{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:01:19Z","timestamp":1760781679842,"version":"3.44.0"},"reference-count":55,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research in Veterinary Science"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1016\/j.rvsc.2011.07.018","type":"journal-article","created":{"date-parts":[[2011,8,22]],"date-time":"2011-08-22T03:24:03Z","timestamp":1313983443000},"page":"336-342","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Effects of Solanum glaucophyllum toxicity on cell proliferation and apoptosis in the small and large intestine of rabbits"],"prefix":"10.1016","volume":"93","author":[{"given":"C.N.","family":"Zanuzzi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Nishida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.L.","family":"Portiansky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.A.","family":"Fontana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.J.","family":"Gimeno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.G.","family":"Barbeito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"year":"1990","series-title":"Theory and Practice of Histological Techniques","author":"Bancroft","key":"10.1016\/j.rvsc.2011.07.018_b0005"},{"key":"10.1016\/j.rvsc.2011.07.018_b0010","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1053\/jcpa.2000.0415","article-title":"Cell differentiation and bone protein synthesis in the lungs of sheep with spontaneous calcinosis","volume":"123","author":"Barros","year":"2000","journal-title":"Journal of Comparative Pathology"},{"key":"10.1016\/j.rvsc.2011.07.018_b0015","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1097\/BOR.0b013e32818e9d58","article-title":"What is new in vitamin D: 2006\u20132007","volume":"19","author":"Bikle","year":"2007","journal-title":"Current Opinion in Rheumatology"},{"key":"10.1016\/j.rvsc.2011.07.018_b0020","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1210\/jc.2008-1454","article-title":"Nonclassic actions of vitamin D","volume":"94","author":"Bikle","year":"2008","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.rvsc.2011.07.018_b0025","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1203\/00006450-200205000-00014","article-title":"Polyamine participation in the maturation of glycoprotein fucosylation, but not sialylation, in rat small intestine","volume":"51","author":"Biol-N\u2019 Garagba","year":"2002","journal-title":"Pediatric Research"},{"key":"10.1016\/j.rvsc.2011.07.018_b0030","first-page":"161","article-title":"Isolation of the Vitamin D3 metabolites from Solanum malacoxylon leaf extracts incubated with ruminal fluid","volume":"1","author":"Boland","year":"1986","journal-title":"Planta Medica"},{"key":"10.1016\/j.rvsc.2011.07.018_b0035","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1152\/ajpgi.00358.2006","article-title":"Chronic psychological stress alters epithelial cell turn over in rat ileum","volume":"292","author":"Boudry","year":"2007","journal-title":"American Journal of Physiology. Gastrointestinal and Liver Physiology"},{"key":"10.1016\/j.rvsc.2011.07.018_b0275","first-page":"238","article-title":"A case of Solanum malacoxylon toxicity in pigs","volume":"32","author":"Campero","year":"1990","journal-title":"Veterinary and Human Toxicology"},{"key":"10.1016\/j.rvsc.2011.07.018_b0040","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1023\/A:1022849112100","article-title":"Effects of incremental starvation on gut mucosa","volume":"48","author":"Chappell","year":"2003","journal-title":"Digestive Diseases and Sciences"},{"key":"10.1016\/j.rvsc.2011.07.018_b0045","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/j.1751-0813.2001.tb12987.x","article-title":"1,25 (OH)2 vitamin D concentration in the plasma of Solanum glaucophyllum-treated rabbits","volume":"79","author":"Dallorso","year":"2001","journal-title":"Australian Veterinary Journal"},{"key":"10.1016\/j.rvsc.2011.07.018_b0050","first-page":"4635","article-title":"Calcium intake and body weight","volume":"85","author":"Davies","year":"2000","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.rvsc.2011.07.018_b0055","first-page":"2304","article-title":"Apoptosis is induced by the active metabolite of vitamin D3 and its analogue EB1089 in colorectal adenoma and carcinoma cells: possible implications for prevention and therapy","volume":"60","author":"D\u00edaz","year":"2000","journal-title":"Cancer Research"},{"key":"10.1016\/j.rvsc.2011.07.018_b0060","doi-asserted-by":"crossref","first-page":"4614","DOI":"10.3748\/wjg.v12.i29.4614","article-title":"Intestinal mucosal