{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T05:29:57Z","timestamp":1768541397155,"version":"3.49.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research in Veterinary Science"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1016\/j.rvsc.2013.02.013","type":"journal-article","created":{"date-parts":[[2013,3,26]],"date-time":"2013-03-26T23:43:39Z","timestamp":1364341419000},"page":"231-237","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Methadone in healthy goats \u2013 Pharmacokinetics, behaviour and blood pressure"],"prefix":"10.1016","volume":"95","author":[{"given":"L.","family":"Ols\u00e9n","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Olsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Hydbring-Sandberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Bondesson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Ingvast-Larsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.rvsc.2013.02.013_b0005","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1152\/ajplegacy.1956.188.1.178","article-title":"Hematocrit and erythrocyte volume determinations in the goat as related to spleen behavior","volume":"188","author":"Anderson","year":"1957","journal-title":"The American Journal of Physiology"},{"key":"10.1016\/j.rvsc.2013.02.013_b0010","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1467-2995.2011.00595.x","article-title":"Cardiovascular effects of epidural administration of methadone, ropivacaine 0.75% and their combination in isoflurane anaesthetized dogs","volume":"38","author":"Bosmans","year":"2011","journal-title":"Veterinary Anaesthesia and Analgesia"},{"key":"10.1016\/j.rvsc.2013.02.013_b0015","doi-asserted-by":"crossref","first-page":"716","DOI":"10.2460\/ajvr.1981.42.05.716","article-title":"Pharmacology of narcotic analgesics in the horse: selective blockade of narcotic-induced locomotor activity","volume":"42","author":"Combie","year":"1981","journal-title":"American Journal of Veterinary Research"},{"key":"10.1016\/j.rvsc.2013.02.013_b0020","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/j.1467-2995.2010.00528.x","article-title":"Effects of methadone on the minimum alveolar concentration of isoflurane in dogs","volume":"37","author":"Credie","year":"2010","journal-title":"Veterinary Anaesthesia and Analgesia"},{"key":"10.1016\/j.rvsc.2013.02.013_b0025","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1186\/BF03548334","article-title":"Intraruminal fluid administration to goats: effects of handling and fluid temperature","volume":"35","author":"Eriksson","year":"1994","journal-title":"Acta Veterinaria Scandinavia"},{"key":"10.1016\/j.rvsc.2013.02.013_b0030","doi-asserted-by":"crossref","first-page":"764","DOI":"10.2460\/ajvr.72.6.764","article-title":"Plasma concentrations and behavioral, antinociceptive, and physiologic effects of methadone after intravenous and oral transmucosal administration in cats","volume":"72","author":"Ferreira","year":"2011","journal-title":"American Journal of Veterinary Research"},{"key":"10.1016\/j.rvsc.2013.02.013_b0035","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.tvjl.2012.03.019","article-title":"Cardiorespiratory and neuroendocrine changes induced by methadone in conscious and in isoflurane anaesthetised dogs","volume":"194","author":"Garofalo","year":"2012","journal-title":"Veterinary Journal"},{"key":"10.1016\/j.rvsc.2013.02.013_b0040","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0022-3565(24)37940-6","article-title":"Altered plasma and brain disposition and pharmacodynamics of methadone in abstinent rats","volume":"288","author":"Garrido","year":"1999","journal-title":"The Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.rvsc.2013.02.013_b0045","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1751-0813.1996.tb10004.x","article-title":"Efficacy of intra-muscular analgesics for acute pain in sheep","volume":"73","author":"Grant","year":"1996","journal-title":"Australian Veterinary Journal"},{"key":"10.1016\/j.rvsc.2013.02.013_b0050","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0022-3565(25)23653-9","article-title":"Plasma arginine vasopressin response to intravenous methadone and naloxone in conscious dogs","volume":"248","author":"Hellebrekers","year":"1989","journal-title":"The Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.rvsc.2013.02.013_b0055","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1046\/j.1365-201X.1997.00223.x","article-title":"Radiotelemetrically recorded blood pressure and heart rate changes in relation to plasma catecholamine levels during parturition in the conscious, unrestrained