{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:16:43Z","timestamp":1792131403929,"version":"4.4.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research in Veterinary Science"],"published-print":{"date-parts":[[2010,2]]},"DOI":"10.1016\/j.rvsc.2009.05.007","type":"journal-article","created":{"date-parts":[[2009,6,6]],"date-time":"2009-06-06T04:09:31Z","timestamp":1244261371000},"page":"107-110","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"title":["Anthelmintic activity of artesunate against Fasciola hepatica in naturally infected sheep"],"prefix":"10.1016","volume":"88","author":[{"given":"Jennifer","family":"Keiser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Veneziano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Rinaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Mezzino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urs","family":"Duthaler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Cringoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rvsc.2009.05.007_bib1","unstructured":"China Cooperative Research Group on qinghaosu and its derivatives as antimalarials 1982. Studies on the toxicity of qinghaosu and its derivatives. J. Tradit. Chin. Med. 2, 31\u201338."},{"key":"10.1016\/j.rvsc.2009.05.007_bib2","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0940-2993(99)80128-6","article-title":"Differential effects of orally versus parenterally administered qinghaosu derivative artemether in dogs","volume":"51","author":"Classen","year":"1999","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.rvsc.2009.05.007_bib4","first-page":"381","article-title":"FLOTAC, a novel apparatus for a multivalent faecal egg count technique","volume":"48","author":"Cringoli","year":"2006","journal-title":"Parassitologia"},{"key":"10.1016\/j.rvsc.2009.05.007_bib3","unstructured":"Cringoli, G. (Ed.), 2009. FLOTAC\u00ae Manual \u2013 Flotac techniques \u2013 Herbivores, 80p. ISBN 978-88-89132-27-2."},{"key":"10.1016\/j.rvsc.2009.05.007_bib5","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.vetpar.2004.05.021","article-title":"The influence of flotation solution, sample dilution and the choice of McMaster slide area (volume) on the reliability of the McMaster technique in estimating the faecal egg counts of gastrointestinal strongyles and Dicrocoelium dendriticum in sheep","volume":"123","author":"Cringoli","year":"2004","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.rvsc.2009.05.007_bib6","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1017\/S0022149X08982602","article-title":"Screening for Indian isolates of egg-parasitic fungi for use in biological control of fascioliasis and amphistomiasis in ruminant livestock","volume":"82","author":"De","year":"2008","journal-title":"J. Helminthol."},{"key":"10.1016\/j.rvsc.2009.05.007_bib7","doi-asserted-by":"crossref","first-page":"388","DOI":"10.4269\/ajtmh.2008.78.388","article-title":"A randomized controlled pilot study of artesunate versus triclabendazole for human fascioliasis in central Vietnam","volume":"78","author":"Hien","year":"2008","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.rvsc.2009.05.007_bib8","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.exppara.2007.12.015","article-title":"Fasciola hepatica: tegumental alterations in adult flukes following in vitro and in vivo administration of artesunate and artemether","volume":"119","author":"Keiser","year":"2008","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.rvsc.2009.05.007_bib9","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.3201\/eid1110.050614","article-title":"Emerging foodborne trematodiasis","volume":"11","author":"Keiser","year":"2005","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.rvsc.2009.05.007_bib10","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1517\/17460441.2.S1.S9","article-title":"Advances in the discovery and development of novel trematocidal drugs","volume":"2","author":"Keiser","year":"2007","journal-title":"Expert Opin. Drug Discov."},{"key":"10.1016\/j.rvsc.2009.05.007_bib11","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.pt.2007.07.012","article-title":"Food-borne trematodiasis: current chemotherapy and advances with artemisinins and synthetic trioxolanes","volume":"23","author":"Keiser","year":"2007","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.rvsc.2009.05.007_bib12","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1517\/13543784.14.12.1513","article-title":"Triclabendazole for the treatment of fascioliasis and paragonimiasis","volume":"14","author":"Keiser","year":"2005","journal-title":"Expert Opin. Invest. Drugs"},{"key":"10.1016\/j.rvsc.2009.05.007_bib13","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1093\/jac\/dkl125","article-title":"Artesunate and artemether are effective fasciolicides in the rat model and in vitro","volume":"57","author":"Keiser","year":"2006","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.rvsc.2009.05.007_bib14","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1093\/jac\/dkl408","article-title":"The synthetic peroxide OZ78 is effective against Echinostoma caproni and Fasciola