adaptation","volume":"12","author":"Drozdowski","year":"2006","journal-title":"World Journal of Gastroenterology"},{"key":"10.1016\/j.rvsc.2011.07.018_b0065","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0300-9629(84)90156-7","article-title":"Ontogenesis of the rabbit intestinal receptor for 1, 25-dihydroxyvitamin D3\u2013evidence for increased receptor content during late suckling and lactating periods","volume":"78","author":"Duncan","year":"1984","journal-title":"Comparative Biochemistry and Physiology. A, Comparative Physiology"},{"key":"10.1016\/j.rvsc.2011.07.018_b0070","first-page":"47","article-title":"Cambios estructurales y funcionales de \u00f3rganos y c\u00e9lulas del sistema inmune de bovinos experimentalmente intoxicados con Solanum glaucophyllum","volume":"88","author":"Fontana","year":"2007","journal-title":"Revista de Medicina Veterinaria"},{"key":"10.1016\/j.rvsc.2011.07.018_b0075","unstructured":"Fontana, P.A., 2010. Evaluaci\u00f3n morfol\u00f3gica y funcional del sistema inmune y de c\u00e9lulas asociadas al mismo, en animales intoxicados con Solanum glaucophyllum. PhD degree thesis. School of Veterinary Medicine. National University of La Plata."},{"key":"10.1016\/j.rvsc.2011.07.018_b0080","first-page":"267","article-title":"Evaluation of immunotoxic effects of plant-induced hypervitaminosis D on cattle thymus","volume":"27","author":"Fontana","year":"2009","journal-title":"Pesquisa Veterin\u00e1ria Brasileira"},{"key":"10.1016\/j.rvsc.2011.07.018_b0085","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1046\/j.1439-0442.2000.00279.x","article-title":"Effects of plant-induced hypervitaminosis D on cutaneous structure, cell differentiation and cell proliferation in cattle","volume":"47","author":"Gimeno","year":"2000","journal-title":"Journal of Veterinary Medicine A"},{"key":"10.1016\/j.rvsc.2011.07.018_b0090","series-title":"Poisonous plants and related toxins (CAB-International): Commonwealth Agricultural Bureau","first-page":"84","article-title":"Calcinosis in ruminants due to plant poisoning. Contributions on the pathogenesis","author":"Gimeno","year":"2004"},{"key":"10.1016\/j.rvsc.2011.07.018_b0095","unstructured":"Gomar, M.S., 2006. Efectos de la hipervitaminosis D vegetal en la diferenciaci\u00f3n y proliferaci\u00f3n celulares cut\u00e1neas, a\u00f3rticas y pulmonares del conejo. Doctoral Thesis, School of Veterinary Sciences, National University of La Plata, 2006."},{"key":"10.1016\/j.rvsc.2011.07.018_b0100","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1159\/000199657","article-title":"Influence of stress on epithelial cell proliferation in the gut mucosa of rats","volume":"40","author":"Greant","year":"1988","journal-title":"Digestion"},{"key":"10.1016\/j.rvsc.2011.07.018_b0105","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1080\/07315724.2002.10719213","article-title":"Calcium and Weight: Clinical studies","volume":"21","author":"Heaney","year":"2002","journal-title":"Journal of American College of Nutrition"},{"key":"10.1016\/j.rvsc.2011.07.018_b0110","doi-asserted-by":"crossref","first-page":"4580","DOI":"10.1128\/IAI.69.7.4580-4589.2001","article-title":"Decreased apoptosis in the ileum and ileal Peyer\u2019s patches: a feature after infection with rabbit enteropathogenic Escherichia coli O103","volume":"69","author":"Heczko","year":"2001","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.rvsc.2011.07.018_b0115","first-page":"124","article-title":"Ileal hyperplastic response to starvation in the rat","volume":"251","author":"Holt","year":"1986","journal-title":"American Journal of Physiology"},{"key":"10.1016\/j.rvsc.2011.07.018_b0120","first-page":"113","article-title":"Colonic epithelial cell proliferation decreases with increasing levels of serum 25-hydroxy vitamin D","volume":"11","author":"Holt","year":"2002","journal-title":"Cancer Epidemiology, Biomarkers and Prevention"},{"key":"10.1016\/j.rvsc.2011.07.018_b0125","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/cncr.21618","article-title":"Calcium plus vitamin D alters preneoplastic features of colorectal adenomas and rectal mucosa","volume":"106","author":"Holt","year":"2006","journal-title":"Cancer"},{"key":"10.1016\/j.rvsc.2011.07.018_b0130","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1152\/ajpgi.00398.2007","article-title":"Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier","volume":"294","author":"Kong","year":"2008","journal-title":"American Journal of Physiology. Gastrointestinal and Liver Physiology"},{"key":"10.1016\/j.rvsc.2011.07.018_b0135","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.taap.2006.10.005","article-title":"1,25-Dihydroxyvitamin