.0704642","article-title":"Muscarinic agonist potencies at three different effector systems linked to the M(2) or M(3) receptor in longitudinal smooth muscle of guinea-pig small intestine","volume":"135","author":"Okamoto","year":"2002","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.rvsc.2007.05.012_bib23","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1006\/faat.1993.1006","article-title":"Ligand\/receptor binding for 2,3,7,8-TCDD: implications for risk assessment","volume":"20","author":"Portier","year":"1993","journal-title":"Fundamental and Applied Toxicology"},{"key":"10.1016\/j.rvsc.2007.05.012_bib24","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.2460\/ajvr.1996.57.12.1771","article-title":"Effect of bethanechol or erythromycin on gastric emptying in horses","volume":"57","author":"Ringger","year":"1996","journal-title":"American Journal of Veterinary Research"},{"key":"10.1016\/j.rvsc.2007.05.012_bib25","doi-asserted-by":"crossref","first-page":"111","DOI":"10.2460\/ajvr.1994.55.01.111","article-title":"Abomasal and duodenal motility in yearling cattle after administration of prokinetic drugs","volume":"55","author":"Roussel","year":"1994","journal-title":"American Journal of Veterinary Research"},{"key":"10.1016\/j.rvsc.2007.05.012_bib26","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0022-3565(24)37191-5","article-title":"Contractile roles of the M2 and M3 muscarinic receptors in the guinea pig colon","volume":"284","author":"Sawyer","year":"1998","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.rvsc.2007.05.012_bib27","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/j.1439-0442.1992.tb00214.x","article-title":"Effects of adrenaline, dopamine, serotonin, and different cholinergic agents on smooth muscle preparations from the ansa proximalis coli in cattle: studies in vitro","volume":"39","author":"Steiner","year":"1992","journal-title":"Zentralblatt f\u00fcr Veterin\u00e4rmedizin A"},{"key":"10.1016\/j.rvsc.2007.05.012_bib28","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.2460\/ajvr.1995.56.08.1081","article-title":"Effect of bethanechol, neostigmine, metoclopramide, and propranolol on myoelectric activity of the ileocecocolic area in cows","volume":"56","author":"Steiner","year":"1995","journal-title":"American Journal of Veterinary Research"},{"key":"10.1016\/j.rvsc.2007.05.012_bib29","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/S0026-895X(25)13113-1","article-title":"Functional role for the M2 muscarinic receptor in smooth muscle of guinea pig ileum","volume":"44","author":"Thomas","year":"1993","journal-title":"Molecular Pharmacology"},{"key":"10.1016\/j.rvsc.2007.05.012_bib30","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1540\/jsmr.40.237","article-title":"Muscarinic receptor subtypes of the bladder and gastrointestinal tract","volume":"40","author":"Uchiyama","year":"2004","journal-title":"Journal of Smooth Muscle Research"},{"key":"10.1016\/j.rvsc.2007.05.012_bib31","doi-asserted-by":"crossref","first-page":"3292","DOI":"10.3748\/wjg.v10.i22.3292","article-title":"Mechanisms mediating cholinergic antral circular smooth muscle contraction in rats","volume":"10","author":"Wrzos","year":"2004","journal-title":"World Journal of Gastroenterology"},{"key":"10.1016\/j.rvsc.2007.05.012_bib32","first-page":"943","article-title":"Muscarinic receptors in canine colonic circular smooth muscle. I. Coexistence of M2 and M3 subtypes","volume":"40","author":"Zhang","year":"1991","journal-title":"Molecular Pharmacology"}],"container-title":["Research in Veterinary Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034528807001427?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034528807001427?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T03:40:49Z","timestamp":1758512449000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0034528807001427"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["S0034528807001427"],"URL":"https:\/\/doi.org\/10.1016\/j.rvsc.2007.05.012","relation":{},"ISSN":["0034-5288"],"issn-type":[{"value":"0034-5288","type":"print"}],"subject":[],"published":{"date-parts":[[2008,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vitro effects of bethanechol on smooth muscle preparations from abomasal fundus, corpus, and antrum of dairy cows","name":"articletitle","label":"Article Title"},{"value":"Research in Veterinary Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rvsc.2007.05.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}