hepatica","volume":"58","author":"Keiser","year":"2006","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.rvsc.2009.05.007_bib15","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/j.trstmh.2007.07.012","article-title":"Activity of artemether and OZ78 against triclabendazole-resistant Fasciola hepatica","volume":"101","author":"Keiser","year":"2007","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.rvsc.2009.05.007_bib16","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s00436-008-0998-0","article-title":"Efficacy and safety of artemether against a natural Fasciola hepatica infection in sheep","volume":"103","author":"Keiser","year":"2008","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.rvsc.2009.05.007_bib17","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1093\/jac\/dkn550","article-title":"Pharmacokinetic parameters of artesunate and dihydroartemisinin in Fasciola hepatica-infected rats","volume":"63","author":"Keiser","year":"2009","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.rvsc.2009.05.007_bib18","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/j.2042-7158.1998.tb06173.x","article-title":"The pharmacokinetics and bioavailability of dihydroartemisinin, arteether, artemether, artesunic acid and artelinic acid in rats","volume":"50","author":"Li","year":"1998","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.rvsc.2009.05.007_bib19","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.trstmh.2006.04.010","article-title":"Toxicity evaluation of artesunate and artelinate in Plasmodium berghei-infected and uninfected rats","volume":"101","author":"Li","year":"2007","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.rvsc.2009.05.007_bib20","unstructured":"Martindah, E., Cameron, D., Frank, B., 2003. Participative approaches to enhance adoption of fascioliasis control strategies in cattle in Yokyakarta province, Indonesia. International Farm Management Congress."},{"issue":"Suppl.","key":"10.1016\/j.rvsc.2009.05.007_bib21","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1017\/S0031182006001806","article-title":"Vaccines against the zoonotic trematodes Schistosoma japonicum, Fasciola hepatica and Fasciola gigantica","volume":"133","author":"McManus","year":"2006","journal-title":"Parasitology"},{"key":"10.1016\/j.rvsc.2009.05.007_bib22","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0304-4017(82)90123-6","article-title":"Ecological basis of parasite control: trematodes with special reference to fascioliasis","volume":"11","author":"Over","year":"1982","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.rvsc.2009.05.007_bib23","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1136\/vr.157.7.188","article-title":"Estimating the financial losses due to bovine fasciolosis in Switzerland","volume":"157","author":"Schweizer","year":"2005","journal-title":"Vet. Rec."},{"key":"10.1016\/j.rvsc.2009.05.007_bib24","series-title":"Fasciolosis","first-page":"113","article-title":"Epidemiology and control","author":"Torgerson","year":"1999"},{"key":"10.1016\/j.rvsc.2009.05.007_bib25","first-page":"105","article-title":"Artemisinins for schistosomiasis and beyond","volume":"8","author":"Utzinger","year":"2007","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"10.1016\/j.rvsc.2009.05.007_bib26","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1038\/nature02779","article-title":"Identification of an antimalarial synthetic trioxolane drug development candidate","volume":"430","author":"Vennerstrom","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.rvsc.2009.05.007_bib27","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1126\/science.1155165","article-title":"Qinghaosu (artemisinin): the price of success","volume":"320","author":"White","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.rvsc.2009.05.007_bib28","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0304-4017(95)00806-2","article-title":"World Association for the advancement of veterinary parasitology (W.A.A.V.P.) second edition of guidelines for evaluating the efficacy of anthelmintics in ruminants (bovine, ovine, caprine)","volume":"58","author":"Wood","year":"1995","journal-title":"Vet. Parasitol."}],"container-title":["Research in Veterinary Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034528809001337?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034528809001337?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T03:48:11Z","timestamp":1758512891000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0034528809001337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["S0034528809001337"],"URL":"https:\/\/doi.org\/10.1016\/j.rvsc.2009.05.007","relation":{},"ISSN":["0034-5288"],"issn-type":[{"value":"0034-5288","type":"print"}],"subject":[],"published":{"date-parts":[[2010,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anthelmintic activity of artesunate against Fasciola hepatica in naturally infected sheep","name":"articletitle","label":"Article Title"},{"value":"Research in Veterinary Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rvsc.2009.05.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}