D3 regulates genes responsible for detoxification in intestine","volume":"218","author":"Kutuzova","year":"2007","journal-title":"Toxicology and Applied Pharmacology"},{"key":"10.1016\/j.rvsc.2011.07.018_b0140","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.arr.2007.02.002","article-title":"Premature aging in klotho mutant mice: Cause or consequence?","volume":"6","author":"Lanske","year":"2007","journal-title":"Ageing Research Reviews"},{"key":"10.1016\/j.rvsc.2011.07.018_b0145","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.domaniend.2006.05.008","article-title":"Effects of gestation and lactation on vitamin D receptor amounts in goat and sheep","volume":"33","author":"Liesegang","year":"2007","journal-title":"Domestic Animal Endocrinology"},{"key":"10.1016\/j.rvsc.2011.07.018_b0150","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1083\/jcb.200803024","article-title":"FGF-23-Klotho signaling stimulates proliferation and prevents vitamin D-induced apoptosis","volume":"182","author":"Medici","year":"2008","journal-title":"The Journal of Cell Biology"},{"key":"10.1016\/j.rvsc.2011.07.018_b0155","first-page":"353","article-title":"Kalzinogene Pflanzen und der Inkubations Effekt durch Pansensaft","volume":"99","author":"Mello","year":"1992","journal-title":"Dtsch Tier\u00e4ztl Wochenschr"},{"key":"10.1016\/j.rvsc.2011.07.018_b0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0041-0101(02)00241-6","article-title":"Calcinosis-calcinogenic plants","volume":"41","author":"Mello","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.rvsc.2011.07.018_b0165","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1159\/000244232","article-title":"Effects of calcitriol on proliferation and differentiation of human fetal jejunum","volume":"68","author":"Menard","year":"1995","journal-title":"Biology of the Neonate"},{"key":"10.1016\/j.rvsc.2011.07.018_b0170","first-page":"2067","article-title":"Calcium, vitamin D and colon cancer","volume":"52","author":"Newmark","year":"1992","journal-title":"Cancer Research"},{"key":"10.1016\/j.rvsc.2011.07.018_b0175","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3181\/0706-RM-169","article-title":"Suppression of intestinal mucosal apoptosis by ghrelin in fasting rats","volume":"233","author":"Park","year":"2008","journal-title":"Experimental Biology and Medicine"},{"key":"10.1016\/j.rvsc.2011.07.018_b0180","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1136\/vr.150.2.42","article-title":"Collagenous and elastic system fibres in the aorta of cattle poisoned by Solanum glaucophyllum","volume":"150","author":"Portiansky","year":"2002","journal-title":"Veterinary Record"},{"key":"10.1016\/j.rvsc.2011.07.018_b0185","first-page":"54","article-title":"Regeneration in epithelial proliferative units as exemplified by small intestinal crypts","volume":"160","author":"Potten","year":"1991","journal-title":"Ciba Foundation Symposium"},{"key":"10.1016\/j.rvsc.2011.07.018_b0190","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/stem.150082","article-title":"Regulation and significance of apoptosis in the stem cells of the gastrointestinal epithelium","volume":"15","author":"Potten","year":"1997","journal-title":"Stem Cells"},{"key":"10.1016\/j.rvsc.2011.07.018_b0195","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1055\/s-2008-1074989","article-title":"The antirachitic activity of Solanum glaucophyllum leaves","volume":"40","author":"Puche","year":"1981","journal-title":"Planta Medica"},{"key":"10.1016\/j.rvsc.2011.07.018_b0200","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.molmed.2006.05.002","article-title":"Hypervitaminosis D and premature aging: lessons learned from Fgf23 and Klotho mutant mice","volume":"12","author":"Razzaque","year":"2006","journal-title":"Trends in Molecular Medicine"},{"key":"10.1016\/j.rvsc.2011.07.018_b0205","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/jmor.10574","article-title":"Vitamin D receptor distribution in intestines of domesticated sheep Ovis ammon f.aries","volume":"269","author":"Riner","year":"2008","journal-title":"Journal of Morphology"},{"key":"10.1016\/j.rvsc.2011.07.018_b0210","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1136\/gut.26.8.816","article-title":"Morphometric study of the small intestinal mucosa in young, adult, and old rats submitted to protein deficiency and rehabilitation","volume":"26","author":"Rodrigues","year":"1985","journal-title":"Gut"},{"key":"10.1016\/j.rvsc.2011.07.018_b0280","first-page":"597","article-title":"Enteque