goat","volume":"161","author":"Hydbring","year":"1997","journal-title":"Acta Physiologica Scandinavica"},{"key":"10.1016\/j.rvsc.2013.02.013_b0255","series-title":"A resorbable device for ligation of blood vessels","isbn-type":"print","author":"H\u00f6glund","year":"2012","ISBN":"https:\/\/id.crossref.org\/isbn\/9789157676863"},{"key":"10.1016\/j.rvsc.2013.02.013_b0065","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1467-2995.2009.00476.x","article-title":"Clinical pharmacology of methadone in dogs","volume":"37","author":"Ingvast-Larsson","year":"2010","journal-title":"Veterinary Anaesthesia and Analgesia"},{"key":"10.1016\/j.rvsc.2013.02.013_b0070","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1365-2885.2007.00858.x","article-title":"Clinical pharmacology of buprenorphine in healthy, lactating goats","volume":"30","author":"Ingvast-Larsson","year":"2007","journal-title":"Journal of Veterinary Pharmacology and Therapeutics"},{"key":"10.1016\/j.rvsc.2013.02.013_b0075","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/0041-008X(87)90138-4","article-title":"Mechanism of hematocrit increase induced by the combined administration of morphine and adriamycin: role of histamine release","volume":"90","author":"Innis","year":"1987","journal-title":"Toxicology and Applied Pharmacology"},{"key":"10.1016\/j.rvsc.2013.02.013_b0080","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/clpt.1990.77","article-title":"Pharmacokinetic-pharmacodynamic relationships of methadone infusions in patients with cancer pain","volume":"47","author":"Inturrisi","year":"1990","journal-title":"Clinical Pharmacology and Therapeutics"},{"key":"10.1016\/j.rvsc.2013.02.013_b0085","first-page":"212","article-title":"Pharmacokinetics of oxymorphone in titi monkeys (Callicebus spp.) and rhesus macaques (Macaca mulatta)","volume":"50","author":"Kelly","year":"2011","journal-title":"Journal of the American Association for Laboratory Animal Science"},{"key":"10.1016\/j.rvsc.2013.02.013_b0090","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1097\/00000542-200003000-00023","article-title":"An experimental itch model in monkeys: characterization of intrathecal morphine-induced scratching and antinociception","volume":"92","author":"Ko","year":"2000","journal-title":"Anesthesiology"},{"key":"10.1016\/j.rvsc.2013.02.013_b0095","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1124\/jpet.103.061101","article-title":"The role of central mu opioid receptors in opioid-induced itch in primates","volume":"310","author":"Ko","year":"2004","journal-title":"The Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.rvsc.2013.02.013_b0100","first-page":"503","article-title":"Pharmacokinetic properties of methadone hydrochloride after single intramuscular administration in adult dairy goats","volume":"44","author":"Kock","year":"1994","journal-title":"Laboratory Animal Science"},{"key":"10.1016\/j.rvsc.2013.02.013_b0105","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/j.1467-2995.2007.00369.x","article-title":"The disposition and behavioral effects of methadone in greyhounds","volume":"35","author":"Kukanich","year":"2008","journal-title":"Veterinary Anaesthesia and Analgesia"},{"key":"10.1016\/j.rvsc.2013.02.013_b0110","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/j.1365-2885.2005.00681.x","article-title":"The effects of inhibiting cytochrome p450 3a, p-glycoprotein, and gastric acid secretion on the oral bioavailability of methadone in dogs","volume":"28","author":"Kukanich","year":"2005","journal-title":"Journal of Veterinary Pharmacology and Therapeutics"},{"key":"10.1016\/j.rvsc.2013.02.013_b0115","series-title":"Veterinary Pharmacology and Therapeutics","first-page":"307","article-title":"Opioid analgesic drugs","author":"Kukanich","year":"2009"},{"key":"10.1016\/j.rvsc.2013.02.013_b0120","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1111\/j.1365-2885.2008.00987.x","article-title":"Pharmacokinetics and behavioral effects of oxymorphone after intravenous and subcutaneous administration to healthy dogs","volume":"31","author":"Kukanich","year":"2008","journal-title":"Journal of Veterinary Pharmacology and Therapeutics"},{"key":"10.1016\/j.rvsc.2013.02.013_b0125","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0022-3565(25)32504-8","article-title":"Methadone: radioimmunoassay and pharmacokinetics in the rat","volume":"217","author":"Ling","year":"1981","journal-title":"The Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.rvsc.2013.02.013_b0130","first-page":"170","article-title":"The effects of droperidol on fentanyl induced dysphoria in the sheep","author":"Livingston","year":"1991","journal-title":"Acta Veterinaria Scandinavica"},{"key":"10.1016\/j.rvsc.2013.02.013_b0135","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/1056-8719(94)00051-5","article-title":"A method for frequent measurement of sedation and analgesia in sheep using the response to a ramped electrical stimulus","volume":"33","author":"Ludbrook","year":"1995","journal-title":"Journal of Pharmacological and Toxicological Methods"},{"key":"10.1016\/j.rvsc.2013.02.013_b0140","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1365-2885.2008.01042.x","article-title":"Comparison of the cardio-respiratory effects of methadone and morphine in conscious dogs","volume":"32","author":"Maiante","year":"2009","journal-title":"Journal of Veterinary Pharmacology and Therapeutics"},{"key":"10.1016\/j.rvsc.2013.02.013_b0145","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/BF00542102","article-title":"Single dose pharmacokinetics and bioavailability of methadone in man studied with a stable isotope method","volume":"20","author":"Meresaar","year":"1981","journal-title":"European Journal of Clinical Pharmacology"},{"key":"10.1016\/j.rvsc.2013.02.013_b0150","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/j.1467-2995.2008.00412.x","article-title":"Effects of methadone, alone or in combination with acepromazine or xylazine, on sedation and physiologic values in dogs","volume":"35","author":"Monteiro","year":"2008","journal-title":"Veterinary Anaesthesia and Analgesia"},{"key":"10.1016\/j.rvsc.2013.02.013_b0155","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1467-2995.2008.00424.x","article-title":"Comparative study on the sedative effects of morphine, methadone, butorphanol or tramadol, in combination with acepromazine, in dogs","volume":"36","author":"Monteiro","year":"2009","journal-title":"Veterinary Anaesthesia and Analgesia"},{"key":"10.1016\/j.rvsc.2013.02.013_b0160","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.1439-0442.2005.00710.x","article-title":"Anti-nociceptive efficacy of carprofen, levomethadone and buprenorphine for pain relief in cats following major orthopaedic surgery","volume":"52","author":"M\u00f6llenhoff","year":"2005","journal-title":"Journal of Veterinary Medicine A, Physiology, Pathology, Clinical Medicine"},{"key":"10.1016\/j.rvsc.2013.02.013_b0165","doi-asserted-by":"crossref","first-page":"941","DOI":"10.2460\/ajvr.67.6.941","article-title":"Analgesic effects of subarachnoidally administered hyperbaric opioids in horses","volume":"67","author":"Natalini","year":"2006","journal-title":"American Journal of Veterinary Research"},{"key":"10.1016\/j.rvsc.2013.02.013_b0170","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0022-3565(25)32252-4","article-title":"The effects of methadone on respiration and ventilation in pygmy goats","volume":"215","author":"Neal","year":"1980","journal-title":"The Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.rvsc.2013.02.013_b0175","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1111\/j.1476-5381.1987.tb11353.x","article-title":"Investigation of the antinociceptive activity of buprenorphine in sheep","volume":"92","author":"Nolan","year":"1987","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.rvsc.2013.02.013_b0180","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1046\/j.1467-2995.2003.00145.x","article-title":"A comparison of the analgesic effects of caudal epidural methadone and lidocaine in the horse","volume":"30","author":"Olbrich","year":"2003","journal-title":"Veterinary Anaesthesia and Analgesia"},{"key":"10.1016\/j.rvsc.2013.02.013_b0185","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1113\/eph8602078","article-title":"A serial study of heart function during pregnancy, lactation and the dry period in dairy goats using echocardiography","volume":"86","author":"Olsson","year":"2001","journal-title":"Experimental Physiology"},{"key":"10.1016\/j.rvsc.2013.02.013_b0190","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1023\/A:1016117218760","article-title":"Sex specificity in methadone analgesia in the rat: a population pharmacokinetic and pharmacodynamic approach","volume":"19","author":"Rodriguez","year":"2002","journal-title":"Pharmaceutical Research"},{"key":"10.1016\/j.rvsc.2013.02.013_b0195","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.1002\/jps.20171","article-title":"Alpha-1-acid glycoprotein directly affects the pharmacokinetics and the analgesic effect of methadone in the rat beyond protein binding","volume":"93","author":"Rodriguez","year":"2004","journal-title":"Journal of Pharmaceutical Sciences"},{"key":"10.1016\/j.rvsc.2013.02.013_b0200","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1467-2987.2004.00148.x","article-title":"Comparison