Seco en equinos, caprinos y ovinos","volume":"39","author":"Ruager","year":"1977","journal-title":"Gaceta Veterinaria"},{"key":"10.1016\/j.rvsc.2011.07.018_b0215","first-page":"113","article-title":"Hyperplasia, hyperproliferation and decreased migration rate of colonic epithelial cells in mice fed a diet deficient in vitamin D","volume":"87","author":"Sadava","year":"1996","journal-title":"Biocell"},{"key":"10.1016\/j.rvsc.2011.07.018_b0220","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1146\/annurev.nu.10.070190.001211","article-title":"The role of vitamin D in bone and intestinal cell differentiation","volume":"10","author":"Suda","year":"1990","journal-title":"Annual Review of Nutrition"},{"key":"10.1016\/j.rvsc.2011.07.018_b0225","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3109\/10520299609117171","article-title":"Comparative study of antigen retrieval heating methods: microwave, microwave and pressure cooker, autoclave, and steamer","volume":"71","author":"Taylor","year":"1996","journal-title":"Biotechnic and Histochemistry"},{"key":"10.1016\/j.rvsc.2011.07.018_b0230","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1136\/gut.33.12.1660","article-title":"Vitamin D and its metabolites inhibit cell proliferation in human rectal mucosa and a colon cancer cell line","volume":"33","author":"Thomas","year":"1992","journal-title":"Gut"},{"key":"10.1016\/j.rvsc.2011.07.018_b0235","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1152\/ajpgi.2000.279.5.G1037","article-title":"Selective sparing of goblet cells and Paneth cells in the intestine of metrotrexate-treated rats","volume":"279","author":"Verburg","year":"2000","journal-title":"American Journal of Physiology. Grastrointestinal and Liver Physiology"},{"key":"10.1016\/j.rvsc.2011.07.018_b0240","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1292\/jvms.59.815","article-title":"Apoptosis of enterocytes induced by inoculation of a strain of attaching and effacing Escherichia coli and verotoxin","volume":"59","author":"Wada","year":"1997","journal-title":"Journal of Veterinary Medical Science"},{"key":"10.1016\/j.rvsc.2011.07.018_b0245","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1126\/science.183.4129.1092","article-title":"Calcium absorption and calcium binding protein synthesis: Solanum malacoxylon reverses strontium inhibition","volume":"183","author":"Wasserman","year":"1974","journal-title":"Science"},{"key":"10.1016\/j.rvsc.2011.07.018_b0270","series-title":"Physiology of the gastrointestinal tract","first-page":"1753","article-title":"Vitamin D 3: synthesis, actions, and mechanisms in the intestine and colon","author":"Wesley","year":"2006"},{"key":"10.1016\/j.rvsc.2011.07.018_b0255","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/215072a0","article-title":"\u201cEnteque seco\u201d, calcification and wasting in grazing animals in the Argentine","volume":"215","author":"Worker","year":"1967","journal-title":"Nature"},{"key":"10.1016\/j.rvsc.2011.07.018_b0260","doi-asserted-by":"crossref","first-page":"93","DOI":"10.4081\/1193","article-title":"Paneth cells: histochemical and morphometric study in control and Solanum glaucophyllum-treated rabbits","volume":"52","author":"Zanuzzi","year":"2008","journal-title":"European Journal of Histochemistry"},{"key":"10.1016\/j.rvsc.2011.07.018_b0265","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.rvsc.2010.03.002","article-title":"Glycoconjugate histochemistry in the small and large intestine of normal and Solanum glaucophyllum-treated rabbits","volume":"89","author":"Zanuzzi","year":"2010","journal-title":"Research in Veterinary Science"}],"container-title":["Research in Veterinary Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034528811002700?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034528811002700?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T03:58:44Z","timestamp":1758513524000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0034528811002700"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S0034528811002700"],"URL":"https:\/\/doi.org\/10.1016\/j.rvsc.2011.07.018","relation":{},"ISSN":["0034-5288"],"issn-type":[{"type":"print","value":"0034-5288"}],"subject":[],"published":{"date-parts":[[2012,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of Solanum glaucophyllum toxicity on cell proliferation and apoptosis in the small and large intestine of rabbits","name":"articletitle","label":"Article Title"},{"value":"Research in Veterinary Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rvsc.2011.07.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}