of perioperative racemic methadone, levo-methadone and dextromoramide in cats using indicators of post-operative pain","volume":"31","author":"Rohrer Bley","year":"2004","journal-title":"Veterinary Anaesthesia and Analgesia"},{"key":"10.1016\/j.rvsc.2013.02.013_b0205","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/j.1365-2885.2006.00800.x","article-title":"Effects of subcutaneous methadone, morphine, buprenorphine or saline on thermal and pressure thresholds in cats","volume":"29","author":"Steagall","year":"2006","journal-title":"Journal of Veterinary Pharmacology and Therapeutics"},{"key":"10.1016\/j.rvsc.2013.02.013_b0210","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1124\/jpet.103.056515","article-title":"Opioid interactions in rhesus monkeys: effects of delta + mu and delta + kappa agonists on schedule-controlled responding and thermal nociception","volume":"307","author":"Stevenson","year":"2003","journal-title":"The Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.rvsc.2013.02.013_b0215","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0006-8993(92)91227-6","article-title":"Effects of central administration of opioids on facial scratching in monkeys","volume":"585","author":"Thomas","year":"1992","journal-title":"Brain Research"},{"key":"10.1016\/j.rvsc.2013.02.013_b0220","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/j.1365-2885.1994.tb00278.x","article-title":"Plasma concentrations and therapeutic efficacy of phenylbutazone and flunixin meglumine in the horse: pharmacokinetic\/pharmacodynamic modelling","volume":"17","author":"Toutain","year":"1994","journal-title":"Journal of Veterinary Pharmacology and Therapeutics"},{"key":"10.1016\/j.rvsc.2013.02.013_b0225","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1365-2885.2004.00613.x","article-title":"Integration and modelling of pharmacokinetic and pharmacodynamic data to optimize dosage regimens in veterinary medicine","volume":"27","author":"Toutain","year":"2004","journal-title":"Journal of Veterinary Pharmacology and Therapeutics"},{"key":"10.1016\/j.rvsc.2013.02.013_b0230","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/j.1532-950X.1996.tb01410.x","article-title":"Experiences with morphine injected into the subarachnoid space in sheep","volume":"25","author":"Wagner","year":"1996","journal-title":"Veterinary Surgery"},{"key":"10.1016\/j.rvsc.2013.02.013_b0235","doi-asserted-by":"crossref","first-page":"813","DOI":"10.2460\/ajvr.70.7.813","article-title":"Use of epidurally derived evoked potentials for quantification of caudal nociception in ponies","volume":"70","author":"van Loon","year":"2009","journal-title":"American Journal of Veterinary Research"},{"key":"10.1016\/j.rvsc.2013.02.013_b0240","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.2042-3306.2009.00023.x","article-title":"Lumbosacral spinal cord somatosensory evoked potentials for quantification of nociception in horses","volume":"42","author":"van Loon","year":"2010","journal-title":"Equine Veterinary Journal"},{"key":"10.1016\/j.rvsc.2013.02.013_b0245","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0034-5288(91)90024-I","article-title":"Analgesic activity and respiratory effects of butorphanol in sheep","volume":"51","author":"Waterman","year":"1991","journal-title":"Research in Veterinary Science"},{"key":"10.1016\/j.rvsc.2013.02.013_b0250","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/j.1365-2885.1991.tb00831.x","article-title":"Further studies on the antinociceptive activity and respiratory effects of buprenorphine in sheep","volume":"14","author":"Waterman","year":"1991","journal-title":"Journal of Veterinary Pharmacology and Therapeutics"}],"container-title":["Research in Veterinary Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034528813000672?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034528813000672?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T03:53:15Z","timestamp":1758513195000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0034528813000672"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["S0034528813000672"],"URL":"https:\/\/doi.org\/10.1016\/j.rvsc.2013.02.013","relation":{},"ISSN":["0034-5288"],"issn-type":[{"value":"0034-5288","type":"print"}],"subject":[],"published":{"date-parts":[[2013,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Methadone in healthy goats \u2013 Pharmacokinetics, behaviour and blood pressure","name":"articletitle","label":"Article Title"},{"value":"Research in Veterinary Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rvsc.2013.02.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}